On the mechanisms of phenothiazine-induced mitochondrial permeability transition: Thiol oxidation, strict Ca2+ dependence, and cyt c release

Biochemical Pharmacology

Volumn 80, Issue 8, 2010, Pages 1284-1295

  Cruz, Thiago S ^a   Faria, Priscila A ^a,b   Santana, Débora P ^a   Ferreira, Juliana C ^c   Oliveira, Vitor ^c   Nascimento, Otaciro R ^d   Cerchiaro, Giselle ^b   Curti, Carlos ^d   Nantes, Iseli L ^a,b   Rodrigues, Tiago ^a,b  

^a UNIVERSIDADE DE MOGI DAS CRUZES   (Brazil)

^b UNIVERSIDADE FEDERAL DO ABC   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Calcium dependence; Cation radicals; Hepatotoxicity; Mitochondrial permeability transition; Phenothiazines; Thiol oxidation

Indexed keywords

CALCIUM ION; CYANIDE; CYCLOSPORIN A; CYTOCHROME C; FLUPHENAZINE; MAGNESIUM ION; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; PEROXIDASE; REACTIVE OXYGEN METABOLITE; THIOL GROUP; THIORIDAZINE; TRIFLUOPERAZINE; CALCIUM; CYCLOSPORIN; MAGNESIUM; PHENOTHIAZINE DERIVATIVE; THIOL DERIVATIVE;

ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME RELEASE; LIVER MITOCHONDRION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; MITOCHONDRIAL MEMBRANE; OXIDATION REDUCTION REACTION; PERMEABILITY; PHYSIOLOGY; WISTAR RAT;

ANIMALS; CALCIUM; CYANIDES; CYCLOSPORINE; CYTOCHROMES C; MAGNESIUM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE PROTEINS; MITOCHONDRIAL MEMBRANES; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PERMEABILITY; PEROXIDASES; PHENOTHIAZINES; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS;

EID: 77956225216     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.06.052     Document Type: Article

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