Formation of hydroxyl radicals in the human lens is related to the severity of nuclear cataract

Experimental Eye Research

Volumn 70, Issue 1, 2000, Pages 81-88

  Garner, Brett ^a   Davies, Michael J ^b   Truscott, Roger J W ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b HEART RESEARCH INSTITUTE   (Australia)

Author keywords

Ascorbyl radical; Cataract; EPR spectroscopy; Hydrogen peroxide; Hydroxyl radical; Metal ion; Protein oxidation

Indexed keywords

ASCORBIC ACID; HYDROGEN PEROXIDE; HYDROXYL RADICAL; METAL ION;

ARTICLE; CATARACT; CATARACTOGENESIS; CONTROLLED STUDY; DISEASE SEVERITY; ELECTRON SPIN RESONANCE; HUMAN; HUMAN TISSUE; LENS NUCLEUS; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0033977610     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.1999.0754     Document Type: Article

References (50)

1. Augusteyn R. C. Human lens albuminoid. Jap. J. Ophthalmol. 18:1974;127-134.
2. Berman, E. R. (1991). Biochemistry of the eye. Plenum Press, New York, U.S.A.
3. Buettner G. R. Spin trapping: ESR parameters of spin adducts. Free Radic. Biol. Med. 3:1987;259-303.
4. Bleau G., Giasson C., Brunette I. Measurement of hydrogen peroxide in biological samples containing high levels of ascorbic acid. Anal. Biochem. 263:1998;13-17.
5. Borkman R. F., Lerman S. Evidence for a free radical mechanism in aging and u.v.-irradiated ocular disease. Exp. Eye Res. 25:1977;303-309.
6. Cazzola M., Bergamaschi G., Tonon L., Arbustini E., Grasso M., Vercesi E., Barosi G., Bianchi P. E., Cairo G., Arosio P. Hereditary hyperferritinemia-cataract syndrome: Relationship between phenotypes and specific mutations in the iron-responsive element of ferritin light-chain mRNA. Blood. 90:1997;814-821.
7. Cekic O. Copper, lead, cadmium and calcium in cataractous lenses. Ophthal. Res. 30:1998;49-53.
8. Cekic O., Bardak Y., Totan Y., Kavakli S., Akyol O., Ozdemir O., Karel F. Nickel, chromium, manganese, iron and aluminium levels in human cataractous and normal lenses. Ophthal. Res. 31:1999;332-336.
9. Cook C. S., McGahan M. C. Copper concentration in cornea, iris, normal, and cataractous lenses and intraocular fluid of vertebrates. Curr. Eye Res. 5:1986;69-77.
10. 2exposure on lens morphology and biochemistry. Exp. Eye Res. 57:1993;156-167.
11. Davies, M. J. and Dean, R. T. (1997). Radical-Mediated Protein Oxidation. From Chemistry to Medicine. Oxford University Press, Oxford, United Kingdom.
12. Dische Z., Zil H. Studies on the oxidation of cysteine to cystine in lens proteins during cataract formation. Am. J. Ophthalmol. 34:1951;104-113.
13. Eaton, J. (1997). Is the lens canned? Free Radic. Biol. Med. 11, 201-13.
14. Eckhert C. D. Elemental concentrations in ocular tissues of various spacies. Exp. Eye Res. 37:1983;639-647.
15. Fecondo J. V., Augesteyn R. C. Superoxide dismutase, catalase and glutathione peroxidase in human cataractous lens. Exp. Eye Res. 36:1983;15-23.
16. Fu S., Dean R. T., Southan M., Truscott R. J. W. The hydroxyl radical in lens nuclear cataractogenesis. J. Biol. Chem. 273:1998;28603-28609.
17. Garland D. Role of site-specific, metal-catalyzed oxidation in lens aging and cataract. Exp. Eye Res. 50:1990;677-682.
18. Garland D., Zigler S. J., Kinoshita J. Structural changes in bovine lens crystallins induced by ascorbate, metal, and oxygen. Arch. Biochem. Biophys. 251:1986;771-776.
19. Garner B., Li W., Roberg K., Brunk U. T. On the cytoprotective role of ferritin in macrophages and its ability to enhance lysosomal stability. Free Rad. Res. 27:1997;487-500.
20. Garner M. H., Spector A. Selective oxidation of cysteine and methionine in normal and senile cataractous lenses. Proc. Natl. Acad. Sci. USA. 77:1980;1274-1277.
21. Guptasarma P., Balasubramanian D., Matsugo S., Saito I. Hydroxyl radical mediated damage to proteins, with special reference to the crystallins. Biochemistry. 31:1992;4296-4303.
22. Halliwell, B. and Gutteridge, J. M. C. (1989). Free Radicals in Biology and Medicine. Oxford University Press, Oxford, United Kingdom.
23. Huizinga A., Bot A. C. C., De Mul F. F. M., Vrensen G. F. J. M., Greve J. Local variation in absolute water content of human and rabbit eye lenses measured by Raman microspectroscopy. Exp. Eye Res. 48:1989;487-496.
24. Kupfer C, Underwood B., Gillen T. Leading causes of visual impairment world wide. Albert D. M., Jakobiec F. A. Principles and Practice of Ophthalmology Basic Science. 1994;W. B. Saunders & Co.
25. Lakomaa E. L., Eklund P. Trace element analysis of human cataractous lenses by neutron activation analysis and atomic absorption spectrometry with special reference to pseudo-exfoliation of the lens capsule. Ophthal. Res. 10:1978;302-306.
26. Lerman S., Borkman R. Spectroscopic evaluation and classification of the normal, aging, and cataractous lens. Ophthal. Res. 8:1976;335-353.
27. Lerman S., Kuck J. F., Borkman R., Saker E. Acceleration of an aging parameter (fluorogen) in the ocular lens. Ann. Ophthalmol. 5:1976;558-561.
28. Levi S., Santambrogio P., Cozzi A., Rovida E., Corsi B., Tamborini E., Spada S. The role of the L-chain in ferritin iron incorporation-studies of homo and heteropolymers. J. Mol. Biol. 238:1994;649-654.
29. Lohmann W., Schmehl W., Strobel J. Nuclear cataract: oxidative damage to the lens. Exp. Eye Res. 43:1986;859-862.
30. McCormick M. L., Buettner G. R., Britigan B. E. Endogenous superoxide dismutase levels regulate iron-dependent hydroxyl radical formation in escherichia coli exposed to hydrogen peroxide. J. Bacteriol. 180:1998;622-625.
31. Nath R., Srivastava S. K., Singh K. Accumulation of copper and inhibition of lactate dehydrogenase activity in human senile cataractous lens. Exp. Biology. 7:1969;25-26.
32. Pilas B., Sarna T., Kalyanaraman B., Swartz H. M. The effect of melanin on iron associated decomposition of hydrogen peroxide. Free Radic. Biol. Med. 4:1988;285-293.
33. Pirie A. Color and solubility of the proteins of human cataract. Invest. Ophthalmol. 7:1968;634-642.
34. Reddan J. R., Giblin F. J., Kadry R., Leverenz V. R., Pena J. T., Dziedzic D. C. Protection from oxidative insult in glutathione depleted lens epithelial cells. Exp. Eye Res. 68:1999;117-127.
35. Saxena, P., Saxena, A. K. and Monnier, V. M. (1998). Evidence of transition metal-catalyzed oxidation of ascorbate by advanced glycation end products in the cataractous human lens (abstract). Invest. Ophthalmol. Vis. Sci. 39, S-891.
36. Smith J. B., Jiang X. G., Abraham E. C. Identification of hydrogen peroxide oxidation sites of alpha-A- and alpha-B-crystallins. Free Rad. Res. 26:1997;103-111.
37. Spector A. Oxidative stress-induced cataract: mechanism of action. FASEB J. 9:1995;1173-1182.
38. Spector A., Garner W. H. Hydrogen peroxide and human cataract. Exp. Eye Res. 33:1981;673-681.
39. 2. Invest. Ophthalmol. Vis. Sci. 39:1998;1188-1197.
40. 2and photochemically induced cataract. Curr. Eye Res. 12:1993;163-179.
41. Swanson A. A., Truesdale A. W. Elemental analysis in normal and cataractous human lens tissue. Biochem. Biophys. Res. Comm. 45:1971;1488-1497.
42. Sweeney M. H. J., Truscott R. J. W. An impediment to glutathione diffusion in older normal human lenses: A possible precondition for nuclear cataract. Exp. Eye Res. 67:1998;587-595.
43. Truscott R. J. W., Augusteyn R. C. Changes in human lens proteins during nuclear cataract formation. Exp. Eye Res. 24:1977a;159-170.
44. Truscott R. J. W., Augusteyn R. C. Oxidative changes in human lens proteins during senile nuclear cataract formation. Biochim. Biophys. Acta. 492:1977b;43-52.
45. van Reyk D. M., Brown A. J., Jessup W., Dean R. T. Batch-to-batch variation of chelex-100 confounds metal-catalysed oxidation. Leaching of inhibitory compounds from a batch of chelex-100 and their removal by a pre-washing procedure. Free Rad. Res. 23:1995;533-535.
46. Vazquez S., Garner B., Sheil M. M., Truscott R. J. W. Characterisation of the major autoxidation products of 3-hydroxykynurenine under physiological conditions. Free Rad. Res. 1999;in the press.
47. Weil, J. A., Bolton, J. R. and Wertz, J. E. (1994). Electron paramagnetic resonance: Elementary theory and practical applications. John Wiley and Sons, New York, U.S.A.
48. Yugay M. T., Pereira P. C., Leiria F., Mota M. C. Oxidative damage to lens membranes induced by metal-catalyzed systems. Ophthal. Res. 28:1996;92-96.
49. 2and chelated iron. Free Radic. Biol. Med. 7:1989;499-505.
50. Zigman S., Schultz J. B., Schultz M. Measurement of oxygen production by in vitro human and animal lenses with an oxygen electrode. Curr. Eye Res. 17:1998;115-119.