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Volumn 32, Issue 1, 1996, Pages 30-38

Role of Oxygen Free Radicals in Cancer Development

Author keywords

Antioxidants; Apoptosis; DNA repair; Mutagenesis; Oxidative stress; p53; Tumour promotion

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CATALASE; FREE RADICAL; OXYGEN RADICAL; SUPEROXIDE DISMUTASE;

EID: 0029918901     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-8049(95)00531-5     Document Type: Review
Times cited : (801)

References (115)
  • 2
    • 0010471495 scopus 로고
    • Cellular defenses against damage from reactive oxygen species
    • Yu BP. Cellular defenses against damage from reactive oxygen species. Biol Rev 1994, 74, 139-162.
    • (1994) Biol Rev , vol.74 , pp. 139-162
    • Yu, B.P.1
  • 3
    • 0027276072 scopus 로고
    • Protein modification by oxidants and the role of proteolytic enzymes
    • Davies KJ. Protein modification by oxidants and the role of proteolytic enzymes. Biochem Soc Transact 1993, 21, 346-353.
    • (1993) Biochem Soc Transact , vol.21 , pp. 346-353
    • Davies, K.J.1
  • 4
    • 0027278557 scopus 로고
    • Instability and decay of the primary structure of DNA
    • Lindahl T. Instability and decay of the primary structure of DNA. Nature 1993, 362, 709-715.
    • (1993) Nature , vol.362 , pp. 709-715
    • Lindahl, T.1
  • 5
    • 0026636441 scopus 로고
    • Free radicals, antioxidants, and human disease: Where are we now?
    • Halliwell B, Gutteridge JMC, Cross CE. Free radicals, antioxidants, and human disease: Where are we now? J Lab Clin Med 1992, 119, 598-620.
    • (1992) J Lab Clin Med , vol.119 , pp. 598-620
    • Halliwell, B.1    Gutteridge, J.M.C.2    Cross, C.E.3
  • 6
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames NB, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993, 90, 7915-7922.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7915-7922
    • Ames, N.B.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 7
    • 0015254643 scopus 로고
    • Electron spin resonance studies of carcinogenesis
    • New York, Research Academic
    • Swartz HM. Electron spin resonance studies of carcinogenesis. In Advances in Cancer, Vol. 15. New York, Research Academic, 1972, 227-252.
    • (1972) Advances in Cancer , vol.15 , pp. 227-252
    • Swartz, H.M.1
  • 8
    • 0002718377 scopus 로고
    • Application of radiation chemistry to biology
    • New York, Academic Press
    • Bielinski BH, Gebieki JM. Application of radiation chemistry to biology. In Free Radicals in Biology, Vol. 3. New York, Academic Press, 1977.
    • (1977) In Free Radicals in Biology , vol.3
    • Bielinski, B.H.1    Gebieki, J.M.2
  • 9
    • 0019794990 scopus 로고
    • Mutation caused by human phagocytes
    • Weitzman SA, Stossel TP. Mutation caused by human phagocytes. Science 1981, 212, 546-547.
    • (1981) Science , vol.212 , pp. 546-547
    • Weitzman, S.A.1    Stossel, T.P.2
  • 10
    • 0019758243 scopus 로고
    • Free radicals in pharmacology and toxicology
    • Mason RP, Chignell CF. Free radicals in pharmacology and toxicology. Pharmacol Rev 1982, 33, 189-211.
    • (1982) Pharmacol Rev , vol.33 , pp. 189-211
    • Mason, R.P.1    Chignell, C.F.2
  • 11
    • 0021919104 scopus 로고
    • Cigarette-smoke induced DNA single-strand breaks in human cells
    • Nakayama T, Nagata C, Kodama M, Kaneko MK. Cigarette-smoke induced DNA single-strand breaks in human cells. Nature 1985, 314, 462-464.
    • (1985) Nature , vol.314 , pp. 462-464
    • Nakayama, T.1    Nagata, C.2    Kodama, M.3    Kaneko, M.K.4
  • 12
    • 0020508747 scopus 로고
    • Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases
    • Ames NB. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 1983, 221, 1256-1264.
    • (1983) Science , vol.221 , pp. 1256-1264
    • Ames, N.B.1
  • 13
    • 0027194309 scopus 로고
    • Oxidative mechanisms in carcinogenesis
    • Guyton KZ, Kensler TW. Oxidative mechanisms in carcinogenesis. Brit Med Bull 1993, 49, 523-544.
    • (1993) Brit Med Bull , vol.49 , pp. 523-544
    • Guyton, K.Z.1    Kensler, T.W.2
  • 14
    • 0028345763 scopus 로고
    • Reactive oxygen species in tumorigenesis
    • Feig DI, Reid TM, Loeb LA. Reactive oxygen species in tumorigenesis. Cancer Res 1994, 54, 1890s-1894s.
    • (1994) Cancer Res , vol.54
    • Feig, D.I.1    Reid, T.M.2    Loeb, L.A.3
  • 15
    • 0027938689 scopus 로고
    • Oxy-radicals and cancer
    • Cerutti PA. Oxy-radicals and cancer. Lancet 1994, 344, 862-863.
    • (1994) Lancet , vol.344 , pp. 862-863
    • Cerutti, P.A.1
  • 16
    • 0023611733 scopus 로고
    • The approaching era of tumor suppressor genes
    • Klein G. The approaching era of tumor suppressor genes. Science 1987, 238, 1539-1545.
    • (1987) Science , vol.238 , pp. 1539-1545
    • Klein, G.1
  • 17
    • 0028365709 scopus 로고
    • Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene
    • Hussain SP, Aguilar F, Amstad P, Cerutti P. Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene. Oncogene 1994, 9, 2277-2281.
    • (1994) Oncogene , vol.9 , pp. 2277-2281
    • Hussain, S.P.1    Aguilar, F.2    Amstad, P.3    Cerutti, P.4
  • 18
    • 0023864201 scopus 로고
    • Early superoxide dismutase-sensitive event promotes neoplastic transformation in mouse epidermal JB6 cells
    • Nakamura Y, Gindhart T, Winterstein D, Tomita I, Seed J, Colburn N. Early superoxide dismutase-sensitive event promotes neoplastic transformation in mouse epidermal JB6 cells. Carcinogenesis 1988, 9, 203-207.
    • (1988) Carcinogenesis , vol.9 , pp. 203-207
    • Nakamura, Y.1    Gindhart, T.2    Winterstein, D.3    Tomita, I.4    Seed, J.5    Colburn, N.6
  • 19
    • 0027503178 scopus 로고
    • The permissive role of oxygen-derived free radicals in the development of colonic cancer in the rat. a new theory for carcinogenesis
    • Salim AS. The permissive role of oxygen-derived free radicals in the development of colonic cancer in the rat. A new theory for carcinogenesis. Int J Cancer 1993, 53, 1031-1035.
    • (1993) Int J Cancer , vol.53 , pp. 1031-1035
    • Salim, A.S.1
  • 20
    • 0020427486 scopus 로고
    • Biology of disease. Free radicals and tissue injury
    • Freeman BA, Crapo JD. Biology of disease. Free radicals and tissue injury. Lab Invest 1982, 47, 421-426.
    • (1982) Lab Invest , vol.47 , pp. 421-426
    • Freeman, B.A.1    Crapo, J.D.2
  • 21
    • 0021351203 scopus 로고
    • Oxygen toxicity, oxygen radicals, transition metals and disease
    • Halliwell B, Gutteridge JMC. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 1984, 219, 1-14.
    • (1984) Biochem J , vol.219 , pp. 1-14
    • Halliwell, B.1    Gutteridge, J.M.C.2
  • 22
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappaB transcription factor and HIV-1
    • Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappaB transcription factor and HIV-1. EMBO J 1991, 10, 2247-2258.
    • (1991) EMBO J , vol.10 , pp. 2247-2258
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.A.3
  • 23
    • 0025972738 scopus 로고
    • DNA damage by oxygen-derived species. Its mechanisms of action and measurements in mammalian system
    • Halliwell B, Aruoma OI. DNA damage by oxygen-derived species. Its mechanisms of action and measurements in mammalian system. FEBS Lett 1991, 281, 9-19.
    • (1991) FEBS Lett , vol.281 , pp. 9-19
    • Halliwell, B.1    Aruoma, O.I.2
  • 24
    • 0028198779 scopus 로고
    • The Fenton oxidation mechanism: Reactivities of biologically relevant substrates with two oxidizing intermediates differ from those predicted for the hydroxyl radical
    • Wink DA, Nimes RW, Saavedra JE, Utermahlen WE, Ford PC. The Fenton oxidation mechanism: reactivities of biologically relevant substrates with two oxidizing intermediates differ from those predicted for the hydroxyl radical. Proc Natl Acad Sci USA 1994, 91, 6604-6608.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6604-6608
    • Wink, D.A.1    Nimes, R.W.2    Saavedra, J.E.3    Utermahlen, W.E.4    Ford, P.C.5
  • 25
    • 0027249188 scopus 로고
    • Oxy radicals and antioxidative responses in cancer: 12th Sapporo Cancer Seminar Meeting Report
    • Taniguchi N, Pickett CB, Griffith OW. Oxy radicals and antioxidative responses in cancer: 12th Sapporo Cancer Seminar Meeting Report. Cancer Res 1993, 53, 3207-3210.
    • (1993) Cancer Res , vol.53 , pp. 3207-3210
    • Taniguchi, N.1    Pickett, C.B.2    Griffith, O.W.3
  • 27
    • 0028151406 scopus 로고
    • Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation
    • Rubbo H, Radi R, Trujillo M, et al. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. J Biol Chem 1994, 269, 26 066-26 075.
    • (1994) J Biol Chem , vol.269 , pp. 26066-26075
    • Rubbo, H.1    Radi, R.2    Trujillo, M.3
  • 28
    • 0023886170 scopus 로고
    • DNA damage and oxygen radical toxicity
    • Imlay JA, Linn S. DNA damage and oxygen radical toxicity. Science 1988, 240, 1302-1309.
    • (1988) Science , vol.240 , pp. 1302-1309
    • Imlay, J.A.1    Linn, S.2
  • 29
    • 0026035117 scopus 로고
    • Inflammation and oxidative stress in carcinogenesis
    • Cerutti PA, Trump BF. Inflammation and oxidative stress in carcinogenesis. Cancer Cells 1991, 3, 1-7.
    • (1991) Cancer Cells , vol.3 , pp. 1-7
    • Cerutti, P.A.1    Trump, B.F.2
  • 30
    • 0024602827 scopus 로고
    • Tissue distruction by neutrophils
    • Weiss SJ. Tissue distruction by neutrophils. N Engl J Med 1989, 320, 365-376.
    • (1989) N Engl J Med , vol.320 , pp. 365-376
    • Weiss, S.J.1
  • 31
    • 0025083101 scopus 로고
    • Inflammation and cancer: Role of phagocyte-generated oxidants in carcinogenesis
    • Weitzman SA, Gordon LI. Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis. Blood 1990, 76, 655-663.
    • (1990) Blood , vol.76 , pp. 655-663
    • Weitzman, S.A.1    Gordon, L.I.2
  • 32
    • 0023237958 scopus 로고
    • Colon cancer, dysplasia, and surveillance in patients with ulcerative colitis. a critical review
    • Collins RH, Feldman M, Fordtran JS. Colon cancer, dysplasia, and surveillance in patients with ulcerative colitis. A critical review. N Engl J Med 1987, 316, 1654-1658.
    • (1987) N Engl J Med , vol.316 , pp. 1654-1658
    • Collins, R.H.1    Feldman, M.2    Fordtran, J.S.3
  • 33
    • 0025156969 scopus 로고
    • Asbestos: Scientific development and implications for public policy
    • Mossman BT, Bignon J, Corn M, Seaton A, Gee JBL. Asbestos: scientific development and implications for public policy. Science 1990, 247, 294-301.
    • (1990) Science , vol.247 , pp. 294-301
    • Mossman, B.T.1    Bignon, J.2    Corn, M.3    Seaton, A.4    Gee, J.B.L.5
  • 34
    • 0028196674 scopus 로고
    • Inflammation, chromosomal instability, and cancer: The Schistosomiasis model
    • Rosin MP, Anwar WA, Ward A. Inflammation, chromosomal instability, and cancer: The Schistosomiasis model. Cancer Res 1994, 54, 1929s-1933s.
    • (1994) Cancer Res , vol.54
    • Rosin, M.P.1    Anwar, W.A.2    Ward, A.3
  • 35
    • 0021328075 scopus 로고
    • Hepatitis B, hepatocellular carcinoma, and strategies for prevention
    • Arthur MJP, Hall AJ, Wright R. Hepatitis B, hepatocellular carcinoma, and strategies for prevention. Lancet 1984, 1, 607-610.
    • (1984) Lancet , vol.1 , pp. 607-610
    • Arthur, M.J.P.1    Hall, A.J.2    Wright, R.3
  • 36
    • 0028339240 scopus 로고
    • Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis
    • Shimoda R, Nagashima M, Sakamoto M, et al. Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis. Cancer Res 1994, 54, 3171-3172.
    • (1994) Cancer Res , vol.54 , pp. 3171-3172
    • Shimoda, R.1    Nagashima, M.2    Sakamoto, M.3
  • 37
    • 0019829568 scopus 로고
    • The causes of cancer. Quantitative estimates of avoidable risks of cancer in the United States today
    • Doll R, Peto R. The causes of cancer. Quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 1981, 66, 1191-1308.
    • (1981) J Natl Cancer Inst , vol.66 , pp. 1191-1308
    • Doll, R.1    Peto, R.2
  • 38
    • 0028502218 scopus 로고
    • Cigarettes: Then and now
    • Stone K, Pryor WA. Cigarettes: then and now. J Lab Clin Med 1994, 124, 313-314.
    • (1994) J Lab Clin Med , vol.124 , pp. 313-314
    • Stone, K.1    Pryor, W.A.2
  • 39
    • 0022387208 scopus 로고
    • The metal-mediated formation of hydroxyl radicals by aqueous extract of cigarette tar
    • Cosgrove JP, Church DF, Borish ET, Pryor WA. The metal-mediated formation of hydroxyl radicals by aqueous extract of cigarette tar. Biochem Biophys Res Comm 1985, 132, 390-396.
    • (1985) Biochem Biophys Res Comm , vol.132 , pp. 390-396
    • Cosgrove, J.P.1    Church, D.F.2    Borish, E.T.3    Pryor, W.A.4
  • 40
    • 0025866304 scopus 로고
    • Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid
    • Frei B, Forte TM, Ames BN, Cross CE. Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochem J 1991, 277, 133-138.
    • (1991) Biochem J , vol.277 , pp. 133-138
    • Frei, B.1    Forte, T.M.2    Ames, B.N.3    Cross, C.E.4
  • 41
    • 84968961316 scopus 로고
    • Pathobiological effects of tobacco smoke, tumor promotors, and asbestos in human lung cells in vitro
    • New York, Alan R. Liss Inc.
    • Harris CC, Graftstrom R, Willey JC, et al. Pathobiological effects of tobacco smoke, tumor promotors, and asbestos in human lung cells in vitro. In Oxy-radicals in Molecular Biology and Pathology. New York, Alan R. Liss Inc., 1988.
    • (1988) Oxy-radicals in Molecular Biology and Pathology
    • Harris, C.C.1    Graftstrom, R.2    Willey, J.C.3
  • 42
    • 0020533852 scopus 로고
    • Metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation
    • Dix TA, Marnett LJ. Metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation. Science 1983, 221, 77-79.
    • (1983) Science , vol.221 , pp. 77-79
    • Dix, T.A.1    Marnett, L.J.2
  • 43
    • 0000134825 scopus 로고
    • Benzo(a)pyrene-induced oxidative DNa damage: A possible mechanism for promotion by complete carcinogens
    • New York, Alan R. Liss Inc.
    • Frenkel K, Donahue JM, Banerjee S. Benzo(a)pyrene-induced oxidative DNA damage: a possible mechanism for promotion by complete carcinogens. In Oxy-radicals in Molecular Biology and Pathology. New York, Alan R. Liss Inc., 1988, 509-524.
    • (1988) Oxy-radicals in Molecular Biology and Pathology , pp. 509-524
    • Frenkel, K.1    Donahue, J.M.2    Banerjee, S.3
  • 44
    • 37049102236 scopus 로고
    • Effects of ionizing radiation on deoxyribonucleic acid and related systems. 1. the role of oxygen
    • Boon PJ, Cullis PM, Symons MCR, Wren BW. Effects of ionizing radiation on deoxyribonucleic acid and related systems. 1. The role of oxygen. J Chem Soc Perkin Trans 1984, II 8, 1393-1399.
    • (1984) J Chem Soc Perkin Trans , vol.2 , Issue.8 , pp. 1393-1399
    • Boon, P.J.1    Cullis, P.M.2    Symons, M.C.R.3    Wren, B.W.4
  • 46
    • 0025215161 scopus 로고
    • Free radicals and the etiology of colon cancer
    • Babbs CF. Free radicals and the etiology of colon cancer. Free Rad Biol Med 1990, 8, 191-200.
    • (1990) Free Rad Biol Med , vol.8 , pp. 191-200
    • Babbs, C.F.1
  • 47
    • 0026512285 scopus 로고
    • Dietary iron and colorectal cancer risk
    • Nelson RL. Dietary iron and colorectal cancer risk. Free Radical Biol Med 1992, 12, 161-168.
    • (1992) Free Radical Biol Med , vol.12 , pp. 161-168
    • Nelson, R.L.1
  • 49
    • 0019427283 scopus 로고
    • Cholesterol and cholesterol epoxides in nipple aspirates of human breast fluid
    • Petrakis NL, Gruenke LD, Craig JC. Cholesterol and cholesterol epoxides in nipple aspirates of human breast fluid. Cancer Res 1981, 41, 2563-2565.
    • (1981) Cancer Res , vol.41 , pp. 2563-2565
    • Petrakis, N.L.1    Gruenke, L.D.2    Craig, J.C.3
  • 50
    • 0027015818 scopus 로고
    • Alcohol acts to promote incidence of tumors
    • Mufti SI. Alcohol acts to promote incidence of tumors. Cancer Detect Prev 1992, 16, 157-162.
    • (1992) Cancer Detect Prev , vol.16 , pp. 157-162
    • Mufti, S.I.1
  • 51
    • 0028342951 scopus 로고
    • Repair of oxidative damage to DNA: Enzymology and biology
    • Demple B, Harrison L. Repair of oxidative damage to DNA: enzymology and biology. Annu Rev Biochem 1994, 63, 915-948.
    • (1994) Annu Rev Biochem , vol.63 , pp. 915-948
    • Demple, B.1    Harrison, L.2
  • 53
    • 0025122267 scopus 로고
    • Mutagenesis by hydrogen peroxide treatment of mammalian cells: A molecular basis
    • Moraes EC, Keyse SM, Tyrrell RM. Mutagenesis by hydrogen peroxide treatment of mammalian cells: a molecular basis. Carcinogenesis 1990, 11, 283-293.
    • (1990) Carcinogenesis , vol.11 , pp. 283-293
    • Moraes, E.C.1    Keyse, S.M.2    Tyrrell, R.M.3
  • 54
    • 0024988298 scopus 로고
    • Radical-mediated DNA damage in the presence of oxygen
    • von Sonntag C, Schuchmann HP. Radical-mediated DNA damage in the presence of oxygen. Meth Enzymol 1990, 186, 511-520.
    • (1990) Meth Enzymol , vol.186 , pp. 511-520
    • Von Sonntag, C.1    Schuchmann, H.P.2
  • 56
    • 0028270384 scopus 로고
    • Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer
    • Jaruga P, Zastawny TH, Skokowski J, Dizdaroglu M, Olinski R. Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer. FEBS Lett 1994, 341, 59-64.
    • (1994) FEBS Lett , vol.341 , pp. 59-64
    • Jaruga, P.1    Zastawny, T.H.2    Skokowski, J.3    Dizdaroglu, M.4    Olinski, R.5
  • 57
    • 0028335058 scopus 로고
    • Reverse chemical mutagenesis: Identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA
    • Feig DI, Sowers LC, Loeb LA. Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA. Proc Natl Acad Sci USA 1994, 91, 6609-6613.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6609-6613
    • Feig, D.I.1    Sowers, L.C.2    Loeb, L.A.3
  • 58
    • 0024335402 scopus 로고
    • Iron-dependent modification of bases in DNA by the superoxide radical-generating system hypoxanthine xanthine oxidase
    • Aruoma OI, Dizdaroglu M, Halliwell B. Iron-dependent modification of bases in DNA by the superoxide radical-generating system hypoxanthine xanthine oxidase. J Biol Chem 1989, 264, 3024-3028.
    • (1989) J Biol Chem , vol.264 , pp. 3024-3028
    • Aruoma, O.I.1    Dizdaroglu, M.2    Halliwell, B.3
  • 59
    • 0027324378 scopus 로고
    • Mutagenesis by 8-oxoguanine: An enemy within
    • Grollman AP, Moriya M. Mutagenesis by 8-oxoguanine: an enemy within. Trends Genet 1993, 9, 246-249.
    • (1993) Trends Genet , vol.9 , pp. 246-249
    • Grollman, A.P.1    Moriya, M.2
  • 60
    • 0023898932 scopus 로고
    • The ras gene family and human carcinogenesis
    • Bos J. The ras gene family and human carcinogenesis. Mutat Res 1988, 195, 255-271.
    • (1988) Mutat Res , vol.195 , pp. 255-271
    • Bos, J.1
  • 61
    • 0024452546 scopus 로고
    • P53: A frequent target for genetic abnormalities in lung cancer
    • Takahashi T, Gazdar AF, Chiba I, et al. p53: a frequent target for genetic abnormalities in lung cancer. Science 1989, 246, 491-494.
    • (1989) Science , vol.246 , pp. 491-494
    • Takahashi, T.1    Gazdar, A.F.2    Chiba, I.3
  • 62
    • 0025732215 scopus 로고
    • Mutational hotspot in the p53 gene in human hepatocellular carcinomas
    • Hsu I, Metcalf R, Sun T, Welsh J, Wang N, Harris C. Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 1991, 350, 427-428.
    • (1991) Nature , vol.350 , pp. 427-428
    • Hsu, I.1    Metcalf, R.2    Sun, T.3    Welsh, J.4    Wang, N.5    Harris, C.6
  • 63
    • 0024336555 scopus 로고
    • Calcium chelator Quin 2 prevents hydrogen-peroxide-induced DNA breakage and cytotoxicity
    • Cantoni O, Sestili P, Cattabeni F, et al. Calcium chelator Quin 2 prevents hydrogen-peroxide-induced DNA breakage and cytotoxicity. Eur J Biochem 1989, 2, 290-212.
    • (1989) Eur J Biochem , vol.2 , pp. 290-1212
    • Cantoni, O.1    Sestili, P.2    Cattabeni, F.3
  • 65
    • 0026640753 scopus 로고
    • Importance of various antioxidant enzymes for cell stability. Confrontation between theoretical and experimental data
    • Remacle J, Lambert D, Raes M, Pigeolet E, Michiels C, Toussaint O. Importance of various antioxidant enzymes for cell stability. Confrontation between theoretical and experimental data. Biochem J 1992, 286, 41-46.
    • (1992) Biochem J , vol.286 , pp. 41-46
    • Remacle, J.1    Lambert, D.2    Raes, M.3    Pigeolet, E.4    Michiels, C.5    Toussaint, O.6
  • 67
    • 0022510621 scopus 로고
    • Uric acid-iron complexes: A new aspect of the antioxidant function of uric acid
    • Davies KJ, Sevanian A, Muakkassah-Kelli SF, Hochstein P. Uric acid-iron complexes: a new aspect of the antioxidant function of uric acid. Biochem J 1986, 235, 747-754.
    • (1986) Biochem J , vol.235 , pp. 747-754
    • Davies, K.J.1    Sevanian, A.2    Muakkassah-Kelli, S.F.3    Hochstein, P.4
  • 69
    • 0010607277 scopus 로고
    • The effect of vitamin e and beta-carotene on the incidence of lung cancer and other cancers in male smokers
    • Heinonen OP, Albanes D for the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group. The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994, 330, 1029-1035.
    • (1994) N Engl J Med , vol.330 , pp. 1029-1035
    • Heinonen, O.P.1    Albanes, D.2
  • 70
    • 1642459230 scopus 로고
    • Beta carotene, vitamin E, and lung cancer
    • Marantz PR. Beta carotene, vitamin E, and lung cancer [Letter]. N Engl J Med 1994, 331, 661.
    • (1994) N Engl J Med , vol.331 , pp. 661
    • Marantz, P.R.1
  • 71
    • 0025109174 scopus 로고
    • A clinical trial of beta-carotene to prevent basal-cell and squamous cell cancers of the skin
    • Greenberg ER, Baron JA, Stukel TA, et al. and the Skin Cancer Prevention Group. A clinical trial of beta-carotene to prevent basal-cell and squamous cell cancers of the skin. N Engl J Med 1990, 323, 789-795.
    • (1990) N Engl J Med , vol.323 , pp. 789-795
    • Greenberg, E.R.1    Baron, J.A.2    Stukel, T.A.3
  • 72
    • 0028264472 scopus 로고
    • A clinical trial of antioxidant vitamins to prevent colorectal adenoma
    • Greenberg ER, Baron JA, Tosteson TD, et al. for the Polyp Prevention Study Group. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N Engl J Med 1994, 331, 141-147.
    • (1994) N Engl J Med , vol.331 , pp. 141-147
    • Greenberg, E.R.1    Baron, J.A.2    Tosteson, T.D.3
  • 73
    • 0019787519 scopus 로고
    • Uric acid provides an antioxidant defense against oxidant- And radical-caused aging and cancer: A hypothesis
    • Ames NB, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci USA 1981, 78, 6858-6862.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 6858-6862
    • Ames, N.B.1    Cathcart, R.2    Schwiers, E.3    Hochstein, P.4
  • 74
    • 0042366980 scopus 로고
    • Superoxide-dependent production of hydroxyl radicals in the presence of iron salts
    • Winterbourn CC. Superoxide-dependent production of hydroxyl radicals in the presence of iron salts (Letter). Biochem J 1982, 205, 463.
    • (1982) Biochem J , vol.205 , pp. 463
    • Winterbourn, C.C.1
  • 75
    • 0025888901 scopus 로고
    • Immunocompetence and oxidant defense during ascorbate depletion of healthy men
    • Jacob RA, Keley DS, Pianalto FS, et al. Immunocompetence and oxidant defense during ascorbate depletion of healthy men. Am J Clin Nutr 1991, 54, 1302S-1309S.
    • (1991) Am J Clin Nutr , vol.54
    • Jacob, R.A.1    Keley, D.S.2    Pianalto, F.S.3
  • 76
    • 0027275148 scopus 로고
    • Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population
    • Blot WJ, Li J-Y, Taylor PR, Li B. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 1993, 85, 1483-1492.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1483-1492
    • Blot, W.J.1    Li, J.-Y.2    Taylor, P.R.3    Li, B.4
  • 77
    • 0022454807 scopus 로고
    • The antioxidant efficiency of vitamin C is concentration-dependent
    • Wayner DDM, Burton GW, Ingold KU. The antioxidant efficiency of vitamin C is concentration-dependent. Biochim Biophys Acta 1986, 884, 119-123.
    • (1986) Biochim Biophys Acta , vol.884 , pp. 119-123
    • Wayner, D.D.M.1    Burton, G.W.2    Ingold, K.U.3
  • 78
    • 0006171777 scopus 로고
    • Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer
    • Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA 1976, 73, 3685-3689.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 3685-3689
    • Cameron, E.1    Pauling, L.2
  • 79
    • 0027318778 scopus 로고
    • DNa excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions
    • Satoh MS, Jones CJ, Wood RD, Lindahl, T. DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions. Proc Natl Acad Sci USA 1993, 90, 6335-6339.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6335-6339
    • Satoh, M.S.1    Jones, C.J.2    Wood, R.D.3    Lindahl, T.4
  • 80
    • 0015982924 scopus 로고
    • Xeroderma pigmentosum. An inherited disease with sun sensitivity, multiple cutaneous neoplasms, and abnormal DNA repair
    • Robbins HJ, Kraemer KH, Lutzner MA, Festoff BW, Coon HG. Xeroderma pigmentosum. An inherited disease with sun sensitivity, multiple cutaneous neoplasms, and abnormal DNA repair. Ann Intern Med 1974, 80, 221-248.
    • (1974) Ann Intern Med , vol.80 , pp. 221-248
    • Robbins, H.J.1    Kraemer, K.H.2    Lutzner, M.A.3    Festoff, B.W.4    Coon, H.G.5
  • 81
    • 0028501216 scopus 로고
    • DNA repair: Looking back and peering forward
    • Friedberg EC. DNA repair: looking back and peering forward. BioEssays 1994, 16, 645-649.
    • (1994) BioEssays , vol.16 , pp. 645-649
    • Friedberg, E.C.1
  • 82
    • 0028603429 scopus 로고
    • DNA repair works its way to the top
    • Culotta E, Koshland DE. DNA repair works its way to the top. Science 1994, 266, 1926-1929.
    • (1994) Science , vol.266 , pp. 1926-1929
    • Culotta, E.1    Koshland, D.E.2
  • 84
    • 0028831129 scopus 로고
    • Characterization of a mammalian homolog of the Escherischia coli MutY mismatch repair protein
    • McGoldrick JP, Yeh YC, Solomon M, Essigmann JM, Lu AL. Characterization of a mammalian homolog of the Escherischia coli MutY mismatch repair protein. Mol Cell Biol 1995, 15, 989-996.
    • (1995) Mol Cell Biol , vol.15 , pp. 989-996
    • McGoldrick, J.P.1    Yeh, Y.C.2    Solomon, M.3    Essigmann, J.M.4    Lu, A.L.5
  • 86
    • 0028606403 scopus 로고
    • Mechanisms of DNA excision repair
    • Sancar A. Mechanisms of DNA excision repair. Science 1994, 266, 1954-1956.
    • (1994) Science , vol.266 , pp. 1954-1956
    • Sancar, A.1
  • 87
    • 0028564949 scopus 로고
    • Mismatch repair, genetic stability, and cancer
    • Modrich P. Mismatch repair, genetic stability, and cancer. Science 1994, 266, 1959-1960.
    • (1994) Science , vol.266 , pp. 1959-1960
    • Modrich, P.1
  • 88
    • 0027977269 scopus 로고
    • It was a very good year for DNa repair
    • Cleaver JE. It was a very good year for DNA repair. Cell 1994, 76, 1-4.
    • (1994) Cell , vol.76 , pp. 1-4
    • Cleaver, J.E.1
  • 89
    • 0026730009 scopus 로고
    • Histone shuttling by polyADP-ribosylation
    • Realini CA, Althaus FR. Histone shuttling by polyADP-ribosylation. J Biol Chem 1992, 267, 18 858-18 865.
    • (1992) J Biol Chem , vol.267 , pp. 18858-18865
    • Realini, C.A.1    Althaus, F.R.2
  • 91
    • 0021964203 scopus 로고
    • Prooxidant states and tumor promotion
    • Cerutti PA. Prooxidant states and tumor promotion. Science 1985, 227, 375-381.
    • (1985) Science , vol.227 , pp. 375-381
    • Cerutti, P.A.1
  • 92
    • 0024458551 scopus 로고
    • Constitutive and phorbol-myristate acetate regulated antioxidant defense of mouse epidermal JB6 cells
    • Crawford D, Amstad D, Foo Y, Cerutti P. Constitutive and phorbol-myristate acetate regulated antioxidant defense of mouse epidermal JB6 cells. Mol Carcinogenesis 1989, 2, 136-143.
    • (1989) Mol Carcinogenesis , vol.2 , pp. 136-143
    • Crawford, D.1    Amstad, D.2    Foo, Y.3    Cerutti, P.4
  • 93
    • 0026093495 scopus 로고
    • An overview of the relationship between oxidative stress and chemical carcinogenesis
    • Trush MA, Kensler TW. An overview of the relationship between oxidative stress and chemical carcinogenesis. Free Rad Biol Med 1991, 10, 211-216.
    • (1991) Free Rad Biol Med , vol.10 , pp. 211-216
    • Trush, M.A.1    Kensler, T.W.2
  • 94
    • 0028897321 scopus 로고
    • Differential effects of superoxide, hydrogen peroxide, and hydroxyl radical on intracellular calcium in human endothelial cells
    • Dreher D, Junod AF. Differential effects of superoxide, hydrogen peroxide, and hydroxyl radical on intracellular calcium in human endothelial cells. J Cell Physiol 1995, 162, 147-153.
    • (1995) J Cell Physiol , vol.162 , pp. 147-153
    • Dreher, D.1    Junod, A.F.2
  • 95
    • 0023941812 scopus 로고
    • Oxidant stress induces the proto-oncogenes c-fos and m-myc in mouse epiderma cells
    • Crawford D, Zbinden I, Amstad P, Cerutti P. Oxidant stress induces the proto-oncogenes c-fos and m-myc in mouse epiderma cells. Oncogene 1988, 3, 27-32.
    • (1988) Oncogene , vol.3 , pp. 27-32
    • Crawford, D.1    Zbinden, I.2    Amstad, P.3    Cerutti, P.4
  • 98
    • 0024461627 scopus 로고
    • Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure in mouse epidermal cells to oxidants
    • Larsson R, Cerutti P. Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure in mouse epidermal cells to oxidants. Cancer Res 1989, 49, 5627-5632.
    • (1989) Cancer Res , vol.49 , pp. 5627-5632
    • Larsson, R.1    Cerutti, P.2
  • 99
    • 0024269573 scopus 로고
    • Oxidants induce phosphorylation of ribosomal protein S6
    • Larsson R, Cerutti P. Oxidants induce phosphorylation of ribosomal protein S6. J Biol Chem 1988, 263, 17 452-17 458.
    • (1988) J Biol Chem , vol.263 , pp. 17452-17458
    • Larsson, R.1    Cerutti, P.2
  • 100
    • 0024724936 scopus 로고
    • 2+- And phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain
    • 2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain. Proc Natl Acad Sci USA 1989, 86, 6758-6762.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 6758-6762
    • Gopalakrishna, R.1    Anderson, W.2
  • 101
    • 0025214474 scopus 로고
    • Transcriptional regulator of oxidative stress-inducible genes: Direct activation by oxidation
    • Storz G, Tartiglia LA, Ames BN. Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation. Science 1990, 248, 189-194.
    • (1990) Science , vol.248 , pp. 189-194
    • Storz, G.1    Tartiglia, L.A.2    Ames, B.N.3
  • 102
    • 0025852479 scopus 로고
    • Modulation of transcription factor NF-kappaB binding activity by oxidation-reduction in vitro
    • Toledano MD, Leonard WJ. Modulation of transcription factor NF-kappaB binding activity by oxidation-reduction in vitro. Proc Natl Acad Sci USA 1991, 88, 4328-4332.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4328-4332
    • Toledano, M.D.1    Leonard, W.J.2
  • 103
    • 0025835619 scopus 로고
    • Malignant transformation by mutant rel proteins
    • Gilmore TD. Malignant transformation by mutant rel proteins. Trends Genet 1991, 7, 318-332.
    • (1991) Trends Genet , vol.7 , pp. 318-332
    • Gilmore, T.D.1
  • 106
    • 0026705327 scopus 로고
    • P53: The ultimate tumor suppressor gene?
    • Oren M. p53: the ultimate tumor suppressor gene? FASEB J 1992, 6, 3169-3176.
    • (1992) FASEB J , vol.6 , pp. 3169-3176
    • Oren, M.1
  • 107
    • 0026669469 scopus 로고
    • P53 function and dysfunction
    • Vogelstein B, Kinzler KW. p53 function and dysfunction. Cell 1992, 70, 523-526.
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 108
    • 0028168643 scopus 로고
    • P53-deficient mice are extremely susceptible to radiation-induced tumorigenesis
    • Kemp CJ, Wheldon T, Balmain A. p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nature Genetics 1994, 8, 66-69.
    • (1994) Nature Genetics , vol.8 , pp. 66-69
    • Kemp, C.J.1    Wheldon, T.2    Balmain, A.3
  • 109
    • 0028176651 scopus 로고
    • Oxidative stress as a mediator of apoptosis
    • Buttke TM, Sandstrom PA. Oxidative stress as a mediator of apoptosis. Immunol Today 1994, 15, 7-10.
    • (1994) Immunol Today , vol.15 , pp. 7-10
    • Buttke, T.M.1    Sandstrom, P.A.2
  • 110
    • 0026655474 scopus 로고
    • Bcl-2 initiates a new category of oncogenes: Regulators of cell death
    • Korsmeyer SJ. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 1992, 80, 879-886.
    • (1992) Blood , vol.80 , pp. 879-886
    • Korsmeyer, S.J.1
  • 112
    • 0027130238 scopus 로고
    • Bcl-2/Bax: A rheostat that regulates an anti-oxidant pathway and cell death
    • Korsmeyer SJ, Shutter JR, Veis DJ, Merry DE, Oltvai ZN. Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Cancer Biol 1992, 4, 327-332.
    • (1992) Cancer Biol , vol.4 , pp. 327-332
    • Korsmeyer, S.J.1    Shutter, J.R.2    Veis, D.J.3    De Merry4    Oltvai, Z.N.5
  • 113
    • 0026451714 scopus 로고
    • Projecting international lung cancer mortality rates: First approximations with tobacco-consumption data
    • Pierce JP, Thurmond L, Rosbrook B. Projecting international lung cancer mortality rates: first approximations with tobacco-consumption data. Monogr J Natl Cancer Inst 1992, 12, 45-49.
    • (1992) Monogr J Natl Cancer Inst , vol.12 , pp. 45-49
    • Pierce, J.P.1    Thurmond, L.2    Rosbrook, B.3
  • 114
    • 0042868054 scopus 로고
    • P53 tumor suppressor gene-therapy of cancer-preclinical studies
    • Maneval DC, Harris M, Tam K, et al. p53 tumor suppressor gene-therapy of cancer-preclinical studies. Abstr Am Chem Soc 1994, 207, 110.
    • (1994) Abstr am Chem Soc , vol.207 , pp. 110
    • Maneval, D.C.1    Harris, M.2    Tam, K.3
  • 115
    • 0041365258 scopus 로고
    • Tumor-suppressor gene-therapy of cancer - Adenoviral mediated gene-transfer of the p53 cDNA into human tumor cell lines
    • Gregory RJ, Maneval DC, Sutjipto S, et al. Tumor-suppressor gene-therapy of cancer - adenoviral mediated gene-transfer of the p53 cDNA into human tumor cell lines. J Cell Biochem 1994, S18A, 237.
    • (1994) J Cell Biochem , vol.S18A , pp. 237
    • Gregory, R.J.1    Maneval, D.C.2    Sutjipto, S.3


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