Conjugates of gonadotropin releasing hormone (GnRH) with carminic acid: Synthesis, generation of reactive oxygen species (ROS) and biological evaluation

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 14, 2008, Pages 6789-6798

  Lev Goldman, Vered ^a   Mester, Brenda ^a   Ben Aroya, Nurit ^a   Hanoch, Tamar ^a   Rupp, Barbara ^b   Stanoeva, Tsvetanka ^b   Gescheidt, Georg ^b   Seger, Rony ^a   Koch, Yitzhak ^a   Weiner, Lev ^a   Fridkin, Mati ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Anthraquinone; Carminic acid; Drug targeting; GnRH; Photosensitizer; Reactive oxygen species (ROS)

Indexed keywords

7 ALPHA GLUCOPYRANOSYL 9,10 DIHYDRO 3,5,6,8 TETRAHYDROXY 1 METHYL 9,10 DIOXO 2 ANTHRACENE CARBOXYLIC ACID; CARMINIC ACID; EMODIN; GONADORELIN; MITOGEN ACTIVATED PROTEIN KINASE; OXYGEN RADICAL; REACTIVE OXYGEN METABOLITE; SINGLET OXYGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG SYNTHESIS; DRUG TARGETING; ELECTRON SPIN RESONANCE; FEMALE; HYPOPHYSIS CELL; IRRADIATION; LUTEINIZING HORMONE RELEASE; NONHUMAN; OXIDATION REDUCTION REACTION; PHOTODYNAMIC THERAPY; PROTEIN PHOSPHORYLATION; RAT; SPIN TRAPPING;

ANIMALS; CARMINE; CELLS, CULTURED; ELECTRON SPIN RESONANCE SPECTROSCOPY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FREE RADICALS; GONADOTROPIN-RELEASING HORMONE; LUTEINIZING HORMONE; OXIDATION-REDUCTION; PHOSPHORYLATION; PHOTOCHEMISTRY; PITUITARY GLAND; RATS; REACTIVE OXYGEN SPECIES; SINGLET OXYGEN;

RATTUS;

EID: 47349118604     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.057     Document Type: Article

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