Smoking induces bimodal DNA damage in mouse lung

Toxicological Sciences

Volumn 120, Issue 2, 2011, Pages 322-330

  Ueno, Shunji ^a   Kashimoto, Takashige ^a   Susa, Nobuyuki ^a   Ishikawa, Masaaki ^a   Kawagoe, Tadahiro ^a   Mizuta, Kenji ^a   Nishimura, Masaaki ^a   Homma Takeda, Shino ^b   Temma, Kyosuke ^a  

^a KITASATO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Hydroxyl radical; Mouse lung; SCG assay; Smoking

Indexed keywords

CIGARETTE SMOKE; FREE RADICAL; HYDROGEN PEROXIDE; HYDROXYL RADICAL; TAR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; EXPOSURE; LUNG; MALE; MOUSE; NONHUMAN; SMOKING; TIME;

EID: 79953106793     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq397     Document Type: Article

References (25)

1. Alberg, J. (2002). The influence of cigarette smoking on circulating concentrations of antioxidant micronutrients. Toxicology 180, 121-137.
2. Bond, J. A., Chen, B. T., Griffith, W. C., and Mauderly, J. L. (1989). Inhaled cigarette smoke induces the formation of DNA adducts in lungs of rats. Toxicol. Appl. Pharmacol. 99, 161-172.
3. Chen, H. W., Chien, M. L., Chaung, Y. H., Lii, C. K., and Wangs, T. S. (2004). Extracts from cigarette smoke induce DNA damage and cell adhesion molecule expression through different pathways. Chem. Biol. Interact. 150, 233-241.
4. Church, D. F., and Pryor, W. A. (1985). Free-radical chemistry of cigarette smoke and its toxicological implications. Environ. Health Perspect. 64, 111-126.
5. Cosgrove, J. P., Borish, E. T., Church, D. F., and Pryor, W. A. (1985). The metal mediated formation of hydroxyl radical by aqueous extracts of cigarette tar. Biochem. Biophys. Res. Commun. 132, 390-396.
6. Culcasi, M., Muller, A., Mercier, A., Clement, J. L., Payet, O., Rockenbauer, A., Marchand, V., and Pietri, S. (2006). Early specific free radical-related cytotoxicity of gas phase cigarette smoke and its paradoxical temporary inhibition by tar: an electron paramagnetic resonance study with the spin trap DEPMPO. Chem. Biol. Interact. 162, 215-231.
7. Feng, Z., Hu, W., Hu, Y., and Tang, M. S. (2006). Acrolein is a major cigarette-related lung cancer agent: preferential binding at p53 mutational hotspots and inhibition of DNA repair. Proc. Natl. Acad. Sci. U.S.A. 103, 15404-15409.
8. Fujii, S., Yoshimura, T., and Kamada, H. (1996). Nitric oxide trapping efficiencies of water-soluble iron(III) complexes with dithiocarbamate derivatives. Chem. Lett. 9, 785-786.
9. Leanderson, P., and Tagesson, C. (1992). Cigarette smoke-induced DNA damage in cultured human lung cells: role of hydroxyl radicals and endonuclease activation. Chem. Biol. Interact. 81, 197-208.
10. Nagata, C., Kodama, M., Ioki, Y., and Kikuma, T. (1982). Free radicals produced from chemical carcinogens and their significance in carcinogenesis. In Free Radicals and Cancer (R. A. Floyd, Ed.), pp. 1-62. Maracel Dekker, Inc, New York, NY.
11. Nakayama, T., Church, D. F., and Pryor, W. A. (1989). Quantitative analysis of the hydrogen peroxide formed in aqueous cigarette tar extracts. Free Radic. Biol. Med. 7, 9-15.
12. Pryor, W. A., Dooley, M. M., and Church, D. F. (1986). The inactivation of alpha-1-proteinase inhibitor by gas-phase cigarette smoke: protection by antioxidants and reducing species. Chem. Biol. Interact. 57, 271-283.
13. Pryor, W. A., Hales, B. J., Premovic, P. I., and Church, D. F. (1983). The radicals in cigarette tar: their nature and suggested physiological implications. Science 220, 425-427.
14. Pryor, W. A., Stone, K., Zang, L. Y., and Bermúdez, E. (1998). Fractionation of aqueous cigarette tar extracts: fractions that contain the tar radical cause DNA damage. Chem. Res. Toxicol. 11, 441-448.
15. Rahman, I., and McNee, W. (1996). Role of oxidants/antioxidants in smokinginduced lung diseases. Free Radic. Biol. Med. 21, 669-681.
16. Reiter, T. A., Pang, B., Dedon, P., and Demple, B. (2006). Resistance to nitric oxide-induced necrosis in heme oxygenase-1 overexpressing pulmonary epithelial cells associated with decreased lipid peroxidation. J. Biol. Chem. 281, 36603-36612.
17. Sasaki, Y. F., Kasaguchi, S., Kamaya, A., Ohshita,M., Kabasawa, K., Iwama, K., Taniguchi, K., and Tsuda, S. (2002). The comet assay with 8 mouse organs: results with 39 currently used food additives. Mutat. Res. 519, 103-119.
18. Sullivan, N. F., and Willis, A. E. (1994). Environmental carcinogens; tobacco and lung cancer. In The Molecular Mechanisms of Cancer Predisposition. pp. 127-135. R.G. Landes Company, Austin, TX.
19. Tokimoto, T., and Shinagawa, K. (2001). Nitric oxide generation in aqueous solutions of cigarette smoke and approaches to its origin. Biol. Chem. 382, 1613-1619.
20. Tsuda, S., Matsusaka, N., Ueno, S., Susa, N., and Sasaki, Y. F. (2000). The influence of antioxidants on cigarette smoke-induced DNA single-strand breaks in mouse organs: a preliminary study with the alkaline single cell gel electrophoresis assay. Toxicol. Sci. 54, 104-109.
21. Ueno, S., Kashimoto, T., Susa, N., Natsume, H., Toya, M., Ito, N., Takeda-Homma, S., Nishimura, Y., Sasaki, Y. F., and Sugiyama, M. (2007a). Assessment of DNA damage in multiple organs of mice after whole body X-irradiation using the comet assay. Mutat. Res. 634, 135-145.
22. Ueno, S., Kashimoto, T., Susa, N., Shiho, K., Seki, T., Ito, N., Takeda-Homma, S., Nishimura, Y., and Sugiyama, M. (2007b). Estimation of hydroxyl radical generation by salicylate hydroxylation method in kidney of mice exposed to ferric nitrilotriacetate and potassium bromate. Free Radic. Res. 41, 1246-1252.
23. Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., and Mazur, M. (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 160, 1-40.
24. Yasui, H., Fujii, S., Yoshimura, T., and Sakurai, H. (2004). Spinnokinetic analyses of blood disposition and biliary excretion of nitric oxide (NO)-Fe(II)-N-(dithiocarboxy)sarcosine complex in rats: BCM-ESR and BEMESR studies. Free Radic. Res. 38, 1061-1072.
25. Zang, L. Y., Stone, K., and Pryor, W. A. (1995). Detection of free radicals in aqueous extracts of cigarette tar by electron spin resonance. Free Radic. Biol. Med. 19, 161-167.