Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line

Toxicology and Applied Pharmacology

Volumn 227, Issue 1, 2008, Pages 115-124

  Li, Hui ^a   van Berlo, Damien ^a   Shi, Tingming ^a   Speit, Günter ^b   Knaapen, Ad M ^c   Borm, Paul J A ^a,d   Albrecht, Catrin ^a   Schins, Roel P F ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d ZUYD UNIVERSITY OF APPLIED SCIENCES   (Netherlands)

Author keywords

Curcumin; Cyclooxygenase 2; Heme oxygenase 1; Inflammation; Lung epithelial cells; Oxidative DNA damage; Respirable quartz

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CURCUMIN; CYCLOOXYGENASE 2; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; HEME OXYGENASE 1; HYDROGEN PEROXIDE; HYDROXYL RADICAL; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; SILICON DIOXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG MECHANISM; ELECTRON SPIN RESONANCE; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALS; BASE SEQUENCE; CELL LINE; CELL SURVIVAL; CURCUMIN; DNA DAMAGE; DNA PRIMERS; EPITHELIAL CELLS; HUMANS; INFLAMMATION; LUNG; OXIDATIVE STRESS; QUARTZ; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

CURCUMA LONGA; RATTUS;

EID: 38749097023     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.10.002     Document Type: Article

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