EPR and DNP Properties of Certain Novel Single Electron Contrast Agents Intended for Oximetric Imaging

Journal of Magnetic Resonance

Volumn 133, Issue 1, 1998, Pages 1-12

  Ardenkjaer Larsen J H ^a,b   Laursen, I ^b   Leunbach, I ^a   Ehnholm, G ^c   Wistrand, L G ^a   Petersson, J S ^a   Golman, K ^a  

^a Nycomed Innovation AB   (Sweden)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c Picker Nordstar Inc   (Finland)

Author keywords

Contrast agents; DNP; EPR; MRI; Oximetry

Indexed keywords

CONTRAST MEDIUM; ISOTONIC SOLUTION; OXYGEN; SODIUM CHLORIDE; TRITYL DERIVATIVE; WATER;

ALGORITHM; ARTICLE; BLOOD; CHEMICAL MODEL; CHEMISTRY; ELECTRON; ELECTRON SPIN RESONANCE; HUMAN; IMAGE ENHANCEMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIMETRY; PHYSICAL CHEMISTRY; PLASMA; SOLUBILITY; STATISTICAL MODEL; TEMPERATURE;

ALGORITHMS; CHEMISTRY, PHYSICAL; CONTRAST MEDIA; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTRONS; HUMANS; IMAGE ENHANCEMENT; ISOTONIC SOLUTIONS; LINEAR MODELS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; OXIMETRY; OXYGEN; PLASMA; SODIUM CHLORIDE; SOLUBILITY; TEMPERATURE; TRITYL COMPOUNDS; WATER;

EID: 0032112280     PISSN: 10907807     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmre.1998.1438     Document Type: Article

References (44)

1. G. Ehnholm, U.S. Patent 5,289,125 (1994).
2. I. Leunbach and J. H. Ardenkjær-Larsen, U.S. Patent Application Serial No. 08/546,146.
3. J. H. Ardenkjær-Larsen, "Oximetric Implications of Dynamic Nuclear Polarisation," Thesis, Technical University of Denmark (1994).
4. D. Lurie, J. M. S. Hutchison, L. H. Bell, I. Nicholson, D. M. Bussell, and J. R. Mallard, Field-cycled proton-electron double-resonance imaging of free radicals in large aqueous samples, J. Magn. Reson. 84, 431-437 (1989).
5. H. J. Halpern, D. P. Spencer, J. Polen, M. K. Bowman, A. C. Nelson, E. M. Dowey, and B. A. Teicher, Imaging radio frequency electron-spin-resonance spectrometer with high resolution and sensitivity for in vivo measurements, Rev. Sci. Instrum. 60, 1040-1050 (1989).
6. H. M. Swartz and J. F. Glockner, in "Advanced EPR. Applications in Biology and Biochemistry" (A. Hoff, Ed.), Chapter 21, Elsevier, Amsterdam (1991).
7. A. I. Smirnov, R. B. Clarkson, and R. L. Belford, EPR linewidth (T2) method to measure oxygen permeability of phospholipid bilayers and its use to study the effect of low ethanol concentrations, J. Magn. Reson. B 111, 149-157 (1996).
8. I. Leunbach, U.S. Patent 4, 984, 573 (1991).
9. D. Grucker and J. Chambron, Oxygen imaging in perfused hearts by dynamic nuclear polarization, Magn. Reson. Imaging 11, 691-696 (1993).
10. P. Kuppusamy, M. Chzhan, K. Vij, M. Shteynbuk, D. J. Lefer, E. Giannella, and J. L. Zweier, Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: A technique for imaging tissue metabolism and oxygenation, Proc. Natl. Acad. Sci. USA 91, 3388-3392 (1993).
11. M. K. Stehling, F. Schmitt, and R. Ladebeck, Echo-planar MR imaging of human brain oxygenation changes, J. Magn. Reson. Imaging 3, 471-474 (1993).
12. 19FNMR probes of oxygen tension and temperature, J. Magn. Reson. B 106, 131-141 (1995).
13. P. Röschmann, Radiofrequency penetration and absorption in the human body: Limitations to high-field whole-body nuclear magnetic resonance imaging, Med. Phys. 14, 922-931 (1987).
14. H. Konijnenburg and A. F. Mehlkopf, Optimal field strength and pulse-sequence parameters for in vivo dynamic-polarization imaging, J. Mag. Reson. B 113, 53-58 (1996).
15. A. Aabye, T. Almén, S. Anderson, K. Golman, M. Jørgensen, F. Rise, R. Seevin, H. Wikström, and L.-G. Wistrand, EP 0515458 (1995).
16. S. Anderson, K. Golman, F. Rise, H. Wikström, and L.-G. Wistrand, U.S. Patent 5,530,140 (1996).
17. A. W. Overhauser, Polarization of nuclei in metals, Phys. Rev. 92, 411-415 (1953).
18. A. Abragam, "Principles of Nuclear Magnetism," Oxford University Press, Oxford (1961).
19. J. Trommel, "Molecular Motions and Collisions in Organic Free Radical Solutions as Studied by Dynamic Nuclear Polarization," Thesis, Technische Hogeschool Delft, The Netherlands (1978).
20. J. Potenza, Measurement and applications of dynamic nuclear polarization, Advan. Mol. Relaxation Processes 4, 229-354 (1972).
21. Y. Ayant, E. Belorizky, J. Alizon, and J. Gallice, Calcul des densités Spectrales résultant d'un mouvement aléatoire de translation en relaxation par interaction dipolaire magnetique dans les liquides, Le Journal de Physique 36, 991-1004 (1975).
22. B. L. Bales, in "Biological Magnetic Resonance. Spin Labeling. Theory and Applications" (L. Berliner and J. Reuben, Eds.), Plenum, New York (1989).
23. K. Ramani, S. Ganapathy, and R. Srinivasan, A. Fourier transform approach to Voigt profile analysis and its application to nuclear magnetic resonance, J. Magn. Res. 24, 231-237 (1976).
24. K. M. Salikhov, A. B. Doctorov, Yu. N. Molin, and K. I. Zamaraev, Exchange broadening of ESR lines for solutions of free radicals and transition metal complexes, J. Magn. Res. 5, 189-205 (1971).
25. 1 method, Biochim. Biophys. Acta 643, 283-291 (1981).
26. L. P. Hwang and J. H. Freed, Dynamic effects of pair correlation function on spin relaxation by translational diffusion in liquids, J. Chem. Phys. 63, 4017-4025 (1975).
27. M. B. Ravin and W. A. Briscoe, Blood-gas transfer, hemolysis, and diffusion capacity in a bubble tonometer, J. Appl. Physiol. 19, 784-790 (1964).
28. S. H. Koenig and R. D. Brown, in "NMR Spectroscopy of Cells and Organisms," Vol. II, CRC Press, Boca Raton, FL (1987).
29. R. G. Kooser, W. V. Volland, and J. H. Freed, ESR relaxation studies on orbitally degenerate free radicals. I. Benzene anion and tropenyl, J. Chem. Phys. 50, 5243-5257 (1969).
30. M. Mehdizadeh, "An Investigation on Electromagnetic Fields and Properties of the Loop-Gap Resonator, a Lumped Mode Microwave Resonant Structure," Thesis, Marquette University, Wisconsin (1983).
31. W. H. Press, S. A. Teukolsky, W. T. Vetterling, and B. P. Flannery, "Numerical Recipes in C," 2nd ed., Cambridge University Press, Cambridge, U.K. (1992).
32. "CRC Handbook of Chemistry and Physics," 70th ed., CRC Press, Boca Raton, FL (1989).
33. Y. Ayant, E. Belorizky, P. Fries, and J. Rosset, Effet des interactions dipolaires magnétiques intermoléculaires sur la relaxation nucléaire de molécules polyatomiques dans les liquides, Le Journal de Physique 38, 325-337 (1977).
34. P. Vallet, "Relaxivités des Radicaux Libres Stables de Type Nitroxide. Évaluation par la Méthode du Champ Cyclé et Optimisation," Thesis, Université de Mons-Hainaut (1992).
35. L. Verlet and J. J. Weiss, Exact solution of the Percus-Yevick integral equation for hard spheres, equilibrium theory of simple liquids, J. Phys. Rev. A 5, 939-952 (1972).
36. M. S. Wertheim, Phys. Rev. Lett. 10, E501 (1963).
37. E. Thiele, Equation of state for hard spheres, J. Chem. Phys. 39, 474-479 (1963).
38. K. H. Hausser and D. Stehlik, Dynamic nuclear polarization in liquids, in "Advances in Magnetic Resonance," Vol. 3 (J. S. Waugh, Ed.), Academic Press, New York (1968).
39. 12*, J. Am. Chem. Soc. 75, 503 (1953).
40. J. S. Hyde, ENDOR of free radicals in solution, J. Chem. Phys. 43, 1806-1818 (1965).
41. J. H. Freed and G. K. Fraenkel, Theory of linewidths in electron spin resonance spectra, J. Chem. Phys. 39, 326-348 (1963).
42. Yu. N. Molin, K. M. Salikhov, and K. I. Zamaraev, "Spin Exchange," Springer-Verlag, Heidelberg (1980).
43. C. E. St.-Denis and C. J. D. Fell, Diffusivity of oxygen in water, Can. J. Chem. Eng. 49, 885 (1971).
44. T. Goldstick and I. Fatt, Diffusion of oxygen in solutions of blood proteins, Chem. Eng. Prog. Symp. Series 66, 101-113 (1970).