Assessment of subclinical, toxicant-induced hepatic gene expression profiles after low-dose, short-term exposures in mice

Regulatory Toxicology and Pharmacology

Volumn 60, Issue 1, 2011, Pages 54-72

  Zheng, Jenny L ^a   Parfett, Craig ^a   Williams, Andrew ^a   Yagminas, Al ^a   Zhou, Gu ^a   Douglas, George R ^a   Yauk, Carole L ^a  

^a HEALTH CANADA   (Canada)

Author keywords

Dose response; Mode of action; Phenotypic anchoring; RNA profiling; Toxicogenomics

Indexed keywords

3,3',4,4',5 PENTACHLOROBIPHENYL; BIOCHEMICAL MARKER; CYTOCHROME P450; ISOPRENALINE; LEAD ACETATE; PHENOBARBITAL;

ADVERSE OUTCOME; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA MICROARRAY; DNA SEQUENCE; ENZYME ACTIVITY; GENE EXPRESSION PROFILING; HYPERTENSION; INSULIN RESISTANCE; LIVER METABOLISM; LIVER TOXICITY; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; TOXICITY TESTING; TOXICOGENETICS;

ANIMALS; BODY WEIGHT; CLINICAL CHEMISTRY TESTS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; GENE EXPRESSION PROFILING; ISOPROTERENOL; LIVER; LIVER FUNCTION TESTS; MALE; MICE; MICE, INBRED STRAINS; MICROARRAY ANALYSIS; MICROSOMES, LIVER; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN SIZE; ORGANOMETALLIC COMPOUNDS; PHENOBARBITAL; POLYCHLORINATED BIPHENYLS; RNA, MESSENGER; XENOBIOTICS;

MUS;

EID: 79955987896     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.02.006     Document Type: Article

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