Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse: Novel model system for a severely compromised oxidative stress response

Journal of Biological Chemistry

Volumn 277, Issue 51, 2002, Pages 49446-49452

  Yang, Yi ^a   Dieter, Matthew Z ^a,b   Chen, Ying ^a   Shertzer, Howard G ^a   Nebert, Daniel W ^a   Dalton, Timothy P ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; BIOSYNTHESIS; CATALYSIS; CHARACTERIZATION; ENZYMES; GENETIC ENGINEERING; PATHOLOGY; PHYSIOLOGY;

BIOSYNTHETIC PATHWAYS;

BIOCHEMISTRY;

GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HOLOENZYME; HYDROGEN PEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ECOTOXICITY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBUNIT; ERYTHROCYTE; EVALUATION; FETUS; FIBROBLAST; KNOCKOUT MOUSE; LIVER; LUNG; MOUSE; NONHUMAN; NULL ALLELE; OXIDATION; OXIDATIVE STRESS; PANCREAS; PHENOTYPE; PLASMA; PRIORITY JOURNAL;

AGE FACTORS; ALLELES; ANIMALS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; BODY WEIGHT; CELL DEATH; CHROMATOGRAPHY, GEL; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GENOTYPE; GLUTAMATE-CYSTEINE LIGASE; GLUTAMIC ACID; GLUTATHIONE; HOMOZYGOTE; HYDROGEN PEROXIDE; IMMUNOBLOTTING; KIDNEY; KINETICS; LIVER; MICE; MICE, KNOCKOUT; MODELS, GENETIC; MUTAGENESIS, SITE-DIRECTED; OXIDATIVE STRESS; OXYGEN; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, TERTIARY; TIME FACTORS; TISSUE DISTRIBUTION;

ANIMALIA; EUKARYOTA;

EID: 0037147240     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209372200     Document Type: Article

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