Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 9, 2001, Pages 5211-5216

  Holla, Vijaykumar R ^a   Adas, Fadi ^a   Imig, John D ^b   Zhao, Xueying ^b   Price Jr , Edward ^a   Olsen, Nancy ^a   Kovacs, William J ^a   Magnuson, Mark A ^a   Keeney, Diane S ^a   Breyer, Matthew D ^a   Falck, John R ^c   Waterman, Michael R ^a   Capdevila, Jorge H ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

20 HYDROXYARACHIDONIC ACID; ANDROGEN; ARACHIDONIC ACID DERIVATIVE; CYTOCHROME P450 4A MONOOXYGENASE; CYTOCHROME P450 4A12; CYTOCHROME P450 4A14; CYTOCHROME P450 ISOENZYME; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CASTRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME REGULATION; GENE DISRUPTION; HYDROXYLATION; HYPERTENSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SEX DIFFERENCE;

ALKANE 1-MONOOXYGENASE; ANDROGENS; ANIMALS; ARACHIDONIC ACID; BLOOD PRESSURE; CASTRATION; CYTOCHROME P-450 ENZYME SYSTEM; DIHYDROTESTOSTERONE; ENZYME INDUCTION; FEMALE; GENE DELETION; HYDROXYEICOSATETRAENOIC ACIDS; HYPERTENSION; KIDNEY; MALE; MICE; MICE, KNOCKOUT; MICROSOMES; MIXED FUNCTION OXYGENASES; RENAL CIRCULATION; RNA, MESSENGER; SEX CHARACTERISTICS; TESTOSTERONE; VASCULAR RESISTANCE;

ANIMALIA;

EID: 0035942194     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.081627898     Document Type: Article

References (35)