Prediction of compound signature using high density gene expression profiling

Toxicological Sciences

Volumn 67, Issue 2, 2002, Pages 232-240

  Hamadeh, Hisham K ^a   Bushel, Pierre R ^a   Jayadev, Supriya ^b   DiSorbo, Olimpia ^b   Bennett, Lee ^a   Li, Leping ^a   Tennant, Raymond ^a   Stoll, Raymond ^b   Barrett, J Carl ^a   Paules, Richard S ^a   Blanchard, Kerry ^b   Afshari, Cynthia A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Algorithms; Discriminant genes; DNA arrays; Gene expression database; Prediction; Toxicogenomics

Indexed keywords

CLOFIBRATE; GEMFIBROZIL; HEXOBARBITAL; PEROXISOME PROLIFERATOR; PHENOBARBITAL; PHENYTOIN; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PIRINIXIC ACID; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DATA BASE; DNA MICROARRAY; ENVIRONMENTAL EXPOSURE; ENZYME INDUCTION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ALGORITHM; GENETIC TOXICOLOGY; HAZARD ASSESSMENT; LIVER; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; RAT; RNA ANALYSIS; SAMPLING; STATISTICAL ANALYSIS;

ALGORITHMS; ANIMALS; COMPUTATIONAL BIOLOGY; DATABASES, FACTUAL; DIETHYLHEXYL PHTHALATE; DISCRIMINANT ANALYSIS; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENOMICS; HEXOBARBITAL; LIVER; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PATTERN RECOGNITION, AUTOMATED; PHENYTOIN; PREDICTIVE VALUE OF TESTS; PROTEIN BIOSYNTHESIS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; RNA, MESSENGER; SINGLE-BLIND METHOD; STRUCTURE-ACTIVITY RELATIONSHIP; XENOBIOTICS;

ANIMALIA; EUKARYOTA;

EID: 0142065599     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/67.2.232     Document Type: Article

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