Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue

Environmental Health Perspectives

Volumn 115, Issue 4, 2007, Pages 572-578

  Auman, J Todd ^a   Chou, Jeff ^a   Gerrish, Kevin ^a   Huang, Qihong ^b   Jayadev, Supriya ^b   Blanchard, Kerry ^b   Paules, Richard S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

DNA microarray; Gene expression; Hepatotoxicity; Liver; Methapyrilene; Toxicogenomics

Indexed keywords

METHAPYRILENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ANALYSIS; HISTOPATHOLOGY; KIDNEY; LIVER; LIVER INJURY; LIVER TOXICITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RNA ISOLATION; STRESS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; HISTAMINE H1 ANTAGONISTS; KIDNEY; LIVER; MALE; METHAPYRILENE; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

RATTUS;

EID: 34247096610     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.9396     Document Type: Article

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