Qualification of Cardiac Troponin I Concentration in Mouse Serum Using Isoproterenol and Implementation in Pharmacology Studies to Accelerate Drug Development

Toxicologic Pathology

Volumn 37, Issue 5, 2009, Pages 617-628

  Engle, Steven K ^a   Jordan, William H ^a   Pritt, Michael L ^a   Chiang, Alan Y ^a   Davis, Myrtle A ^a,b   Zimmermann, John L ^a,c   Rudmann, Daniel G ^a   Heinz Taheny, Kathleen M ^a   Irizarry, Armando R ^a   Yamamoto, Yumi ^a   Mendel, David ^a   Schultze, A Eric ^a   Cornwell, Paul D ^a   Watson, David E ^a  

^a ELI LILLY AND COMPANY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c VetPathServices   (United States)

Author keywords

biomarker; cardiac; drug development; mouse; necrosis; troponin

Indexed keywords

MUS;

ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CARDIOTONIC AGENT; CREATINE KINASE; FABP3 PROTEIN, MOUSE; FATTY ACID BINDING PROTEIN; ISOPRENALINE; PROTEIN KINASE INHIBITOR; TROPONIN I; FATTY ACID BINDING PROTEIN 3; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BLOOD; CHEMICALLY INDUCED DISORDER; CYTOCHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DEVELOPMENT; DRUG EFFECT; FEMALE; HEART DISEASE; HEART MUSCLE; HEART VENTRICLE; INFLAMMATION; METABOLISM; METHODOLOGY; MOUSE; NECROSIS; PATHOLOGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CARDIOTOXICITY; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; HEART MUSCLE INJURY; HISTOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; CARDIOTONIC AGENTS; CREATINE KINASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FATTY ACID-BINDING PROTEINS; FEMALE; HEART DISEASES; HEART VENTRICLES; HISTOCYTOCHEMISTRY; INFLAMMATION; ISOPROTERENOL; MICE; MICE, INBRED BALB C; MYOCARDIUM; NECROSIS; PROTEIN KINASE INHIBITORS; TROPONIN I;

EID: 70350451513     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/0192623309339502     Document Type: Article

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