Metallothionein gene therapy for chemical-induced liver fibrosis in mice

Molecular Therapy

Volumn 10, Issue 6, 2004, Pages 1130-1139

  Jiang, Youchun ^a   Kang, Y James ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Adenovirus; Carbon tetrachloride; Fibrinolysis; Fibrosis; Hepatocytes; Immunohistochemistry; Liver; Metallothionein; Mice; Regeneration

Indexed keywords

ADENOVIRUS VECTOR; CARBON TETRACHLORIDE; COLLAGENASE; CORN OIL; METALLOTHIONEIN; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG MECHANISM; ENZYME ACTIVITY; KNOCKOUT MOUSE; LIVER FIBROSIS; LIVER LEVEL; LIVER PROTECTION; LIVER REGENERATION; LIVER TOXICITY; METABOLIC REGULATION; MOUSE; NONHUMAN; PROTEIN FUNCTION; VIRAL GENE THERAPY; WILD TYPE; ZINC METABOLISM;

ANIMALS; CARBON TETRACHLORIDE; ENZYME ACTIVATION; FIBRINOLYSIS; GENE THERAPY; LIVER CIRRHOSIS; METALLOTHIONEIN; MICE; MICE, KNOCKOUT;

ADENOVIRIDAE; ZEA MAYS;

EID: 10344245018     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.08.011     Document Type: Article

References (45)

1. A. Pietrangelo Metals, oxidative stress, and hepatic fibrogenesis Semin. Liver Dis. 16 1996 13-30
2. A. Monto et al. Risks of a range of alcohol intake on hepatitis C-related fibrosis Hepatology 39 2004 826-834
3. K. Ikejima et al. Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals Hepatology 34 2001 288-297
4. A.M. Jezequel G. Ballardini R. Mancini F. Paolucci F.B. Bianchi F. Orlandi Modulation of extracellular matrix components during dimethylnitrosamine-induced cirrhosis J. Hepatol. 11 1990 206-214
5. R. Lichtinghagen K. Breitenstein B. Arndt T. Kuhbacher Comparison of matrix metalloproteinase expression in normal and cirrhotic human liver Virchows Arch. 432 1998 153-158
6. Y. Inagaki et al. Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice Hepatology 38 2003 890-899
7. Y. Kim S. Peyrol C.K. So C.D. Boyd K. Csiszar Coexpression of the lysyl oxidase-like gene (LOXL) and the gene encoding type III procollagen in induced liver fibrosis J. Cell Biochem. 72 1999 181-188
8. H. Masuda M. Fukumoto K. Hirayoshi K. Nagata Coexpression of the collagen-binding stress protein HSP47 gene alpha 1 (I) and alpha 1 (III) collagen genes in carbon tetrachloride rat liver fibrosis J. Clin. Invest. 94 1994 2481-2488
9. M. Bickel et al. Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hydroxylase inhibitor Hepatology 28 1998 404-411
10. I. Okazaki T. Watanabe S. Hozawa M. Arai K. Maruyama Molecular mechanism of the reversibility of hepatic fibrosis: With special reference to the role of matrix metalloproteinases J. Gastroenterol. Hepatol. 15 2000 D26-32
11. T. Watanabe et al. Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat J. Hepatol. 35 2001 465-473
12. T. Knittel M. Mehde A. Grundmann B. Saile J.G. Scharf G. Ramadori Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat Histochem. Cell Biol. 113 2000 443-453
13. H.S. Lee et al. Expression of matrix metalloproteinases in spontaneous regression of liver fibrosis Hepatogastroenterology 48 2001 1114-1117
14. T. Watanable et al. Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride J. Hepatol. 33 2000 224-235
15. J. Myllyharju K.I. Kivirikko Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase EMBO J. 16 1997 1173-1180
16. H. Anttinen U. Puistola T. Pihlajaniemi K.I. Kivirikko Differences between proline and lysine hydroxylations in their inhibition by zinc or by ascorbate deficiency during collagen synthesis in various cell types Biochim. Biophys. Acta 674 1981 336-344
17. J.L. Seltzer J. Jeffrey A.Z. Eisen Evidence for mammalian collagenases as zinc ion metalloenzymes Biochim. Biophys. Acta 485 1977 179-187
18. M. Cabre J. Camps N. Ferre J.L. Paternain J. Joven The antioxidant and hepatoprotective effects of zinc are related to hepatic cytochrome P450 depression and metallothionein induction in rats with experimental cirrhosis Int. J. Vitam. Nutr. Res. 71 2001 229-236
19. A. Gimenez et al. Fibrogenic and collagenolytic activity in carbon-tetrachloride-injured rats: Beneficial effects of zinc administration J. Hepatol. 21 1994 292-298
20. B.L. Vallee The function of metallothionein Neurochem. Int. 27 1995 23-33
21. D.U. Spahl D. Berendji-Grun C.V. Suschek V. Kolb-Bachofen K. Kroncke Regulation of zinc homeostasis by inducible NO synthase-derived NO: nuclear metallothionein translocation and intranuclear Zn2+ release Proc. Natl. Acad. Sci. USA 100 2003 13952-13957
22. M.M. Martinez G.M. Hill J.E. Link N.E. Raney R.J. Tempelman C.W. Ernst Pharmacological zinc and phytase supplementation enhance metallothionein mRNA abundance and protein concentration in newly weaned pigs J. Nutr. 134 2004 538-544
23. R.S. Chung A.K. West A role for extracellular metallothionein in CNS injury and repair Neuroscience 123 2004 595-599
24. L.G. Puskas et al. Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: A DNA microarray study FEBS Lett. 562 2004 99-104
25. L. Tapia et al. Metallothionein is crucial for safe intracellular copper storage and cell survival at normal and supra-physiological exposure level Biochem. J. 378 Pt 2 2004 617-624
26. W. Maret Cellular zinc and redox states converge in the metallothionein/thionein pair J. Nutr. 133 5 Suppl. 1 2003 1460S-1462S
27. J.Y. Lee J.H. Kim R.D. Palmiter J.Y. Koh Zinc released from metallothionein-III may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury Exp. Neurol. 184 2003 337-347
28. L.G. Lu et al. Grading and staging of hepatic fibrosis, and its relationship with noninvasive diagnostic parameters World J. Gastroenterol. 9 2003 2574-2578
29. Y. Kamada et al. Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin Gastroenterology 125 2003 1796-1807
30. Y. Inagaki et al. Interferon alfa down-regulates collagen gene transcription and suppression experimental hepatic fibrosis mice Hepatology 38 2003 890-899
31. K.L. Rudolph S. Chang M. Millard N. Schreiber-Agus R. DePinho A. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery Science 287 2000 1253-1258
32. M.J. Perez A.I. Cederbaum Metallothionein 2A induction by zinc protects HEPG2 cells against CYP2E1-dependent toxicity Free Radical Biol. Med. 34 2003 443-455
33. Z. Zhou X. Sun J.Y. Kang Metallothionein protection against alcoholic liver injury through inhibition of oxidative stress Exp. Biol. Med. 227 2002 214-222
34. C.O. Quinn et al. Rat collagenase: Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells J. Biol. Chem. 265 1990 22342-22347
35. P. Henriet G.G. Rousseau Y. Eeckhout Cloning and sequencing of mouse collagenase cDNA and -divergence of mouse and rat collagenase from the other mammalian collagenases FEBS Lett. 310 1992 175-178
36. J. Garcia-Banuelos et al. Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors: evidence of cirrhosis reversion Gene Ther. 9 2002 127-134
37. F. Siller-Lopez et al. Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis Gastroenterology 126 2004 1122-1133
38. Y. Iimura et al. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat Gastroenterology 124 2003 445-458
39. S. Salgado et al. Liver cirrhosis is reverted by urokinase-type plasminogen activator gene therapy Mol. Ther. 2 2000 545-551
40. T. Ueki et al. Hepatocyte growth factor gene therapy of liver cirrhosis in rats Nat. Med. 5 1999 226-230
41. + channels Neuron 41 2004 351-365
42. B.A. Masters E.J. Kelly C.J. Quaife R.L. Brinster R.D. Palmiter Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium Proc. Natl. Acad. Sci. USA 91 1994 584-588
43. L.C. Junqueira G. Bignolas R.R. Brentani Picrosirius staining plus polarization microscopy: A specific method for collagen detection in tissue sections Histochem. J. 11 1979 447-455
44. K.I. Kivirikko O. Laitinen D.J. Prockop Modification of a specific assay for hydroxyproline in urine Anal. Biochem. 19 1967 249-255
45. Y.J. Kang Y. Chen A. Yu M. McVoss-Cowan P.N. Epstein Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity J. Clin. Invest. 100 1997 1501-1506