Serum cardiac troponin T as a biomarker for acute myocardial injury induced by low doses of isoproterenol in rats

Cardiovascular Toxicology

Volumn 6, Issue 3-4, 2006, Pages 211-221

  Herman, Eugene ^a   Zhang, Jun ^a   Knapton, Alan ^a   Lipshultz, Steven E ^b   Rifai, Nader ^c   Sistare, Frank ^a,d  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cardiac troponin T; Isoproterenol; Low dose; Myocardial damage

Indexed keywords

BIOLOGICAL MARKER; ISOPRENALINE; TROPONIN T;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; DISEASE MARKER; FOLLOW UP; HEART MUSCLE INJURY; INJURY SEVERITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT;

ANIMALIA; RATTUS;

ACUTE DISEASE; ADRENERGIC BETA-AGONISTS; ANIMALS; BIOLOGICAL MARKERS; CARDIOMYOPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ISOPROTERENOL; MALE; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TROPONIN T;

EID: 33947110514     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1385/ct:6:3:211     Document Type: Article

References (17)

1. Chappel, C.I., Rona, G., Balazs, T., et al. (1959). Severe myocardial necrosis produced by isoproterenol in the rat. Arch. Int. Pharmacodyn. Ther. 122:123-128.
2. Rona, G., Chappel, C. I., Balazs, T., et al. (1959). An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat. Arch. Pathol. 67:448-453.
3. Rona, G., Kahn, D.S., and Chappel, C.I. (1963). Studies on the infarct-like myocardial necrosis produced by isoproterenol. A review. Rev. Can. Biol. 22:241-255.
4. Davies, M.J. (1977). The pathology of myocardial ischaemia. J. Clin. Pathol. Suppl. (R. Coll. Pathol.) 11:45-52.
5. Mair, J. (1997). Progress in myocardial damage detection: new biochemical markers for clinicians. Cri. Rev. Clin. Lab. Sci. 34:1-66.
6. Katus, H.A., Remppis, A., Neuman, F.J., et al. (1991). Diagnostic efficiency of troponin T measurements in acute myocardial infarction. Circulation 83:902-912.
7. Adams, J.E. III, Bodor, G.S., Davila-Roman, V.G., et al. (1993). Cardiac troponin I. A marker with high specificity for cardiac injury. Circulation 88:101-106.
8. O'Brien, P.J., Daweron, G.W., Beck, M.L., et al. (1997). Troponin T is a sensitive, specific biomarker of cardiac injury in laboratory animals. Lab. Animal Sci. l47:486-495.
9. O'Brien, P.J., Landt, Y., and Ladenson, J.H. (1997). Differential reactivity of cardiac and skeletal muscle from various species in a cardiac troponin I immunoassay. Clin. Chem. 43:2333-2338.
10. O'Brien, P.J., Dameron, G.W., Beck, M.L., et al. (1998). Differential reactivity of cardiac and skeletal muscle from various species in two generations of cardiac troponin-T immunoassays. Res. Vet. Sci. 65:135-137.
11. Bleuel, H., Deschl, U., Bertsch, T., et al. (1995). Diagnostic efficiency of troponin T measurements in rats with experimental myocardial damage. Exp. Toxicol. Pathol. 47:121-127.
12. Bertsch, T., Bleuel, H., Aufenanger, J., et al. (1997). Comparison of cardiac troponin T and cardiac troponin I concentrations in peripheral blood during orciprenaline induced tachycardia in rats. Exp. Toxicol. Pathol. 49:467-468.
13. Bertsch, T., Bleuel, H., Deschl, U., et al. (1999). A new sensitive cardiac troponin T rapid test (TROPT) for the detection of experimental acute damage in rats. Exp. Toxicol. Pathol. 51:565-569.
14. Bertinchant, J.P., Robert, E., Polge, A., et al. (2000). Comparison of the diagnostic value of cardiac troponin I and T determinations for detecting early myocardial damage and the relationship with histological findings after isoproterenol-induced cardiac injury. Clin. Chimica Acta 298:13-28.
15. Bartsch, V.W., Roesch, E., Hebold, G., et al. (1974). Einbeitrag zur differenzierang zwischein echter und scheinbarer, β-rezeptoren blockade am herzen. Arzneim-Forsch (Drug Res.) 24:303-308.
16. Mueller-Bardorf, M., Hallermayer, K., Schroder, A., et al. (1997). Improved troponin T ELISA specific for cardiac troponin T isoform: assay development and analytical and clinical validation. Clin. Chem. 43:458-466.
17. Noronha-Dutra, A.A., Steen, E.M., and Woolf, N. (1984). The early changes induced by isoproterenol in the endocardium and adjacent myocardium. Am. J. Pathol. 114:231-239.