Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat

Toxicological Sciences

Volumn 105, Issue 2, 2008, Pages 368-383

  Andersen, Melvin E ^a   Clewell, Harvey J ^a   Bermudez, Edilberto ^a   Willson, Gabrielle A ^a   Thomas, Russell S ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

Dose dependent transitions; Epithelial cell responses; Formaldehyde; Genomics; Mode of action; Phenotypic anchoring; Progression

Indexed keywords

FORMALDEHYDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPITHELIUM HYPERPLASIA; EXPOSURE; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENOMICS; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; MALE; MICROARRAY ANALYSIS; NONHUMAN; NOSE MUCOSA; RAT; SQUAMOUS CELL METAPLASIA;

ANIMALS; CELL MEMBRANE; CELL PROLIFERATION; CLUSTER ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR MATRIX; FORMALDEHYDE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HYPERPLASIA; INHALATION EXPOSURE; MALE; METAPLASIA; NASAL MUCOSA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED F344; TIME FACTORS; TOXICITY TESTS; TRANSCRIPTION, GENETIC;

RATTUS;

EID: 51849115581     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn097     Document Type: Article

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