The role of cytokines in atopic asthma

Current Medicinal Chemistry

Volumn 18, Issue 10, 2011, Pages 1476-1487

  Finiasz, M ^a   Otero, C ^a   Bezrodnik, L ^b   Fink, S ^a  

^a INST DE INVEST HEMATOLOGICAS   (Argentina)

^b HOSPITAL DE NIÑOS RICARDO GUTIÉRREZ   (Argentina)

Author keywords

Airway hyperresponsiveness; Asthma therapy; Atopic asthma; CD4+ Tcell subsets; Cytokines; Th2 cells

Indexed keywords

ADALIMUMAB; ALLERGEN; ALPHA INTERFERON; ALTRAKINCEPT; ARACHIDONIC ACID DERIVATIVE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA INTERFERON; CELL ADHESION MOLECULE; CHEMOKINE; CORTICOSTEROID; CYTOKINE; DNA VACCINE; ETANERCEPT; FLUTICASONE; HISTAMINE; INFLIXIMAB; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; METALLOPROTEINASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MEDI 528; PASCOLIZUMAB; PITRAKINRA; RECOMBINANT INTERLEUKIN 12; RESLIZUMAB; SALMETEROL; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ABSENCE OF SIDE EFFECTS; ALLERGIC ASTHMA; ARTICLE; BRONCHUS HYPERREACTIVITY; CHRONIC INFLAMMATION; COUGHING; CYTOKINE PRODUCTION; DEGRANULATION; DYSPNEA; HISTAMINE RELEASE; HUMAN; IMMUNOTHERAPY; INFLAMMATION; MEDIATOR RELEASE; MUCUS SECRETION; NONHUMAN; REGULATORY T LYMPHOCYTE; SMOOTH MUSCLE CONTRACTION; SYMPTOM; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH17 CELL; TH2 CELL; UNSPECIFIED SIDE EFFECT; WHEEZING;

ANIMALS; ASTHMA; CYTOKINES; EOSINOPHILS; EPITHELIAL CELLS; HUMANS; MAST CELLS; RECEPTORS, CYTOKINE; T-LYMPHOCYTES; TH2 CELLS;

EID: 79955010084     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986711795328346     Document Type: Article

References (134)

1. Finn, P. W.; Bigby, T. D. Innate immunity and asthma. Proc. Am. Thorac. Soc. 2009, 6(3), 260-265.
2. Bateman, E. D.; Hurd, S. S.; Barnes, P. J.; Bousquet, J.; Drazen, J. M.; Fitz Gerald, M.; Gibson, P.; Ohta, K.; O'Byrne, P.; Pedersen, S. E.; Pizzichini, E.; Sullivan, S. D.; Wenzel, S. E.; Zar, H. J. Global strategy for asthma management and prevention: GINA executive summary. Eur. Respir. J. 2008, 31(1), 143-178.
3. Fanta, C. H. Asthma. N. Engl. J. Med. 2009, 360(10), 1002-1014.
4. Ober, C.; Hoffjan, S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun. 2006, 7(2), 95-100. (Pubitemid 43336051)
5. Long, A. A. Immunomodulators in the treatment of asthma. Allergy Asthma Proc. 2009, 30(2), 109-119.
6. Minai-Fleminger, Y.; Levi-Schaffer, F. Mast cells and eosinophils: the two key effector cells in allergic inflammation. Inflamm. Res. 2009, 58(10), 631-638.
7. Levi-Schaffer, F.; Garbuzenko, E.; Rubin, A.; Reich, R.; Pickholz, D.; Gillery, P.; Emonard, H.; Nagler, A.; Maquart, F. A. Human eosinophils regulate human lung-and skin-derived fibroblast properties in vitro: a role for transforming growth factor beta (TGF-beta). Proc. Natl. Acad. Sci. U.S.A. 1999, 96(17), 9660-9665. (Pubitemid 29398788)
8. Woodruff, P. G.; Modrek, B.; Choy, D. F.; Jia, G.; Abbas, A. R.; Ellwanger, A.; Koth, L. L.; Arron, J. R.; Fahy, J. V. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am. J. Respir. Crit. Care Med. 2009, 180(5), 388-395.
9. Moore, W. C.; Meyers, D. A.; Wenzel, S. E.; Teague, W. G.; Li, H.; Li, X.; D'Agostino, R. Jr.; Castro, M.; Curran-Everett, D.; Fitzpatrick, A. M.; Gaston, B.; Jarjour, N. N.; Sorkness, R.; Calhoun, W. J.; Chung, K. F.; Comhair, S. A.; Dweik, R. A.; Israel, E.; Peters, S. P.; Busse, W. W.; Erzurum, S. C.; Bleecker, E. R. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am. J. Respir. Crit. Care Med. 2010, 181(4), 315-323.
10. Koppelman, G. H.; Meyers, D. A.; Howard, T. D.; Zheng, S. L.; Hawkins, G. A.; Ampleford, E. J.; Xu, J.; Koning, H.; Bruinenberg, M.; Nolte, I. M.; van Diemen, C. C.; Boezen, H. M.; Timens, W.; Whittaker, P. A.; Stine, O. C.; Barton, S. J.; Holloway, J. W.; Holgate, S. T.; Graves, P. E.; Martinez, F. D.; van Oosterhout, A. J.; Bleecker, E. R.; Postma, D. S. Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. Am. J. Respir. Crit. Care Med. 2009, 180(10), 929-935.
11. Lloyd, C. M.; Saglani, S. Asthma and allergy: the emerging epithelium. Nat. Med. 2010, 16(3), 273-274.
12. Walters, E. H.; Soltani, A.; Reid, D. W.; Ward, C. Vascular remodelling in asthma. Curr. Opin. Allergy Clin. Immunol. 2008, 8(1), 39-43.
13. Ribatti, D.; Puxeddu, I.; Crivellato, E.; Nico, B.; Vacca, A.; Levi-Schaffer, F. Angiogenesis in asthma. Clin. Exp. Allergy 2009, 39(12), 1815-1821.
14. Simcock, D. E.; Kanabar, V.; Clarke, G. W.; O'Connor, B. J.; Lee, T. H.; Hirst, S. J. Proangiogenic activity in bronchoalveolar lavage fluid from patients with asthma. Am. J. Respir. Crit. Care Med. 2007, 176(2), 146-153. (Pubitemid 47057850)
15. Macfarlane, A. J.; Kon, O. M.; Smith, S. J.; Zeibecoglou, K.; Khan, L. N.; Barata, L. T.; McEuen, A. R.; Buckley, M. G.; Walls, A. F.; Meng, Q.; Humbert, M.; Barnes, N. C.; Robinson, D. S.; Ying, S.; Kay, A. B. Basophils, eosinophils, and mast cells in atopic and nonatopic asthma and in latephase allergic reactions in the lung and skin. J. Allergy Clin. Immunol. 2000, 105(1 Pt 1), 99-107. (Pubitemid 30059109)
16. Nouri-Aria, K. T.; Irani, A. M.; Jacobson, M. R.; O'Brien, F.; Varga, E. M.; Till, S. J.; Durham, S. R.; Schwartz, L. B. Basophil recruitment and IL-4 production during human allergen-induced late asthma. J. Allergy Clin. Immunol. 2001, 108(2), 205-211. (Pubitemid 32735402)
17. Obata, K.; Mukai, K.; Tsujimura, Y.; Ishiwata, K.; Kawano, Y.; Minegishi, Y.; Watanabe, N.; Karasuyama, H. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 2007, 110(3), 913-920. (Pubitemid 47267429)
18. Nakanishi, K. Basophils as APC in Th2 response in allergic inflammation and parasite infection. Curr Opin. Immunol. 2010, 22(6), 814-820.
19. Gauchat, J. F.; Henchoz, S.; Mazzei, G.; Aubry, J. P.; Brunner, T.; Blasey, H.; Life, P.; Talabot, D.; Flores-Romo, L.; Thompson, J.; Kishi, K.; Butterfield, J.; Dahinden, C.; Bonnefoy, J.-Y. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 1993, 365(6444), 340-343. (Pubitemid 23288974)
20. Yanagihara, Y.; Kajiwara, K.; Basaki, Y.; Ikizawa, K.; Akiyama, K.; Saito, H. Induction of human IgE synthesis in B cells by a basophilic cell line, KU812. Clin. Exp. Immunol. 1997, 108(2), 295-301. (Pubitemid 27223469)
21. Foley, S. C.; Prefontaine, D.; Hamid, Q. Images in allergy and immunology: role of eosinophils in airway remodeling. J. Allergy Clin. Immunol. 2007, 119(6), 1563-1566. (Pubitemid 46855869)
22. Jacobsen, E. A.; Ochkur, S. I.; Lee, N. A.; Lee, J. J. Eosinophils and asthma. Curr. Allergy Asthma Rep. 2007, 7(1), 18-26. (Pubitemid 46655380)
23. Hai, C. M. Airway smooth muscle cell as therapeutic target of inflammation. Curr. Med. Chem. 2007, 14(1), 67-76.
24. Holgate, S. T. The airway epithelium is central to the pathogenesis of asthma. Allergol. Int. 2008, 57(1), 1-10. (Pubitemid 351413241)
25. Sha, Q.; Truong-Tran, A. Q.; Plitt, J. R.; Beck, L. A.; Schleimer, R. P. Activation of airway epithelial cells by toll-like receptor agonists. Am. J. Respir. Cell Mol. Biol. 2004, 31(3), 358-64. (Pubitemid 39180307)
26. Takhar, P.; Corrigan, C. J.; Smurthwaite, L.; O'Connor, B. J.; Durham, S. R.; Lee, T. H.; Gould, H. J. Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma. J. Allergy Clin. Immunol. 2007, 119(1), 213-218. (Pubitemid 46037820)
27. Barnes, P. J. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev. Immunol 2008, 8(3), 183-192. (Pubitemid 351323287)
28. Lambrecht, B. N.; Hammad, H. Biology of lung dendritic cells at the origin of asthma. Immunity 2009, 31(3), 412-424.
29. Hammad, H.; Lambrecht, B. N. Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation. J. Allerg Clin. Immunol. 2006, 118(2), 331-336. (Pubitemid 44142704)
30. Liu, Y. J. Thymic stromal lymphopoietin: master switch for allergic inflammation. J. Exp. Med. 2006, 203(2), 269-273.
31. Akdis, C. A.; Akdis, M. Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J. Allergy Clin. Immunol. 2009, 123(4), 735-746; quiz 747-748.
32. Belkaid, Y.; Rouse, B. T. Natural regulatory T cells in infectious disease. Nat Immunol. 2005, 6(4), 353-360. (Pubitemid 41716772)
33. Vermaelen, K.; Pauwels, R. Accelerated airway dendritic cell maturation, trafficking, and elimination in a mouse model of asthma. Am. J. Respir. Cell. Mol. Biol. 2003, 29(3 Pt 1), 405-409. (Pubitemid 37094000)
34. Shalaby, K. H.; Martin, J. G. Overview of asthma; the place of the T cell. Curr. Opin. Pharmacol. 2010, 10(3), 218-225.
35. Robinson, D. S. Regulatory T cells and asthma. Clin. Exp. Allergy 2009, 39(9), 1314-23.
36. Martin, J. G.; Suzuki, M.; Ramos-Barbon, D.; Isogai, S. T cell cytokines: animal models. Paediatr. Respir. Rev. 2004, 5(Suppl A), S47-S51.
37. Barnes, P. J. Role of GATA-3 in allergic diseases. Curr. Mol. Med. 2008, 8(5), 330-334.
38. Blanchard, C.; Rothenberg, M. E. Biology of the eosinophil. Adv. Immunol. 2009, 101, 81-121.
39. Rothenberg, M. E.; Hogan, S. P. The eosinophil. Annu. Rev. Immunol. 2006, 24, 147-174.
40. Shimbara, A.; Christodoulopoulos, P.; Soussi-Gounni, A.; Olivenstein, R.; Nakamura, Y.; Levitt, R. C.; Nicolaides, N. C.; Holroyd, K. J.; Tsicopoulos, A.; Lafitte, J. J.; Wallaert, B.; Hamid, Q. A. IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. J. Allergy Clin. Immunol. 2000, 105(1 Pt 1), 108-115. (Pubitemid 30059110)
41. Soroosh, P.; Doherty, T. A. Th9 and allergic disease. Immunology 2009, 127(4), 450-458.
42. Doherty, T.; Broide, D. Cytokines and growth factors in airway remodeling in asthma. Curr. Opin. Immunol. 2007, 19(6), 676-680. (Pubitemid 350236803)
43. Dodd, J. S.; Lum, E.; Goulding, J.; Murr, R.; Van Snick, J.; Openshaw, P. J. IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection. J. Immunol. 2009, 183(11), 7006-7013.
44. Devos, S.; Cormont, F.; Vrtala, S.; Hooghe-Peters, E.; Pirson, F.; Snick, J. Allergen-induced interleukin-9 production in vitro: correlation with atopy in human adults and comparison with interleukin-5 and interleukin-13. Clin. Exp. Allergy 2006, 36(2), 174-182.
45. Erpenbeck, V. J.; Hohlfeld, J. M.; Volkmann, B.; Hagenberg, A.; Geldmacher, H.; Braun, A.; Krug, N. Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes. J. Allergy Clin. Immunol. 2003, 111(6), 1319-1327. (Pubitemid 36683688)
46. Borish, L.; Aarons, A.; Rumbyrt, J.; Cvietusa, P.; Negri, J.; Wenzel, S. Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin. Immunol. 1996, 97(6), 1288-1296. (Pubitemid 26192279)
47. Lim, S.; Crawley, E.; Woo, P.; Barnes, P. J. Haplotype associated with low interleukin-10 production in patients with severe asthma. Lancet 1998, 352(9122), 113. (Pubitemid 28321327)
48. Akbari, O.; DeKruyff, R. H.; Umetsu, D. T. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2001, 2(8), 725-731. (Pubitemid 32747162)
49. Taylor, A.; Akdis, M.; Joss, A.; Akkoc, T.; Wenig, R.; Colonna, M.; Daigle, I.; Flory, E.; Blaser, K.; Akdis, C. A. IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1. J. Allergy ClinImmunol. 2007, 120(1), 76-83. (Pubitemid 46990499)
50. Oral, H. B.; Kotenko, S. V.; Yilmaz, M.; Mani, O.; Zumkehr, J.; Blaser, K.; Akdis, C. A.; Akdis, M. Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26. Eur. J. Immunol. 2006, 36(2), 380-388. (Pubitemid 43257461)
51. Kato, M.; Yamada, Y.; Maruyama, K.; Hayashi, Y. Serum eosinophil cationic protein and 27 cytokines/chemokines in acute exacerbation of childhood asthma. Int. Arch. Allergy Immunol. 2010, 152(Suppl 1), 62-66.
52. Wills-Karp, M. Interleukin-13 in asthma pathogenesis. Immunol. Rev. 2004, 202, 175-190. (Pubitemid 39576912)
53. Hahn, C.; Teufel, M.; Herz, U.; Renz, H.; Erb, K. J.; Wohlleben, G.; Brocker, E. B.; Duschl, A.; Sebald, W.; Grunewald, S. M. Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma. J. Allergy Clin. Immunol. 2003, 111(6), 1361-1369. (Pubitemid 36683693)
54. Bullens, D. M.; Truyen, E.; Coteur, L.; Dilissen, E.; Hellings, P. W.; Dupont, L. J.; Ceuppens, J. L. IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir. Res. 2006, 7, 135.
55. Wang, Y. H.; Liu, Y. J. The IL-17 cytokine family and their role in allergic inflammation. Curr. Opin. Immunol. 2008, 20(6), 697-702.
56. Wolk, K.; Witte, E.; Witte, K.; Warszawska, K.; Sabat, R. Biology of interleukin-22. Semin. Immunopathol. 2010, 32(1), 17-31.
57. Zhao, Y.; Yang, J.; Gao, Y. D.; Guo, W. Th17 Immunity in Patients with Allergic Asthma. Int. Arch. Allergy Immunol. 2009, 151(4), 297-307.
58. Eyerich, S.; Eyerich, K.; Pennino, D.; Carbone, T.; Nasorri, F.; Pallotta, S.; Cianfarani, F.; Odorisio, T.; Traidl-Hoffmann, C.; Behrendt, H.; Durham, S. R.; Schmidt-Weber, C. B.; Cavani, A. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J. Clin. Invest. 2009, 119(12), 3573-3585.
59. Prefontaine, D.; Lajoie-Kadoch, S.; Foley, S.; Audusseau, S.; Olivenstein, R.; Halayko, A. J.; Lemiere, C.; Martin, J. G.; Hamid, Q. Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. J. Immunol. 2009, 183(8), 5094-5103.
60. Broide, D. H. Immunomodulation of allergic disease. Annu. Rev. Med. 2009, 60, 279-291.
61. Hartl, D.; Griese, M.; Nicolai, T.; Zissel, G.; Prell, C.; Konstantopoulos, N.; Gruber, R.; Reinhardt, D.; Schendel, D. J.; Krauss-Etschmann, S. Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough. J. Allergy Clin. Immunol. 2005, 115(4), 728-736. (Pubitemid 40460846)
62. Tamachi, T.; Maezawa, Y.; Ikeda, K.; Iwamoto, I.; Nakajima, H. Interleukin 25 in allergic airway inflammation. Int. Arch. Allergy Immunol. 2006, 140 Suppl 1, 59-62. (Pubitemid 43882387)
63. Dillon, S. R.; Sprecher, C.; Hammond, A.; Bilsborough, J.; Rosenfeld Franklin, M.; Presnell, S. R.; Haugen, H. S.; Maurer, M.; Harder, B.; Johnston, J.; Bort, S.; Mudri, S.; Kuijper, J. L.; Bukowski, T.; Shea, P.; Dong, D. L.; Dasovich, M.; Grant, F. J.; Lockwood, L.; Levin, S. D.; LeCiel, C.; Waggie, K.; Day, H.; Topouzis, S.; Kramer, J.; Kuestner, R.; Chen, Z.; Foster, D.; Parrish-Novak, J.; Gross, J. A. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat. Immunol. 2004, 5(7), 752-760. (Pubitemid 39023308)
64. Kakkar, R.; Lee, R. T. The IL-33/ST2 pathway: therapeutic target and novel biomarker. Nat.Rev. Drug Discov. 2008, 7(10), 827-840.
65. Romagnani, S. Immunologic influences on allergy and the TH1/TH2 balance. J. Allergy Clin. Immunol. 2004, 113(3), 395-400. (Pubitemid 38338939)
66. Adcock, I. M.; Caramori, G.; Chung, K. F. New targets for drug development in asthma. Lancet 2008, 372(9643), 1073-1087.
67. Rengarajan, J.; Szabo, S. J.; Glimcher, L. H. Transcriptional regulation of Th1/Th2 polarization. Immunol Today 2000, 21(10), 479-483.
68. Weaver, C. T.; Harrington, L. E.; Mangan, P. R.; Gavrieli, M.; Murphy, K. M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006, 24(6), 677-688. (Pubitemid 43867371)
69. Romagnani, S. Human Th17 cells. Arthritis Res. Ther. 2008, 10(2), 206.
70. Chang, H. C.; Sehra, S.; Goswami, R.; Yao, W.; Yu, Q.; Stritesky, G. L.; Jabeen, R.; McKinley, C.; Ahyi, A. N.; Han, L.; Nguyen, E. T.; Robertson, M. J.; Perumal, N. B.; Tepper, R. S.; Nutt, S. L.; Kaplan, M. H. The transcription factor PU. 1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat. Immunol., 2010, 11(6), 527-534.
71. Mosmann, T. R.; Cherwinski, H.; Bond, M. W.; Giedlin, M. A.; Coffman, R. L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 1986, 136(7), 2348-2357. (Pubitemid 16136806)
72. Meiler, F.; Zimmermann, M.; Blaser, K.; Akdis, C. A.; Akdis, M. T-cell subsets in the pathogenesis of human asthma. Curr. Allergy Asthma Rep. 2006, 6(2), 91-96.
73. Akdis, C. A.; Blaser, K.; Akdis, M. Apoptosis in tissue inflammation and allergic disease. Curr. Opin. Immunol. 2004, 16(6), 717-723. (Pubitemid 39423659)
74. Mazzoni, A.; Young, H. A.; Spitzer, J. H.; Visintin, A.; Segal, D. M. Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J. Clin. Invest. 2001, 108(12), 1865-1873. (Pubitemid 34015132)
75. Osna, N.; Elliott, K.; Khan, M. M. Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes. Int. Immunopharmacol. 2001, 1(1), 85-96. (Pubitemid 32193604)
76. Kunzmann, S.; Mantel, P. Y.; Wohlfahrt, J. G.; Akdis, M.; Blaser, K.; Schmidt-Weber, C. B. Histamine enhances TGF-beta1-mediated suppression of Th2 responses. FASEB J. 2003, 17(9), 1089-1095. (Pubitemid 36676395)
77. Akdis, C. A.; Blaser, K. Bypassing IgE and targeting T cells for specific immunotherapy of allergy. Trends Immunol. 2001, 22(4), 175-178. (Pubitemid 32673650)
78. Annunziato, F.; Romagnani, S. do studies in humans better depict Th17 cells? Blood 2009, 114(11), 2213-2219.
79. Dardalhon, V.; Awasthi, A.; Kwon, H.; Galileos, G.; Gao, W.; Sobel, R. A.; Mitsdoerffer, M.; Strom, T. B.; Elyaman, W.; Ho, I. C.; Khoury, S.; Oukka, M.; Kuchroo, V. K. IL-4 inhibits TGF-beta-induced Foxp3+T cells and, together with TGF-beta, generates IL-9+IL-10+Foxp3(-) effector T cells. Nat. Immunol. 2008, 9(12), 1347-1355.
80. Veldhoen, M.; Uyttenhove, C.; van Snick, J.; Helmby, H.; Westendorf, A.; Buer, J.; Martin, B.; Wilhelm, C.; Stockinger, B. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 2008, 9(12), 1341-1346.
81. Bettelli, E.; Korn, T.; Oukka, M.; Kuchroo, V. K. Induction and effector functions of T(H)17 cells. Nature 2008, 453(7198), 1051-1057. (Pubitemid 351871737)
82. Sergejeva, S.; Ivanov, S.; Lotvall, J.; Linden, A. Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation. Am. J. Respir. Cell. Mol. Biol. 2005, 33(3), 248-253. (Pubitemid 41254291)
83. Schmidt-Weber, C. B.; Akdis, M.; Akdis, C. A. TH17 cells in the big picture of immunology. J. Allergy Clin. Immunol. 2007, 120(2), 247-254. (Pubitemid 47102403)
84. Nurieva, R.; Yang, X. O.; Martinez, G.; Zhang, Y; Panopoulos, A. D.; Ma, L.; Schluns, K.; Tian, Q.; Watowich, S. S.; Jetten, A. M.; Dong, C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007, 448(7152), 480-483. (Pubitemid 47123514)
85. Nowak, E. C.; Weaver, C. T.; Turner, H.; Begum-Haque, S.; Becher, B.; Schreiner, B.; Coyle, A. J.; Kasper, L. H.; Noelle, R. J. IL-9 as a mediator of Th17-driven inflammatory disease. J. Exp. Med. 2009, 206(8), 1653-1660.
86. Chen, Z.; Laurence, A.; O'Shea, J. J. Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin. Immunol. 2007, 19(6), 400-408.
87. Chen, W.; Jin, W.; Hardegen, N.; Lei, K. J.; Li, L.; Marinos, N.; McGrady, G.; Wahl, S. M. Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 2003, 198(12), 1875-1886. (Pubitemid 38032120)
88. Xu, L.; Kitani, A.; Fuss, I.; Strober, W. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3-T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J. Immunol. 2007, 178(11), 6725-6729. (Pubitemid 46847395)
89. O'Connor, W. Jr.; Zenewicz, L. A.; Flavell, R. A. The dual nature of T(H)17 cells: shifting the focus to function. Nat. Immunol. 2010, 11(6), 471-476.
90. Moller, G. do suppressor T cells exist? Scand. J. Immunol. 1988, 27(3), 247-250. (Pubitemid 18076747)
91. Palomares, O.; Yaman, G.; Azkur, A. K.; Akkoc, T.; Akdis, M.; Akdis, C. A. Role of T regulatory cells in immune regulation of allergic diseases. Eur. J. Immunol. 2010, 40(5), 1232-1240.
92. Curotto de Lafaille, M. A.; Kutchukhidze, N.; Shen, S.; Ding, Y; Yee, H.; Lafaille, J. J. Adaptive Foxp3+regulatory T cell-dependent and-independent control of allergic inflammation. Immunity 2008, 29(1), 114-126.
93. Ling, E. M.; Smith, T.; Nguyen, X. D.; Pridgeon, C.; Dallman, M.; Arbery, J.; Carr, V. A.; Robinson, D. S. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004, 363(9409), 608-615. (Pubitemid 38264178)
94. Huber, S.; Schramm, C.; Lehr, H. A.; Mann, A.; Schmitt, S.; Becker, C.; Protschka, M.; Galle, P. R.; Neurath, M. F.; Blessing, M. Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells. J. Immunol. 2004, 173(11), 6526-6531. (Pubitemid 39541034)
95. Akdis, M. Healthy immune response to allergens: T regulatory cells and more. Curr. Opin. Immunol. 2006, 18(6), 738-744. (Pubitemid 44635172)
96. Anderson, A. E.; Mackerness, K. J.; Aizen, M.; Carr, V. A.; Nguyen, D.; Du Pre, F.; Durham, S. R.; Robinson, D. S. Seasonal changes in suppressive capacity of CD4+ CD25+ T cells from patients with hayfever are allergenspecific and may result in part from expansion of effector T cells among the CD25+ population. Clin. Exp. Allergy 2009, 39(11), 1693-1739.
97. Akdis, M.; Verhagen, J.; Taylor, A.; Karamloo, F.; Karagiannidis, C.; Crameri, R.; Thunberg, S.; Deniz, G.; Valenta, R.; Fiebig, H.; Kegel, C.; Disch, R.; Schmidt-Weber, C. B.; Blaser, K.; Akdis, C. A. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J. Exp. Med. 2004, 199(11), 1567-1575. (Pubitemid 38780411)
98. Miyara, M.; Wing, K.; Sakaguchi, S. Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion. J. Allergy Clin. Immunol. 2009, 123(4), 749-755; quiz 756-757.
99. Strickland, D. H.; Wikstrom, M. E.; Turner, D. J.; Holt, P. G. Mucosal regulatory T cells in airway hyperresponsiveness. Chem. Immunol. Allergy 2008, 94, 40-47.
100. Lee, J. H.; Yu, H. H.; Wang, L. C.; Yang, Y. H.; Lin, Y. T.; Chiang, B. L. The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma. Clin. Exp. Immunol. 2007, 148(1), 53-63.
101. Walker, M. R.; Carson, B. D.; Nepom, G. T.; Ziegler, S. F.; Buckner, J. H. De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25-cells. Proc. Natl Acad. Sci. U S A 2005, 102(11), 4103-4108. (Pubitemid 40388562)
102. Maggi, L.; Santarlasci, V.; Liotta, F.; Frosali, F.; Angeli, R.; Cosmi, L.; Maggi, E.; Romagnani, S.; Annunziato, F. Demonstration of circulating allergen-specific CD4+CD25highFoxp3+ T-regulatory cells in both nonatopic and atopic individuals. J. Allergy Clin. Immunol. 2007, 120(2), 429-436. (Pubitemid 47411530)
103. Orihara, K.; Narita, M.; Tobe, T.; Akasawa, A.; Ohya, Y.; Matsumoto, K.; Saito, H. Circulating Foxp3+CD4+ cell numbers in atopic patients and healthy control subjects. J. Allergy Clin. Immunol. 2007, 120(4), 960-962. (Pubitemid 47531835)
104. Holt, P. G.; Strickland, D. H. Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbations. J. Allergy Clin. Immunol. 2010, 125(5), 963-972; quiz 973-974.
105. Caramori, G.; Groneberg, D.; Ito, K.; Casolari, P.; Adcock, I. M.; Papi, A. New drugs targeting Th2 lymphocytes in asthma. J. Occup. Med. Toxicol. 2008, 3(Suppl 1), S6.
106. Barnes, P. J. How corticosteroids control inflammation: Quintiles Prize Lecture 2005. Br. J. Pharmacol. 2006, 148(3), 245-254. (Pubitemid 43804814)
107. Peek, E. J.; Richards, D. F.; Faith, A.; Lavender, P.; Lee, T. H.; Corrigan, C. J.; Hawrylowicz, C. M. Interleukin-10-secreting "regulatory" T cells induced by glucocorticoids and beta2-agonists. Am. J. Respir. Cell. Mol. Biol. 2005, 33(1), 105-111. (Pubitemid 40961020)
108. Chetta, A.; Zanini, A.; Torre, O.; Olivieri, D. Vascular remodelling and angiogenesis in asthma: morphological aspects and pharmacological modulation. Inflamm. Allergy Drug Targets 2007, 6(1), 41-45. (Pubitemid 46488297)
109. Finegold, I. Allergen immunotherapy: present and future. Allergy Asthma Proc. 2007, 28(1), 44-49.
110. Larche, M.; Akdis, C. A.; Valenta, R. Immunological mechanisms of allergen-specific immunotherapy. Nat. Rev. Immunol 2006, 6(10), 761-771. (Pubitemid 44453462)
111. Abramson, M. J.; Puy, R. M.; Weiner, J. M. Allergen immunotherapy for asthma. Cochrane Database Syst. Rev 2003, (4), CD001186.
112. Nagata, M.; Nakagome, K. Allergen Immunotherapy in Asthma: Current Status and Future Perspectives. Allergol. Int. 2010, 59(1).
113. Wegmann, M. Th2 cells as targets for therapeutic intervention in allergic bronchial asthma. Expert. Rev. Mol. Diagn. 2009, 9(1), 85-100.
114. Hart, T. K.; Blackburn, M. N.; Brigham-Burke, M.; Dede, K.; Al-Mahdi, N.; Zia-Amirhosseini, P.; Cook, R. M. Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma. Clin. Exp. Immunol. 2002, 130(1), 93-100.
115. Ma, Y.; Hayglass, K. T.; Becker, A. B.; Halayko, A. J.; Basu, S.; Simons, F. E.; Peng, Z. Novel cytokine peptide-based vaccines: an interleukin-4 vaccine suppresses airway allergic responses in mice. Allergy 2007, 62(6), 675-682. (Pubitemid 46763447)
116. Singh, D.; Kane, B.; Molfino, N. A.; Faggioni, R.; Roskos, L.; Woodcock, A. A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma. BMC Pulm. Med. 2010, 10(1), 3.
117. Kasaian, M. T.; Miller, D. K. IL-13 as a therapeutic target for respiratory disease. Biochem. Pharmacol. 2008, 76(2), 147-155.
118. Wenzel, S.; Wilbraham, D.; Fuller, R.; Getz, E. B.; Longphre, M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 2007, 370(9596), 1422-1431. (Pubitemid 47576168)
119. Leckie, M. J.; ten Brinke, A.; Khan, J.; Diamant, Z.; O'Connor, B. J.; Walls, C. M.; Mathur, A. K.; Cowley, H. C.; Chung, K. F.; Djukanovic, R.; Hansel, T. T.; Holgate, S. T.; Sterk, P. J.; Barnes, P. J. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000, 356(9248), 2144-2148.
120. Kips, J. C.; O'Connor, B. J.; Langley, S. J.; Woodcock, A.; Kerstjens, H. A.; Postma, D. S.; Danzig, M.; Cuss, F.; Pauwels, R. A. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am.J. Respir. Crit. Care Med. 2003, 167(12), 1655-1659. (Pubitemid 36760679)
121. Redington, A. E.; Madden, J.; Frew, A. J.; Djukanovic, R.; Roche, W. R.; Holgate, S. T.; Howarth, P. H. Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluid. Am. J. Respir. Crit. Care Med. 1997, 156(2 Pt 1), 642-647. (Pubitemid 27352007)
122. Li, M. O.; Wan, Y. Y.; Sanjabi, S.; Robertson, A. K.; Flavell, R. A. Transforming growth factor-beta regulation of immune responses. Annu. Rev. Immunol. 2006, 24, 99-146.
123. White, B.; Leon, F.; White, W.; Robbie, G. Two first-in-human, open-label, phase I dose-escalation safety trials of MEDI-528, a monoclonal antibody against interleukin-9, in healthy adult volunteers. Clin. Ther. 2009, 31 (4), 728-740.
124. Boyman, O.; Kovar, M.; Rubinstein, M. P.; Surh, C. D.; Sprent, J. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 2006, 311(5769), 1924-1927.
125. Tournoy, K. G.; Kips, J. C.; Pauwels, R. A. Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness. Clin. Exp. Allergy 2000, 30(6), 775-783. (Pubitemid 30341280)
126. Bryan, S. A.; O'Connor, B. J.; Matti, S.; Leckie, M. J.; Kanabar, V.; Khan, J.; Warrington, S. J.; Renzetti, L.; Rames, A.; Bock, J. A.; Boyce, M. J.; Hansel, T. T.; Holgate, S. T.; Barnes, P. J. Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000, 356(9248), 2149-2153.
127. Brightling, C.; Berry, M.; Amrani, Y. Targeting TNF-alpha: a novel therapeutic approach for asthma. J. Allergy Clin. Immunol. 2008, 121 (1), 5-10; quiz 11-12.
128. Kline, J. N.; Krieg, A. M. Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy. Drug News Perspect. 2008, 21(8), 434-439.
129. Roth, M.; Black, J. L. An imbalance in C/EBPs and increased mitochondrial activity in asthmatic airway smooth muscle cells: novel targets in asthma therapy? Br. J. Pharmacol. 2009, 157(3), 334-341.
130. Black, J. L.; Roth, M. Intrinsic asthma: is it intrinsic to the smooth muscle? Clin Exp. Allergy 2009, 39(7), 962-965.
131. Karagiannidis, C.; Akdis, M.; Holopainen, P.; Woolley, N. J.; Hense, G.; Ruckert, B.; Mantel, P. Y.; Menz, G.; Akdis, C. A.; Blaser, K.; SchmidtWeber, C. B. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J. Allergy Clin. Immunol. 2004, 114(6), 1425-1433. (Pubitemid 39575901)
132. Carson, W. F. t.; Guernsey, L. A.; Singh, A.; Vella, A. T.; Schramm, C. M.; Thrall, R. S. Accumulation of regulatory T cells in local draining lymph nodes of the lung correlates with spontaneous resolution of chronic asthma in a murine model. Int. Arch. Allergy Immunol. 2008, 145(3), 231-243. (Pubitemid 351301315)
133. Holgate, S. T. Cytokine and anti-cytokine therapy for the treatment of asthma and allergic disease. Cytokine 2004, 28(4-5), 152-157. (Pubitemid 39573501)
134. Kim, H. Y.; DeKruyff, R. H.; Umetsu, D. T. The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat. Immunol. 2010, 11(7), 577-584.