Vascular remodelling in asthma

Current Opinion in Allergy and Clinical Immunology

Volumn 8, Issue 1, 2008, Pages 39-43

  Walters, Eugene Haydn ^a   Soltani, Amir ^a   Reid, David William ^a   Ward, Chris ^b  

^a UNIVERSITY OF TASMANIA   (Australia)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Asthma; Inhaled corticosteroid; Therapy; Vascular endothelial growth factor; Vascularity

Indexed keywords

GELATINASE B; NITRIC OXIDE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ASTHMA; ENZYME SYNTHESIS; HUMAN; IMMUNOPATHOGENESIS; INFLAMMATION; NEOVASCULARIZATION (PATHOLOGY); PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; REVIEW; VIRUS INFECTION;

ADOLESCENT; ALBUTEROL; ANIMALS; ASTHMA; BRONCHODILATOR AGENTS; CHILD; CHILD, PRESCHOOL; HUMANS; MATRIX METALLOPROTEINASE 9; MICE; MICE, TRANSGENIC; NEOVASCULARIZATION, PATHOLOGIC; NITRIC OXIDE SYNTHASE; RESPIRATORY SYSTEM; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 38049153455     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e3282f42696     Document Type: Review

References (16)

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8. Makinde T, Murphy RF, Agrawal DK. Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling. Curr Mol Med 2006; 6:831-834. This overview of the field is also well worth reading.
9. ••], but in a small space it covers a remarkable amount of the recent literature and recent conceptual developments.
10. Bhandari V, Choo-Wing R, Chapaval SP, et al. Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci USA 2006; 103:11021-11026. This is a classic paper in the making, providing important data. It also provides a good route into this area as an introduction to their transgenic mutant murine airway model of VEGF over-production, which has provided so much new information on asthma pathogenesis.
11. Zanini A, Chetta A, Saetta M, et al. Chymase-positive mast cells play a role in the vascular component of airway remodeling in asthma. J Allergy Clin Immunol 2007; 120:329-333. This is an interesting paper on the possible core asthmagenic potential of VEGF.
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15. Abel-Rahman AM, el-Sahrigy SA, Bakr SI. A comparative study of two angiogenic factors: vascular endothelial growth factor and angiogenin in induced sputum from asthmatic children in acute attack. Chest 2006; 129:266-271. This report provides further confirmation of angiogenic factors in the airways throughout the spectrum of asthma phenotypes.
16. Feltis BN, Wignarajah D, Zheng L, et al. Increased vascular endothelial growth factor and receptors: relation to angiogenesis in asthma. Am J Respir Crit Care Med 2006; 173:1201-1207. This is a comprehensive investigation of relationships between VEGF, VEGFRs and angiogenesis in asthma in both the airway wall and lumen. The authors indicate that comparable comprehensive work is required on the angiopoietins and Tie receptors. The report provides a first description of angiogenic sprouts in human airways.