Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness

Clinical and Experimental Allergy

Volumn 30, Issue 6, 2000, Pages 775-783

  Tournoy, K G ^a   Kips, J C ^a   Pauwels, R A ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Airway inflammation; Airway responsiveness; Eosinophil; IL 10

Indexed keywords

ALLERGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; OVALBUMIN;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOREGULATION; IN VIVO STUDY; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; TH2 CELL;

ALLERGENS; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; CARBACHOL; CYTOKINES; DISEASE MODELS, ANIMAL; GERM-FREE LIFE; IMMUNOGLOBULIN E; INFLAMMATION; INTERLEUKIN-10; LUNG; MALE; MICE; MICE, INBRED C57BL; OVALBUMIN;

EID: 0034045109     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2000.00838.x     Document Type: Article

References (36)

1. 1 Beasley R, Roche WR, Roberts JA, Holgate ST. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 1989; 139:806-17.
2. 2 Synek M, Beasley R, Frew AJ, Goulding D, Holloway L, Lampe FC, Roche WR, Holgate ST. Cellular infiltration of the airways in asthma of varying severity. Am J Respir Crit Care Med 1996; 154:224-30.
3. 3 Cho SH, Seo JY, Choi DC, Yoon HJ, Cho YJ, Min KU, Lee GK, Seo JW, Kim YY. Pathological changes according to the severity of asthma. Clin Exp Allergy 1996; 26:1210-9.
4. 4 Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, Durham SR, Kay AB. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326:298-304.
5. 5 Bousquet J, Chanez P, Lacoste J, Barnéon G, Ghavanian N, Enander I, Venge P, Ahlstedt S, Simony-Lafontaine J, Godard P, Michel F. Eosinophilic inflammation in asthma. N Engl J Med 1990; 323:1033-9.
6. 6 Drazen JM, Arm JP, Austen KF. Sorting out the cytokines of asthma. J Exp Med 1996; 183:1-5.
7. 7 Swain SL. Who does the polarizing? Eur J Immunol 1995; 5:849-51.
8. 8 Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170: 2081-95.
9. 9 Borish L. IL-10: evolving concepts. J Allergy Clin Immunol 1998; 101:293-7.
10. 10 Lim S, Crawley E, Woo P, Barnes PJ. Haplotype associated with low interleukin-10 production in patients with severe asthma. Lancet 1998; 352:113.
11. 11 John M, Lim S, Seybold J, Jose P, Robichaud A, O'Connor B, Barnes PJ, Chung KF. Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1 alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. Am J Respir Crit Care Med 1998; 157:256-62.
12. 12 Barnes PJ. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci 1998; 94:557-72.
13. 13 Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993; 75:263-74.
14. 14 Kips JC, Brusselle GJ, Joos GF, Peleman RA, Tavernier JH, Devos RR, Pauwels RA. Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice. Am J Respir Crit Care Med 1996; 153:535-9.
15. 15 Curtis JL, Byrd PK, Warnock ML, Kaltreider HB. Requirement of CD4-positive T cells for cellular recruitment to the lungs of mice in response to a particulate intratracheal antigen. J Clin Invest 1991; 88:1244-54.
16. 16 Del Prete G, De Carli M, Almerigogna F, Giudizi MG, Biagiotti R, Romagnani S. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 1993; 150:353-60.
17. 17 Enk AH, Angeloni VL, Udey MC, Katz SI. Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance. J Immunol 1993; 151:2390-8.
18. 18 Zuany-Amorim C, Haile S, Leduc D, Dumarey C, Huerre M, Vargaftig BB, Pretolani M. Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J Clin Invest 1995; 95:2644-51.
19. 19 Van Scott MR, Bradfield J, Metzger WJ, Welch CA, Knox C, Sigounas A, Kukoly C, Sur S. IL-10 inhibits ragweed-induced lung inflammation, but increases airway resistance in allergic mice. Am J Respir Crit Care Med 1997; 155:A734.
20. 20 Wang J, Palmer K, Lotvall J, Milan S, Lei XF, Matthaei KI, Gauldie J, Inman MD, Jordana M, Xing Z. Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia. J Clin Invest 1998; 102:1132-41.
21. 21 Grunig G, Corry DB, Leach MW, Seymour BWP, Kurup VP, Rennick DM. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J Exp Med 1997; 185:1089-99.
22. + lymphocyte and eosinophil infiltration into the mouse peritoneal cavity. J Immunol 1996; 157:377-84.
23. 23 Berg DJ, Davidson N, Kuhn R, Muller W, Menon S, Holland G, Thompson Snipes L, Leach MW, Rennick D. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4 (+) TH1-like responses. J Clin Invest 1996; 98:1010-20.
24. 1m1Cgn, an interleukin-10 gene targeted mutation. Jax Notes 1997; 471.
25. 25 Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener Kronish JP, Locksley RM. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med 1996; 183:109-17.
26. 26 Lefort J, Bachelet CM, Leduc D, Vargaftig BB. Effect of antigen provocation of IL-5 transgenic mice on eosinophil mobilization and bronchial hyperresponsiveness. J Allergy Clin Immunol 1996; 97:788-99.
27. 27 Matsubara S, Fushimi K, Ogawa K, Kikkawa H, Nakata A, Kameda R, Kikuchi M, Naito K, Ikezawa K. Inhibition of pulmonary eosinophilia does not necessarily prevent the airway hyperresponsiveness induced by Sephadex beads. Int Arch Allergy Immunol 1998; 116:67-75.
28. 28 Hogan SP, Matthaei KI, Young JM, Koskinen A, Young IG, Foster PS. A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J Immunol 1998; 161:1501-9.
29. 29 Hessel EM, Van Oosterhout AJ, Van Ark I, Van Esch B, Hofman G, Van Loveren H, Savelkoul FJ, Nijkamp FP. Development of airway hyperresponsivenes is dependent on interferon-and independent of eosinophil infiltration. Am J Respir Cell Mol Biol 1997; 16:325-34.
30. 30 Coyle AJ, Kohler G, Tsuyuki S, Brombacher F, Kopf M. Eosinophils are not required to induce airway hyperresponsiveness after nematode infection. Eur J Immunol 1998; 28: 2640-7.
31. 31 Zuany-Amorim C, Ruffie C, Haile S, Vargaftig BB, Pereira P, Pretolani M. Requirement for gamma delta T cells in allergic airway inflammation. Science 1998; 280:1265-7.
32. 32 Jeannin P, Lecoanet S, Delneste Y, Gauchat JF, Bonnefoy JY. IgE versus IgG4 production can be differentially regulated by IL-10. J Immunol 1998; 160:3555-61.
33. 33 Ohmori H, Kanda T, Takai T, Hikida M. Induction of antigen-specific IgE response in murine lymphocytes by IL-10. Immunol Lett 1995; 47:127-32.
34. 34 Snapper CM, Paul WE. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 1987; 236:944-7.
35. 35 Pene J, Rousset F, Briere F, Chretien I, Bonnefoy JY, Spits H, Yokota T, Arai N, Aral K, Banchereau J et al. IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proc Natl Acad Sci USA 1988; 85:6880-4.
36. 36 Levy F, Kristofic C, HeusSeries C, Brinkmann V. Role of IL-13 in CD4 T cell-dependent IgE production in atopy. Int Arch Allergy Immunol 1997; 112:49-58.