Basophil recruitment and IL-4 production during human allergen-induced late asthma

Journal of Allergy and Clinical Immunology

Volumn 108, Issue 2, 2001, Pages 205-211

  Nouri Aria, Kayhan T ^a   Jacobson, Mikila R ^a   O’Brien, Fiona ^a   Varga, Eva M ^a   Till, Stephen J ^a   Durham, Stephen R ^a   Irani, Anne Marie A ^b   Schwartz, Lawrence B ^c  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b Maternal and Fetal Medicine Section   (United Kingdom)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Asthma; Basophils; IL 4; Late asthmatic responses

Indexed keywords

ALLERGEN; INTERLEUKIN 4; MESSENGER RNA;

ADULT; ALLERGIC ASTHMA; ARTICLE; BASOPHIL; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN TISSUE; MALE; MEDIATOR RELEASE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN LOCALIZATION;

EID: 0034903128     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2001.117175     Document Type: Article

References (37)

1. Molecular and cellular biology of mast cells and basophils
2. Immnunocytologic analysis of nasal cells obtained by nasal lavage: A comparative study with a standard method of cell identification
3. A research method to induce and examine a mild exacerbation of asthma by withdrawal of inhaled corticosteroid
4. Histamine-containing cells obtained from the nose hours after antigen challenge have functional and phenotypic characteristics of basophils
5. Identification of IgE-bearing cells in the late-phase response to antigen in the lung as basophils
6. Accumulation of basophils and their chemotactic activity in the airways during natural airway narrowing in asthmatic individuals
7. Identification and partial characterization of a unique marker for human basophils
8. Immunohistochemical detection of human basophils in late-phase skin reactions
9. Increased numbers of both airway basophils and mast cells in sputum after allergen challenge of atopic asthmatics
10. Development and characterisation of a monoclonal antibody specific for human basophils and the identification of a unique secretory product of basophil activation
11. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: Association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24 hours tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES)
12. Basophils, eosinophils, and mast cells in atopic and non-atopic asthma and in late-phase allergic reactions in the lung and skin
13. IL-4 and IL-5 mRNA and protein in bronchial biopsies from atopic and non-atopic asthmatics: Evidence against "intrinsic" asthma being a distinct immmunopathological entity
14. Regulation of IgE synthesis in humans: A tale of two signals
15. Associations between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression, and the infiltration of eosinophils, macrophages, and T cells in allergen-induced late-phase cutaneous reactions in atopic subjects
16. Increased expression of IL-16 immunoreactivity in bronchial mucosa after segmental allergen challenge in patients with asthma
17. T cells from human allergen-induced late asthmatic responses express IL-12 receptor β2 subunit mRNA and respond to IL-12 in vitro
18. Immunohistology of the nasal mucosa following allergen-induced rhinitis. Identification of activated T lymphocytes, eosinophils, and neutrophils
19. Cytokine expression during allergen-induced late nasal responses: IL-4 and IL-5 mRNA is expressed early (at 6 hours) predominantly by eosinophils
20. Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects
21. Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics
22. Secretion of IL-4 from human basophils. The relationship between IL-4 mRNA and protein in resting and stimulated basophils
23. Platelet-activating factor induces mediator release by human basophils primed with IL-3, granulocyte-macrophage colony-stimulating factor, or IL-5
24. The production of macrophage inflammatory protein-1 alpha by human basophils
25. Cytokine generation by human basophils
26. Cytokine priming of human basophils: Description of allergen "nonreleasers
27. New concepts: The basophil
28. Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation
29. Purified human peripheral blood basophils release interleukin-13 and preformed interleukin-4 following immunological activation
30. IL-13 released by and localized in human basophils
31. Regulation of cytokine expression by human blood basophils
32. Unstimulated basophils in atopic and nonatopic subjects express intracellular interleukin-4: Detection by flow cytometry
33. Regulation of isotype switching
34. Functional CD40 ligand is expressed by T cells in rheumatoid arthritis
35. Induction of human IgE synthesis in B cells by mast cells and basophils
36. Associations between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression, and the infiltration of eosinophils, macrophages, and T cells in allergen-induced late-phase cutaneous reactions in atopic subjects
37. Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial