IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection

Journal of Immunology

Volumn 183, Issue 11, 2009, Pages 7006-7013

  Dodd, Jonathan S ^a   Lum, Eda ^a   Goulding, John ^b   Muir, Roshell ^a   Van Snick, Jacques ^c   Openshaw, Peter J M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 9; VACCINIA VACCINE; IMMUNOGLOBULIN G;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SPLEEN; TH1 CELL; TH2 CELL; VIRUS INFECTION; ANIMAL; BAGG ALBINO MOUSE; BLOOD; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; PATHOLOGY; RESPIRATORY SYNCYTIAL VIRUS INFECTION; VIROLOGY;

ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNOGLOBULIN G; IMMUNOLOGIC MEMORY; INTERLEUKIN-9; MICE; MICE, INBRED BALB C; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; TH1 CELLS; TH2 CELLS;

EID: 73349114622     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900085     Document Type: Article

References (27)

1. Openshaw, P. J., and J. S. Tregoning. 2005. Immune responses and disease enhancement during respiratory syncytial virus infection. Clin. Microbiol. Rev. 18: 541-555.
2. Henrickson, K. J., S. Hoover, K. S. Kehl, and W. Hua. 2004. National disease burden of respiratory viruses detected in children by polymerase chain reaction. Pediatr. Infect. Dis. J. 23: S11-S18.
3. Stein, R. T., D. Sherrill, W. J. Morgan, C. J. Holberg, M. Halonen, L. M. Taussig, A. L. Wright, and F. D. Martinez. 1999. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 354: 541-545.
4. Falsey, A. R., P. A. Hennessey, M. A. Formica, C. Cox, and E. E. Walsh. 2005. Respiratory syncytial virus infection in elderly and high-risk adults. N. Engl. J. Med. 352: 1749-1759. (Pubitemid 40570923)
5. Openshaw, P. J. M. 2005. Anti-viral immune responses, asthma and chronic obstructive lung disease. Proc. Am Thorac. Soc. 2: 121-125.
6. Alwan, W. H., W. J. Kozlowska, and P. J. M. Openshaw. 1994. Distinct types of lung disease caused by functional subsets of antiviral T cells. J. Exp. Med. 179: 81-89.
7. + T cells, while that induced by Vac-F or Vac-G recombinants is mediated by antibodies. J. Virol. 66: 1277-1281.
8. Matthews, S. P., J. S. Tregoning, A. J. Coyle, T. Hussell, and P. J. Openshaw. 2005. Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection. J. Virol. 79: 2050-2057. (Pubitemid 40204562)
9. Culley, F. J., A. M. Pennycook, J. S. Tregoning, J. S. Dodd, G. Walzl, T. N. Wells, T. Hussell, and P. J. Openshaw. 2006. Role of CCL5 (RANTES) in viral lung disease. J. Virol. 80: 8151-8157.
10. + T cells, genomic organization, and comparison with the mouse gene. J. Immunol. 144: 4235-4241.
11. Monteyne, P., J. C. Renauld, J. Van Broeck, D. W. Dunne, F. Brombacher, and J. P. Coutelier. 1997. IL-4-independent regulation of in vivo IL-9 expression. J. Immunol. 159: 2616-2623. (Pubitemid 127681279)
12. Shimbara, A., P. Christodoulopoulos, A. Soussi-Gounni, R. Olivenstein, Y. Nakamura, R. C. Levitt, N. C. Nicolaides, K. J. Holroyd, A. Tsicopoulos, J. J. Lafitte, et al. 2000. IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. J. Allergy Clin. Immunol. 105: 108-115.
13. McNamara, P. S., B. F. Flanagan, L. M. Baldwin, P. Newland, C. A. Hart, and R. L. Smyth. 2004. Interleukin 9 production in the lungs of infants with severe respiratory syncytial virus bronchiolitis. Lancet 363: 1031-1037. (Pubitemid 38410776)
14. Louahed, J., A. Kermouni, J. Van Snick, and J.-C. Renauld. 1995. IL-9 induces expression of granzymes and high-affinity IgE receptor in murine T helper clones. J. Immunol. 154: 5061-5070.
15. Hultner, L., C. Druez, J. Moeller, C. Uyttenhove, E. Schmitt, E. Rude, P. Dormer, and J. Van Snick. 1990. Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9). Eur. J. Immunol. 20: 1413-1416. (Pubitemid 20206111)
16. Finkelman, F. D., and J. F. Urban, Jr. 2001. The other side of the coin: the protective role of the TH2 cytokines. J. Allergy Clin. Immunol. 107: 772-780.
17. Devos, S., F. Cormont, S. Vrtala, E. Hooghe-Peters, F. Pirson, and J. Snick. 2006. Allergen-induced interleukin-9 production in vitro: correlation with atopy in human adults and comparison with interleukin-5 and interleukin-13. Clin. Exp. Allergy 36: 174-182.
18. Legg, J. P., I. R. Hussain, J. A. Warner, S. L. Johnston, and J. O. Warner. 2003. Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Am. J. Respir. Crit. Care Med. 168: 633-639. (Pubitemid 37175965)
19. Hussell, T., U. Khan, and P. J. M. Openshaw. 1997. IL-12 treatment attenuates Th2 and B cell responses but does not improve vaccine-enhanced lung illness. J. Immunol. 159: 328-334. (Pubitemid 127493716)
20. Hussell, T., L. C. Spender, A. Georgiou, A. O'Garra, and P. J. M. Openshaw. 1996. Th1 and Th2 cytokine induction in pulmonary T-cells during infection with respiratory syncytial virus. J. Gen. Virol. 77: 2447-2455. (Pubitemid 26348366)
21. Tang, Y. W., and B. S. Graham. 1994. Anti-IL-4 treatment at immunization modulates cytokine expression, reduces illness, and increases cytotoxic T lymphocyte activity in mice challenged with respiratory syncytial virus. J. Clin. Invest. 94: 1953-1958.
22. Lukacs, N. W., K. K. Tekkanat, A. Berlin, C. M. Hogaboam, A. Miller, H. Evanoff, P. Lincoln, and H. Maassab. 2001. Respiratory syncytial virus predisposes mice to augmented allergic airway responses via IL-13-mediated mechanisms. J. Immunol. 167: 1060-1065.
23. Scales, H. E., M. X. Ierna, and C. E. Lawrence. 2007. The role of IL-4, IL-13 and IL-4Rα in the development of protective and pathological responses to Trichinella spiralis. Parasite Immunol. 29: 81-91.
24. Arendse, B., J. Van Snick, and F. Brombacher. 2005. IL-9 is a susceptibility factor in Leishmania major infection by promoting detrimental Th2/type 2 responses. J. Immunol. 174: 2205-2211. (Pubitemid 40223966)
25. + T cell survival but not for antigen proliferation. Nat. Immunol. 1: 54-58.
26. + T cells. Eur. Cytokine Netw. 16: 233-239.
27. Lu, L. F., E. F. Lind, D. C. Gondek, K. A. Bennett, M. W. Gleeson, K. Pino-Lagos, Z. A. Scott, A. J. Coyle, J. L. Reed, J. Van Snick, et al. 2006. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 442: 997-1002.