Overview of asthma; the place of the T cell

Current Opinion in Pharmacology

Volumn 10, Issue 3, 2010, Pages 218-225

  Shalaby, Karim H ^a   Martin, James G ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CORTICOSTEROID; CYTOKINE; INTEGRIN; LYMPHOCYTE ANTIGEN RECEPTOR;

AIRWAY REMODELING; ALLERGIC ASTHMA; ASTHMA; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; DISEASE COURSE; DISEASE EXACERBATION; DISEASE MODEL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; NATURAL KILLER CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT INFLAMMATION; REVIEW; T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL; ANIMAL; DRUG DELIVERY SYSTEM; IMMUNOLOGY; INFLAMMATION;

ALLERGENS; ANIMALS; ASTHMA; DRUG DELIVERY SYSTEMS; HUMANS; INFLAMMATION; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 77954640259     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2010.03.004     Document Type: Review

References (97)

1. Friedlander S.L., Busse W.W. The role of rhinovirus in asthma exacerbations. J Allergy Clin Immunol 2005, 116:267-273.
2. Kariyawasam H.H., Aizen M., Barkans J., Robinson D.S., Kay A.B. Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma. Am J Respir Crit Care Med 2007, 175:896-904.
3. Holgate S.T., Holloway J., Wilson S., Bucchieri F., Puddicombe S., Davies D.E. Epithelial-mesenchymal communication in the pathogenesis of chronic asthma. Proc Am Thorac Soc 2004, 1:93-98.
4. Denburg J.A., Sehmi R., Saito H., Pil-Seob J., Inman M.D., O'Byrne P.M. Systemic aspects of allergic disease: bone marrow responses. J Allergy Clin Immunol 2000, 106:S242-S246.
5. Isogai S., Miyata S., Martin J.G., Hamid Q.A. CD4+T cells migrate from airway to bone marrow following antigen inhalation in rats. J Allergy Clin Immunol 2002, 109:S32-S33.
6. Walker C., Kaegi M.K., Braun P., Blaser K. Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity. J Allergy Clin Immunol 1991, 88:935-942.
7. Walker C., Bode E., Boer L., Hansel T.T., Blaser K., Virchow J.C. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 1992, 146:109-115.
8. Wills-Karp M., Luyimbazi J., Xu X., Schofield B., Neben T.Y., Karp C.L., Donaldson D.D. Interleukin-13: central mediator of allergic asthma. Science 1998, 282:2258-2261.
9. Lazaar A.L., Albelda S.M., Pilewski J.M., Brennan B., Pure E., Panettieri R.A. T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis. J Exp Med 1994, 180:807-816.
10. Ramos-Barbon D., Presley J.F., Hamid Q.A., Fixman E.D., Martin J.G. Antigen-specific CD4+ T cells drive airway smooth muscle remodeling in experimental asthma. J Clin Invest 2005, 115:1580-1589.
11. Faffe D.S., Flynt L., Bourgeois K., Panettieri R.A., Shore S.A. Interleukin-13 and interleukin-4 induce vascular endothelial growth factor release from airway smooth muscle cells: role of vascular endothelial growth factor genotype. Am J Respir Cell Mol Biol 2006, 34:213-218.
12. Whittaker L., Niu N., Temann U.A., Stoddard A., Flavell R.A., Ray A., Homer R.J., Cohn L. Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. Am J Respir Cell Mol Biol 2002, 27:593-602.
13. Robinson D.S., Hamid Q., Ying S., Tsicopoulos A., Barkans J., Bentley A.M., Corrigan C., Durham S.R., Kay A.B. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992, 326:298-304.
14. Robinson D., Hamid Q., Bentley A., Ying S., Kay A.B., Durham S.R. Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol 1993, 92:313-324.
15. Woodruff P.G., Modrek B., Choy D.F., Jia G., Abbas A.R., Ellwanger A., Koth L.L., Arron J.R., Fahy J.V. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009, 180:388-395.
16. Watanabe A., Mishima H., Renzi P.M., Xu L.J., Hamid Q., Martin J.G. Transfer of allergic airway responses with antigen-primed CD4+ but not CD8+ T cells in Brown Norway rats. J Clin Invest 1995, 96:1303-1310.
17. Gavett S.H., Chen X., Finkelman F., Wills-Karp M. Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol 1994, 10:587-593.
18. Zhou L., Chong M.M., Littman D.R. Plasticity of CD4+ T cell lineage differentiation. Immunity 2009, 30:646-655.
19. Sokol C.L., Barton G.M., Farr A.G., Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 2008, 9:310-318.
20. Yang D., Chen Q., Su S.B., Zhang P., Kurosaka K., Caspi R.R., Michalek S.M., Rosenberg H.F., Zhang N., Oppenheim J.J. Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J Exp Med 2008, 205:79-90.
21. Machida I., Matsuse H., Kondo Y., Kawano T., Saeki S., Tomari S., Obase Y., Fukushima C., Kohno S. Cysteinyl leukotrienes regulate dendritic cell functions in a murine model of asthma. J Immunol 2004, 172:1833-1838.
22. Wills-Karp M. Interleukin-13 in asthma pathogenesis. Immunol Rev 2004, 202:175-190.
23. Kips J.C., Brusselle G.J., Joos G.F., Peleman R.A., Tavernier J.H., Devos R.R., Pauwels R.A. Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice. Am J Respir Crit Care Med 1996, 153:535-539.
24. Huang T.J., MacAry P.A., Wilke T., Kemeny D.M., Chung K.F. Inhibitory effects of endogenous and exogenous interferon-gamma on bronchial hyperresponsiveness, allergic inflammation and T-helper 2 cytokines in Brown-Norway rats. Immunology 1999, 98:280-288.
25. Sutton T.C., Tayyari F., Khan M.A., Manson H.E., Hegele R.G. T helper 1 background protects against airway hyperresponsiveness and inflammation in guinea pigs with persistent respiratory syncytial virus infection. Pediatr Res 2007, 61:525-529.
26. Finotto S., Neurath M.F., Glickman J.N., Qin S.X., Lehr H.A., Green F.H.Y., Ackerman K., Haley K., Gatte P.R., Szabo S.J., et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002, 295:336-338.
27. Finotto S., Hausding M., Doganci A., Maxeiner J.H., Lehr H.A., Luft C., Galle P.R., Glimcher L.H. Asthmatic changes in mice lacking T-bet are mediated by IL-13. Int Immunol 2005, 17:993-1007.
28. Tantisira K.G., Hwang E.S., Raby B.A., Silverman E.S., Lake S.L., Richter B.G., Peng S.L., Drazen J.M., Glimcher L.H., Weiss S.T. TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc Natl Acad Sci U S A 2004, 101:18099-18104.
29. Hayashi N., Yoshimoto T., Izuhara K., Matsui K., Tanaka T., Nakanishi K. T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production. Proc Natl Acad Sci U S A 2007, 104:14765-14770.
30. Cui J., Pazdziorko S., Miyashiro J.S., Thakker P., Pelker J.W., Declercq C., Jiao A., Gunn J., Mason L., Leonard J.P., et al. TH1-mediated airway hyperresponsiveness independent of neutrophilic inflammation. J Allergy Clin Immunol 2005, 115:309-315.
31. Hessel E.M., Cruikshank W.W., Van Ark I., De Bie J.J., Van Esch B., Hofman G., Nijkamp F.P., Center D.M., Van Oosterhout A.J. Involvement of IL-16 in the induction of airway hyper-responsiveness and up-regulation of IgE in a murine model of allergic asthma. J Immunol 1998, 160:2998-3005.
32. De Bie J.J., Jonker E.H., Henricks P.A., Hoevenaars J., Little F.F., Cruikshank W.W., Nijkamp F.P., Van Oosterhout A.J. Exogenous interleukin-16 inhibits antigen-induced airway hyper-reactivity, eosinophilia and Th2-type cytokine production in mice. Clin Exp Allergy 2002, 32:1651-1658.
33. Laberge S., Pinsonneault S., Varga E.M., Till S.J., Nouri-Aria K., Jacobson M., Cruikshank W.W., Center D.M., Hamid Q., Durham S.R. Increased expression of IL-16 immunoreactivity in bronchial mucosa after segmental allergen challenge in patients with asthma. J Allergy Clin Immunol 2000, 106:293-301.
34. Ishikawa Y., Yoshimoto T., Nakanishi K. Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness. Int Immunol 2006, 18:847-855.
35. Durrant D.M., Gaffen S.L., Riesenfeld E.P., Irvin C.G., Metzger D.W. Development of allergen-induced airway inflammation in the absence of T-bet regulation is dependent on IL-17. J Immunol 2009, 183:5293-5300.
36. Fujiwara M., Hirose K., Kagami S., Takatori H., Wakashin H., Tamachi T., Watanabe N., Saito Y., Iwamoto I., Nakajima H. T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways. J Allergy Clin Immunol 2007, 119:662-670.
37. Wakashin H., Hirose K., Maezawa Y., Kagami S., Suto A., Watanabe N., Saito Y., Hatano M., Tokuhisa T., Iwakura Y., et al. IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. Am J Respir Crit Care Med 2008, 178:1023-1032.
38. Hellings P.W., Kasran A., Liu Z., Vandekerckhove P., Wuyts A., Overbergh L., Mathieu C., Ceuppens J.L. Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am J Respir Cell Mol Biol 2003, 28:42-50.
39. Molet S., Hamid Q., Davoine F., Nutku E., Taha R., Page N., Olivenstein R., Elias J., Chakir J. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 2001, 108:430-438.
40. Dragon S., Rahman M.S., Yang J., Unruh H., Halayko A.J., Gounni A.S. IL-17 enhances IL-1beta-mediated CXCL-8 release from human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2007, 292:L1023-L1029.
41. van den B.A., Kuiper M., Snoek M., Timens W., Postma D.S., Jansen H.M., Lutter R. Interleukin-17 induces hyperresponsive interleukin-8 and interleukin-6 production to tumor necrosis factor-alpha in structural lung cells. Am J Respir Cell Mol Biol 2005, 33:97-104.
42. Tang W., Geba G.P., Zheng T., Ray P., Homer R.J., Kuhn C., Flavell R.A., Elias J.A. Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. J Clin Invest 1996, 98:2845-2853.
43. Wilson R.H., Whitehead G.S., Nakano H., Free M.E., Kolls J.K., Cook D.N. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med 2009, 180:720-730.
44. Pichavant M., Goya S., Meyer E.H., Johnston R.A., Kim H.Y., Matangkasombut P., Zhu M., Iwakura Y., Savage P.B., DeKruyff R.H., et al. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J Exp Med 2008, 205:385-393.
45. McGee HS, Stallworth AL, Agrawal T, Shao Z, Lorence L, Agrawal DK: Flt3-ligand decreases Th17 cells and SOCS proteins in the lung of house dust mite-sensitized and challenged mice. Am J Respir Cell Mol Biol, in press.
46. Angkasekwinai P., Park H., Wang Y.H., Wang Y.H., Chang S.H., Corry D.B., Liu Y.J., Zhu Z., Dong C. Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med 2007, 204:1509-1517.
47. Ballantyne S.J., Barlow J.L., Jolin H.E., Nath P., Williams A.S., Chung K.F., Sturton G., Wong S.H., McKenzie A.N. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J Allergy Clin Immunol 2007, 120:1324-1331.
48. Tamachi T., Maezawa Y., Ikeda K., Kagami S., Hatano M., Seto Y., Suto A., Suzuki K., Watanabe N., Saito Y., et al. IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice. J Allergy Clin Immunol 2006, 118:606-614.
49. Schnyder-Candrian S., Togbe D., Couillin I., Mercier I., Brombacher F., Quesniaux V., Fossiez F., Ryffel B., Schnyder B. Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med 2006, 203:2715-2725.
50. Zhao Y., Yang J., Gao Y.D., Guo W. Th17 immunity in patients with allergic asthma. Int Arch Allergy Immunol 2009, 151:297-307.
51. Barczyk A., Pierzchala W., Sozanska E. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med 2003, 97:726-733.
52. Al Ramli W., Prefontaine D., Chouiali F., Martin J.G., Olivenstein R., Lemiere C., Hamid Q. T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma. J Allergy Clin Immunol 2009, 123:1185-1187.
53. McKinley L., Alcorn J.F., Peterson A., Dupont R.B., Kapadia S., Logar A., Henry A., Irvin C.G., Piganelli J.D., Ray A., Kolls J.K. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol 2008, 181:4089-4097.
54. Vijayanand P., Seumois G., Pickard C., Powell R.M., Angco G., Sammut D., Gadola S.D., Friedmann P.S., Djukanovic R. Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease. N Engl J Med 2007, 356:1410-1422.
55. Akbari O., Faul J.L., Hoyte E.G., Berry G.J., Wahlstrom J., Kronenberg M., Dekruyff R.H., Umetsu D.T. CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med 2006, 354:1117-1129.
56. Kim J.O., Kim D.H., Chang W.S., Hong C., Park S.H., Kim S., Kang C.Y. Asthma is induced by intranasal coadministration of allergen and natural killer T-cell ligand in a mouse model. J Allergy Clin Immunol 2004, 114:1332-1338.
57. Akbari O., Stock P., Meyer E., Kronenberg M., Sidobre S., Nakayama T., Taniguchi M., Grusby M.J., Dekruyff R.H., Umetsu D.T. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med 2003, 9:582-588.
58. Nagata Y., Kamijuku H., Taniguchi M., Ziegler S., Seino K. Differential role of thymic stromal lymphopoietin in the induction of airway hyperreactivity and Th2 immune response in antigen-induced asthma with respect to natural killer T cell function. Int Arch Allergy Immunol 2007, 144:305-314.
59. Terashima A., Watarai H., Inoue S., Sekine E., Nakagawa R., Hase K., Iwamura C., Nakajima H., Nakayama T., Taniguchi M. A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. J Exp Med 2008, 205:2727-2733.
60. Kim E.Y., Battaile J.T., Patel A.C., You Y., Agapov E., Grayson M.H., Benoit L.A., Byers D.E., Alevy Y., Tucker J., et al. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat Med 2008, 14:633-640.
61. Rubtsov Y.P., Rasmussen J.P., Chi E.Y., Fontenot J., Castelli L., Ye X., Treuting P., Siewe L., Roers A., Henderson W.R., et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008, 28:546-558.
62. Gardner L.M., Thien F.C., Douglass J.A., Rolland J.M., O'Hehir R.E. Induction of T 'regulatory' cells by standardized house dust mite immunotherapy: an increase in CD4+ CD25+ interleukin-10+ T cells expressing peripheral tissue trafficking markers. Clin Exp Allergy 2004, 34:1209-1219.
63. Karagiannidis C., Akdis M., Holopainen P., Woolley N.J., Hense G., Ruckert B., Mantel P.Y., Menz G., Akdis C.A., Blaser K., Schmidt-Weber C.B. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J Allergy Clin Immunol 2004, 114:1425-1433.
64. O'Hehir R.E., Gardner L.M., de Leon M.P., Hales B.J., Biondo M., Douglass J.A., Rolland J.M., Sandrini A. House dust mite sublingual immunotherapy: the role for transforming growth factor-beta and functional regulatory T cells. Am J Respir Crit Care Med 2009, 180:936-947.
65. Thunberg S., Gafvelin G., Nord M., Gronneberg R., Grunewald J., Eklund A., van Hage M. Allergen provocation increases TH2-cytokines and FOXP3 expression in the asthmatic lung. Allergy 2009, 65:311-318.
66. Curotto de Lafaille M.A., Kutchukhidze N., Shen S., Ding Y., Yee H., Lafaille J.J. Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation. Immunity 2008, 29:114-126.
67. Burchell J.T., Wikstrom M.E., Stumbles P.A., Sly P.D., Turner D.J. Attenuation of allergen-induced airway hyperresponsiveness is mediated by airway regulatory T cells. Am J Physiol Lung Cell Mol Physiol 2009, 296:L307-L319.
68. Carson W.F., Guernsey L.A., Singh A., Vella A.T., Schramm C.M., Thrall R.S. Accumulation of regulatory T cells in local draining lymph nodes of the lung correlates with spontaneous resolution of chronic asthma in a murine model. Int Arch Allergy Immunol 2008, 145:231-243.
69. Strickland D.H., Stumbles P.A., Zosky G.R., Subrata L.S., Thomas J.A., Turner D.J., Sly P.D., Holt P.G. Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells. J Exp Med 2006, 203:2649-2660.
70. Boudousquie C., Pellaton C., Barbier N., Spertini F. CD4+CD25+ T cell depletion impairs tolerance induction in a murine model of asthma. Clin Exp Allergy 2009, 39:1415-1426.
71. Hartl D., Koller B., Mehlhorn A.T., Reinhardt D., Nicolai T., Schendel D.J., Griese M., Krauss-Etschmann S. Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma. J Allergy Clin Immunol 2007, 119:1258-1266.
72. Lin Y.L., Shieh C.C., Wang J.Y. The functional insufficiency of human CD4+CD25 high T-regulatory cells in allergic asthma is subjected to TNF-alpha modulation. Allergy 2008, 63:67-74.
73. Provoost S., Maes T., van Durme Y.M., Gevaert P., Bachert C., Schmidt-Weber C.B., Brusselle G.G., Joos G.F., Tournoy K.G. Decreased FOXP3 protein expression in patients with asthma. Allergy 2009, 64:1539-1546.
74. Foster P.S., Yang M., Herbert C., Kumar R.K. CD4(+) T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthma. Lab Invest 2002, 82:455-462.
75. Leigh R., Southam D.S., Ellis R., Wattie J.N., Sehmi R., Wan Y., Inman M.D. T-cell-mediated inflammation does not contribute to the maintenance of airway dysfunction in mice. J Appl Physiol 2004, 97:2258-2265.
76. Doherty T.A., Soroosh P., Broide D.H., Croft M. CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling. Am J Physiol Lung Cell Mol Physiol 2009, 296:L229-L235.
77. Southam D.S., Ellis R., Wattie J., Glass W., Inman M.D. Goblet cell rebound and airway dysfunction with corticosteroid withdrawal in a mouse model of asthma. Am J Respir Crit Care Med 2008, 178:1115-1122.
78. Kajiwara K., Morishima H., Akiyama K., Yanagihara Y. Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int 2009, 58:573-583.
79. Qian X., Agematsu K., Freeman G.J., Tagawa Y., Sugane K., Hayashi T. The ICOS-ligand B7-H2, expressed on human type II alveolar epithelial cells, plays a role in the pulmonary host defense system. Eur J Immunol 2006, 36:906-918.
80. Kurosawa S., Myers A.C., Chen L., Wang S., Ni J., Plitt J.R., Heller N.M., Bochner B.S., Schleimer R.P. Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells. Am J Respir Cell Mol Biol 2003, 28:563-573.
81. Stanciu L.A., Bellettato C.M., Laza-Stanca V., Coyle A.J., Papi A., Johnston S.L. Expression of programmed death-1 ligand (PD-L) 1, PD-L2, B7-H3, and inducible costimulator ligand on human respiratory tract epithelial cells and regulation by respiratory syncytial virus and type 1 and 2 cytokines. J Infect Dis 2006, 193:404-412.
82. Heinecke L., Proud D., Sanders S., Schleimer R.P., Kim J. Induction of B7-H1 and B7-DC expression on airway epithelial cells by the Toll-like receptor 3 agonist double-stranded RNA and human rhinovirus infection: in vivo and in vitro studies. J Allergy Clin Immunol 2008, 121:1155-1160.
83. Leigh R., Ellis R., Wattlie J.N., Hirota J.A., Matthaei K.I., Foster P.S., O'Byrne P.M., Inman M.D. Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice. Am J Respir Crit Care Med 2004, 169:860-867.
84. Zhu Z., Homer R.J., Wang Z., Chen Q., Geba G.P., Wang J., Zhang Y., Elias J.A. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999, 103:779-788.
85. Moynihan B., Tolloczko B., Michoud M.C., Tamaoka M., Ferraro P., Martin J.G. MAP kinases mediate interleukin-13 effects on calcium signaling in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2008, 295:L171-L177.
86. Kuperman D.A., Huang X., Koth L.L., Chang G.H., Dolganov G.M., Zhu Z., Elias J.A., Sheppard D., Erle D.J. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002, 8:885-889.
87. van Rensen E.L., Sont J.K., Evertse C.E., Willems L.N., Mauad T., Hiemstra P.S., Sterk P.J. Bronchial CD8 cell infiltrate and lung function decline in asthma. Am J Respir Crit Care Med 2005, 172:837-841.
88. Isogai S., Jedrzkiewicz S., Taha R., Hamid Q., Martin J.G. Resident CD8+ T cells suppress CD4+ T cell-dependent late allergic airway responses. J Allergy Clin Immunol 2005, 115:521-526.
89. Isogai S., Athiviraham A., Fraser R.S., Taha R., Hamid Q., Martin J.G. Interferon-gamma-dependent inhibition of late allergic airway responses and eosinophilia by CD8+ gammadelta T cells. Immunology 2007, 122:230-238.
90. Isogai S., Taha R., Tamaoka M., Yoshizawa Y., Hamid Q., Martin J.G. CD8(+) alpha beta T cells can mediate late airway responses and airway eosinophilia in rats. J Allergy Clin Immunol 2004, 114:1345-1352.
91. Schwarze J., Cieslewicz G., Joetham A., Ikemura T., Hamelmann E., Gelfand E.W. CD8 T cells are essential in the development of respiratory syncytial virus-induced lung eosinophilia and airway hyperresponsiveness. J Immunol 1999, 162:4207-4211.
92. Koya T., Miyahara N., Takeda K., Matsubara S., Matsuda H., Swasey C., Balhorn A., Dakhama A., Gelfand E.W. CD8+ T cell-mediated airway hyperresponsiveness and inflammation is dependent on CD4+IL-4+ T cells. J Immunol 2007, 179:2787-2796.
93. McMenamin C., Pimm C., McKersey M., Holt P.G. Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells. Science 1994, 265:1869-1871.
94. McMenamin C., McKersey M., Kuhnlein P., Hunig T., Holt P.G. Gamma delta T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens. J Immunol 1995, 154:4390-4394.
95. Hahn Y.S., Taube C., Jin N., Takeda K., Park J.W., Wands J.M., Aydintug M.K., Roark C.L., Lahn M., O'Brien R.L., et al. V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice. J Immunol 2003, 171:3170-3178.
96. Lahn M., Kanehiro A., Takeda K., Terry J., Hahn Y.S., Aydintug M.K., Konowal A., Ikuta K., O'Brien R.L., Gelfand E.W., Born W.K. MHC class I-dependent Vgamma4+ pulmonary T cells regulate alpha beta T cell-independent airway responsiveness. Proc Natl Acad Sci U S A 2002, 99:8850-8855.
97. Alexander A.G., Barnes N.C., Kay A.B. Trial of cyclosporin in corticosteroid-dependent chronic severe asthma. Lancet 1992, 339:324-328.