Interleukin-10-secreting "regulatory" T cells induced by glucocorticoids and β2-agonists

American Journal of Respiratory Cell and Molecular Biology

Volumn 33, Issue 1, 2005, Pages 105-111

  Peek, Emma J ^a   Richards, David F ^a   Faith, Alexander ^a   Lavender, Paul ^a   Lee, Tak H ^a   Corrigan, Christopher J ^a   Hawrylowicz, Catherine M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

2 agonists; Glucocorticoids; Interleukin 10; Regulatory T cells

Indexed keywords

ALLERGEN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CD4 ANTIGEN; FLUTICASONE PROPIONATE; GLUCOCORTICOID; INTERLEUKIN 10; INTERLEUKIN 13; SALBUTAMOL; SALMETEROL;

ADULT; ARTICLE; ASTHMA; ATOPY; CELL CULTURE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; STATISTICAL ANALYSIS; T LYMPHOCYTE; TH2 CELL;

ADRENERGIC BETA-AGONISTS; ADULT; ALBUTEROL; ALLERGENS; ANDROSTADIENES; ANTI-INFLAMMATORY AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CYTOKINES; DERMATITIS, ATOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCOCORTICOIDS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-13; INTERLEUKIN-5; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; RECEPTORS, ADRENERGIC, BETA-2; T-LYMPHOCYTES; TH2 CELLS;

EID: 21844445109     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2005-0100OC     Document Type: Article

References (35)

1. Kay AB. Allergy and allergic diseases: first of two parts. N Engl J Med 2001;344:30-37.
2. Kay AB. Allergy and allergic diseases: second of two parts. N Engl J Med 2001;344:109-113.
3. Gemou-Engesaeth V, Bush A, Kay AB, Hamid Q, Corrigan CJ. Inhaled glucocorticoid therapy of childhood asthma is associated with reduced peripheral blood T cell activation and 'Th2-type' cytokine mRNA expression. Pediatrics 1997;99:695-703.
4. Till SJ, Durham SR, Rajakulasingam K, Humbert M, Huston D, Dickason R, Kay AB, Corrigan CJ. Allergen-induced proliferation and interleukin-5 production by bronchoalveolar lavage and blood T cells after segmental allergen challenge. Am J Respir Crit Care Med 1998;158:404-411.
5. Umland SP, Schleimer RP, Johnston SL. Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma. Pulm Pharmacol Ther 2002;15:35-50.
6. Leung DY, Martin RJ, Szefler SJ, Sher ER, Ying S, Kay AB, Hamid Q. Dysregulation of interleukin 4, interleukin 5, and Interferon gamma gene expression in steroid-resistant asthma. J Exp Med 1995;181:33-40.
7. Pearlman DS, Chervinsky P, LaForce C, Seltzer JM, Southern DL, Kemp JP, Dockhorn RJ, Grossman J, Liddle RF, Yancey SW, et al. A comparison of salmeterol with albuterol in the treatment of mild-to-moderate asthma. N Engl J Med 1992;327:1420-1425.
8. Johnson M. Effects of beta2-agonists on resident and infiltrating inflammatory cells. J Allergy Clin Immunol 2002;110:S282-S290.
9. Pauwels RA, Lofdahl CG, Postma DS, Tattersfield AE, O'Byrne P, Barnes PJ, Ullman A. Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. N Engl J Med 1997;337:1405-1411.
10. Greening AP, Ind PW, Northfield M, Shaw G. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen and Hanburys Limited UK Study Group. Lancet 1994;344:219-224.
11. Wallin A, Sandstrom T, Soderberg M, Howarth P, Lundback B, Della-Cioppa G, Wilson S, Judd M, Djukanovic R, Holgate S, et al. The effects of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma. Am J Respir Crit Care Med 1999;159:79-86.
12. Barnes PJ. Scientific rationale for inhaled combination therapy with long-acting beta2-agonists and corticosteroids. Eur Respir J 2002;19:182-191.
13. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Anna Rev Immunol 2001;19:683-765.
14. John M, Lim S, Seybold J, Jose P, Robichaud A, O'Connor B, Barnes PJ, Chung KF. Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1a, granulocyte-macrophage stimulating factor and Interferon-g release from alveolar macrophages in asthma. Am J Respir Crit Care Med 1998;157:256-262.
15. Richards DF, Fernandez M, Caulfield J, Hawrylowicz CM. Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production. Eur J Immunol 2000;30:2344-2354.
16. Hawrylowicz C, Richards D, Loke TK, Corrigan C, Lee T. A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients. J Allergy Clin Immunol 2002;109:369-370.
17. Dytham C. Choosing and using statistics: a biologist's guide. Oxford: Blackwell Science Ltd; 1999.
18. Imada M, Simons F, Jay F, Hayglass K. Allergen-stimulated intrleukin-4 and interferon-gamma production in primary culture: responses of subjets with allergic rhinitis and normal cotrols. Immunology 1995;85:373-380.
19. Lim S, Crawley E, Woo P, Barnes PJ. Haplotype associated with low interleukin-10 production in patients with severe asthma. Lancet 1998;352:113.
20. Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001;2:725-731.
21. Oh JW, Seroogy CM, Meyer EH, Akbari O, Berry G, Fathman CG, Dekruyff RH, Umetsu DT. CD4 T-helper cells engineered, to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J Allergy Clin Immunol 2002;110:460-468.
22. Sekut L, Champion BR, Page K, Menius JA Jr, Connolly KM. Anti-inflammatory activity of salmeterol: down-regulation of cytokine production. Clin Exp Immunol 1995;99:461-466.
23. Mohede IC, Van Ark I, Brons FM, Van Oosterhout AJ, Nijkamp FP. Salmeterol inhibits interferon-gamma and interleukin-4 production by human peripheral blood mononuclear cells. Int J Immimopharmacol 1996;18:193-201.
24. Holen E, Elsayed S. Effects of beta2 adrenoceptor agonists on T-cell subpopulations. APMIS 1998;106:849-857.
25. Borger P, Hoekstra Y, Esselink MT, Postma DS, Zaagsma J, Vellenga E, Kauffman HF. β-Adrenoceptor-mediated inhibition of IFN-γ, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the β2-adrenoceptor subtype. Am J Respir Cell Mol Biol 1998;19:400-407.
26. Wallin A, Sandstrom T, Cioppa GD, Holgate S, Wilson S. The effects of regular inhaled formoterol and budesonide on preformed Th-2 cytokines in mild asthmatics. Respir Med 2002;96:1021-1025.
27. Goleva E, Dunlap A, Leung DY. Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with beta2-adrenergic agonists. J Allergy Clin Immunol 2004;114:183-191.
28. Malfait AM, Malik AS, Marinova-Mutafchieva L, Butler DM, Maini RN, Feldmann M. The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of action. J Immunol 1999;162:6278-6283.
29. Kips JC, O'Connor BJ, Inman MD, Svensson K, Pauwels RA, O'Byrne PM. A long-term study of the antiinflammatory effect of low-dose budesonide plus formoterol versus high-dose budesonide in asthma. Am J Respir Crit Care Med 2000;161:996-1001.
30. Li X, Ward C, Thien F, Bish R, Bamford T, Bao X, Bailey M, Wilson JW, Haydn Walters E. An antiinflammatory effect of salmeterol, a long-acting β2 agonist, assessed in airway biopsies and bronchoalveolar lavage in asthma. Am J Respir Crit Care Med 1999;160:1493-1499.
31. Jeffery PK, Venge P, Gizycki MJ, Egerod I, Dahl R, Faurschou P. Effects of salmeterol on mucosal inflammation in asthma: a placebo-controlled study. Eur Respir J 2002;20:1378-1385.
32. Lindqvist A, Karjalainen EM, Laitinen LA, Kava T, Altraja A, Pulkkinen M, Halme M, Laitinen A. Salmeterol resolves airway obstruction but does not possess anti-eosinophil efficacy in newly diagnosed asthma: a randomized, double-blind, parallel group biopsy study comparing the effects of salmeterol, fluticasone propionate, and disodium cromoglycate. J Allergy Clin Immunol 2003;112:23-28.
33. Roth M, Johnson PR, Rudiger JJ, King GG, Ge Q, Burgess JK, Anderson G, Tamm M, Black JL. Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling. Lancet 2002;360:1293-1299.
34. Eickelberg O, Roth M, Lorx R, Bruce V, Rudiger J, Johnson M, Block LH. Ligand-independent activation of the glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells. J Biol Chem 1999;274:1005-1010.
35. Chung K, Adcock I. Combination therapy of long-acting beta2-adrenoceptor agonists and corticosteroids for asthma. Treat Respir Med 2004;3:279-289.