How corticosteroids control inflammation: Quintiles Prize Lecture 2005

British Journal of Pharmacology

Volumn 148, Issue 3, 2006, Pages 245-254

  Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Glucocorticoid receptor; Glucocorticosteroid; Histone acetyltransferase; Histone deacetylase; Nuclear factor B; Steroid resistance; Theophylline; Transcription factor

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BUDESONIDE; CORTICOSTEROID; EBSELEN; FLUTICASONE PROPIONATE; GLUCOCORTICOID RECEPTOR; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 2; HOMODIMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MIFEPRISTONE; NITRIC OXIDE SYNTHASE INHIBITOR; RU 24858; RU 40066; STEROID; THEOPHYLLINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ACETYLATION; ASTHMA; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHRONIC INFLAMMATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); DISEASE SEVERITY; DNA TRANSCRIPTION; DRUG DNA INTERACTION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; GROWTH RETARDATION; HUMAN; NONHUMAN; OSTEOPOROSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MODIFICATION; REVIEW; SKIN FRAGILITY; TRANSCRIPTION REGULATION;

ADRENAL CORTEX HORMONES; DRUG RESISTANCE; HISTONES; HUMANS; INFLAMMATION; TRANSCRIPTION, GENETIC;

EID: 33744477341     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706736     Document Type: Review

References (94)

1. ADCOCK, I.M., COSIO, B., TSAPROUNI, L., BARNES, P.J. & ITO, K. (2005). Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response. Antioxid. Redox. Signal., 7, 144-152.
2. ADCOCK, I.M., NASUHARA, Y., STEVENS, D.A. & BARNES, P.J. (1999). Ligand-induced differentiation of glucocorticoid receptor trans-repression and transactivation: preferential targetting of NF-κB and lack of I-κB involvement. Br. J. Pharmacol., 127, 1003-1011.
3. ANDERSON, P., PHILLIPS, K., STOECKLIN, G. & KEDERSHA, N. (2004). Post-transcriptional regulation of proinflammatory proteins. J. Leukoc. Biol., 76, 42-47.
4. BANNISTER, A.J., SCHNEIDER, R. & KOUZARIDES, T. (2002). Histone methylation: dynamic or static? Cell, 109, 801-806.
5. BARNES, P.J. (2003). Theophylline: new perspectives on an old drug. Am. J. Respir. Crit. Care Med., 167, 813-818.
6. BARNES, P.J. (2004a). Distribution of receptor targets in the lung. Proc. Am. Thorac. Soc., 1, 345-351.
7. BARNES, P.J. (2004b). Mediators of chronic obstructive pulmonary disease. Pharm. Rev., 56, 515-548.
8. BARNES, P.J. (2005a). Targeting histone deacetylase 2 in chronic obstructive pulmonary disease treatment. Expert. Opin. Ther. Targets, 9, 1111-1121.
9. BARNES, P.J. (2005b). Theophylline in chronic obstructive pulmonary disease: new horizons. Proc. Am. Thorac. Soc., 2, 334-339.
10. BARNES, P.J. & ADCOCK, I.M. (1998). Transcription factors and asthma. Eur. Respir. J., 12, 221-234.
11. BARNES, P.J. & ADCOCK, I.M. (2003). How do corticosteroids work in asthma? Ann. Intern. Med., 139, 359-370.
12. BARNES, P.J., CHUNG, K.F. & PAGE, C.P. (1998). Inflammatory mediators of asthma: an update. Pharmacol. Rev., 50, 515-596.
13. BARNES, P.J., ITO, K. & ADCOCK, I.M. (2004). A mechanism of corticosteroid resistance in COPD: inactivation of histone deacetylase. Lancet, 363, 731-733.
14. BARNES, P.J. & KARIN, M. (1997). Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. New Engl. J. Med., 336, 1066-1071.
15. BERGER, S.L. (2001). An embarrassment of niches: the many covalent modifications of histones in transcriptional regulation. Oncogene, 20, 3007-3013.
16. BERGMANN, M., BARNES, P.J. & NEWTON, R. (2000). Molecular regulation of granulocyte macrophage colony-stimulating factor in human lung epithelial cells by interleukin (IL)-1β, IL-4, and IL-13 involves both transcriptional and post-transcriptional mechanisms. Am. J. Respir. Cell. Mol. Biol., 22, 582-589.
17. BERGMANN, M.W., STAPLES, K.J., SMITH, S.J., BARNES, P.J. & NEWTON, R. (2004). Glucocorticoid inhibition of GM-CSF from T cells is independent of control by NF-kB and CLE0. Am. J. Respir. Cell. Mol. Biol., 30, 555-563.
18. BLEDSOE, R.K., MONTANA, V.G., STANLEY, T.B., DELVES, C.J., APOLITO, C.J., MCKEE, D.D., CONSLER, T.G., PARKS, D.J., STEWART, E.L., WILLSON, T.M., LAMBERT, M.H., MOORE, J.T., PEARCE, K.H. & XU, H.E. (2002). Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell, 110, 93-105.
19. BOARDLEY, J.E., CAREY, R.A. & HARVEY, A.M. (1949). Preliminary observations on the effect of adrenocorticotropic hormone in allergic diseases. Bull. Johns Hopkins Hosp., 85, 396-410.
20. BODWELL, J.E., WEBSTER, J.C., JEWELL, C.M., CIDLOWSKI, J.A., HU, J.M. & MUNCK, A. (1998). Glucocorticoid receptor phosphorylation: overview, function and cell cycle-dependence. J. Steroid. Biochem. Mol. Biol., 65, 91-99.
21. BRINDICCI, C., ITO, K., RESTA, O., PRIDE, N.B., BARNES, P.J. & KHARITONOV, S.A. (2005). Exhaled nitric oxide from lung periphery is increased in COPD. Eur. Respir. J., 26, 52-59.
22. BROWN, H.M., STOREY, G. & GEORGE, W.H. (1972). Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma. Br. Med. J., 1, 585-590.
23. CARAMORI, G. & PAPI, A. (2004). Oxidants and asthma. Thorax, 59, 170-173.
24. CHALMERS, G.W., MACLEOD, K.J., THOMSON, L., LITTLE, S.A., MCSHARRY, C. & THOMSON, N.C. (2001). Smoking and airway inflammation in patients with mild asthma. Chest, 120, 1917-1922.
25. CHAUDHURI, R., LIVINGSTON, E., MCMAHON, A.D., THOMSON, L., BORLAND, W. & THOMSON, N.C. (2003). Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am. J. Respir. Crit. Care Med., 168, 1265-1266.
26. CHIKANZA, I.C. & KOZACI, D.L. (2004). Corticosteroid resistance in rheumatoid arthritis: molecular and cellular perspectives. Rheumatology (Oxford), 43, 1337-1345.
27. COSIO, B.G., MANN, B., ITO, K., JAZRAWI, E., BARNES, P.J., CHUNG, K.F. & ADCOCK, I.M. (2004a). Histone acetylase and deacetylase activity in alveolar macrophages and blood monocytes in asthma. Am. J. Respir. Crit. Care Med., 170, 141-147.
28. COSIO, B.G., TSAPROUNI, L., ITO, K., JAZRAWI, E., ADCOCK, I.M. & BARNES, P.J. (2004b). Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J. Exp. Med., 200, 689-695.
29. CULPITT, S.V., NIGHTINGALE, J.A. & BARNES, P.J. (1999). Effect of high dose inhaled steroid on cells, cytokines and proteases in induced sputum in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 160, 1635-1639.
30. CULPITT, S.V., ROGERS, D.F., SHAH, P., DE MATOS, C., RUSSELL, R.E., DONNELLY, L.E. & BARNES, P.J. (2003). Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 167, 24-31.
31. CUZZOCREA, S., THIEMERMANN, C. & SALVEMINI, D. (2004). Potential therapeutic effect of antioxidant therapy in shock and inflammation. Curr. Med. Chem., 11, 1147-1162.
32. DE RUIJTER, A.J., VAN GENNIP, A.H., CARON, H.N., KEMP, S. & VAN KUILENBURG, A.B. (2003). Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem. J., 370, 737-749.
33. DEAN, J.L., SULLY, G., CLARK, A.R. & SAKLATVALA, J. (2004). The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation. Cell. Signal., 16, 1113-1121.
34. DI STEFANO, A., CARAMORI, G., CAPELLI, A., LUSUARDI, M., GNEMMI, I., IOLI, F., CHUNG, K.F., DONNER, C.F., BARNES, P.J. & ADCOCK, I.M. (2002). Increased expression of NF-kB in bronchial biopsies from smokers and patients with COPD. Eur. Resp. J., 20, 556-563.
35. DOSTERT, A. & HEINZEL, T. (2004). Negative glucocorticoid receptor response elements and their role in glucocorticoid action. Curr. Pharm. Des., 10, 2807-2816.
36. FU, M., WANG, C., ZHANG, X. & PESTELL, R.G. (2004). Acetylation of nuclear receptors in cellular growth and apoptosis. Biochem. Pharmacol., 68, 1199-1208.
37. GLOZAK, M.A., SENGUPTA, N., ZHANG, X. & SETO, E. (2005). Acetylation and deacetylation of non-histone proteins. Gene, 363, 15-23.
38. HALL, S.E., LIM, S., WITHERDEN, I.R., TETLEY, T.D., BARNES, P.J., KAMAL, A.M. & SMITH, S.F. (1999). Lung type II cell and macrophage annexin I release: differential effects of two glucocorticoids. Am. J. Physiol., 276, L114-L121.
39. HANSEL, T.T., KHARITONOV, S.A., DONNELLY, L.E., ERIN, E.M., CURRIE, M.G., MOORE, W.M., MANNING, P.T., RECKER, D.P. & BARNES, P.J. (2003). A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB. J., 17, 1298-1300.
40. HART, L., LIM, S., ADCOCK, I., BARNES, P.J. & CHUNG, K.F. (2000). Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor-kB in asthma. Am. J. Respir. Crit. Care Med., 161, 224-231.
41. HART, L.A., KRISHNAN, V.L., ADCOCK, I.M., BARNES, P.J. & CHUNG, K.F. (1998). Activation and localization of transcription factor, nuclear factor-κB, in asthma. Am. J. Respir. Crit. Care Med., 158, 1585-1592.
42. HECHT, K., CARLSTEDT-DUKE, J., STIERNA, P., GUSTAFFSON, J.-Å., BRONNEGARD, M. & WILKSTROM, A.-C. (1997). Evidence that the β-isoform of the human glucocorticoid receptor does not act as a physiologically significant repressor. J. Biol. Chem., 272, 26659-26664.
43. HECK, S., BENDER, K., KULLMANN, M., GOTTLICHER, M., HERRLICH, P. & CATO, A.C. (1997). IκB alpha-independent downregulation of NF-κB activity by glucocorticoid receptor. EMBO. J., 16, 4698-4707.
44. HECK, S., KULLMANN, M., GRAST, A., PONTA, H., RAHMSDORF, H.J., HERRLICH, P. & CATO, A.C.B. (1994). A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO. J., 13, 4087-4095.
45. HOGG, J.C., CHU, F., UTOKAPARCH, S., WOODS, R., ELLIOTT, W.M., BUZATU, L., CHERNIACK, R.M., ROGERS, R.M., SCIURBA, F.C., COXSON, H.O. & PARE, P.D. (2004). The nature of small-airway obstruction in chronic obstructive pulmonary disease. New Engl. J. Med., 350, 2645-2653.
46. IMHOF, A. & WOLFFE, A.P. (1998). Transcription: gene control by targeted histone acetylation. Curr. Biol., 8, R422-R424.
47. ISMAILI, N. & GARABEDIAN, M.J. (2004). Modulation of glucocorticoid receptor function via phosphorylation. Ann. NY Acad. Sci., 1024, 86-101.
48. ITO, K., BARNES, P.J. & ADCOCK, I.M. (2000). Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits IL-1b-induced histone H4 acetylation on lysines 8 and 12. Mol. Cell. Biol., 20, 6891-6903.
49. ITO, K., CARAMORI, G., LIM, S., OATES, T., CHUNG, K.F., BARNES, P.J. & ADCOCK, I.M. (2002a). Expression and activity of histone deacetylases (HDACs) in human asthmatic airways. Am. J. Respir. Crit. Care Med., 166, 392-396.
50. ITO, K., ITO, M., ELLIOTT, W.M., COSIO, B., CARAMORI, G., KON, O.M., BARCZYK, A., HAYASHI, M., ADCOCK, I.M., HOGG, J.C. & BARNES, P.J. (2005). Decreased histone deacetylase activity in chronic obstructive pulmonary disease. New Engl. J. Med., 352, 1967-1976.
51. ITO, K., JAZRAWI, E., COSIO, B., BARNES, P.J. & ADCOCK, I.M. (2001a). p65-activated histone acetyltransferase activity is repressed by glucocorticoids: Mifepristone fails to recruit HDAC2 to the p65/HAT complex. J. Biol. Chem., 276, 30208-30215.
52. ITO, K., LIM, S., CARAMORI, G., CHUNG, K.F., BARNES, P.J. & ADCOCK, I.M. (2001b). Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression and inhibits glucocorticoid actions in alveolar macrophages. FASEB. J., 15, 1100-1102.
53. ITO, K., LIM, S., CARAMORI, G., COSIO, B., CHUNG, K.F., ADCOCK, I.M. & BARNES, P.J. (2002b). A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc. Natl. Acad. Sci. U.S.A., 99, 8921-8926.
54. ITO, K., TOMITA, T., BARNES, P.J. & ADCOCK, I.M. (2004). Oxidative stress reduces histone deacetylase (HDAC)2 activity and enhances IL-8 gene expression: role of tyrosine nitration. Biochem. Biophys. Res. Commun., 315, 240-245.
55. ITO, K., YAMAMURA, S., ESSILFIE-QUAYE, S., COSIO, B., ITO, M., BARNES, P.J. & ADCOCK, I.M. (2006). Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kB suppression. J. Exp. Med., 203, 7-13.
56. JAFFUEL, D., DEMOLY, P., GOUGAT, C., BALAGUER, P., MAUTINO, G., GODARD, P., BOUSQUET, J. & MATHIEU, M. (2000). Transcriptional potencies of inhaled glucocorticoids. Am. J. Respir. Crit. Care Med., 162, 57-63.
57. JALONEN, U., LAHTI, A., KORHONEN, R., KANKAANRANTA, H. & MOILANEN, E. (2005). Inhibition of tristetraprolin expression by dexamethasone in activated macrophages. Biochem. Pharmacol., 69, 733-740.
58. KAGOSHIMA, M., WILCKE, T., ITO, K., TSAPROUNI, L., BARNES, P.J., PUNCHARD, N. & ADCOCK, I.M. (2001). Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation. Eur. J. Pharmacol., 429, 327-334.
59. KEATINGS, V.M., JATAKANON, A., WORSDELL, Y.M. & BARNES, P.J. (1997). Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am. J. Respir. Crit. Care Med., 155, 542-548.
60. KURIHARA, I., SHIBATA, H., SUZUKI, T., ANDO, T., KOBAYASHI, S., HAYASHI, M., SAITO, I. & SARUTA, T. (2002). Expression and regulation of nuclear receptor coactivators in glucocorticoid action. Mol. Cell. Endocrinol., 189, 181-189.
61. LASA, M., ABRAHAM, S.M., BOUCHERON, C., SAKLATVALA, J. & CLARK, A.R. (2002). Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Mol. Cell. Biol., 22, 7802-7811.
62. LEE, K.-Y., BARNES, P.J. & ADCOCK, I.M. (2006). NF-kB and AP-1 response elements and the role of histone modifications in IL-1b-induced TGF-b1 gene transcription. J. Immunol., 176, 603-615.
63. LEUNG, D.Y.M., HAMID, Q., VOTTERO, A., SZEFLER, S.J., SURS, W., MINSHALL, E., CHROUSOS, G.P. & KLEMM, D.J. (1997). Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor b. J. Exp. Med., 186, 1567-1574.
64. LI, X., WONG, J., TSAI, S.Y., TSAI, M.J. & O'MALLEY, B.W. (2003). Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol. Cell. Biol., 23, 3763-3773.
65. LIM, S., ROCHE, N., OLIVER, B.G., MATTOS, W., BARNES, P.J. & FAN, C.K. (2000). Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers, regulation by interleukin-10. Am. J. Respir. Crit. Care Med., 162, 1355-1360.
66. LOPPOW, D., SCHLEISS, M.B., KANNIESS, F., TAUBE, C., JORRES, R.A. & MAGNUSSEN, H. (2001). In patients with chronic bronchitis a four week trial with inhaled steroids does not attenuate airway inflammation. Respir. Med., 95, 115-121.
67. MICHETTI, P., MOTTET, C., JUILLERAT, P., FELLEY, C., VADER, J.P., BURNAND, B., GONVERS, J.J. & FROEHLICH, F. (2005). Severe and steroid-resistant Crohn's disease. Digestion, 71, 19-25.
68. MINER, J.N., HONG, M.H. & NEGRO-VILAR, A. (2005). New and improved glucocorticoid receptor ligands. Expert. Opin. Investig. Drugs, 14, 1527-1545.
69. MITTELSTADT, P.R. & ASHWELL, J.D. (2001). Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ. J. Biol. Chem., 276, 29603-29610.
70. MONACO, C. & PALEOLOG, E. (2004). Nuclear factor kappaB: a potential therapeutic target in atherosclerosis and thrombosis. Cardiovasc. Res., 61, 671-682.
71. MONTUSCHI, P., CIABATTONI, G., CORRADI, M., NIGHTINGALE, J.A., COLLINS, J.V., KHARITONOV, S.A. & BARNES, P.J. (1999). Increased 8-Isoprostane, a marker of oxidative stress, in exhaled condensates of asthmatic patients. Am. J. Respir. Crit. Care Med., 160, 216-220.
72. MONTUSCHI, P., COLLINS, J.V., CIABATTONI, G., LAZZERI, N., CORRADI, M., KHARITONOV, S.A. & BARNES, P.J. (2000). Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am. J. Respir. Crit. Care Med., 162, 1175-1177.
73. MULLER-LADNER, U., GAY, R.E. & GAY, S. (2002). Role of nuclear factor kB in synovial inflammation. Curr. Rheumatol. Rep., 4, 201-207.
74. MURAHIDY, A., ITO, M., ADCOCK, I.M., BARNES, P.J. & ITO, K. (2005). Reduction is histone deacetylase expression and activity in smoking asthmatics: a mechanism of steroid resistance. Proc. Am. Thorac. Soc., 2, A889.
75. NEWTON, R., HART, L.A., STEVENS, D.A., BERGMANN, M., DONNELLY, L.E., ADCOCK, I.M. & BARNES, P.J. (1998a). Effect of dexamethasone on interleukin-1β-induced nuclear factor-κB and κB-dependent transcription in epithelial cells. Eur. J. Biochem., 254, 81-89.
76. 2 release by dexamethasone occurs by transcriptional and post-transcriptional mechanisms Involving loss of polyadenylated mRNA. J. Biol. Chem., 273, 32312-32321.
77. NEWTON, R., STAPLES, K.J., HART, L., BARNES, P.J. & BERGMANN, M.W. (2001). GM-CSF expression in pulmonary epithelial cells is regulated negatively by posttranscriptional mechanisms. Biochem. Biophys. Res. Commun., 287, 249-253.
78. PETERSON, C.L. (2002). HDAC's at work: everyone doing their part. Mol. Cell, 9, 921-922.
79. PETERSON, C.L. & LANIEL, M.A. (2004). Histones and histone modifications. Curr. Biol., 14, R546-R551.
80. PRIVALSKY, M.L. (2004). The role of corepressors in transcriptional regulation by nuclear hormone receptors. Annu. Rev. Physiol., 66, 315-360.
81. PUJOLS, L., MULLOL, J., ROCA-FERRER, J., TORREGO, A., XAUBET, A., CIDLOWSKI, J.A. & PICADO, C. (2002). Expression of glucocorticoid receptor alpha- and beta-isoforms in human cells and tissues. Am. J. Physiol. Cell. Physiol., 283, C1324-C1331.
82. RAGHAVAN, A., ROBISON, R.L., MCNABB, J., MILLER, C.R., WILLIAMS, D.A. & BOHJANEN, P.R. (2001). HuA and tristetraprolin are induced following T cell activation and display distinct but overlapping RNA binding specificities. J. Biol. Chem., 276, 47958-47965.
83. REICHARDT, H.M., KAESTNER, K.H., TUCKERMANN, J., KRETZ, O., WESSELY, O., BOCK, R., GASS, P., SCHMID, W., HERRLICH, P., ANGEL, P. & SCHUTZ, G. (1998). DNA binding of the glucocorticoid receptor is not essential for survival. Cell, 93, 531-541.
84. REICHARDT, H.M., TUCKERMANN, J.P., GOTTLICHER, M., VUJIC, M., WEIH, F., ANGEL, P., HERRLICH, P. & SCHUTZ, G. (2001). Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO. J., 20, 7168-7173.
85. RHEN, T. & CIDLOWSKl, J.A. (2005). Antiinflammatory action of glucocorticoids - new mechanisms for old drugs. New Engl. J. Med., 353, 1711-1723.
86. ROTH, S.Y., DENU, J.M. & ALLIS, C.D. (2001). Histone acetyltransferases. Annu. Rev. Biochem., 70, 81-120.
87. SCHACKE, H., SCHOTTELIUS, A., DOCKE, W.D., STREHLKE, P., JAROCH, S., SCHMEES, N., REHWINKEL, H., HENNEKES, H. & ASADULLAH, K. (2004). Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects. Proc. Natl. Acad. Sci. U.S.A., 101, 227-232.
88. THIAGALINGAM, S., CHENG, K.H., LEE, H.J., MINEVA, N., THIAGALINGAM, A. & PONTE, J.F. (2003). Histone deacetylases: unique players in shaping the epigenetic histone code. Ann. NY Acad. Sci., 983, 84-100.
89. THOMSON, N.C. & SPEARS, M. (2005). The influence of smoking on the treatment response in patients with asthma. Curr. Opin. Allergy Clin. Immunol., 5, 57-63.
90. VAYSSIERE, B.M., DUPONT, S., CHOQUART, A., PETIT, F., GARCIA, T., MARCHANDEAU, C., GRONEMEYER, H. & RESCHE-RIGON, M. (1997). Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo. Mol. Endocrinol., 11, 1245-1255.
91. WADA, H., KAGOSHIMA, M., ITO, K., BARNES, P.J. & ADCOCK, I.M. (2005). 5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene. Biochem. Biophys. Res. Commun., 331, 93-99.
92. WANG, Y., FISCHLE, W., CHEUNG, W., JACOBS, S., KHORASANIZADEH, S. & ALLIS, C.D. (2004). Beyond the double helix: writing and reading the histone code. Novartis Found. Symp., 259, 3-17.
93. WU, B., LI, P., LIU, Y., LOU, Z., DING, Y., SHU, C., YE, S., BARTLAM, M., SHEN, B. & RAO, Z. (2004). 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. Proc. Natl. Acad. Sci. U.S.A., 101, 8348-8353.
94. YAO, T.P., KU, G., ZHOU, N., SCULLY, R. & LIVINGSTON, D.M. (1996). The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc. Natl. Acad. Sci. U.S.A., 93, 10626-10631.