메뉴 건너뛰기




Volumn 11, Issue 3, 2011, Pages 317-330

Modulation of Protein-Protein Interactions as a Therapeutic Strategy for The Treatment of Neurodegenerative Tauopathies

Author keywords

Aggregation inhibitors; Alzheimer's disease; Microtubule stabilizing agents; Neurodegenerative tauopathies; Protein protein interaction; Tau

Indexed keywords

ANG 1005; CERATAMINE A; CERATAMINE B; CNDR 29; CYCLOSTREPTIN; DICTYOSTATIN; DISCODERMOLIDE; DOCETAXEL; ELEUTHEROBIN; EPOTHILONE A; EPOTHILONE B; EPOTHILONE C; EPOTHILONE D; EPOTHILONE DERIVATIVE; IXABEPILONE; LAROTAXEL; LAULIMALIDE; ORTATAXEL; PACLITAXEL; PACLITAXEL DERIVATIVE; PELORUSIDE A; RPR 109881A; SARCODICTYIN A; SARCODICTYIN B; SB T 1213; SB T 121303; TAU PROTEIN; TAXANE DERIVATIVE; TX 67; TXD 258; UNCLASSIFIED DRUG; UNINDEXED DRUG; WS 9885B;

EID: 78650929447     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802611794072605     Document Type: Article
Times cited : (37)

References (130)
  • 1
    • 0142087554 scopus 로고    scopus 로고
    • Antibodies as therapeutic agents: Vivela renaissance
    • Stockwin, L. H.; Holmes, S. Antibodies as therapeutic agents: vivela renaissance. Exp. Opin. Biol. Ther., 2003, 3, 1133-1152.
    • (2003) Exp. Opin. Biol. Ther , vol.3 , pp. 1133-1152
    • Stockwin, L.H.1    Holmes, S.2
  • 2
    • 0037061646 scopus 로고    scopus 로고
    • Inhibition of protein-protein association by smallmolecules: Approaches and progress
    • Toogood, P. L. Inhibition of protein-protein association by smallmolecules: approaches and progress. J. Med. Chem., 2002, 45,1543-1558.
    • (2002) J. Med. Chem , vol.45 , pp. 1543-1558
    • Toogood, P.L.1
  • 3
    • 33845594315 scopus 로고    scopus 로고
    • Protein-protein interactions as targets for small moleculedrug discovery
    • Fry, D. Protein-protein interactions as targets for small moleculedrug discovery. Biopolymers, 2006, 84, 535-552.
    • (2006) Biopolymers , vol.84 , pp. 535-552
    • Fry, D.1
  • 4
    • 3142781225 scopus 로고    scopus 로고
    • Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
    • Arkin, M. R.; Wells, J. A. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat. Rev. DrugDiscov., 2004, 3, 301-317.
    • (2004) Nat. Rev. DrugDiscov , vol.3 , pp. 301-317
    • Arkin, M.R.1    Wells, J.A.2
  • 6
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • Liu, J.; Farmer, J. D.; Lane, W. S.; Friedman, J.; Weissman, I.; Schreiber, S. L. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell, 1991, 66, 807-815.
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 7
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancerdrugs
    • Jordan, M. A.; Wilson, L. Microtubules as a target for anticancerdrugs. Nat. Rev. Cancer, 2004, 4, 253-265.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 8
    • 0037860938 scopus 로고    scopus 로고
    • Modulation of protein-protein interactions with smallorganic molecules
    • Berg, T. Modulation of protein-protein interactions with smallorganic molecules. Angew. Chem. Int. Ed. Engl., 2003, 42, 2462-2481.
    • (2003) Angew. Chem. Int. Ed. Engl , vol.42 , pp. 2462-2481
    • Berg, T.1
  • 10
    • 34548036227 scopus 로고    scopus 로고
    • Tau-mediatedneurodegeneration In Alzheimer's Disease and Related Disorders
    • Ballatore, C.; Lee, V. M.-Y.; Trojanowski, J. Q. Tau-mediatedneurodegeneration in Alzheimer's disease and related disorders.Nat. Rev. Neurosci., 2007, 8, 663-672.
    • (2007) Nat. Rev. Neurosci , vol.8 , pp. 663-672
    • Ballatore, C.1    Lee, V.M.-Y.2    Trojanowski, J.Q.3
  • 12
    • 0042924434 scopus 로고    scopus 로고
    • Differential Regulation of Microtubule Dynamics By Three-and Four-repeat Tau: Implications For the Onset of Neurodegenerative Disease
    • Panda, D.; Samuel, J. C.; Massie, M.; Feinstein, S. C.; Wilson, L.Differential regulation of microtubule dynamics by three-and four-repeat tau: implications for the onset of neurodegenerative disease.Proc. Natl. Acad. Sci. USA, 2003, 100, 9548-9553.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9548-9553
    • Panda, D.1    Samuel, J.C.2    Massie, M.3    Feinstein, S.C.4    Wilson, L.5
  • 13
    • 2542464892 scopus 로고    scopus 로고
    • Modulation of microtubule dynamics by tau in living cells:Implications for development and neurodegeneration
    • Bunker, J. M.; Wilson, L.; Jordan, M. A.; Feinstein, S. C.Modulation of microtubule dynamics by tau in living cells:implications for development and neurodegeneration. Mol. Biol.Cell, 2004, 15, 2720-2728.
    • (2004) Mol. Biol.Cell , vol.15 , pp. 2720-2728
    • Bunker, J.M.1    Wilson, L.2    Jordan, M.A.3    Feinstein, S.C.4
  • 16
    • 4344572092 scopus 로고    scopus 로고
    • Microtubule structure and its stabilisation
    • Amos, L. A. Microtubule structure and its stabilisation. Org.Biomol. Chem., 2004, 2, 2153-2160.
    • (2004) Org.Biomol. Chem , vol.2 , pp. 2153-2160
    • Amos, L.A.1
  • 17
    • 46649101161 scopus 로고    scopus 로고
    • Nucleation-dependent Tau Filament Formation: Theimportance of Dimerization and An Estimation of Elementary Rateconstantss
    • Congdon, E. E.; Kim, S.; Bonchak, J.; Songrug, T.; Matzavinos,A.; Kuret, J. Nucleation-dependent tau filament formation: theimportance of dimerization and an estimation of elementary rateconstants. J. Biol. Chem., 2008, 283, 13806-13816.
    • (2008) J. Biol. Chem , vol.283 , pp. 13806-13816
    • Congdon, E.E.1    Kim, S.2    Bonchak, J.3    Songrug, T.4    Matzavinos, A.5    Kuret, J.6
  • 18
    • 0022395021 scopus 로고
    • Nerve growth factor-induced neurite outgrowth in PC12 cellsinvolves the coordinate induction of microtubule assembly andassembly-promoting factors
    • Drubin, D. G.; Feinstein, S. C.; Shooter, E. M.; Kirschner, M. W.Nerve growth factor-induced neurite outgrowth in PC12 cellsinvolves the coordinate induction of microtubule assembly andassembly-promoting factors. J. Cell Biol., 1985, 101, 1799-1807.
    • (1985) J. Cell Biol , vol.101 , pp. 1799-1807
    • Drubin, D.G.1    Feinstein, S.C.2    Shooter, E.M.3    Kirschner, M.W.4
  • 19
    • 34447503455 scopus 로고    scopus 로고
    • Untangling tau hyperphos-phorylation in drug design for neurodegenerative diseases
    • Mazanetz, M. P.; Fischer, P. M. Untangling tau hyperphos-phorylation in drug design for neurodegenerative diseases. Nat.Rev. Drug Discov. 2007, 6, 464-479.
    • (2007) Nat.Rev. Drug Discov , vol.6 , pp. 464-479
    • Mazanetz, M.P.1    Fischer, P.M.2
  • 20
    • 3142514201 scopus 로고    scopus 로고
    • Protein aggregation andneurodegenerative disease
    • Ross, C. A.; Poirier, M. A. Protein aggregation andneurodegenerative disease. Nat. Med., 2004, 10 (Suppl), S10-17.
    • (2004) Nat. Med , vol.10 , Issue.SUPPL. , pp. 10-17
    • Ross, C.A.1    Poirier, M.A.2
  • 21
    • 49149083015 scopus 로고    scopus 로고
    • Evidence thatnon-fibrillar tau causes pathology linked to neurodegeneration andbehavioral impairments
    • Brunden, K. R.; Trojanowski, J. Q.; Lee, V. M.-Y. Evidence thatnon-fibrillar tau causes pathology linked to neurodegeneration andbehavioral impairments. J. Alzheimers Dis., 2008, 14, 393-399.
    • (2008) J. Alzheimers Dis , vol.14 , pp. 393-399
    • Brunden, K.R.1    Trojanowski, J.Q.2    Lee, V.M.-Y.3
  • 22
    • 70349638299 scopus 로고    scopus 로고
    • Advances Intau-focused Drug Discovery For Alzheimer's Disease and Relatedtauopathies
    • Brunden, K. R.; Trojanowski, J. Q.; Lee, V. M.-Y. Advances intau-focused drug discovery for Alzheimer's disease and relatedtauopathies. Nat. Rev. Drug Discov., 2009, 8, 783-793.
    • (2009) Nat. Rev. Drug Discov , vol.8 , pp. 783-793
    • Brunden, K.R.1    Trojanowski, J.Q.2    Lee, V.M.-Y.3
  • 25
    • 0035433163 scopus 로고    scopus 로고
    • Effects of paclitaxel on culturedsynovial cells from patients with rheumatoid arthritis
    • Akira Kurose, W. Y. M. Y. T. S. Effects of paclitaxel on culturedsynovial cells from patients with rheumatoid arthritis. Cytometry,2001, 44, 349-354.
    • (2001) Cytometry , vol.44 , pp. 349-354
    • Akira Kurose, W.Y.M.Y.T.S.1
  • 27
    • 0036195791 scopus 로고    scopus 로고
    • Paclitaxel (Taxol) attenuatesclinical disease in a spontaneously demyelinating transgenic mouseand induces remyelination
    • Moscarello, M. A.; Mak, B.; Nguyen, T. A.; Wood, D. D.; Mastronardi, F.; Ludwin, S. K. Paclitaxel (Taxol) attenuatesclinical disease in a spontaneously demyelinating transgenic mouseand induces remyelination. Mult. Scler., 2002, 8, 130-138.
    • (2002) Mult. Scler , vol.8 , pp. 130-138
    • Moscarello, M.A.1    Mak, B.2    Nguyen, T.A.3    Wood, D.D.4    Mastronardi, F.5    Ludwin, S.K.6
  • 28
    • 0027992814 scopus 로고
    • Microtubulestabilizing drugs for the treatment of Alzheimer's disease
    • Lee, V. M.-Y.; Daughenbaugh, R.; Trojanowski, J. Q. Microtubulestabilizing drugs for the treatment of Alzheimer's disease.Neurobiol. Aging, 1994, 15(Suppl) 2, S87-89.
    • (1994) Neurobiol. Aging , vol.15 , Issue.2 SUPPL. , pp. 87-89
    • Lee V., M.-Y.1    Daughenbaugh, R.2    Trojanowski, J.Q.3
  • 30
    • 19044378780 scopus 로고    scopus 로고
    • M.-Y.Microtubule-stabilizing drugs for therapy of Alzheimer's diseaseand other neurodegenerative disorders with axonal transportimpairments
    • Trojanowski, J. Q.; Smith, A. B.; Huryn, D.; Lee, V. M.-Y.Microtubule-stabilizing drugs for therapy of Alzheimer's diseaseand other neurodegenerative disorders with axonal transportimpairments. Expert Opin. Pharmacother., 2005, 6, 683-686.
    • (2005) Expert Opin. Pharmacother , vol.6 , pp. 683-686
    • Trojanowski, J.Q.1    Smith, A.B.2    Huryn, D.3    Lee, V.4
  • 32
    • 0038206660 scopus 로고    scopus 로고
    • Managing taxane toxicities
    • Markman, M. Managing taxane toxicities. Support. Care Cancer2003, 11, 144-7.
    • (2003) Support. Care Cancer , vol.11 , pp. 144-147
    • Markman, M.1
  • 33
    • 17344385879 scopus 로고    scopus 로고
    • The taxoids: Same roots, different drugs
    • S13-3-S13-10
    • Von Hoff, D. D. The taxoids: same roots, different drugs. Semin.Oncol., 1997, 24, S13-3-S13-10.
    • (1997) Semin.Oncol , vol.24
    • von Hoff, D.D.1
  • 35
    • 33645736326 scopus 로고    scopus 로고
    • Peripheral neuropathy induced bymicrotubule-stabilizing agents
    • Lee, J.; Swain, S. M. Peripheral neuropathy induced bymicrotubule-stabilizing agents. J. Clin. Oncol., 2006, 24, 1633-1642.
    • (2006) J. Clin. Oncol , vol.24 , pp. 1633-1642
    • Lee, J.1    Swain, S.M.2
  • 36
    • 0029063397 scopus 로고
    • Structure of tubulin at 6.5 A and location of the taxol-bindingsite
    • Nogales, E.; Wolf, S. G.; Khan, I. A.; Luduena, R. F.; Downing, K.H. Structure of tubulin at 6.5 A and location of the taxol-bindingsite. Nature, 1995, 375, 424-427.
    • (1995) Nature , vol.375 , pp. 424-427
    • Nogales, E.1    Wolf, S.G.2    Khan, I.A.3    Luduena, R.F.4    Downing, K.H.5
  • 37
    • 0037413708 scopus 로고    scopus 로고
    • Repeatmotifs of tau bind to the insides of microtubules in the absence oftaxol
    • Kar, S.; Fan, J.; Smith, M. J.; Goedert, M.; Amos, L. A. Repeatmotifs of tau bind to the insides of microtubules in the absence oftaxol. EMBO J., 2003, 22, 70-77.
    • (2003) EMBO J , vol.22 , pp. 70-77
    • Kar, S.1    Fan, J.2    Smith, M.J.3    Goedert, M.4    Amos, L.A.5
  • 38
    • 0033102385 scopus 로고    scopus 로고
    • How Taxol stabilises microtubule structure
    • Amos, L. A.; Lowe, J. How Taxol stabilises microtubule structure.Chem. Biol., 1999, 6, R65-69.
    • (1999) Chem. Biol , vol.6 , pp. 65-69
    • Amos, L.A.1    Lowe, J.2
  • 39
    • 0028908695 scopus 로고
    • Substoichiometric bindingof taxol suppresses microtubule dynamics
    • Derry, W. B.; Wilson, L.; Jordan, M. A. Substoichiometric bindingof taxol suppresses microtubule dynamics. Biochemistry, 1995, 34,2203-2211.
    • (1995) Biochemistry , vol.34 , pp. 2203-2211
    • Derry, W.B.1    Wilson, L.2    Jordan, M.A.3
  • 40
    • 0042515234 scopus 로고    scopus 로고
    • The effect of P-glycoprotein on paclitaxel brain and brain tumor distribution inmice
    • Gallo, J. M.; Li, S.; Guo, P.; Reed, K.; Ma, J. The effect of P-glycoprotein on paclitaxel brain and brain tumor distribution inmice. Cancer Res., 2003, 63, 5114-5117.
    • (2003) Cancer Res , vol.63 , pp. 5114-5117
    • Gallo, J.M.1    Li, S.2    Guo, P.3    Reed, K.4    Ma, J.5
  • 41
    • 1542313853 scopus 로고    scopus 로고
    • Modulation of drug transporters at theblood-brain barrier
    • Fricker, G.; Miller, D. S. Modulation of drug transporters at theblood-brain barrier. Pharmacology, 2004, 70, 169-176.
    • (2004) Pharmacology , vol.70 , pp. 169-176
    • Fricker, G.1    Miller, D.S.2
  • 45
    • 0030823912 scopus 로고    scopus 로고
    • P-glycoprotein is strongly expressed in the luminal membranes of theendothelium of blood vessels in the brain
    • Beaulieu, E.; Demeule, M.; Ghitescu, L.; Beliveau, R. P-glycoprotein is strongly expressed in the luminal membranes of theendothelium of blood vessels in the brain. Biochem. J., 1997, 326(Pt 2), 539-544.
    • (1997) Biochem. J , vol.326 , Issue.Pt 2 , pp. 539-544
    • Beaulieu, E.1    Demeule, M.2    Ghitescu, L.3    Beliveau, R.4
  • 48
    • 10144251769 scopus 로고    scopus 로고
    • Syntheses and structure-activity relationships of the second-generation antitumor taxoids: Exceptional activity against drug-resistant cancer cells
    • Ojima, I.; Slater, J. C.; Michaud, E.; Kuduk, S. D.; Bounaud, P. Y.; Vrignaud, P.; Bissery, M. C.; Veith, J. M.; Pera, P.; Bernacki, R. J.Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells. J. Med. Chem., 1996, 39, 3889-3896.
    • (1996) J. Med. Chem , vol.39 , pp. 3889-3896
    • Ojima, I.1    Slater, J.C.2    Michaud, E.3    Kuduk, S.D.4    Bounaud, P.Y.5    Vrignaud, P.6    Bissery, M.C.7    Veith, J.M.8    Pera, P.9    Bernacki, R.J.10
  • 52
    • 1842843197 scopus 로고    scopus 로고
    • Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivativesortataxel (IDN-5109, BAY 59-8862) and tRA96023
    • Minderman, H.; Brooks, T. A.; O'Loughlin, K. L.; Ojima, I.; Bernacki, R. J.; Baer, M. R. Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivativesortataxel (IDN-5109, BAY 59-8862) and tRA96023. CancerChemother. Pharmacol., 2004, 53, 363-369.
    • (2004) CancerChemother. Pharmacol , vol.53 , pp. 363-369
    • Minderman, H.1    Brooks, T.A.2    O'Loughlin, K.L.3    Ojima, I.4    Bernacki, R.J.5    Baer M., R.6
  • 53
    • 0038415813 scopus 로고    scopus 로고
    • Nonlinear Accumulation In Thebrain of the New Taxoid TXD258 Following Saturation of P-glycoprotein At the Blood-brain Barrier In Mice and Rats
    • Cisternino, S.; Bourasset, F.; Archimbaud, Y.; Semiond, D.; Sanderink, G.; Scherrmann, J. M. Nonlinear accumulation in thebrain of the new taxoid TXD258 following saturation of P-glycoprotein at the blood-brain barrier in mice and rats. Br. J.Pharmacol., 2003, 138, 1367-1375.
    • (2003) Br. J.Pharmacol , vol.138 , pp. 1367-1375
    • Cisternino, S.1    Bourasset, F.2    Archimbaud, Y.3    Semiond, D.4    Sanderink, G.5    Scherrmann, J.M.6
  • 55
    • 0035990845 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic studies of thetaxoid derivative RPR 109881A administered as a 1-hour or a 3-hour infusion in patients with advanced solid tumors
    • Sessa, C.; Cuvier, C.; Caldiera, S.; Bauer, J.; Van den Bosch, S.; Monnerat, C.; Semiond, D.; Perard, D.; Lebecq, A.; Besenval, M.; Marty, M. Phase I clinical and pharmacokinetic studies of thetaxoid derivative RPR 109881A administered as a 1-hour or a 3-hour infusion in patients with advanced solid tumors. Ann. Oncol.,2002, 13, 1140-1150.
    • (2002) Ann. Oncol , vol.13 , pp. 1140-1150
    • Sessa, C.1    Cuvier, C.2    Caldiera, S.3    Bauer, J.4    Van den Bosch, S.5    Monnerat, C.6    Semiond, D.7    Perard, D.8    Lebecq, A.9    Besenval, M.10    Marty, M.11
  • 57
    • 13444269007 scopus 로고    scopus 로고
    • Chemical modification of paclitaxel (Taxol) reducesP-glycoprotein interactions and increases permeation across theblood-brain barrier in vitro and in situ
    • Rice, A.; Liu, Y.; Michaelis, M. L.; Himes, R. H.; Georg, G. I.; Audus, K. L. Chemical modification of paclitaxel (Taxol) reducesP-glycoprotein interactions and increases permeation across theblood-brain barrier in vitro and in situ. J. Med. Chem., 2005, 48,832-838.
    • (2005) J. Med. Chem , vol.48 , pp. 832-838
    • Rice, A.1    Liu, Y.2    Michaelis, M.L.3    Himes, R.H.4    Georg, G.I.5    Audus, K.L.6
  • 64
    • 0031027531 scopus 로고    scopus 로고
    • Activities of themicrotubule-stabilizing agents epothilones A and B with purifiedtubulin and in cells resistant to paclitaxel (Taxol(R))
    • Kowalski, R. J.; Giannakakou, P.; Hamel, E. Activities of themicrotubule-stabilizing agents epothilones A and B with purifiedtubulin and in cells resistant to paclitaxel (Taxol(R)). J. Biol.Chem., 1997, 272, 2534-2541.
    • (1997) J. Biol.Chem , vol.272 , pp. 2534-2541
    • Kowalski, R.J.1    Giannakakou, P.2    Hamel, E.3
  • 66
    • 0035523572 scopus 로고    scopus 로고
    • Mutations in beta-tubulin mapto domains involved in regulation of microtubule stability inepothilone-resistant cell lines
    • He, L.; Yang, C. P.; Horwitz, S. B. Mutations in beta-tubulin mapto domains involved in regulation of microtubule stability inepothilone-resistant cell lines. Mol. Cancer Ther., 2001, 1, 3-10.
    • (2001) Mol. Cancer Ther , vol.1 , pp. 3-10
    • He, L.1    Yang, C.P.2    Horwitz, S.B.3
  • 68
    • 0038349992 scopus 로고    scopus 로고
    • Epothilone B and its analogs - a new family ofanticancer agents
    • Altmann, K. H. Epothilone B and its analogs - a new family ofanticancer agents. Mini Rev. Med. Chem., 2003, 3, 149-158.
    • (2003) Mini Rev. Med. Chem , vol.3 , pp. 149-158
    • Altmann, K.H.1
  • 72
    • 0033550167 scopus 로고    scopus 로고
    • Complex target-oriented synthesisin the drug discovery process: A case history in the dEpoB series
    • Harris, C. R.; Danishefsky, S. J. Complex target-oriented synthesisin the drug discovery process: A case history in the dEpoB series.J. Org. Chem., 1999, 64, 8434-8456.
    • (1999) J. Org. Chem , vol.64 , pp. 8434-8456
    • Harris, C.R.1    Danishefsky, S.J.2
  • 74
    • 51849114328 scopus 로고    scopus 로고
    • Pharmacokineticprofile of the microtubule stabilizer patupilone in tumor-bearingrodents and comparison of anti-cancer activity with other MTS invitro and in vivo
    • O'Reilly, T.; Wartmann, M.; Brueggen, J.; Allegrini, P. R.; Floersheimer, A.; Maira, M.; McSheehy, P. M. Pharmacokineticprofile of the microtubule stabilizer patupilone in tumor-bearingrodents and comparison of anti-cancer activity with other MTS invitro and in vivo. Cancer Chemother Pharmacol., 2008, 62, 1045-1054.
    • (2008) Cancer Chemother Pharmacol , vol.62 , pp. 1045-1054
    • O'Reilly, T.1    Wartmann, M.2    Brueggen, J.3    Allegrini, P.R.4    Floersheimer, A.5    Maira, M.6    McSheehy, P.M.7
  • 75
    • 0030627521 scopus 로고    scopus 로고
    • Tubulin synthesis andassembly in differentiating neurons
    • Laferriere, N.; MacRae, T.; Brown, D. Tubulin synthesis andassembly in differentiating neurons. Biochem. Cell Biol., 1997, 75,103-117.
    • (1997) Biochem. Cell Biol , vol.75 , pp. 103-117
    • Laferriere, N.1    Macrae, T.2    Brown, D.3
  • 76
    • 0024593690 scopus 로고
    • Dynamics of alpha-tubulindeacetylation in intact neurons
    • Black, M.; Baas, P.; Humphries, S. Dynamics of alpha-tubulindeacetylation in intact neurons. J. Neurosci., 1989, 9, 358-368.
    • (1989) J. Neurosci , vol.9 , pp. 358-368
    • Black, M.1    Baas, P.2    Humphries, S.3
  • 79
    • 0030761586 scopus 로고    scopus 로고
    • The Microtubule-stabilizing Agentdiscodermolide Competitively Inhibits the Binding of Paclitaxel(Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactionsmore Potently Than Paclitaxel, and Inhibits the Growth of Paclitaxel-resistant Cells
    • Kowalski, R. J.; Giannakakou, P.; Gunasekera, S. P.; Longley, R.E.; Day, B. W.; Hamel, E. The microtubule-stabilizing agentdiscodermolide competitively inhibits the binding of paclitaxel(Taxol) to tubulin polymers, enhances tubulin nucleation reactionsmore potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells. Mol. Pharmacol., 1997, 52, 613-622.
    • (1997) Mol. Pharmacol , vol.52 , pp. 613-622
    • Kowalski, R.J.1    Giannakakou, P.2    Gunasekera, S.P.3    Longley, R.E.4    Day, B.W.5    Hamel, E.6
  • 80
    • 0033609037 scopus 로고    scopus 로고
    • Thecoral-derived natural products eleutherobin and sarcodictyins Aand B: Effects on the assembly of purified tubulin with and withoutmicrotubule-associated proteins and binding at the polymer taxoidsite
    • Hamel, E.; Sackett, D. L.; Vourloumis, D.; Nicolaou, K. C. Thecoral-derived natural products eleutherobin and sarcodictyins Aand B: effects on the assembly of purified tubulin with and withoutmicrotubule-associated proteins and binding at the polymer taxoidsite. Biochemistry, 1999, 38, 5490-5498.
    • (1999) Biochemistry , vol.38 , pp. 5490-5498
    • Hamel, E.1    Sackett, D.L.2    Vourloumis, D.3    Nicolaou, K.C.4
  • 83
    • 3142723291 scopus 로고    scopus 로고
    • Synergistic suppression of microtubuledynamics by discodermolide and paclitaxel in non-small cell lungcarcinoma cells
    • Honore, S.; Kamath, K.; Braguer, D.; Horwitz, S. B.; Wilson, L.; Briand, C.; Jordan, M. A. Synergistic suppression of microtubuledynamics by discodermolide and paclitaxel in non-small cell lungcarcinoma cells. Cancer Res., 2004, 64, 4957-4964.
    • (2004) Cancer Res , vol.64 , pp. 4957-4964
    • Honore, S.1    Kamath, K.2    Braguer, D.3    Horwitz, S.B.4    Wilson, L.5    Briand, C.6    Jordan, M.A.7
  • 87
  • 88
    • 23944524786 scopus 로고    scopus 로고
    • Cyclostreptin (FR182877), an antitumor tubulin-polymerizingagent deficient in enhancing tubulin assembly despite its highaffinity for the taxoid site
    • Edler, M. C.; Buey, R. M.; Gussio, R.; Marcus, A. I.; Vanderwal, C. D.; Sorensen, E. J.; Diaz, J. F.; Giannakakou, P.; Hamel, E.Cyclostreptin (FR182877), an antitumor tubulin-polymerizingagent deficient in enhancing tubulin assembly despite its highaffinity for the taxoid site. Biochemistry, 2005, 44, 11525-11538.
    • (2005) Biochemistry , vol.44 , pp. 11525-11538
    • Edler, M.C.1    Buey, R.M.2    Gussio, R.3    Marcus, A.I.4    Vanderwal, C.D.5    Sorensen, E.J.6    Diaz, J.F.7    Giannakakou, P.8    Hamel, E.9
  • 90
    • 42249096447 scopus 로고    scopus 로고
    • Interaction of acyclostreptin analogue with the microtubule taxoid site: Thecovalent reaction rapidly follows binding
    • Bai, R.; Vanderwal, C. D.; Diaz, J. F.; Hamel, E. Interaction of acyclostreptin analogue with the microtubule taxoid site: thecovalent reaction rapidly follows binding. J. Nat. Prod., 2008, 71,370-374.
    • (2008) J. Nat. Prod , vol.71 , pp. 370-374
    • Bai, R.1    Vanderwal, C.D.2    Diaz, J.F.3    Hamel, E.4
  • 92
    • 59649108112 scopus 로고    scopus 로고
    • Differentialeffects of natural product microtubule stabilizers on microtubuleassembly: Single agent and combination studies with taxol,epothilone B, and discodermolide
    • Gertsch, J.; Meier, S.; Müller, M.; Altmann, K.-H. Differentialeffects of natural product microtubule stabilizers on microtubuleassembly: single agent and combination studies with taxol,epothilone B, and discodermolide. ChemBioChem, 2009, 10, 166-175.
    • (2009) ChemBioChem , vol.10 , pp. 166-175
    • Gertsch, J.1    Meier, S.2    Müller, M.3    Altmann, K.-H.4
  • 93
    • 3442894416 scopus 로고    scopus 로고
    • Peloruside A doesnot bind to the taxoid site on beta-tubulin and retains its activity inmultidrug-resistant cell lines
    • Gaitanos, T. N.; Buey, R. M.; Diaz, J. F.; Northcote, P. T.; Teesdale-Spittle, P.; Andreu, J. M.; Miller, J. H. Peloruside A doesnot bind to the taxoid site on beta-tubulin and retains its activity inmultidrug-resistant cell lines. Cancer Res., 2004, 64, 5063-5067.
    • (2004) Cancer Res , vol.64 , pp. 5063-5067
    • Gaitanos, T.N.1    Buey, R.M.2    Diaz, J.F.3    Northcote, P.T.4    Teesdale-Spittle, P.5    Andreu, J.M.6    Miller, J.H.7
  • 95
    • 0033083045 scopus 로고    scopus 로고
    • Laulimalide and isolaulimalide, new paclitaxel-likemicrotubule-stabilizing agents
    • Mooberry, S. L.; Tien, G.; Hernandez, A. H.; Plubrukarn, A.; Davidson, B. S. Laulimalide and isolaulimalide, new paclitaxel-likemicrotubule-stabilizing agents. Cancer Res., 1999, 59, 653-660.
    • (1999) Cancer Res , vol.59 , pp. 653-660
    • Mooberry, S.L.1    Tien, G.2    Hernandez, A.H.3    Plubrukarn, A.4    Davidson, B.S.5
  • 96
    • 18444400213 scopus 로고    scopus 로고
    • The Microtubulestabilizing Agent Laulimalide Does Not Bind In the Taxoid Site, Killscells Resistant to Paclitaxel and Epothilones, and May Not Require Itsepoxide Moiety For Activity
    • Pryor, D. E.; O'Brate, A.; Bilcer, G.; Diaz, J. F.; Wang, Y.; Kabaki, M.; Jung, M. K.; Andreu, J. M.; Ghosh, A. K. The microtubulestabilizing agent laulimalide does not bind in the taxoid site, killscells resistant to paclitaxel and epothilones, and may not require itsepoxide moiety for activity. Biochemistry, 2002, 41, 9109-9115.
    • (2002) Biochemistry , vol.41 , pp. 9109-9115
    • Pryor, D.E.1    O'Brate, A.2    Bilcer, G.3    Diaz, J.F.4    Wang, Y.5    Kabaki, M.6    Jung, M.K.7    Andreu, J.M.8    Ghosh, A.K.9
  • 97
    • 17144385513 scopus 로고    scopus 로고
    • Ceratamines, structurally simple microtubule-stabilizing antimitoticagents with unusual cellular effects
    • Karjala, G.; Chan, Q.; Manzo, E.; Andersen, R. J.; Roberge, M.Ceratamines, structurally simple microtubule-stabilizing antimitoticagents with unusual cellular effects. Cancer Res., 2005, 65, 3040-3043.
    • (2005) Cancer Res , vol.65 , pp. 3040-3043
    • Karjala, G.1    Chan, Q.2    Manzo, E.3    Andersen, R.J.4    Roberge, M.5
  • 100
    • 28844499921 scopus 로고    scopus 로고
    • Microtubule interactions with chemically diverse stabilizing agents:Thermodynamics of binding to the paclitaxel site predictscytotoxicity
    • Buey, R. M.; Barasoain, I.; Jackson, E.; Meyer, A.; Giannakakou, P.; Paterson, I.; Mooberry, S.; Andreu, J. M.; DÌaz, J. F.Microtubule interactions with chemically diverse stabilizing agents:thermodynamics of binding to the paclitaxel site predictscytotoxicity. Chem. Biol., 2005, 12, 1269-1279.
    • (2005) Chem. Biol , vol.12 , pp. 1269-1279
    • Buey, R.M.1    Barasoain, I.2    Jackson, E.3    Meyer, A.4    Giannakakou, P.5    Paterson, I.6    Mooberry, S.7    Andreu, J.M.8    Dìaz, J.F.9
  • 101
    • 3142582005 scopus 로고    scopus 로고
    • A femtomolar actingoctapeptide interacts with tubulin and protects astrocytes againstzinc intoxication
    • Divinski, I.; Mittelman, L.; Gozes, I. A femtomolar actingoctapeptide interacts with tubulin and protects astrocytes againstzinc intoxication. J. Biol. Chem., 2004, 279, 28531-28538.
    • (2004) J. Biol. Chem , vol.279 , pp. 28531-28538
    • Divinski, I.1    Mittelman, L.2    Gozes, I.3
  • 103
    • 35548974346 scopus 로고    scopus 로고
    • Activity-dependentneuroprotective protein snippet NAP reduces tau hyperphos-phorylation and enhances learning in a novel transgenic mousemodel
    • Vulih-Shultzman, I.; Pinhasov, A.; Mandel, S.; Grigoriadis, N.; Touloumi, O.; Pittel, Z.; Gozes, I. Activity-dependentneuroprotective protein snippet NAP reduces tau hyperphos-phorylation and enhances learning in a novel transgenic mousemodel. J. Pharmacol. Exp. Ther., 2007, 323, 438-449.
    • (2007) J. Pharmacol. Exp. Ther , vol.323 , pp. 438-449
    • Vulih-Shultzman, I.1    Pinhasov, A.2    Mandel, S.3    Grigoriadis, N.4    Touloumi, O.5    Pittel, Z.6    Gozes, I.7
  • 104
    • 70350338273 scopus 로고    scopus 로고
    • Pharmacokinetics and distribution to brain after intravenous orintranasal administration to rat
    • Morimoto, B. H.; LannOy, I.; Fox, A. W.; Gozes, I.; Stewart, A.pharmacokinetics and distribution to brain after intravenous orintranasal administration to rat. Chim. Oggi., 2009, 27, 16-20.
    • (2009) Chim. Oggi , vol.27 , pp. 16-20
    • Morimoto, B.H.1    Lannoy, I.2    Fox, A.W.3    Gozes, I.4    Stewart, A.5
  • 106
    • 0029907548 scopus 로고    scopus 로고
    • Assembly of Microtubule-associated Proteintau Into Alzheimer-like Filaments Induced By Sulphatedglycosaminoglycans
    • Goedert, M.; Jakes, R.; Spillantini, M. G.; Hasegawa, M.; Smith, M. J.; Crowther, R. A. Assembly of microtubule-associated proteintau into Alzheimer-like filaments induced by sulphatedglycosaminoglycans. Nature, 1996, 383, 550-553.
    • (1996) Nature , vol.383 , pp. 550-553
    • Goedert, M.1    Jakes, R.2    Spillantini, M.G.3    Hasegawa, M.4    Smith, M.J.5    Crowther, R.A.6
  • 107
    • 0038152836 scopus 로고    scopus 로고
    • Anionic micelles and vesiclesinduce tau fibrillization in vitro
    • Chirita, C. N.; Necula, M.; Kuret, J. Anionic micelles and vesiclesinduce tau fibrillization in vitro. J. Biol. Chem., 2003, 278, 25644-25650.
    • (2003) J. Biol. Chem , vol.278 , pp. 25644-25650
    • Chirita, C.N.1    Necula, M.2    Kuret, J.3
  • 108
    • 34248142548 scopus 로고    scopus 로고
    • High throughput screening for small molecule inhibitors ofheparin-induced tau fibril formation
    • Crowe, A.; Ballatore, C.; Hyde, E.; Trojanowski, J. Q.; Lee, V. M.-Y. High throughput screening for small molecule inhibitors ofheparin-induced tau fibril formation. Biochem. Biophy. Res.Commun., 2007, 358, 1-6.
    • (2007) Biochem. Biophy. Res.Commun , vol.358 , pp. 1-6
    • Crowe, A.1    Ballatore, C.2    Hyde, E.3    Trojanowski, J.Q.4    Lee V., M.-Y.5
  • 111
    • 76649098825 scopus 로고    scopus 로고
    • Binding mode of Thioflavin T and other molecularprobes in the context of amyloid fibrils-current status
    • Groenning, M. Binding mode of Thioflavin T and other molecularprobes in the context of amyloid fibrils-current status. J. Chem.Biol. 2009.
    • (2009) J. Chem.Biol
    • Groenning, M.1
  • 113
    • 77952548786 scopus 로고    scopus 로고
    • Tau-directed drug discovery forAlzheimer's disease and related tauopathies: A focus on tauassembly inhibitors
    • Brunden, K. R.; Ballatore, C.; Crowe, A.; Smith, A. B., III; Lee, V.M.-Y.; Trojanowski, J. Q. Tau-directed drug discovery forAlzheimer's disease and related tauopathies: A focus on tauassembly inhibitors. Exp. Neurol., 2009, 223, 304-310.
    • (2009) Exp. Neurol , vol.223 , pp. 304-310
    • Brunden, K.R.1    Ballatore, C.2    Crowe, A.3    Smith III, A.B.4    Lee, V.M.-Y.5    Trojanowski, J.Q.6
  • 114
    • 14844303721 scopus 로고    scopus 로고
    • Inhibition of heparin-induced taufilament formation by phenothiazines, polyphenols, andporphyrins
    • Taniguchi, S.; Suzuki, N.; Masuda, M.; Hisanaga, S.; Iwatsubo, T.; Goedert, M.; Hasegawa, M. Inhibition of heparin-induced taufilament formation by phenothiazines, polyphenols, andporphyrins. J. Biol. Chem., 2005, 280, 7614-7623.
    • (2005) J. Biol. Chem , vol.280 , pp. 7614-7623
    • Taniguchi, S.1    Suzuki, N.2    Masuda, M.3    Hisanaga, S.4    Iwatsubo, T.5    Goedert, M.6    Hasegawa, M.7
  • 115
    • 1542327644 scopus 로고    scopus 로고
    • Ligand-dependent inhibition andreversal of tau filament formation
    • Chirita, C.; Necula, M.; Kuret, J. Ligand-dependent inhibition andreversal of tau filament formation. Biochemistry, 2004, 43, 2879-2887.
    • (2004) Biochemistry , vol.43 , pp. 2879-2887
    • Chirita, C.1    Necula, M.2    Kuret, J.3
  • 116
    • 33644851265 scopus 로고    scopus 로고
    • InducibleExpression of Tau Repeat Domain in Cell Models of Tauopathy:Aggregation is toxic to cells but can be reversed by inhibitor drugs
    • Khlistunova, I.; Biernat, J.; Wang, Y.; Pickhardt, M.; von Bergen, M.; Gazova, Z.; Mandelkow, E.; Mandelkow, E.-M. InducibleExpression of Tau Repeat Domain in Cell Models of Tauopathy:Aggregation is toxic to cells but can be reversed by inhibitor drugs.J. Biol. Chem., 2006, 281, 1205-1214.
    • (2006) J. Biol. Chem , vol.281 , pp. 1205-1214
    • Khlistunova, I.1    Biernat, J.2    Wang, Y.3    Pickhardt, M.4    von Bergen, M.5    Gazova, Z.6    Mandelkow, E.7    Mandelkow, E.-M.8
  • 117
    • 34548502687 scopus 로고    scopus 로고
    • Phenylthiazolyl-hydrazide and its derivatives are potent inhibitorsof tau aggregation and toxicity in vitro and in cells
    • Pickhardt, M.; Larbig, G.; Khlistunova, I.; Coksezen, A.; Meyer, B.; Mandelkow, E. M.; Schmidt, B.; Mandelkow, E.Phenylthiazolyl-hydrazide and its derivatives are potent inhibitorsof tau aggregation and toxicity in vitro and in cells. Biochemistry,2007, 46, 10016-10023.
    • (2007) Biochemistry , vol.46 , pp. 10016-10023
    • Pickhardt, M.1    Larbig, G.2    Khlistunova, I.3    Coksezen, A.4    Meyer, B.5    Mandelkow, E.M.6    Schmidt, B.7    Mandelkow, E.8
  • 119
    • 34548763018 scopus 로고    scopus 로고
    • Syntheses of (-)-oleocanthal, a natural NSAID found in extra virgin olive oil, the(-)-deacetoxy-oleuropein aglycone, and related analogues
    • Smith, A. B., III; Sperry, J. B.; Han, Q. Syntheses of (-)-oleocanthal, a natural NSAID found in extra virgin olive oil, the(-)-deacetoxy-oleuropein aglycone, and related analogues. J. Org.Chem., 2007, 72, 6891-6900.
    • (2007) J. Org.Chem , vol.72 , pp. 6891-6900
    • Smith III, A.B.1    Sperry, J.B.2    Han, Q.3
  • 120
    • 27644570282 scopus 로고    scopus 로고
    • Synthesis and Assignment of Absolute Configuration of (-)-oleocanthal: A Potent, Naturally Occurring Non-steroidal Anti-inflammatory and Anti-oxidant Agent Derived From Extra Virginolive Oils
    • Smith III, A. B.; Han, Q.; Breslin, P. A. S.; Beauchamp, G. K.Synthesis and assignment of absolute configuration of (-)-oleocanthal: a potent, naturally occurring non-steroidal anti-inflammatory and anti-oxidant agent derived from extra virginolive oils. Org. Lett., 2005, 7, 5075-5078.
    • (2005) Org. Lett , vol.7 , pp. 5075-5078
    • Smith III, A.B.1    Han, Q.2    Breslin, P.A.S.3    Beauchamp, G.K.4
  • 121
    • 67651160771 scopus 로고    scopus 로고
    • Inhibition of tau fibrillization by oleocanthal viareaction with the amino groups of tau
    • Li, W.; Sperry, J. B.; Crowe, A.; Trojanowski, J. Q.; Smith, A. B. III; Lee, V. M. Y. Inhibition of tau fibrillization by oleocanthal viareaction with the amino groups of tau. J. Neurochem., 2009, 110,1339-1351.
    • (2009) J. Neurochem , vol.110 , pp. 1339-1351
    • Li, W.1    Sperry, J.B.2    Crowe, A.3    Trojanowski, J.Q.4    Smith III, A.B.5    Lee, V.M.Y.6
  • 123
    • 23044439880 scopus 로고    scopus 로고
    • Cyanine dye N744 inhibits taufibrillization by blocking filament extension: Implications for thetreatment of tauopathic neurodegenerative diseases
    • Necula, M.; Chirita, C. N.; Kuret, J. Cyanine dye N744 inhibits taufibrillization by blocking filament extension: implications for thetreatment of tauopathic neurodegenerative diseases. Biochemistry,2005, 44, 10227-10237.
    • (2005) Biochemistry , vol.44 , pp. 10227-10237
    • Necula, M.1    Chirita, C.N.2    Kuret, J.3
  • 124
    • 34548023741 scopus 로고    scopus 로고
    • Potencyof a tau fibrillization inhibitor is influenced by its aggregation state
    • Congdon, E. E.; Necula, M.; Blackstone, R. D.; Kuret, J. Potencyof a tau fibrillization inhibitor is influenced by its aggregation state.Arch. Bichem. Biophys., 2007, 465, 127-135.
    • (2007) Arch. Bichem. Biophys , vol.465 , pp. 127-135
    • Congdon, E.E.1    Necula, M.2    Blackstone, R.D.3    Kuret, J.4
  • 125
    • 66749176089 scopus 로고    scopus 로고
    • Structure-activity relationship of cyanine tau aggregationinhibitors
    • Chang, E.; Congdon, E. E.; Honson, N. S.; Duff, K. E.; Kuret, J.Structure-activity relationship of cyanine tau aggregationinhibitors. J. Med. Chem., 2009, 52, 3539-3547.
    • (2009) J. Med. Chem , vol.52 , pp. 3539-3547
    • Chang, E.1    Congdon, E.E.2    Honson, N.S.3    Duff, K.E.4    Kuret, J.5
  • 127
    • 0036810375 scopus 로고    scopus 로고
    • Methylene Blue - a therapeuticdye for all seasons?
    • Wainwright, M.; Crossley, K. B. Methylene Blue - a therapeuticdye for all seasons? J. Chemother., 2002, 14, 431-443.
    • (2002) J. Chemother , vol.14 , pp. 431-443
    • Wainwright, M.1    Crossley, K.B.2
  • 128
    • 0033948654 scopus 로고    scopus 로고
    • Pharmacokinetics and organ distribution of intravenous and oralmethylene blue
    • Peter, C.; Hongwan, D.; Küpfer, A.; Lauterburg, B. H.Pharmacokinetics and organ distribution of intravenous and oralmethylene blue. Eur. J. Clin. Pharmacol., 2000, 56, 247-250.
    • (2000) Eur. J. Clin. Pharmacol , vol.56 , pp. 247-250
    • Peter, C.1    Hongwan, D.2    Küpfer, A.3    Lauterburg, B.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.