Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol®)

Journal of Biological Chemistry

Volumn 272, Issue 4, 1997, Pages 2534-2541

  Kowalski, Richard J ^a   Giannakakou, Paraskevi ^b   Hamel, Ernest ^a,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; EPOTHILONE A; EPOTHILONE B; MACROLIDE; MICROTUBULE PROTEIN; PACLITAXEL; TUBULIN;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; KIDNEY EPITHELIUM; MICROTUBULE ASSEMBLY; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PURIFICATION; STRUCTURE ACTIVITY RELATION;

DRUG RESISTANCE, MULTIPLE; EPOTHILONES; EPOXY COMPOUNDS; GUANOSINE TRIPHOSPHATE; HUMANS; KIDNEY; KINETICS; MICROTUBULE-ASSOCIATED PROTEINS; MITOTIC INDEX; PACLITAXEL; POLYMERS; THIAZOLES; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0031027531     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.4.2534     Document Type: Article

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