RAD51C: A novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer

Carcinogenesis

Volumn 31, Issue 12, 2010, Pages 2031-2038

  Somyajit, Kumar ^a   Subramanya, Shreelakshmi ^a   Nagaraju, Ganesh ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; CHECKPOINT KINASE 2; RAD51 PROTEIN; RAD51C PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FANCONI ANEMIA; GENE MUTATION; GENOMIC INSTABILITY; HOMOLOGOUS RECOMBINATION; HUMAN; MOLECULAR MECHANICS; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; SINGLE STRANDED DNA BREAK; TUMOR SUPPRESSOR GENE;

BREAST NEOPLASMS; DNA DAMAGE; DNA-BINDING PROTEINS; FANCONI ANEMIA; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MUTATION; RECOMBINATION, GENETIC;

EID: 78649778694     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq210     Document Type: Article

References (168)

1. Takata,M. et al. (1998) Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J., 17, 5497-5508.
2. Johnson,R.D. et al. (2000) Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells. EMBO J., 19, 3398-3407.
3. Branzei,D. et al. (2008) Regulation of DNA repair throughout the cell cycle. Nat. Rev. Mol. Cell Biol., 9, 297-308.
4. Thompson,L.H. et al. (2002) Recombinational DNA repair and human disease. Mutat. Res., 509, 49-78.
5. Sung,P. et al. (2006) Mechanism of homologous recombination: mediators and helicases take on regulatory functions. Nat. Rev. Mol. Cell Biol., 7, 739-750.
6. Nagaraju,G. et al. (2007) Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks. DNA Repair (Amst.), 6, 1018-1031.
7. McKinnon,P.J. et al. (2007) DNA strand break repair and human genetic disease. Annu. Rev. Genomics Hum. Genet., 8, 37-55.
8. O'Driscoll,M. et al. (2006) The role of double-strand break repair-insights from human genetics. Nat. Rev. Genet., 7, 45-54.
9. Moynahan,M.E. et al. (2010) Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat. Rev. Mol. Cell Biol., 11, 196-207.
10. van Gent,D.C. et al. (2001) Chromosomal stability and the DNA doublestranded break connection. Nat. Rev. Genet., 2, 196-206.
11. Scully,R. et al. (2000) In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature, 408, 429-432.
12. Venkitaraman,A.R. (2002) Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell, 108, 171-182.
13. Khanna,K.K. et al. (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet., 27, 247-254.
14. Eppink,B. et al. (2006) Multiple interlinked mechanisms to circumvent DNA replication roadblocks. Exp. Cell Res., 312, 2660-2665.
15. Branzei,D. et al. (2010) Maintaining genome stability at the replication fork. Nat. Rev. Mol. Cell Biol., 11, 208-219.
16. Aguilera,A. et al. (2008) Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet., 9, 204-217.
17. Chen,C. et al. (1999) Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants. Nat. Genet., 23, 81-85.
18. Lambert,S. et al. (2007) Arrested replication fork processing: interplay between checkpoints and recombination. DNA Repair (Amst.), 6, 1042-1061.
19. Budzowska,M. et al. (2009) Mechanisms of dealing with DNA damageinduced replication problems. Cell Biochem. Biophys., 53, 17-31.
20. Raschle,M. et al. (2008) Mechanism of replication-coupled DNA interstrand crosslink repair. Cell, 134, 969-980.
21. Muniandy,P.A. et al. (2010) DNA interstrand crosslink repair in mammalian cells: step by step. Crit. Rev. Biochem. Mol. Biol., 45, 23-49.
22. Dronkert,M.L. et al. (2001) Repair of DNA interstrand cross-links. Mutat. Res., 486, 217-247.
23. Mimitou,E.P. et al. (2009) Nucleases and helicases take center stage in homologous recombination. Trends Biochem. Sci., 34, 264-272.
24. San Filippo,J. et al. (2008) Mechanism of eukaryotic homologous recombination. Annu. Rev. Biochem., 77, 229-257.
25. Li,X. et al. (2008) Homologous recombination in DNA repair and DNA damage tolerance. Cell Res., 18, 99-113.
26. Ferguson,D.O. et al. (1996) Recombinational repair of gaps in DNA is asymmetric in Ustilago maydis and can be explained by a migrating D-loop model. Proc. Natl Acad. Sci. USA, 93, 5419-5424.
27. Paques,F. et al. (1999) Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev, 63, 349-404.
28. Wyman,C. et al. (2006) DNA double-strand break repair: all's well that ends well. Annu. Rev. Genet., 40, 363-383.
29. Wu,L. et al. (2003) The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature, 426, 870-874.
30. Plank,J.L. et al. (2006) Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration. Proc. Natl Acad. Sci. USA, 103, 11118-11123.
31. Wu,L. et al. (2006) BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. Proc. Natl Acad. Sci. USA, 103, 4068-4073.
32. Krogh,B.O. et al. (2004) Recombination proteins in yeast. Annu. Rev. Genet., 38, 233-271.
33. Symington,L.S. (2002) Role. of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol. Mol. Biol. Rev., 66, 630-670.
34. Nagaraju,G. et al. (2006) Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Mol. Cell Biol., 26, 8075-8086.
35. Nassif,N. et al. (1994) Efficient copying of nonhomologous sequences from ectopic sites via P-element-induced gap repair. Mol. Cell. Biol., 14, 1613-1625.
36. Strathern,J.N. et al. (1982) Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locus. Cell, 31, 183-192.
37. New,J.H. et al. (1998) Rad52. protein stimulates DNA strand exchange by Rad51 and replication protein A. Nature, 391, 407-410.
38. Shinohara,A. et al. (1998) Stimulation by Rad52 of yeast Rad51-mediated recombination. Nature, 391, 404-407.
39. San Filippo,J. et al. (2008) Mechanism. of eukaryotic homologous recombination. Annu. Rev. Biochem, 77, 229-257.
40. Sung,P. (1997) Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase. Genes Dev., 11, 1111-1121.
41. Hays,S.L. et al. (1995) Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins. Proc. Natl Acad. Sci. USA, 92, 6925-6929.
42. Johnson,R.D. et al. (1995) Functional differences and interactions among the putative RecA homologs Rad51, Rad55, and Rad57. Mol. Cell. Biol., 15, 4843-4850.
43. Golub,E.I. et al. (1997) Interaction of human recombination proteins Rad51 and Rad54. Nucleic Acids Res., 25, 4106-4110.
44. Mazina,O.M. et al. (2004) Human Rad54 protein stimulates DNA strand exchange activity of hRad51 protein in the presence of Ca2+. J. Biol. Chem., 279, 52042-52051.
45. Mazin,A.V. et al. (2010) Rad54, the motor of homologous recombination. DNA Repair (Amst.), 9, 286-302.
46. Heyer,W.D. et al. (2006) Rad54: the Swiss Army knife of homologous recombination? Nucleic Acids Res., 34, 4115-4125.
47. Tan,T.L. et al. (2003) Rad54, a Jack of all trades in homologous recombination. DNA Repair (Amst.), 2, 787-794.
48. Liu,N. et al. (1998) XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Mol. Cell, 1, 783-793.
49. Cartwright,R. et al. (1998) The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family. Nucleic Acids Res., 26, 3084-3089.
50. Pittman,D.L. et al. (1998) Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene. Genomics, 49, 103-111.
51. Dosanjh,M.K. et al. (1998) Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes. Nucleic Acids Res., 26, 1179-1184.
52. Albala,J.S. et al. (1997) Identification of a novel human RAD51 homolog, RAD51B. Genomics, 46, 476-479.
53. Thompson,L.H. et al. (1999) The contribution of homologous recombination in preserving genome integrity in mammalian cells. Biochimie, 81, 87-105.
54. Thacker,J. et al. (1990) DNA-break repair, radioresistance of DNA synthesis, and camptothecin sensitivity in the radiation-sensitive irs mutants: comparisons to ataxia-telangiectasia cells. Mutat. Res., 235, 49-58.
55. Caldecott,K. et al. (1991) Cross-sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents. Mutat. Res., 255, 111-121.
56. Thacker,J. (2005) The RAD51 gene family, genetic instability and cancer. Cancer Lett., 219, 125-135.
57. Griffin,C.S. et al. (2000) Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation. Nat. Cell Biol., 2, 757-761.
58. Bishop,D.K. et al. (1998) Xrcc3 is required for assembly of Rad51 complexes in vivo. J. Biol. Chem., 273, 21482-21488.
59. O'Regan,P. et al. (2001) XRCC2 is a nuclear RAD51-like protein required for damage-dependent RAD51 focus formation without the need for ATP binding. J. Biol. Chem., 276, 22148-22153.
60. Pierce,A.J. et al. (1999) XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev., 13, 2633-2638.
61. Johnson,R.D. et al. (1999) Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature, 401, 397-399.
62. Takata,M. et al. (2000) The Rad51 paralog Rad51B promotes homologous recombinational repair. Mol. Cell. Biol., 20, 6476-6482.
63. Takata,M. et al. (2001) Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs. Mol. Cell. Biol., 21, 2858-2866.
64. Godthelp,B.C. et al. (2002) Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Nucleic Acids Res., 30, 2172-2182.
65. French,C.A. et al. (2002) Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J. Biol. Chem., 277, 19322-19330.
66. Hinz,J.M. et al. (2006) Repression of mutagenesis by Rad51D-mediated homologous recombination. Nucleic Acids Res., 34, 1358-1368.
67. Shu,Z. et al. (1999) Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can be partially rescued in a p53(-/-) background. Mol. Cell. Biol., 19, 8686-8693.
68. Pittman,D.L. et al. (2000) Midgestation lethality in mice deficient for the RecA-related gene, Rad51d/Rad51l3. Genesis, 26, 167-173.
69. Deans,B. et al. (2000) Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice. EMBO J., 19, 6675-6685.
70. Kuznetsov,S. et al. (2007) RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J. Cell Biol., 176, 581-592.
71. Yonetani,Y. et al. (2005) Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage. Nucleic Acids Res., 33, 4544-4552.
72. Masson,J.Y. et al. (2001) Identification and purification of two distinct complexes containing the five RAD51 paralogs. Genes Dev., 15, 3296-3307.
73. Sigurdsson,S. et al. (2001) Mediator function of the human Rad51BRad51C complex in Rad51/RPA-catalyzed DNA strand exchange. Genes Dev., 15, 3308-3318.
74. Kurumizaka,H. et al. (2002) Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex. J. Biol. Chem., 277, 14315-14320.
75. Lio,Y.C. et al. (2003) Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro. J. Biol. Chem., 278, 2469-2478.
76. Braybrooke,J.P. et al. (2000) The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2. J. Biol. Chem., 275, 29100-29106.
77. Kurumizaka,H. et al. (2001) Homologous-pairing activity of the human DNA-repair proteins Xrcc3.Rad51C. Proc. Natl Acad. Sci. USA, 98, 5538-5543.
78. Yokoyama,H. et al. (2003) Holliday junction binding activity of the human Rad51B protein. J. Biol. Chem., 278, 2767-2772.
79. Yokoyama,H. et al. (2004) Preferential binding to branched DNA strands and strand-annealing activity of the human Rad51B, Rad51C, Rad51D and Xrcc2 protein complex. Nucleic Acids Res., 32, 2556-2565.
80. Liu,Y. et al. (2004) RAD51C is required for Holliday junction processing in mammalian cells. Science, 303, 243-246.
81. Ip,S.C. et al. (2008) Identification of Holliday junction resolvases from humans and yeast. Nature, 456, 357-361.
82. Brenneman,M.A. et al. (2002) XRCC3 controls the fidelity of homologous recombination: roles for XRCC3 in late stages of recombination. Mol. Cell, 10, 387-395.
83. Nagaraju,G. et al. (2009) XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids. Mol. Cell. Biol., 29, 4283-4294.
84. Hartlerode,A.J. et al. (2009) Mechanisms of double-strand break repair in somatic mammalian cells. Biochem. J., 423, 157-168.
85. Ira,G. et al. (2003) Srs2 and Sgs1-Top3 suppress crossovers during doublestrand break repair in yeast. Cell, 115, 401-411.
86. Adams,M.D. et al. (2003) Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing. Science, 299, 265-267.
87. Braybrooke,J.P. et al. (2003) Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D). J. Biol. Chem., 278, 48357-48366.
88. Badie,S. et al. (2009) RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation. J. Cell Biol., 185, 587-600.
89. Renglin Lindh,A. et al. (2007) RAD51C (RAD51L2) is involved in maintaining centrosome number in mitosis. Cytogenet. Genome Res., 116, 38-45.
90. Tarsounas,M. et al. (2004) Telomere maintenance requires the RAD51D recombination/repair protein. Cell, 117, 337-347.
91. Petermann,E. et al. (2010) Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol. Cell, 37, 492-502.
92. Henry-Mowatt,J. et al. (2003) XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Mol. Cell, 11, 1109-1117.
93. Wang,R.C. et al. (2004) Homologous recombination generates T-loop-sized deletions at human telomeres. Cell, 119, 355-368.
94. Jackson,S.P. (2002) Sensing and repairing DNA double-strand breaks. Carcinogenesis, 23, 687-696.
95. Bartek,J. et al. (2003) Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell, 3, 421-429.
96. Warmerdam,D.O. et al. (2010) Dealing with DNA damage: relationships between checkpoint and repair pathways. Mutat. Res., 704, 2-11.
97. Antoni,L. et al. (2007) CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin? Nat. Rev. Cancer, 7, 925-936.
98. Lee,J.S. et al. (2000) hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature, 404, 201-204.
99. Zhang,J. et al. (2004) Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol. Cell. Biol., 24, 708-718.
100. Tan,Y. et al. (2007) Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol. Cell. Biol., 27, 1007-1016.
101. Kastan,M.B. et al. (2004) Cell-cycle checkpoints and cancer. Nature, 432, 316-323.
102. Nevanlinna,H. et al. (2006) The CHEK2 gene and inherited breast cancer susceptibility. Oncogene, 25, 5912-5919.
103. Vaz,F. et al. (2010) Mutation of the RAD51C gene in a Fanconi anemialike disorder. Nat. Genet., 42, 406-409.
104. Meindl,A. et al. (2010) Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat. Genet., 42, 410-414.
105. Alter,B.P. (2003) Cancer in Fanconi anemia, 1927-2001. Cancer, 97, 425-440.
106. Kennedy,R.D. et al. (2005) The Fanconi anemia/BRCA pathway: new faces in the crowd. Genes Dev., 19, 2925-2940.
107. Joenje,H. et al. (2001) The emerging genetic and molecular basis of Fanconi anaemia. Nat. Rev. Genet., 2, 446-457.
108. Wang,W. (2007) Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nat. Rev. Genet., 8, 735-748.
109. D'Andrea,A.D. (2003) The Fanconi road to cancer. Genes Dev., 17, 1933-1936.
110. Smogorzewska,A. et al. (2007) Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell, 129, 289-301.
111. Garcia-Higuera,I. et al. (2001) Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol. Cell, 7, 249-262.
112. Ali,A.M. et al. (2009) FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA. Mutat. Res., 668, 20-26.
113. Meetei,A.R. et al. (2003) A novel ubiquitin ligase is deficient in Fanconi anemia. Nat. Genet., 35, 165-170.
114. Cantor,S. et al. (2004) The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations. Proc. Natl Acad. Sci. USA, 101, 2357-2362.
115. Levitus,M. et al. (2005) The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J. Nat. Genet., 37, 934-935.
116. Xia,B. et al. (2006) Fanconi. anemia is associated with a defect in the BRCA2 partner PALB2. Nat. Genet, 39, 159-161.
117. Patel,K.J. (2007) Fanconi anemia and breast cancer susceptibility. Nat. Genet., 39, 142-143.
118. Howlett,N.G. et al. (2002) Biallelic inactivation of BRCA2 in Fanconi anemia. Science, 297, 606-609.
119. Cantor,S.B. et al. (2001) BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell, 105, 149-160.
120. Taniguchi,T. et al. (2002) S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood, 100, 2414-2420.
121. Wang,X. et al. (2004) Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol. Cell. Biol., 24, 5850-5862.
122. Niedernhofer,L.J. et al. (2005) Fanconi anemia (cross)linked to DNA repair. Cell, 123, 1191-1198.
123. Wang,L.C. et al. (2008) Fanconi anemia proteins stabilize replication forks. DNA Repair (Amst.), 7, 1973-1981.
124. Thompson,L.H. et al. (2009) Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights. Mutat. Res., 668, 54-72.
125. Andreassen,P.R. et al. (2004) ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev., 18, 1958-1963.
126. Wang,W. (2008) A major switch for the Fanconi anemia DNA damageresponse pathway. Nat. Struct. Mol. Biol., 15, 1128-1130.
127. D'Andrea,A.D. (2010) Susceptibility pathways in Fanconi's anemia and breast cancer. N. Engl. J. Med., 362, 1909-1919.
128. Ishiai,M. et al. (2008) FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat. Struct. Mol. Biol., 15, 1138-1146.
129. Moldovan,G.L. et al. (2009) How the fanconi anemia pathway guards the genome. Annu. Rev. Genet., 43, 223-249.
130. Kee,Y. et al. (2010) Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev., 24, 1680-1694.
131. Wilson,J.B. et al. (2008) FANCG. promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Oncogene, 27, 3641-3652.
132. Niedzwiedz,W. et al. (2004) The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Mol. Cell, 15, 607-620.
133. Scully,R. et al. (2002) BRCA1 and BRCA2 in hereditary breast cancer. Biochimie, 84, 95-102.
134. Scully,R. et al. (1997) Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell, 88, 265-275.
135. Mizuta,R. et al. (1997) RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proc. Natl Acad. Sci. USA, 94, 6927-6932.
136. Chen,J. et al. (1998) Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell, 2, 317-328.
137. Patel,K.J. et al. (1998) Involvement of Brca2 in DNA repair. Mol. Cell, 1, 347-357.
138. Shen,S.X. et al. (1998) A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene, 17, 3115-3124.
139. Venkitaraman,A.R. (2009) Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment. Annu. Rev. Pathol., 4, 461-487.
140. Baer,R. et al. (1998) Functional domains of the BRCA1 and BRCA2 proteins. J. Mammary Gland Biol. Neoplasia, 3, 403-412.
141. Moynahan,M.E. et al. (2001) BRCA2 is required for homology-directed repair of chromosomal breaks.[comment]. Mol. Cell, 7, 263-272.
142. Moynahan,M.E. et al. (1999) Brca1 controls homology-directed DNA repair. Mol. Cell, 4, 511-518.
143. Cortez,D. et al. (1999) Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science, 286, 1162-1166.
144. Tibbetts,R.S. et al. (2000) Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev., 14, 2989-3002.
145. Xu,B. et al. (2002) Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. Cancer Res., 62, 4588-4591.
146. Gudmundsdottir,K. et al. (2006) The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability. Oncogene, 25, 5864-5874.
147. O'Donovan,P.J. et al. (2010) BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis, 31, 961-967.
148. Wang,H.C. et al. (2006) Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer Res., 66, 1391-1400.
149. Zhuang,J. et al. (2006) Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining. Cancer Res., 66, 1401-1408.
150. Sharan,S.K. et al. (1997) Embryonic. lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature, 386, 804-810.
151. Bignell,G. et al. (1997) The BRC repeats are conserved in mammalian BRCA2 proteins. Hum. Mol. Genet., 6, 53-58.
152. Yuan,S.S. et al. (1999) BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo. Cancer Res., 59, 3547-3551.
153. Marston,N.J. et al. (1999) Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals. Mol. Cell. Biol., 19, 4633-4642.
154. Gudmundsdottir,K. et al. (2004) DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells. EMBO Rep., 5, 989-993.
155. Kojic,M. et al. (2003) The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis. Mol. Cell, 12, 1043-1049.
156. Yang,H. et al. (2005) The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction. Nature, 433, 653-657.
157. San Filippo,J. et al. (2006) Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide. J. Biol. Chem., 281, 11649-11657.
158. Jensen,R.B. et al. (2010) Purified. human BRCA2 stimulates RAD51-mediated recombination. Nature, 467, 678-683.
159. Thorslund,T. et al. (2010) The. breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Nat. Struct. Mol. Biol, 17, 1263-1265.
160. Liu,J. et al. (2010) Human. BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Nat. Struct. Mol. Biol, 17, 1260-1262.
161. Turnbull,C. et al. (2008) Genetic predisposition to breast cancer: past, present, and future. Annu. Rev. Genomics Hum. Genet., 9, 321-345.
162. Levy-Lahad,E. (2010) Fanconi anemia and breast cancer susceptibility meet again. Nat. Genet., 42, 368-369.
163. Xu,X. et al. (1999) Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoformdeficient cells. Mol. Cell, 3, 389-395.
164. Yu,V.P. et al. (2000) Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation. Genes Dev., 14, 1400-1406.
165. French,C.A. et al. (2003) Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion. J. Biol. Chem., 278, 45445-45450.
166. Rodrigue,A. et al. (2006) Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J., 25, 222-231.
167. Kuznetsov,S.G. et al. (2009) Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice. Cancer Res., 69, 863-872.
168. Thomas,G. et al. (2009) A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat. Genet., 41, 579-584.