BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo

Cancer Research

Volumn 59, Issue 15, 1999, Pages 3547-3551

  Yuan, Shyng Shiou F ^a   Lee, Sou Ying ^a   Chen, Gang ^a   Song, Meihua ^a   Tomlinson, Gail E ^b   Lee, Eva Y H P ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN;

ANIMAL CELL; ARTICLE; BREAST CANCER; COMPLEX FORMATION; DNA REPAIR; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY;

ANIMALS; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CISPLATIN; COS CELLS; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; GENES, BRCA1; HUMANS; MACROMOLECULAR SUBSTANCES; NEOPLASM PROTEINS; RAD51 RECOMBINASE; RECOMBINANT FUSION PROTEINS; RECOMBINATION, GENETIC; TRANSCRIPTION FACTORS;

EID: 0033179235     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Zhang, H., Tombline, G., and Weber, B. L. BRCA1, BRCA2, and DNA damage response: collision or collusion? Cell, 92: 433-436, 1998.
2. Knudson, A. G., Jr., Hethcote, H. W., and Brown, B. W. Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma. Proc. Natl. Acad. Sci. USA, 72; 5116-5120, 1975.
3. Shen, S. X., Weaver, Z., Xu, X., Li, C., Weinstein, M., Chen, L., Guan, X. Y., Ried, T., and Deng, C. X. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene, 17: 3115-3124, 1998.
4. Gowen, L. C., Avrutskaya, A. V., Latour, A. M., Koller, B. H., and Leadon, S. A. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science (Washington DC), 281: 1009-1012, 1998.
5. Abbott, D. W., Freeman, M. L., and Holt, J. Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. J. Natl. Cancer Inst., 90: 6-13, 1998.
6. Connor, F., Bertwistle, D., Mee, J., Ross, G. M., Swift, S., Grigorieva, E., Tybulewicz, V., and Ashworth, A. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nat. Genet., 17: 423-430, 1997.
7. Patel, K. J., Yu, V., Lee, H., Corcoran, A., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B., and Venkitaraman, A. R. Involvement of Brca2 in DNA repair. Mol. Cell, 1: 347-357, 1998.
8. Morimatsu, M., Donoho, G., and Hasty, P. Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence. Cancer Res., 58: 3441-3447, 1998.
9. Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D. S., Regel, E., Dinh, C., Sands, A., Eichele, G., Hasty, P., and Bradley, A. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature (Lond), 386: 804-810, 1997.
10. Chen, P. L., Chen, C. F., Chen, Y., Xiao, J., Sharp, D., and Lee, W-H. The BRC repeats in BRCA2 are critical for Rad51 binding and resistance to methyl methane-sulfonate treatment. Proc. Natl. Acad. Sci. USA, 95: 5287-5292, 1998.
11. Goggins, M., Schutte, M., Lu, J., Moskaluk, C. A., Weinstein, C. L., Peterson, G. M., Yeo, C. J., Jackson, L. E., Lynch, H. T., Hruban, R. H., and Kern, S. E. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res., 56: 5360-5364, 1996.
12. Liang, F., Han, M., Romanienko, P. J., and Jasin, M. Homology-directed repair is a major double-strand break repair pathway in mammalian cells. Proc. Natl. Acad. Sci. USA, 95: 5172-5177, 1998.
13. Baumann, P., and West, S. C. Role of the human RAD51 protein in homologous recombination and double-stranded-break repair. Trends Biochem. Sci., 23: 247-251, 1998.
14. Haaf, T., Golub, E. I., Reddy, G., Radding, C. M., and Ward, D. C. Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes. Proc. Natl. Acad. Sci. USA, 92: 2298-2302, 1995.
15. Raderschall, E., Golub, E. I., and Haaf, T. Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage. Proc. Natl. Acad. Sci. USA, 96: 1921-1926, 1999.
16. Gasior, S. L., Wong, A. K., Kora, Y., Shinohara, A., and Bishop, D. K. Rad52 associates with RPA and functions with rad55 and rad57 to assemble meiotic recombination complexes. Genes Dev., 12: 2208-2221, 1998.
17. Bishop, D. K., Ear, U., Bhattacharyya, A., Calderone, C., Beckett, M., Weichselbaum, R. R., and Shinohara, A. XRCC3 is required for assembly of Rad51 complexes in vivo. J. Biol. Chem., 273: 21482-21488, 1998.
18. Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., and Livingston, D. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell, 88: 265-275, 1997.
19. Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., and Scully, R. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell, 2: 317-328, 1998.
20. Wong, A., Pero, R., Ormonde, P. A., Tavtigian, S. V., and Bartel, P. L. Rad51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. J. Biol. Chem., 272: 31941-31944, 1997.
21. Tomlinson, G. E., Chen, T. T., Stastny, V. A., Virmani, A. K., Spillman, M. A., Tonk, V., Blum, J. L., Schneider, N. R., Wistuba, I. I., Shay, J. W., Minna, J. D., and Gazdar, A. F. Characterization of a breast cancer cell line derived from a germ-line BSCA1 mutation carrier. Cancer Res., 58: 3237-3242, 1998.
22. Bradford, M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254, 1976.
23. Harlow, E., and Lane, D. Antibodies: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1988.
24. Carney, J. P., Maser, R. S., Olivares, H., Davis, B. M., Le Beau, M., Yates, J. R., III, Hays, L., Morgan, W. F., and Petrini, J. H. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell, 93: 477-486, 1998.
25. Paull, T. T., and Gellert, M. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol. Cell, 1: 969-979, 1998.
26. Trujillo, K. M., Yuan, S. S., Lee, E. Y., and Sung, P. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J. Biol. Chem., 273: 21447-21450, 1998.
27. Maser, R. S., Monsen, K. J., Nelms, B. E., and Petrini, J. H. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks, Mol. Cell. Biol., 17: 6087-6096, 1997.
28. Durfee, T., Mancini, M. A., Jones, D., Elledge, S. J., and Lee, W. H. The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. J. Cell Biol., 127; 609-622, 1994.
29. Tan, T. L. R., Citterio, E., Swagemakers, S. M. A., de Wit, J., Benson, F. E., Hoejimakers, J. H. J., and Kanaar, R. Mouse Rad54 affects DNA conformation and DNA damage-induced Rad51 foci formation. Curr. Biol., 9: 325-328, 1999.