RAD51C Is Required for Holliday Junction Processing in Mammalian Cells

Science

Volumn 303, Issue 5655, 2004, Pages 243-246

  Liu, Yilun ^a   Masson, Jean Yves ^a,b   Shah, Rajvee ^a   O'Regan, Paul ^a   West, Stephen C ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; CHROMOSOMES; DNA; GENETIC ENGINEERING; MUTAGENESIS;

GENETIC RECOMBINATION;

BIOMEDICAL ENGINEERING;

GENE PRODUCT; PROTEIN XRCC3; RAD51 PROTEIN; RAD51C PROTEIN; RESOLVASE; UNCLASSIFIED DRUG;

RNA; VIRUS;

ARTICLE; CHROMOSOME BREAKAGE; CROSSING OVER; ENZYME ACTIVITY; GENE MUTATION; GENETIC COMPLEMENTATION; GENETIC RECOMBINATION; HOLLIDAY JUNCTION; HUMAN; HUMAN CELL; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; DNA REPAIR; DNA, CRUCIFORM; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HELA CELLS; HOLLIDAY JUNCTION RESOLVASES; HUMANS; MUTATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC;

ANIMALIA; MAMMALIA;

EID: 0346340054     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1093037     Document Type: Article

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27. We thank K. Elborough, H. Hyde, B. Kysela, A. Davies, and A. Constantinou, whose efforts provided the springboard for the present work; A. Ciccia and E. Yong for carrying out flap endonuclease and HJ resolvase assays; I. Hickson for providing purified RAD51D-XRCC2; and P. Jeggo and J. Thacker for cell lines. This work was funded by Cancer Research UK and the Swiss Bridge Fund. Y.L. and J.-Y.M. were supported by American Cancer Society and National Cancer Institute (Canada) fellowships, respectively.