Natural products from mediterranean diet: From anti-inflammatory agents to dietary epigenetic modulators

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry

Volumn 9, Issue 2, 2010, Pages 101-124

  Kontogiorgis, C A ^a,b   Bompou, E M ^b   Ntella, M ^b   Vanden Berghe, W ^c,d  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b ALEXANDER TECHNOLOGICAL EDUCATIONAL INSTITUTE OF THESSALONIKI   (Greece)

^c GHENT UNIVERSITY   (Belgium)

^d UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Dietary epigenetic modulators; Inflammation; Mediterranean diet; Natural products

Indexed keywords

ANTIINFLAMMATORY AGENT; ARACHIDONIC ACID; CAFFEIC ACID; CAROTENOID; COUMARIN DERIVATIVE; CYTOKINE; DNA METHYLTRANSFERASE; ERYTHRODIOL; FLAVONOID; HISTONE DEACETYLASE; HOMOVANILLIC ACID; KAEMPFEROL; LIPOXYGENASE; NATURAL PRODUCT; OLEIC ACID; OLEUROPEIN; OLIVE OIL; PARA COUMARIC ACID; PHOSPHOLIPASE; PLANT EXTRACT; POLYPHENOL; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; SIRTUIN; SITOSTEROL; SYRINGIC ACID; TERPENOID; UNINDEXED DRUG; VANILLIC ACID; VITAMIN;

ACHILLEA AGERATUM; ADAPTIVE IMMUNITY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CANCER PREVENTION; CELL DAMAGE; CHRONIC INFLAMMATION; CROCUS SATIVUS; DIET SUPPLEMENTATION; DIETARY FIBER; DRUG STRUCTURE; EATING HABIT; EPIGENETICS; FENNEL; GARLIC; GERMANDER; HUMAN; INFLAMMATION; INFLAMMATORY DISEASE; INNATE IMMUNITY; LETTUCE; LIFESTYLE; LIPID MEMBRANE; MATRICARIA; MEDIATOR RELEASE; MEDICINAL PLANT; MEDITERRANEAN DIET; NEPETA SIBTHORPII; NEUTROPHIL CHEMOTAXIS; NONHUMAN; ONION; OREGANO; OXIDATIVE STRESS; PARSLEY; PATHOPHYSIOLOGY; PHYSICAL ACTIVITY; PISTACHIO; QUALITY OF LIFE; ROSEMARY; RUTA CHALEPENSIS; RUTA GRAVEOLENS; SALVIA OFFICINALIS; THYME; VITAMIN INTAKE;

EID: 78049451028     PISSN: 18715230     EISSN: 1875614X     Source Type: Journal    
DOI: 10.2174/187152310791110652     Document Type: Article

References (234)

1. Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod., 2007, 70, 461-477.
2. Jachak, S.M.; Saklani, A. Challenges and opportunities in drug discovery from plants. Curr. Sci., 2007, 92, 1251-1257.
3. Vane, J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol., 1971, 231, 232-235.
4. Grivetti, L.E. The CRC Press Modern Nutrition Series, Lincoln, 2001, pp. 3-30.
5. Keys, A.; Menotti, A.; Karvonen, M.J.; Aravanis, C.; Blackburn, H.; Buzina, R.; Djordjevic, B.S.; Dontas, A.S.; Fidanza, F.; Keys, M.H. The diet and 15-year death rate in the Seven Countries Study. Am. J. Epidemiol., 1986, 124, 903-915.
6. De Lorgeril, M.; Salen, P.; Martin, J.L.; Monjaud, I.; Delaye, J.; Mamelle, N. Mediterranean diet, traditional risk factors, and the rate of Cardiovascular complications after myocardial infarction: Final report of the Lyon heart study. Circulation, 1999, 99, 779-785.
7. Perez-Lopez, F.R.; Chedraui, P.; Haya, J.; Cuadros, J.L. Effects of the Mediterranean diet on longevity and age-related morbid conditions. Maturitas, 2009, 64(2), 67-79.
8. Kromhout, D.; Bloemberg, B. Diet and coronary heart disease in the Seven Countries Study. In: Kromhout, D.; Menotti, A.; Black-burh, H. Eds. Preventation of coronary heart disease. Diet, Lifestyle nd risk factos in the Seven Countries Study. Norwell/Dordrecht: Kluwer, Academic Publishers, 2002.
9. Kushi, L.H.; Lenart, E.B.; Willett, W.C. Health implications of Mediterranean diets in light of contemporary knowledge. 1. Plant foods and dairy products. Am. J. Clin. Nutr., 1995, 61, 1407S-1415S.
10. Kushi, L.H.; Lenart, E.B.; Willett, W.C. Health implications of Mediterranean diets in light of contemporary knowledge. 2. Meat, wine, fats, and oils. Am. J. Clin. Nutr., 1995, 61,1416S-1427S.
11. Trichopoulou, A.; Vasilopoulou, E.; Hollman, P.; Chamalides, C; Foufa, E.; Kaloudis, T.; Kromhout, D.; Miskaki, P.; Petrochilou, I.; Poulima, E.; Stafilakis, K.; Theophilou, D. Nutritional composition and flavonoid content of edible wild greens and green pies: a potential rich source of antioxidant nutrients in the Mediterranean diet. Food Chem., 2000, 70, 319-323.
12. Ehnholm, C; Huttunen, J.K.; Pietinen, P.; Leino, U.; Mutanen, M.; Kostiainen, E.; Pikkarainen, J.; Dougherty, R.; Iacono, J.; Puska, P.N. Effect of diet on serum lipoproteins in a population with a high risk of coronary heart disease. Engl. J. Med., 1982, 307, 850-855.
13. Ferro-Luzzi, A.; Strazzullo, P.; Scaccini, C; Siani, A.; Sette, S.; Mariani, M. A.; Mastranzo, P.; Dougherty, R. M.; Iacono, J. M.; Mancini, M. Changing the Mediterranean diet: effects on blood lipids. Am. J. Clin. Nutr., 1984, 40, 1027-1037.
14. Puska, P.; Iacono, J.M.; Nissinen, A.; Korhonen, H.J.; Vartianinen, E.; Pietinen, P.; Dougherty, R.; Leino, U.; Mutanen, M.; Moisio, S.; Huttunen, J. Controlled, randomised trial of the effect of dietary fat on blood pressure. Lancet, 1983, 1(1), 1-5.
15. Zhang, J.; Sasaki, S.; Amano, K.; Kesteloot, H. Fish consumption and mortality from all causes, ischemic heart disease, and stroke: An ecological study. Prev. Med., 1999, 28, 520-529.
16. Kris-Etherton, P.M.; Hecker, K.D.; Binkoski, A.E. Polyunsaturated fatty acids and cardiovascular health. Nutr. Rev., 2004, 62(11), 414-426.
17. Tang, F.Y.; Cho, H.J.; Pai, M.H.; Chen, Y.H. Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells. J. Nutr. Biochem., 2009, 20(6), 426-434.
18. Menendez, J.A.; Vazquez-Martin, A.; Colomer, R.; Brunet, J.; Carrasco-Pancorbo, A.; Garcia-Villalba, R.; Fernandez-Gutierrez, A.; Segura-Carretero, A. Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin™) in HER2-overexpressing breast cancer cells. BMC Cancer, 2007, 7, 80.
19. Chen, C. C; Liu, L. K.; Hsu, J. D.; Huang, H. P.; Yang, M. Y.; Wang, C. J. Mulberry extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. Food Chem., 2005, 91, 601-607.
20. Prior, R. L. Fruits and vegetables in the prevention of cellular oxidative damage. Am. J. Clin Nutr., 2003, 78, 570S-578S.
21. Saleem, A.; Husheem, M.; Harkonen, P.; Pihlaja, K. Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz. fruit. J. Ethnopharmacol., 2002, 81, 327-336.
22. Zhang, Y.; Vareed, S. K.; Nair, M. G. Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. Life Sci., 2005, 76, 1465-1472.
23. Chen, P.N.; Chu, S. C; Chiou, H. L.; Kuo, W. H.; Chiang, C. L.; Hsieh, Y.S. Mulberry anthocyanins, cyanidin 3-rutinoside and cya-nidin3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. Cancer lett., 2006, 235, 248-259.
24. Qian, J. Y.; Liu, D.; Huang, A. G. The efficiency of flavonoids in polar extracts of Lycium chinense Mill fruits as free radical scavenger. Food Chem., 2004, 87, 283-288.
25. Subbaramaiah, K.; Bulic, P.; Lin, Y.; Dannenberg, A. J.; Pasco, D. J. Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription. Biomol. Screen, 2001, 6 (2), 101-110.
26. Dey, M.; Ripoll, C; Pouleva, R.; Dorn, R.; Aranovich, I.; Zaurov, D.; Kurmukov, A.; Eliseyeva, M.; Belolipov, I.; Akimaliev, A.; Sodombekov, I.; Akimaliev, D.; Lila, M. A.; Raskin, I. Plant ex-tracts from central Asia showing antiinflammatory activities in gene expression assays. Phytother. Res., 2008, 22(7), 929-934.
27. Woolf, A.D.; Pfleger, B. Burden of major musculoskeletal conditions. Bull. World Health Org., 2003, 81, 646-656.
28. Smith, R.J. Therapies for rheumatoid arthritis: hope springs eternal. Drug Discov. Today., 2005, 10, 1598-1606.
29. Pan, M. H.; Ghai, G.; Ho, C. T. Food bioactives, apoptosis, and cancer. Mol. Nutr. Food Res., 2008, 52, 43-52.
30. Kontogiorgis, C.; Mantzanidou, M.; Hadjipavlou-Litina, D. Chalcones and their potential role in inflammation. Mini Rev. Med. Chem., 2008, 8, 1224-1242.
31. Springer, T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell, 1994, 76, 301.
32. Wagner, O.F.; Jilma, B. Putative role of adhesion molecules in metabolic disorders. Horm. Metab. Res., 1997, 29, 627.
33. Salkowski, C.A.; Detore, G.; McNally, R.; Van Rooijen, N.; Vogel, S.N. Regulation of inducible nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccharide in vivo: the roles of macrophages, endogenous IFN-gamma, and TNF receptor-1-mediated signaling. J. Immunol., 1997, 158, 905.
34. Middleton, E.; Kandaswami, C. Effects of flavonoids on immune and inflammatory cell functions. Biochem. Pharmacol., 1992, 43, 1167.
35. Vane, J.R.; Botting, R.M., In Aspirin and Other Salicylates, Chapman and Hall Medical: London, 1992, pp 3-16.
36. Kovacs, E.J.; Frazier-Jessen M.R. In Xenobiotics and Inflammation, Schook, B.L.; Laskin, D.L.; Eds. Academic Press: United Kingdom, 1994.
37. Dannhardt, G.; Kiefer, W. Cyclooxygenase inhibitors--current status and future prospects. Eur. J. Med. Chem., 2001, 36, 109-126.
38. Kontogiorgis, C.A.; Hadjipavlou-Litina, D. Non-steroidal antiin-flammatory and anti-allergy agents. Curr. Med. Chem., 2002, 9, 89.
39. Herencia, F.; Ferrándiz, M.L; Ubeda, A.; Guillén, I.; Dominguez, J.N.; Charris, J.E.; Lobo, G.M.; Alcaraz M.J. FEBS Lett., 1999, 453, 1219-135.
40. Schmitz, M.L.; Bacher, S. Novel molecualr targets in the search for anti-infalmmatory agents. Phytochem. Rev., 2005, 4, 19-25.
41. Hamelmann, E.; Gelfard, E.W. Role of IL-5 in the development of allergen-induced airway hyperresponsiveness. Int. Arch. Allergy Immunol., 1999, 120, 8-16.
42. Allakhverdi, Z.; Allam, M.; Renzi, P.M. Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common beta chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma. Am. J. Respir. Crit. Care Med., 2002, 165, 1015-1021.
43. Takaki, S.; Tominaga, A.; Hitoshi, Y.; Mita, S.; Sonoda, E.; Yama-guchi, N.; Takatsu, K. Molecular cloning and expression of the murine interleukin-5 receptor. EMBO J., 1990, 9, 4367-4374.
44. Maeda, S.; Omata, M. Inflammation and cancer: role of nuclear factor-kappaB activation. Cancer Sci., 2008, 99(5), 836-842.
45. Natoli, G.; Saccani, S.; Bosisio, D.; Marazzi, I. Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time. Nat. Immunol., 2005, 6(5), 439-445.
46. Natoli, G. Tuning up inflammation: how DNA sequence and chro-matin organization control the induction of inflammatory genes by NF-kappaB. FEBS Lett., 2006, 580(2), 2843-2849.
47. Vanden Berghe, W.; Ndlovu, M.N.; Hoya-Arias, R.; Dijsselbloem, N.; Gerlo, S.; Haegeman, G. Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigene-tics. Biochem. Pharmacol., 2006, 72(9), 1114-1131.
48. Backdahl, L.; Bushell, A.; Beck, S. Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation. Int. J. Biochem. Cell Biol., 2009, 41(1), 176-184.
49. Jirtle, R.L.; Skinner, M.K. Environmental epigenomics and disease susceptibility. Nat. Rev. Genet., 2007, 8(4), 253-262.
50. Arasaradnam, R.P.; Commane, D.M.; Bradburn, D.; Mathers, J.C. A review of dietary factors and its influence onDNA methylation in colorectal carcinogenesis. Epigenetics, 2008, 3(4), 193-198.
51. Delage, B.; Dashwood, R.H. Dietary manipulation of histone structure and function. Annu. Rev. Nutr., 2008, 28, 347-366.
52. Dobosy, J.R.; Fu, V.X.; Desotelle, J.A.; Srinivasan, R.; Kenowski, M.L.; Almassi, N.; Weindruch, R.; Svaren, J.; Jarrard, D.F. A methyl-deficient diet modifies histone methylation and alters Igf2 and H19 repression in the prostate. Prostate, 2008, 68, 1187-1195.
53. Junien, C. Impact of diets and nutrients/drugs on early epigenetic programming. J. Inherit. Metab. Dis., 2006, 29(2-3), 359-365.
54. Mariman, E.C. Epigenetic manifestations in diet-related disorders. J. Nutrigenet Nutrigenomics., 2008, 1(5), 232-239.
55. McGowan, P.O.; Meaney, M.J, Szyf, M. Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res., 2008,1237, 12-24.
56. Mattick, J.S.; Amaral, P.P.; Dinger, M.E.; Mercer, T.R.; Mehler, M.F. RNA regulation of epigenetic processes. Bioessays, 2009, 31(1), 51-59.
57. Taft, R.J.; Glazov, E.A.; Cloonan, N.; Simons, C.; Stephen, S.; Faulkner, G.J.; Lassmann, T.; Forrest, A.R.; Grimmond, S.M.; Schroder, K.; Irvine, K.; Arakawa, T.; Nakamura, M.; Kubosaki, A.; Hayashida, K.; Kawazu, C.; Murata, M.; Nishiyori, H.; Fukuda, S.; Kawai, J.; Daub, C.O.; Hume, D.A.; Suzuki, H.; Orlando, V.; Carninci, P.; Hayashizaki, Y.; Mattick, J.S. Tiny RNAs associated with transcription start sites in animals. Nat. Genet., 2009, 41, 572-578.
58. Seet, B.T.; Dikic, I.; Zhou, M.M.; Pawson, T. Reading protein modifications with interaction domains. Nat. Rev. Mol. Cell Biol., 2006, 7, 473-483.
59. Dolinoy, D.C.; Weidman, J.R.; Waterland, R.A.; Jirtle, R.L. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ. Health Perspect., 2006, 114, 567-572.
60. Waterland, R.A.; Jirtle, R.L. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol. Cell Biol., 2003, 23, 5293-5300.
61. Waterland, R.A.; Travisano, M.; Tahiliani, K.G.; Rached, M.T.; Mirza, S. Methyl donor supplementation prevents transgenerational amplification of obesity. Int. J. Obes. (Lond)., 2008, 32, 1373-1379.
62. Ladurner, A.G. Chromatin places metabolism center stage. Cell,2009,138, 18-20.
63. Lee, W.J.; Shim, J.Y.; Zhu, B.T. Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol. Pharmacol., 2005, 68, 1018-1030.
64. Dashwood, R.H.; Myzak, M.C.; Ho, E. Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? Carcino-genesis, 2006, 27, 344-349.
65. Nian, H.; Delage, B.; Ho, E.; Dashwood, R.H. Modulation of his-tone deacetylase activity by dietary isothiocyanates and allyl sul-fides: studies with sulforaphane and garlic organosulfur compounds. Environ. Mol. Mutagen. 2009, 50, 213-221.
66. Vaquero, A.; Reinberg, D. Calorie restriction and the exercise of chromatin. Genes Dev., 2009, 23, 1849-1869.
67. Cooney, C.A. Germ cells carry the epigenetic benefits of grandmother's diet. Proc. Natl. Acad. Sci. USA, 2006, 103, 17071-17072.
68. Guerrero-Bosagna, C.M.; Sabat, P.; Valdovinos, F.S.; Valladares, L.E.; Clark, S.J. Epigenetic and phenotypic changes result from a continuous pre and post natal dietary exposure to phytoestrogens in an experimental population of mice. BMC Physiol., 2008, 8, 17.
69. Hunter, P. We are what we eat: the link between diet, evolution and non-genetic inheritance. EMBO Rep., 2008, 9, 413-415.
70. Bremner, P.; Heinrich, M. Natural products as targeted modulators of the nuclear factor-kappaB pathway. J. Pharm. Pharmacol., 2002, 54, 453-472.
71. Deorukhkar, A.; Krishnan, S.; Sethi, G.; Aggarwal, B.B. Back to basics: how natural products can provide the basis for new therapeutics. Expert Opin. Investig. Drugs., 2007, 16, 1753-1773.
72. Karin, M.; Yamamoto, Y.; Wang, Q.M. The IKK NF-kappa B system: a treasure trove for drug development. Nat. Rev. Drug Dis-cov., 2004, 3, 17-26.
73. Khanna, D.; Sethi, G.; Ahn, K.S.; Pandey, M.K.; Kunnumakkara, A.B.; Sung, B.; Aggarwal, A.; Aggarwal, B.B. Natural products as a gold mine for arthritis treatment. Curr. Opin Pharmacol., 2007, 7, 344-351.
74. Paul, A.T.; Gohil, V.M.; Bhutani, K.K. Modulating TNF-alpha signaling with natural products. Drug Discov Today., 2006, 11, 725-732.
75. Rios, J.L.; Recio, M.C.; Escandell, J.M.; Andujar, I. Inhibition of transcription factors by plant-derived compounds and their implications in inflammation and cancer. Curr. Pharm. Des., 2009, 15, 1212-1237.
76. Surh, Y.J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer, 2003, 3, 768-780.
77. Simopoulos, A.P. Omega-3 fatty acids and antioxidants in edible wild plants. Biol. Res., 2004, 37, 263-277.
78. Trichopoulou, A.; Costacou, T.; Bamia, C.; Trichopoulos, D. N. Adherence to a Mediterranean diet and survival in a Greek population. N. Engl. J. Med., 2003, 348, 2599-2608.
79. Hertog, M.G.; Kromhout, D.; Aravanis, C.; Blackburn, H.; Buzina, R.; Fidanza, F.; Giampaoli, S.; Jansen, A.; Menotti, A.; Nedeljko-vic, S. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Intern. Med., 1995, 155, 381-386.
80. Menotti, A.; Kromhout, D.; Blackburn, H.; Fidanza, F.; Buzina, R.; Nissinen, A. Food intake patterns and 25-year mortality from coronary heart disease: cross-cultural correlations in the Seven Countries Study. The Seven Countries Study Research Group. Eur. J. Epidemiol., 1999, 15, 507-515.
81. Rodriguez-Cabezas, M.E.; Galvez, J.; Camuesco, D.; Lorente, M.D.; Concha, A.; Martinez-Augustin, O.; Redondo, L.; Zarzuelo, A. Intestinal anti-inflammatory activity of dietary fiber (Plantago ovata seeds) in HLA-B27 transgenic rats. Clin. Nutrition., 2003, 22, 463-471.
82. Van Deventer, S. J. Tumour necrosis factor and Crohn's disease. Gut, 1997, 40, 443-448.
83. Huang, N.; Katz, J P.; Martin, D R.; Wu, G D. Inhibition of IL-8 gene expression in Caco-2 cells by compounds which induce his-tone hyperacetylation. Cytokine, 1997, 9, 27-36.
84. de la Puerta, R.; Martinez-Dominguez, E.; Ruiz-Gutierrezba, V. Effect of minor components of virgin olive oil on topical antiin-flammatory assays. Z Naturfosch C., 2000, 55, 814-819.
85. Perona, J.S.; Martinez-Gonzalez, J.; Sanchez-Dominguez, J.M.; Badimon, L.; Ruiz-Gutierrez, V. he unsaponifiable fraction of virgin olive oil in chylomicrons from men improves the balance between vasoprotective and prothrombotic factors released by endot-helial cells. J. Nutr., 2004, 134, 3284-3289.
86. Visioli, F.; Caruso, D.; Grande, S.; Bosisio, R.; Vila, M.; Galli, G.; Sirtori, C.; Galli, C. Virgin Olive Oil Study (VOLOS): vasoprotec-tive potential of extra virgin olive oil in mildly dyslipidemic patients. Eur. J. Nutr., 2005, 44, 121-127.
87. Oubina, P.; Sanchez-Muniz, F.J.; Rodenas, S.; Cuesta, C. Eicosa-noid production, thrombogenic ratio, and serum and LDL peroxides in normo- and hypercholesterolaemic post-menopausal women consuming two oleic acid-rich diets with different content of minor components. Br. J. Nutr., 2001, 85, 41-47.
88. Bogani, P.; Galli, C.; Villa, M.; Visioli, F. Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. Atherosclerosis, 2007, 190, 181-186.
89. Miles, E.A.; Zoubouli, P.; Calder P.C. Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures. Nutrition, 2005, 21, 389-394.
90. Beauchamp, G.K.; Keast, R.S.; Morel, D.; Lin, J.; Pika, J.; Han, Q.; Lee, C.H.; Smith, A.B.; Breslin, P.A. Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature, 2005, 437, 45-46.
91. Yaqoob, P.; Newsholme, E.A.; Calder, P.C. Inhibition of natural killer cell activity by dietary lipids. Immunol Lett., 1994, 41, 241-247.
92. Yaqoob, P.; Newsholme, E.A.; Calder, P.C. The effect of dietary lipid manipulation on rat lymphocyte subsets and proliferation. Immunology, 1994, 82, 603-610.
93. Tsimikas, S.; Philis-Tsimikas, A.; Alexopoulos, S.; Sigari, F.; Lee, C.; Reaven, P.D. LDL isolated from Greek subjects on a typical diet or from American subjects on an oleate-supplemented diet induces less monocyte chemotaxis and adhesion when exposed to o-xidative stress. Arterioscler. Thromb. Vasc. Biol., 1999, 19, 122-130.
94. Carluccio, M.A.; Massaro, M.; Bonfrate, C.; Siculella, L.; Maffia, M.; Nicolardi, G.; Distante, A.; Storelli, C.; De Caterina, R. Oleic acid inhibits endothelial activation: A direct vascular antiatheroge-nic mechanism of a nutritional component in the mediterranean diet. Arterioscler. Thromb. Vasc. Biol., 1999, 19, 220-228.
95. Massaro, M.; Carluccio, M.A.; Paolicchi, A.; Bosetti, F.; Solani, G.; De Caterina, R. Mechanisms for reduction of endothelial activation by oleate: inhibition of nuclear factor-kappaB through anti-oxidant effects. Prostaglandins Leukot. Essent. Fatty Acids, 2002, 67, 175-181.
96. Ali, M.; Thomson, M.; Afzal, M. Garlic and onions: their effect on eicosanoid metabolism and its clinical relevance. Prostaglandins Leukot. Essent. Fatty Acids, 2000, 6, 55-73.
97. Pittler, M.H.; Ernst, E. Clinical effectiveness of garlic (Allium sativum). Mol. Nutr. Food Res., 2007, 51, 1382-1385
98. Lang, A.; Lahav, M.; Sakhnini, E.; Barshack, I.; Fidder, H.H.; Avidan, B.; Bardan, E.; Hershkoviz, R.; Bar-Meir, S.; Chowers, Y. Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Clin. Nutr., 2004, 23, 1199-1208.
99. Sohn, D.W, Ha, C.H.; Jun, Y.S.; Ki, S.I.; Ki, S.W.; Cho, Y.H. Antiinflammatory and antimicrobial effects of garlic and synergis-tic effect between garlic and ciprofloxacin in a chronic bacterial prostatitis rat model. Inter. J. Antimicrob. Agents, 2009, 34, 215-219.
100. Baricevic, D.; Sosa, S.; Loggia, R.D.; Tubaro, A.; Simonovska, B.; Krasna, A.; Zupancic, A. Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid. J. Ethno-pharmacol., 2001, 75, 125-132.
101. Al-Hindawi, M.K.; Al-Deen, I.H.; Nabi, M.H.; Ismail, M.A. Anti-inflammatory activity of some Iraqi plants using intact rats. J. E-thnopharmacol., 1989, 26, 163-168.
102. Tubaro, A.; Zilli, C.; Redaelli, C.; Loggia, R.D. Evaluation of antiinflammatory activity of a chamomile extract after topical application. Planta Med., 1984, 50, 359.
103. Della Loggia, R.; Carle, R.; Sosa, S.; Tubaro, A. Evaluation of the antiinflammatory activity of chamomile [Chamomilla recutita] preparations. Planta Med., 1990, 56, 657-658.
104. Garcia, M. D.; Puerta, R.; Martinez, S.; Saenz, M. T. Analgesic, antipyretic and antiinflammatory effects of Achillea ageratum. Phytoth. Res., 1997, 11, 376-379.
105. Hosseinzadeh, H., Younesi, H. M. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol., 2002, 2, 7.
106. Abe, K.; Saito, H. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother. Res., 2000, 14, 149-152.
107. Ma, S.; Zhou, S.; Shu, B.; Zhou, J. Pharmacological studies on Crocus glycosides I. Effects on antiinflammatory and immune function. Zhongcaoyao., 1998, 29, 536-539.
108. Choi, E.M.; Hwang, J.K. Antiinflammatory, analgesic and antioxi-dant activities of the fruit of Foeniculum vulgare. Fitoterapia., 2004, 75, 557-565.
109. Al- Howiriny, T.A.; Al-Sohaibani, M.O.; El-Tahir, K.H.; Rafatul-lah, S. Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of Parsley Petroselinum crispum. Am J Chin Med., 2003, 31, 699-711.
110. Miceli, N.; Taviano, M.F.; Giuffrida, D.; Trovato, A.; Tzakou, O.; Galati, E.M. Anti-inflammatory activity of extract and fractions from Nepeta sibthorpii Bentham. J. Ethnopharmacol., 2005, 97, 261-266.
111. Orhan, I.; Kupeli, E.; Aslan, M.; Kartal, M.; Yesilada E. Bioassay-guided evaluation of anti-inflammatory and antinociceptive activities of pistachio, Pistacia vera L. J. Ethnopharmacol., 2006, 105, 235-240.
112. Iauk, L.; Mangano, K.; Rapisarda, A.; Ragusa, S.; Maiolino, L.; Musumeci, R.; Costanzo, R.; Serra, A., Speciale, A. Protection against murine endotoxemia by treatment with Ruta chalepensis L., a plant with anti-inflammatory properties. J. Ethnopharmacol., 2004, 90, 267-272.
113. Raghav, S.K.; Gupta, B.; Agrawal, C.; Goswami, K.; Das, H.R. Anti-inflammatory effect of Ruta graveolens L. in murine macro-phage cells. J. Ethnopharmacol., 2006, 104, 234-239.
114. Ratheesh, M.; Helen, A. Anti-inflammatory activity of Ruta graveolens Linn. on carrageenan induced paw edema in wistar male rats. Afr. J. Biotechnol., 2007, 6, 1209-1211.
115. Conforti, F.; Sosa, S.; Marelli, M.; Menichini, M.; Statti, G.A.; Uzunov, D.; Tubaro, A.; Menichini, F. The protective ability of Mediterranean dietary plants against the oxidative damage: the role of radical oxygen species in inflammation and the polyphenol, fla-vonoid and sterol contents. Food Chem., 2009, 112, 587-594.
116. Garcia, M. D.; Saenz, M. T.; Gomez, M. A.; Fernandez, M. A. Topical antiinflammatory activity of phytosterols isolated from Er-yngium foetidum on chronic and acute inflammation models. Phytoth. Res., 1999, 13, 78-80.
117. Kimura, Y.; Yasukawa, K.; Takido, M.; Akihisa, T.; Tamura, T. Inhibitory effect of some oxygenated stigmastane-type sterols on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. Biol. Pharm. Bull., 1995, 18, 1617-1619.
118. Conforti, F.; Sosa, S.; Marelli, M.; Menichini, F.; Statti, G.A.; Uzunov, D.; Tubaro, A.; Menichini, F.; Loggia, R.D. In vivo antiinflammatory and in vitro antioxidant activities of Mediterranean dietary plants. J. Ethnopharmacol., 2008, 116, 144-151.
119. Trouillas, P.; Calliste, C.A.; Allais, D.P.; Simon, A.; Marfak, A.; Delage, C.; Duroux, J.L. Antioxidant, anti-inflammatory and antiproliferative properties of sixteen water plant extracts used in the Limousin countryside as herbal teas. Food Chem., 2003, 80, 399-407.
120. Mulabagal, V.; Ngouajio, M.; Nair, A.; Zhang, Y.; Gottumukkala, A.L.; Nair, M.G. In vitro evaluation of red and green lettuce (Lac-tuca sativa) for functional food properties. Food Chem., 2010, 118, 300-306.
121. Bukovska, A.; Cikos, S.; Juhas, S.; Ilkova, G.; Rehal, P.; Koppel, J. Effects of a combination of Thyme and Oregano essential oils on TNBS-induced colitis in mice. Mediators Inflamm., 2007, 2007, 23296.
122. Huang, M.T.; Ho, C.T.; Wang, Z.Y. Inhibition of skin tumorigene-sis by rosemary and its constituents carnosol and ursolic acid. Cancer Res., 1994, 54, 701-708.
123. Lo, A.H.; Liang, Y.C.; Lin-Shiau, S.Y. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages. Carcinogenesis, 2002, 23, 983-991.
124. Menichini, F.; Conforti, F.; Rigano, D.; Formisano, C; Piozzi, F.; Senatore F. Phytochemical composition, anti-inflammatory and an-titumour activities of four Teucrium essential oils from Greece. Food Chem., 2009, 115, 679-686.
125. Karaca, M.; Özbek, H.; Him, A.; Tütüncü, M.; Akkan, H.A.; Ka-planoglu, V. Investigation of antiinflammatory activity of Berga-mot oil. Eur. J. Gen. Med., 2007, 4(4), 176-179.
126. Micallef, M.J.; Iwaki, K.; Ishihara, T.; Ushio, S.; Aga, M.; Kunika-ta, T.; Koya- Miyata, S.; Kimoto, T.; Ikeda, M.; Kurimoto, M. The natural plant product tryptanthrin ameliorates dextran sodium sulfa-te-induced colitis in mice. Int. Immunopharmacol, 2002, 2, 565-578.
127. Heinemann, C; Schliemann-Willers, S.; Oberthur, C; Humburger, M.; Elsner, P. Prevention of experimentally induced irritant contact dermatitis by extracts of I satis tinctoria compared to pure tryptanthrin and its impact on UVB-induced erythema. Planta Med., 2004, 70, 385-390.
128. Connor, W.E. Importance of n-3 fatty acids in health and disease. Am. J. Clin. Nutr., 2000, 71, 171S-175S.
129. Cleland, L.G.; French, J.K.; Betts, W.H.; Murphy, G.A.; Elliott, M.J. Clinical and biochemical effects of dietary fish oil supplements in rheumatoid arthritis. J. Rheumatol, 1988, 15, 1471-1475.
130. De Caterina, R.; Libby, P. Control of endothelial leukocyte adhesion molecules by fatty acids. Lipids., 1996, 31, S57-S63.
131. De Caterina, R.; Liao, J.K.; Libby, P. Fatty acid modulation of endothelial activation. Am. J. Clin. Nutr., 2000, 71, 213S-223S.
132. Simopoulos A.P. Omega-3 fatty acids in inflammation and autoimmune diseases. J. Am. Coll. Nutr., 2002, 21(6), 495-505.
133. Seierstad, S.L.; Seljeflot, I.; Johansen, O.; Hansen, R.; Haugen, M.; Rosenlund, G.; Froyland, L.; Arnesen, H. Dietary intake of differently fed salmon; the influence on markers of human atherosclerosis. Eur. J. Clin. Invest., 2005, 35, 52-59.
134. Pischon, T.; Hankinson, S.E.; Hotamisligil, G.S.; Rifai, N.; Willett, W.C.; Rimm, E.B. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation, 2003, 108, 155-160.
135. von Sacky, C. N-3 fatty acids and the prevention of coronary atherosclerosis. Am. J. Clin. Nutr., 2000, 71, 224S-227S.
136. Brown, A.A.; Hu, F.B. Dietary modulation of endothelial function: implications for cardiovascular disease. Am. J. Clin. Nutr., 2001, 73, 673-686.
137. Calder, P.C. Dietary modification of inflammation with lipids. Proc. Nutr. Soc, 2002, 61, 345-358.
138. Ringbom, T.; Huss, U.; Stenholm, A.; Flock, S.; Skattebol, L.; Perera, P.; Bohlin, L. Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J. Nat. Prod., 2001, 64, 745-749.
139. Su, B.N.; Cuendet, M.; Farnsworth, NR.; Fong, HHS.; Pezzuto, J.M.; Kinghorn, A.D. Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. Planta Med., 2002, 68, 1125-1128.
140. Gautam, R.; Jachak, S.M. Recent developments in antiinflammatory natural products. Med. Res. Rev., 2009, 29, 767-820.
141. Kwok, B.H.B.; Koh, B.; Ndubuisi, M.I.; Elofsson, M.; Crews, CM. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem. Biol., 2001, 8, 759-766.
142. Lindenmeyer, M.T.; Kern, C; Sparna, T.; Donauer, J.; Wilpert, J.; Schwager, J.; Porath, D.; Kreutz, C; Timmer, J.; Merfort, I. Mi-croarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells. Life Sci., 2007, 80, 1608-1618.
143. De Marino, S.; Borbone, N.; Zollo, F.; Lanaro, A.; Di Meglio, Iorizzi, M. New sesquiterpene lactones from Laurus nobilis leaves as inhibitors of nitric oxide production. Planta Med., 2005, 71, 706-710.
144. Sen, C.K.; Traber, K.E.; Packer, L. Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthione. Biochem. Bi-ophys. Res. Commun., 1996, 218, 148-153.
145. Chainy, G.B. Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. Oncogene, 2000, 19, 2943-2950.
146. Jachak, S.M. Cyclooxygenase inhibitory natural products: current status. Curr. Med. Chem., 2006, 13, 659-678.
147. Shishodia, S.; Majumdar, S.; Banerjee, S.; Aggarwal, B.B. Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkBcx kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res., 2003, 63, 4375-4383.
148. Ismaili, H.; Milella, L.; Fkih-Tetouani, S.; Ilidrissi, A.; Camporese, A.; Sosa, S.; Altinier, G.; Loggia, RD.; Aquino, R. In vivo topical anti-inflammatory and in vitro antioxidant activities of two extracts of Thymus satureioides leaves. J. Ethnopharmacol., 2004, 91, 31-36.
149. Kapil, A.; Sharma, S. Effect of oleanolic acid on complement in adjuvant- and carrageenan-induced inflammation in rats. J. Pharmacy Pharmacol., 1995, 47, 585-587.
150. Liu, J. Pharmacology of oleanolic acid and ursolic acid. J. Ethnopharmacol., 1995, 49, 57-68.
151. Ringbom, T.; Segura, L.; Noreen, Y.; Perera, P.; Bohlin, L. Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. J. Nat. Prod., 1998, 61, 1212-1215.
152. Diaz, A.M.; Abad, M.J.; Fernández, L.; Recuero, C; Villaescusa, L.; Silvan, AM.; Bermejo, P. In vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifo-lia L. Biol. Pharm. Bull, 2000, 23, 1307-1313.
153. Ryu, S.Y.; Oak, M. H.; Yoon, S. K.; Cho, D. I.; Yoo, G.S.; Kim, T. S.; Kim, K. M. Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris. Planta Med., 2000, 66, 358-360.
154. Subbaramaiah, K.; Michaluart, P.; Sporn, MB.; Dannenberg, A.J. Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Cancer Res., 2000, 60, 2399-2404.
155. Alvarez, M.E.; Rotelli, A.E.; Pelzer, L.E.; Saad, J.R.; Giordano, O. Phytochemical study and anti-inflammatory properties of Lampaya hieronymi Schum. Ex. Moldenke. Farmaco, 2000, 55, 502-505.
156. Giner-Larza, E.M.; Manez, S.; Recio, M.C.; Giner, R.M.; Prieto, J.M.; Cerda-Nicolas, M.; Rios, J.L. Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity. Eur. J. Pharmacol, 2001, 428, 137-143.
157. Appendino, G.; Ottino, M.; Marquez, N.; Bianchi, F.; Giana, A.; Ballero, M.; Sterner, O.; Fiebich, BL.; Munoz, E. Arzanol, an antiinflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum. J. Nat. Prod., 2007, 70, 608-612.
158. Calixto, J.B.; Campos, M.M.; Otuki, M.F.; Santos, AR. Antiinflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta Med., 2004, 70, 93-103.
159. Kang, B.K.; Chungm S.W.; Kim, T.S. Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by hpyericin, an active component of Hypericum perforatum. Planta Med., 2001, 67, 364-366.
160. Marsik, P.; Kokoska, L.; Landa, P.; Nepovim, A.; Soudek, P.; Vanek, T. In vitro inhibitory effects of thymol and quinones of Ni-gella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses. Planta Med., 2005, 71, 739-742.
161. Ferguson, L.R. Role of plant polyphenols in genomic stability. Mutat. Res., 2001, 475, 89-111.
162. Selvam, C; Jachak, S.M.; Oli, R.G.; Thilagavathi, R.; Chakraborti, A.K.; Bhutani, K.K. A new cyclooxygenase (COX) inhibitory pterocarpan from Indigofera aspalathoides: structure elucidation and determination of binding orientations in the active sites of the enzyme by molecular docking. Tetrahedron Lett., 2004, 45, 4311-4314.
163. Kundu, J. K.; Shin, Y. K.; Kim, S. H.; Surh, Y. J. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kB in mouse skin by blocking IkB kinase activity. Carcinogenesis., 2006, 27(7), 1465-1474.
164. Wung, B. S.; Hsu, M. C; Wu, C. C; Hsieh, C. W. Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation. Life Sci., 2005, 78(4), 389-397.
165. Donelly, L.E.; Newton, R.; Kennedy, G.E.; Fenwick, P.S.; Leung, R.H.F.; Ito, K.; Russell, R.E.K.; Barnes, P.J. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am. J. Lung Cell Mol. Physiol., 2004, 287, L774-L783.
166. Murakami, A.; Nakamura, Y.; Torikai, K.; Tanaka, T.; Koshiba, T.; Koshimizu, K.; Kuwahara, S.; Takahashi, Y.; Ogawa, K.; Yano, M.; Tokuda, H.; Nishimo, H.; Mimaki, Y.; Sashida, Y.; Kitanaka, S.; Ohigashi, H. Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice. Cancer Res., 2000, 60, 5059-5066.
167. Murakami, A.; Nakamura, Y.; Ohto, Y.; Yano, M.; Koshiba, T.; Koshimizu, K.; Tokuda, H.; Nishino, H.; Ohigashi, H. Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid. Biofactors, 2000, 12, 187-192.
168. Baur, J.A.; Pearson, K.J.; Price, N.L.; Jamieson, H.A.; Lerin, C; Kalra, A.; Prabhu, V.V.; Allard, J.S.; Lopez-Lluch, G.; Lewis, K.; Pistell, P.J.; Poosala, S.; Becker, K.G.; Boss, O.; Gwinn, D.; Wang, M.; Ramaswamy, S.; Fishbein, K.W.; Spencer, R.G.; Lakatta, E.G.; Le Couteur, D.; Shaw, R.J, Navas, P.; Puigserver, P.; Ingram, D.K.; De Cabo, R.; Sinclair, D.A. Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 2006, 444, 337-342.
169. Baur, J.A.; Sinclair, D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov., 2006, 5, 493-506.
170. Pan, M. H.; Chang, Y. H.; Tsai, M. L.; Lai, C. S.; Ho, S. Y.; Bad-maev, V.; Ho, C. T. Pterostilbene suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. J. Agric. Food Chem., 2008, 56, 7502-7509.
171. Cichocki, M.; Paluszczak, J.; Szaefer, H.; Piechowiak, A.; Ri-mando, A. M.; Baer-Dubowska, W. Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NF-kB, AP-1, COX-2, and iNOS in mouse epidermis. Mol. Nutr. Food Res., 2008, 52, S62-S70.
172. Subbaramaiah, K.; Cole, P. A.; Dannenberg, A.J. Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms. Cancer Res., 2002, 62, 2522-2530.
173. Murray, R.D.H.; Mendez, J.; Brown, R.A. The Natural Coumarins: Occurrence, Chemistry and Biochemistry. Chichester: J. Wiley and Sons, 1982.
174. Murray, R.D.H. In: Progress in the Chemistry of Organic Natural Products, Herz, W.; Kirby, G.W.; Steglich, W., Tamm, C. Eds. New York, Springer-Verlag, 1991, Vol. 58, pp. 84-316.
175. Kontogiorgis, C.A.; Hadjipavlou-Litina, D.J. Synthesis and antiinflammatory activity of coumarin derivatives. J. Med. Chem., 2005, 48, 6400-6408.
176. Olaharski, A.J.; Rine, J.; Marshall, B.L.; Babiarz, J.; Zhang, L.; Verdin, E.; Smith, M.T. The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PloS. Genet., 2005, 1(6), e77.
177. Sekiya, K.; Okuda, H.; Arichi, S. Selective inhibition of platelet lipoxygenase by esculetin. Biochim. Biophys. Acta (BBA)., 1982, 713, 68-72.
178. Lee, R.E.; Bykadi, G.; Ritschel, W.A. Inhibition of prostaglandin biosynthesis by coumarin, 4-hydroxycoumarin, and 7-hydroxycoumarin. Arzneimittelforschung., 1981, 31, 640-642.
179. Hoult, J.R.; Paya, M. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen. Pharmacol, 1996, 27, 713.
180. Lino, C.S.; Taveira, M.L.; Viana, G.S.B.; Matos, F.J.A. Analgesic and antiinflammatory activities of Justicia pectoralis Jacq and its main constituents: coumarin and umbelliferone. Phytother. Res., 1997, 11, 211.
181. Zhu, H.; Huang. Antiinflammatory effect of scopoletin. J. Zhong-Caoyao, 1989, 15, 462, Chem. Abstrs., 1989, 102, 72550b.
182. Yamamoto, M.; Kumagai, A.; Yamamura, Y. Antiinflammatory properties of Bupleurum fruticosum L. Arzneim-Forsch/Drug Res., 1976, 25, 1021.
183. Pelzer, L.E.; Guardia, T.; Osvaldo Juarez, A.; Guerreiro E. Acute and chronic antiinflammatory effects of plant flavonoids. Farmaco, 1998,53, 421-424.
184. Schubert, S.Y.; Neeman, I.; Resnick, N. A novel mechanism for the inhibition of NF-kB activation in vascular endothelial cells by natural antioxidants. FASEB J., 2002, 16, 1931-1933.
185. Panes, J.; Gerritsen, M.E.; Anderson, D.C.; Miyasaka, M.; Granger, D.N. Apigenin inhibits tumor necrosis factor-induced intercellular adhesion molecule-1 upregulation in vivo. Microcirculation, 1996, 3, 279-286.
186. Gerritsen, M.E.; Carley, W.W.; Ranges, G.E.; Shen, C.P.; Phan, S.A.; Ligon, G.F.; Perry, C.A. Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression. Am. J. Pathol., 1995, 147, 278-292.
187. Smolinski, A.T.; Pestka, J.J. Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew). Food Chem. Toxicol., 2003, 41, 1381-1390.
188. Wolle, J.; Hill, R.R.; Ferguson, E.; Devall, L.J.; Trivedi, B.K.; Newton, R.S.; Saxena, U. Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid. Lack of effect on transcription factor NF-kB. Arterioscler Thromb. Vasc. Biol., 1996, 16, 1501-1508.
189. Liang, Y.C.; Huang, Y.T.; Tsai, S.H.; Lin-Shiau, S.Y.; Chen, C.F.; Lin, J.K. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis, 1999, 20, 1945-1952.
190. Benavente-Garcia, O.; Castillo, J. Update on uses and properties of Citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity. J. Agric. Food Chem., 2008, 56, 6185-6205.
191. Kim, S.H.; Shin, K.J.; Kim, D.; Kim, Y.H.; Han, M.S.; Lee, T.G.; Kim, E.; Ryu, S.H.; Suh, P.G. Luteolin inhibits the nuclear factor-kappa B transcriptional activity in Rat-1 fibroblasts. Biochem. Pharmacol, 2003, 66, 955-963.
192. Ferrandiz, M. L.; Alcaraz, M. J. Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. Agents Actions, 1991, 32, 283-288.
193. Kimata, M.; Shichijo, M.; Miura, T.; Serizawa, I.; Inagaki, N.; Nagai, H. Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin. Exp. Allergy., 2000, 30, 501-508.
194. Ueda, H.; Yamazaki, C; Yamazaki, M. A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production. Biosci. Biotech-nol Biochem., 2004, 68, 119-125.
195. Chen, K. H.; Weng, M. S.; Lin, J. K. Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. Biochem. Pharmacol, 2007, 73, 215-227.
196. Hamalainen, M.; Nieminen, R.; Vuorela, P.; Heinonen, M.; Moilanen, E. Anti-inflammatory effects of flavonoids: ge-nistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm., 2007, 45673.
197. Crespo, I.; Garcia-Mediavilla, M. V.; Gutierrez, B.; Sanchez-Campos, S.; Tunon, M. J.; Gonzalez-Gallego, J. A comparison of the effects of kaempferol and quercetin on cytokine-induced proinflammatory status of cultured human endothelial cells. Br. J. Nutr., 2008, 100(5), 968-976.
198. Park, H. H.; Lee, S.; Son, H. Y.; Park, S. B.; Kim, M. S.; Choi, E. J.; Singh, T. S.; Ha, J. H.; Lee, M. G.; Kim, J. E.; Hyun, M. C; Kwon, T. K.; Kim, Y. H.; Kim, S. H. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch. Pharm. Res., 2008, 31, 1303-1311.
199. Ruiz, P. A.; Braune, A.; Holzlwimmer, G.; Quintanilla-Fend, L.; Haller, D. Quercetin inhibits TNF-induced NF-kB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J. Nutr., 2007, 137, 1208-1215.
200. Reiterer, G.; Toborek, M.; Hennig, B. Quercetin protects against linoleic acid-induced porcine endothelial cell dysfunction. J. Nutr., 2004, 134, 771-775.
201. Guardia, T.; Rotelli, A.E.; Juarez, A.O.; Pelzer, L.E. Antiinflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco, 2001, 56, 683-687.
202. Shizuka, H.; Young, K.; Tsuyoshi, G.; Min-Sook, K.; Mineka, Y.; Akio, O.; Rina, Y.; Teruo, K. Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. Life Sci., 2007, 81, 1272-1279.
203. Tanaka, S.; Sato, T.; Akimoto, N.; Yano, M.; Ito, A. Prevention of UVB-induced photoinflammation and photoaging by a polyme-thoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro. Biochem. Pharmacol, 2004, 68, 433-439.
204. Max, H.; Pittler-Edzard, E.R. Diet Nutrition and cancer: A Critical Evaluation. Boca Baton Florida: CRC Press, 1986.
205. •) production in murine macrophages by flavones. Biochem. Pharmacol. 1995, 50, 1031-1035.
206. Dijsselbloem, N.; Goriely, S.; Albarani, V.; Gerlo, S.; Francoz, S.; Marine, J.C.; Goldman, M.; Haegeman, G.; Vanden Berghe, W. A critical role for p53 in the control of NF-kappaB-dependent gene expression in TLR4-stimulated dendritic cells exposed to Genis-tein. J. Immunol, 2007, 178(8), 5048-5057.
207. Dijsselbloem, N.; Vanden Berghe, W.; De Naeyer, A.; Haegeman, G. Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy. Biochem. Pharmacol, 2004, 68, 1171-1185.
208. Molinie, B.; Georgel, P. Genetic and epigenetic regulations of prostate cancer by genistein. Drug News Perspect., 2009, 22, 247-254.
209. Vanden Berghe, W.; Dijsselbloem, N.; Vermeulen, L.; Ndlovu, N.; Boone, E.; Haegeman, G. Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappaB gene expression by soy isoflavones does not require estrogenic activity. Cancer Res., 2006, 66, 4852-4862.
210. Vanden Berghe, W.; Haegeman, G. Beneficial effects of soy isoflavones. Focus on epigenetic and anti-inflammatory effects. Agro Food Industry Hi-Tech., 2008, 19, 57-60.
211. Chew, B.P.; Park, J.S. Carotenoid action on the immune response. J. Nutr., 2004, 134, 257S-261S.
212. Heber, D.; Lu, QY. Overview of Mechanisms of Action of Lyco-pene. Exp. Biol. Med., 2002, 227, 920-923.
213. Hergoz, A.; Siler, V.; Seifert, N.; Denelavas, A.; Buchwald-Hunziker, P.; Hunziker, W.; Goralczyk, R.; Wertz, K. Lycopene reduced gene expression of steroid targets and inflammatory markers in normal rat prostate. FASEB J., 2005, 19, 272-274.
214. van Herpen-Broekmans, W.M.; Klöpping-Ketelaars, I.A.; Bots, M.L.; Kluft, C; Princen, H.; Hendriks, H.F.; Tijburg, L.B.; van Poppel, G.; Kardinaal, A.F. Serum carotenoids and vitamins in relation to markers of endothelial function and inflammation. Eur. J. Epidimiol, 2004, 19, 915-921.
215. Choi, S.K.; Young, S.P.; Choi, D.-K.; Charg, H.-I. Effects of astax-anthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells. J. Microbiol Bio-technol, 2008, 18, 1990-1996.
216. Safayhi, H.; Sabieraj, J.; Sailer, ER.; Ammon, H.P. Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation. Planta Med., 1994, 60, 410-413.
217. Miller, T.; Wittstock, U.; Lindequist, U.; Teuscher, E. Effects of some components of the essential oil of chamomile, Chamomilla recutita, on histamine release from rat mast cells. Planta Med. 1996, 62, 60-61.
218. Lin, W.; Wu, R. T.; Wu, T.; Khor, T. O.; Wang, H.; Kong, A. N. Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem. Pharmacol, 2008, 76, 967-973.
219. Woo, K. J.; Kwon, T. K. Sulforaphane suppresses lipopolysaccha-ride-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter. Int. Im-munopharmacol, 2007, 7, 1776-1783.
220. Murakami, A.; Song, M.; Ohigashi, H. Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages. Biofactors, 2007, 30, 1-11.
221. Jeong, W. S.; Kim, I. W.; Hu, R.; Kong, A. N. Modulatory properties of various natural chemopreventive agents on the activation of NF-kB signaling pathway. Pharm. Res., 2004, 21, 661-670.
222. Nakamura, Y.; Miyoshi, N.; Takabayashi, S.; Osawa, T. Benzyl isothiocyanate inhibits oxidative stress in mouse skin: Involvement of attenuation of leukocyte infiltration. Biofactors, 2004, 21, 255-257.
223. Miyoshi, N.; Takabayashi, S.; Osawa, T.; Nakamura, Y. Benzyl isothiocyanate inhibits excessive superoxide generation in inflammatory leukocytes: implication for prevention against inflammation-related carcinogenesis. Carcinogenesis, 2004, 25, 567-575.
224. Hou, D. X.; Masuzaki, S.; Hashimoto, F.; Uto, T.; Tanigawa, S.; Fujii, M.; Sakata, Y. Green tea proanthocyanidins inhibit cyclooxygenase-2 expression in LPS-activated mouse macrophages: molecular mechanisms and structure-activity relationship. Arch. Biochem. Biophys., 2007, 460, 67-74.
225. Hsieh, M. C; Shen, Y. J.; Kuo, Y. H.; Hwang, L. S. Antioxidative activity and active components of longan (Dimocarpus longan Lour.) flower extracts. J. Agric. Food Chem., 2008, 56, 7010-7016.
226. Seeram, N.P.; Momin, R.A.; Nair, M.G.; Bourqin, L.D. Cyclooxy-genase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine., 2001, 8(5), 362-369.
227. Wang, Q.; Xia, M.; Liu, C; Guo, H.; Ye, Q.; Hu, Y.; Zhang, Y.; Hou, M.; Zhu, H.; Ma, J.; Ling, W. Cyanidin-3-O-p-glucoside inhibits iNOS and COX-2 expression by inducing liver X receptor R activation in THP-1 macrophages. Life Sci., 2008, 83 (5-6), 176-184.
228. Oak, M. H.; Bedoui, J. E.; Madeira, S. V.; Chalupsky, K.; Schini-Kerth, V. B. Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK. Br. J. Pharmacol, 2006, 149, 283-290.
229. Ding, M.; Feng, R.; Wang, S. Y.; Bowman, L.; Lu, Y.; Qian, Y.; Castranova, V.; Jiang, B. H.; Shi, X. Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. J. Biol Chem., 2006, 281, 17359-17368.
230. Baumann, L.S. Active naturals: ancient medicine enters the scientific age. Semin. Cutan. Med. Surg., 2008, 27, 5-7.
231. Garbacki, N.; Gloaguen, V.; Damas, J.; Bodart, P.; Tits, M.; An-Genot, L. Anti-inflammatory and immunological effects of Centau-rea cyanus flower-heads. J. Ethnopharmacol, 1999, 68, 235-241.
232. Manach, C; Scalbert, A.; Morand, C; Remesy, C; Jimenez, L. Polyphenols: food sources and bioavailability. Am. J. Clin. Nutr., 2004, 79, 727-747.
233. Manach, C; Williamson, G.; Morand, C; Scalbert, A.; Remesy, C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr., 2005, 81, 230S-242S.
234. Williamson, G.; Manach, C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am. J. Clin. Nutr., 2005, 81, 243S-255S.