Allicin inhibits spontaneous and TNF-α induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells

Clinical Nutrition

Volumn 23, Issue 5, 2004, Pages 1199-1208

  Lang, Alon ^a   Lahav, Maor ^a   Sakhnini, Emad ^a   Barshack, Iris ^a   Fidder, Herma H ^a   Avidan, Benjamin ^a   Bardan, Eitan ^a   Hershkoviz, Rami ^b   Bar Meir, Simon ^a   Chowers, Yehuda ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b ASSAF HAROFEH MEDICAL CENTER   (Israel)

Author keywords

Allicin; Chemokines; Cytokines; Epithelial cells; Intestine; TNF

Indexed keywords

ALLICIN; ANTIINFLAMMATORY AGENT; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; I KAPPA B; INTERLEUKIN 1BETA; INTERLEUKIN 8; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ATTENUATION; CELL STRAIN CACO 2; CELL STRAIN HT29; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DRUG MECHANISM; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOMODULATION; INTESTINE EPITHELIUM CELL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; RNA ANALYSIS;

ANTI-INFECTIVE AGENTS; CACO-2 CELLS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HT29 CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1; INTERLEUKIN-8; INTESTINAL MUCOSA; PYRIMIDINONES; RNA, MESSENGER; SULFINIC ACIDS; THIAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 4544226878     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2004.03.011     Document Type: Article

References (52)

1. Dinarello C.A. Proinflammatory cytokines Chest 118 2000 503-508
2. Luster A.D. Chemokines-chemotactic cytokines that mediate inflammation N Engl J Med 338 1998 436-445
3. Papadakis K.A. Targan S.R. Role of cytokines in the pathogenesis of inflammatory bowel disease Annu Rev Med 51 2000 289-298
4. Stevens C. Walz G. Singaram C. et al. Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 expression in inflammatory bowel disease Dig Dis Sci 37 1992 818-826
5. Dionne S. Hiscott J. D'Agata I. Duhaime A. Seidman E.G. Quantitative PCR analysis of TNF-alpha and IL-1 beta mRNA levels in pediatric IBD mucosal biopsies Dig Dis Sci 42 1997 1557-1566
6. Gibson P. Rosella O. Interleukin 8 secretion by colonic crypt cells in vitro: response to injury suppressed by butyrate and enhanced in inflammatory bowel disease Gut 37 1995 536-543
7. MacDermott R.P. Sanderson I.R. Reinecker H.C. The central role of chemokines (chemotactic cytokines) in the immunopathogenesis of ulcerative colitis and Crohn's disease Inflamm Bowel Dis 4 1998 54-67
8. DeWitt R.C. Kudsk K.A. The gut's role in metabolism, mucosal barrier function, and gut immunology Infect Dis Clin North Am 13 1999 465-481
9. Cunningham-Rundles S. Nutrition and the mucosal immune system Curr Opin Gastroenterol 17 2001 171-176
10. Sanderson I.R. Naik S. Dietary regulation of intestinal gene expression Annu Rev Nutr 20 2000 311-338
11. Rink L. Kirchner H. Zinc-altered immune function and cytokine production J Nutr 130 2000 1407S-1411S
12. Cui D. Moldoveanu Z. Stephensen C.B. High-level dietary vitamin A enhances T-helper type 2 cytokine productions and secretory immunoglobulin A response to influenza A virus infection in BALB/c mice J Nutr 130 2000 1132-1139
13. Ling S.C. Griffiths A.M. Nutrition in inflammatory bowel disease Curr Opin Clin Nutr Metab Care 3 2000 339-344
14. Zachos M. Griffiths A.M. Enteral feeding and Crohn disease Curr Opin Gastroenterol 17 2001 167-170
15. Block E. The chemistry of garlic and onions Sci Am 252 1985 114-119
16. Ross Z.M. O'Gara E.A. Hill D.J. Sleightholme H.V. Maslin D.J. Antimicrobial properties of garlic oil against human enteric bacteria: evaluation of methodologies and comparisons with garlic oil sulfides and garlic powder Appl Environ Microbiol 67 2001 475-480
17. Ankri S. Mirelman D. Antimicrobial properties of allicin from garlic Microbes Infect 1 1999 125-129
18. Eilat S. Oestraicher Y. Rabinkov A. et al. Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic Coronary Artery Dis 6 1995 985-990
19. Lawson L.D. Ransom D.K. Hughes B.G. Inhibition of whole blood platelet-aggregation by compounds in garlic clove extracts and commercial garlic products Thromb Res 65 1992 141-156
20. Siegers C.P. Robke A. Pentz R. Effects of garlic preparations on superoxide production by phorbol ester activated granulocytes Phytomedicine 6 1999 13-16
21. Dirsch V.M. Gerbes A.L. Vollmar A.M. Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB Mol Pharmacol 53 1998 402-407
22. Chowdhury A.K. Ahsan M. Islam S.N. Ahmed Z.U. Efficacy of aqueous extract of garlic & allicin in experimental shigellosis in rabbits Indian J Med Res 93 1991 33-36
23. Yamada Y. Azuma K. Evaluation of the in vitro antifungal activity of allicin Antimicrob Agents Chemother 11 1977 743-749
24. Ankri S. Miron T. Rabinkov A. Wilchek M. Mirelman D. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica Antimicrob Agents Chemother 41 1997 2286-2288
25. Miron T. Rabinkov A. Mirelman D. Wilchek M. Weiner L. The mode of action of allicin: its ready permeability through phospholipid membranes may contribute to its biological activity Biochim Biophys Acta 1463 2000 20-30
26. Rabinkov A. Miron T. Konstantinovski L. Wilchek M. Mirelman D. Weiner L. The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins Biochim Biophys Acta 1379 1998 233-244
27. Eckmann L. Jung H.C. Schurer-Maly C. et al. Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin 8 Gastroenterology 105 1993 1689-1697
28. Gasperini S. Marchi M. Calzetti F. et al. Gene expression production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils J Immunol 162 1999 4928-4937
29. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 1983 55-63
30. Casini-Raggi V. Kam L. Chong Y.J. Fiocchi C. Pizarro T.T. Cominelli F. Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation J Immunol 154 1995 2434-2440
31. Cominelli F. Pizarro T.T. Interleukin-1 and interleukin-1 receptor antagonist in inflammatory bowel disease Aliment Pharmacol Ther 10 Suppl. 2 1996 49-53
32. Breese E.J. Michie C.A. Nicholls S.W. et al. Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease Gastroenterology 106 1994 1455-1466
33. MacDonald T.T. Hutchings P. Choy M.Y. Murch S. Cooke A. Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine Clin Exp Immunol 81 1990 301-305
34. Dwinell M.B. Lugering N. Eckmann L. Kagnoff M.F. Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells Gastroenterology 120 2001 49-59
35. Dwinell M.B. Eckmann L. Leopard J.D. Varki N.M. Kagnoff M.F. Chemokine receptor expression by human intestinal epithelial cells Gastroenterology 117 1999 359-367
36. Li Q. Verma I.M. NFκB regulation in the immune system Nat Rev 2 2002 725-735
37. Henkel T. Machleidt T. Alkalay I. Kronke M. Ben-Neirah Y. Baeuerie P.A. Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B Nature 365 1993 182-185
38. Brown K. Gerstberger S. Carlson L. Franzoso G. Siebenlist U. Control of IκB alpha proteolysis by site-specific, signal induced phosphorylation Science 267 1995 1485-1488
39. Finco T.S. Baldwin A.S. Mechanistic aspects of NF-kappaB regulation: the emerging role of phosphorylation and proteolysis Immunity 3 1995 263-272
40. Amagase H. Petesch B.L. Matsuura H. Kasuga S. Itakura Y. Intake of garlic and its bioactive components J Nutr 131 2001 955S-962S
41. Schwartz I.F. Hershkovitz R. Iaina A. et al. Garlic attenuates nitric oxide production in rat cardiac myocytes through inhibition of inducible nitric oxide synthase and the arginine transporter CAT-2 (cationic amino acid transporter-2) Clin Sci (London) 102 2002 487-493
42. Mahida Y.R. Ceska M. Effenberger F. Kurlak L. Lindley I. Hawkey C.J. Enhanced synthesis of neutrophil-activating peptide-1/interleukin-8 in active ulcerative colitis Clin Sci (London) 82 1992 273-275
43. Izzo R.S. Witkon K. Chen A.I. Hadjiyane C. Weinstein M.I. Pellecchia C. Neutrophil-activating peptide (interleukin-8) in colonic mucosa from patients with Crohn's disease Scand J Gastroenterol 28 1993 296-300
44. Plevy S.E. Landers C.J. Prehn J. et al. A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease J Immunol 159 1997 6276-6282
45. Baggiolini M. Dewald B. Moser B. Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines Adv Immunol 55 1994 97-179
46. Farber J.M. Mig and IP-10: CXC chemokines that target lymphocytes J Leukoc Biol 61 1997 246-257
47. Taub D.D. Lloyd A.R. Conlon K. et al. Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells J Exp Med 177 1993 1809-1814
48. Shibahara T. Wilcox J.N. Couse T. Madara J.L. Characterization of epithelial chemoattractants for human intestinal intraepithelial lymphocytes Gastroenterology 120 2001 60-70
49. Jung H.C. Eckmann L. Yang S.K. et al. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion J Clin Invest 95 1995 55-65
50. Augusti K.T. Therapeutic values of onion (Allium cepa L) and garlic (Allium sativum L) Indian J Exp Biol 34 1996 634-640
51. Hoshino T. Kashimoto N. Kasuga S. Effects of garlic preparations on the gastrointestinal mucosa J Nutr 131 2001 1109S-1113S
52. Horie T. Awazu S. Itakura Y. Fuwa T. Alleviation by garlic of antitumor drug-induced damage to the intestine J Nutr 131 2001 1071S-1074S