Regulation of Inducible Nitric Oxide Synthase Messenger RNA Expression and Nitric Oxide Production by Lipopolysaccharide in Vivo: The Roles of Macrophages, Endogenous IFN-γ, and TNF Receptor-1-Mediated Signaling

Journal of Immunology

Volumn 158, Issue 2, 1997, Pages 905-912

  Salkowski, Cindy A ^a   Detore, Gregory ^a   McNally, Ranney ^a   Van Rooijen, Nico ^b   Vogel, Stefanie N ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CLASSIFICATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM; MOUSE; MOUSE MUTANT; SIGNAL TRANSDUCTION;

ANIMALS; GENE EXPRESSION REGULATION; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RECEPTORS, TUMOR NECROSIS FACTOR; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031567894     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Manthey, C. L., and S. N. Vogel. 1992. The role of cytokines in the host response to endotoxin. Rev. Med. Microbiol. 3:72.
2. Salkowski, C. A., R. Neta, T. A. Wynn, G. Strassmann, N. van Rooijen, and S. N. Vogel. 1995. Effect of liposome-mediaied macrophage depletion on LPS-induced cytokine gene expression and radioprotection. J. Immunol. 155:3168.
3. Minnard, E. A., J. Shou, H. Naama, A. Cech, H. Gallagher, and J. M. Daly. 1994. Inhibition of nitric oxide synthesis is detrimental during endotoxemia. Arch. Surg. 129:142.
4. Parrillo, J. E. 1993. Pathogenic mechanisms of septic shock. N. Engl. J. Med. 328:1471.
5. Parker, M. M., J. H. Shelhamer, C. Natanson, D. W. Ailing, and J. E. Parrillo. 1987. Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: heart rate as an early predictor of prognosis. Crit. Care Med. 15: 923.
6. Abraham, E., R. Wunderink, H. Silverman, T. M. Perl, S. Nasraway, H. Levy, R. Bone, R. P. Wenzel, R. Balk, R. Allred, J. E. Pennington. and J. C. Wherry. 1995. Efficacy and safety of monoclonal antibody to human tumor necrosis factor α in patients with sepsis syndrome: a randomized, controlled, double-blind, multicenter clinical trial. JAMA 273:934.
7. Ochoa, J. B., A. O. Udekwu, T. R. Billiar, R. D. Curran, F. B. Cerra, R. L. Simmons, and A. B. Peitzman. 1991. Nitrogen oxide levels in patients after trauma and during sepsis. Ann. Surg. 214:621.
8. G-monomethyl-L-arginine or indomethacin. J. Pharmacol. Exp. Ther. 272:452.
9. Knowles, R. G., M. Merrett, M. Salter, and S. Moncada. 1990. Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem. J. 270:833.
10. Thiemermann, C., C. C. Wu, C. Szabó, M. Perretti, and J. R. Vane. 1993. Role of tumor necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock. Br. J. Immunol. 110:177.
11. Petros, A., D. Bennett, and P. Vallance. 1991. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 338:1557.
12. Szabó, C., J. A. Mitchell, C. Thiemermann, and J. R. Vane. 1993. Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br. J. Pharmacol. 108:786.
13. W-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin. J. Exp. Med. 176:1175.
14. MacMicking, J. D., C. Nathan, G. Hom, N. Chartrain, D. S. Fletcher, M. Trumbauer, K. Stevens, Q.-W. Xie, K. Sokol, N. Hutchinson, H. Chen, and J. S. Mudgett. 1995. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641.
15. Laubach, V. E., E. G. Shesely, O. Smithies, and P. A. Sherman. 1995. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc. Natl. Acad. Sci. USA 92:10688.
16. Wei, X.-Q., I. G. Charles, A. Smith, J. Ure, G.-J. Feng, F.-P. Huang, D. Xu, W. Muller, S. Moncada, and F. Y. Liew. 1995. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375:408.
17. Radomski, M. W., R. M. Palmer, and S. Moncada. 1990. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc. Natl. Acad. Sci. USA 87:5193.
18. Kubes, P., M. Suzuke, and D. N. Granger. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Nutl. Acad. Sci. USA 88:4651.
19. Shultz, P. J., and L. Raij. 1992. Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis. J. Clin. Invest. 90:1718.
20. Ding, A., C. F. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407.
21. Kilbourn, R. G., and P. Belloni. 1990. Endothelial cell production of nitrogen oxides in response to interferon γ in combination with tumor necrosis factor, interleukin-1, or endotoxin. J. Natl. Cancer Inst. 80:772.
22. Geller, D. A., A. K. Nussler, M. Di Silvio, C. J. Lowenstein, R. A. Shapiro, S. C. Wang, R. L. Simmons, and T. R. Billiar. 1993. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc. Natl. Acad. Sci. USA 90:522.
23. Evans, T., A. Carpenter, A. Silva, and J. Cohen. 1992. Differential effects of monoclonal antibodies to tumor necrosis factor alpha and gamma interferon on induction of hepatic nitric oxide synthase in experimental Gram-negative sepsis. Infect. Immun. 60:4133.
24. Geller, D. A., M. E. de Vera, D. A. Russell, R. A. Shapiro, A. K. Nussler, R. L. Simmons, and T. R. Billiar. 1995. A central role for IL-1β in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase: IL-1β induces hepatic nitric oxide synthase. J. Immunol. 155:4890.
25. Szabó, C., C.-C. Wu, S. S. Gross, C. Thiemermann, and J. R. Vane. 1993. Interleukin 1 contributes to the induction of nitric oxide synthase by endotoxin in vivo. Eur. J. Pharmacol. 250:157.
26. Leist, M., F. Gantner, S. Jilg, and A. Wendel. 1995. Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J. Immunol. 154:1307.
27. McIntire, F. C., H. W. Sievart, G. H. Barlow, R. A. Finley, and A. A. Lee. 1967. Chemical, physical and biological properties of lipopolysaccharide from Escherichia coli K-235. Biochemistry 6:2363.
28. van Rooijen, N., and A. Sanders. 1994. Liposome-mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol. Methods 174:83.
29. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple detects of immune cell function in mice with disrupted IFN-γ genes. Science 259:1739.
30. Pfeffer, K., T. Matsuyama. T. M. Kündig, A. Wakeham, K. Kishihara, A. Shahinian, K. Wiegmann, P. S. Ohashi, M. Kranke, and T. W. Mak. 1993. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73:457.
31. Manthey, C. L., P. Y. Perera, C. A. Salkowski, and S. N. Vogel. 1994. Taxol provides a second signal for murine macrophage tumoricidal activity. J. Immunol. 152:825.
32. Salkowski, C. A., S. A. Barber, G. R. Detore, and S. N. Vogel. 1996. Differential dysregulation of nitric oxide production in macrophages with targeted disruptions in IRF-1 and IRF-2 genes. J. Immunol. 156:3107.
33. Misko, T. P., R. J. Schilling, D. Salvemini, W. M. Moore, and M. G. Currie. 1993. A fluorometric assay for the measurement of nitrite in biological samples. Anal. Biochem. 214:11.
34. 15N]nitrate in biological fluids. Anal. Biochem. 126:131.
35. van Rooijen, N., and R. van Nieuwmegen. 1984. Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate: an enzyme-histochemical study. Cell Tissue Res. 238:355.
36. van Rooijen, N., N. Kors, M. van de Ende, and C. D. Dijkstra. 1990. Depletion and repopulation of macrophage in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate. Cell Tissue Res. 260:215.
37. Qian, Q., M. A. Jutila, N. van Rooijen, and J E. Cutler. 1994. Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis J. Immunol. 152:5000.
38. van Rooijen, N., N. Kors, and G. Kraal. 1989. Macrophage subset repopulation in the spleen: differential kinetics after liposome-mediated elimination. J. Leukocyte Biol. 45:97.
39. Bogers, W. M. J. M., R.-K. Stad, D. J. Janssen, N. van Rooijen, L. A. van Es, and M. R. Daha. 1991. Kupffer cell depletion in vivo results in preferential elimination of IgG aggregates and immune complexes via specific Fc receptors on rat liver endothelial cells. Clin. Exp. Immunol. 86:328.
40. Ding, A. H., C. F. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407.
41. Vodovotz, Y., C. Bogdan, J. Paik, Q.-W. Xie, and C. Nathan. 1993. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor β. J. Exp. Med. 178:605.
42. Vieira, L. Q., M. Goldschmidt, M. Nashleanas. K. Pfeffer, T. Mak, and P. Scott. 1996. Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication. J. Immunol. 157: 827.
43. Billiar, T. R., R. D. Curran, D. J. Stuehr, M. A. West, B. G. Bentz, and R. L. Simmons. 1989. An L-arginine-dependent mechanism mediates Kupfler cell inhibition of hepatocyte protein synthesis in vitro. J. Exp. Med. 169: 1467.
44. Curran, R. D., T. R. Billiar, D. J. Stuehr, J. B. Ochoa, B. G. Harbrecht, S. G. Flint, and R. L. Simmons. 1990. Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis. Ann. Surg. 212:462.
45. Szabó, C., C.-C. Wu, J. A. Mitchell, S. S. Gross, C. Thiemennann, and J. R. Vane. 1993. Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide. Circ. Res. 73:991.
46. Bogdan, C., Y. Vodovotz, J. Paik, Q.-W. Xie, and C. Nathan. 1994. Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages. J. Leukocyte Biol. 55:227.
47. Gazzinelli, R. T., I. P. Oswald, S. L. James, and A. Sher. 1992. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ-activated macrophages. J. Immunol. 148:1792.