Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity

European Journal of Pharmacology

Volumn 428, Issue 1, 2001, Pages 137-143

  Giner Larza, Eva M ^a   Máez, Salvador ^a   Recio, M Carmen ^a   Giner, Rosa M ^a   Prieto, José M ^a   Cerdá Nicolás, Miguel ^a   Ríos, J Luis ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

(Pistacia terebinthus); Inflammation; Leukotriene; Oleanonic acid; Skin; Triterpenoid

Indexed keywords

12 DEOXYPHORBOL 13 PHENYLACETATE; 3 OXOTRITERPENE; ARACHIDONATE 5 LIPOXYGENASE; BRADYKININ; CALCIMYCIN; KETONE; LEUKOTRIENE B4; OLEANOLIC ACID DERIVATIVE; PHENYLACETIC ACID DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE A2; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DERMATITIS; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; EDEMA; ENZYME ACTIVITY; IC 50; LEUKOCYTE; MOUSE; NONHUMAN; OXIDATION; PAW EDEMA; PISTACIA TEREBINTHUS; PLANT; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD PLATELETS; CYCLOOXYGENASE INHIBITORS; DRUG SCREENING ASSAYS, ANTITUMOR; EAR, EXTERNAL; EDEMA; FEMALE; FOOT; HUMANS; HYPERSENSITIVITY, DELAYED; INFLAMMATION; LEUKOTRIENE B4; LEUKOTRIENES; MICE; NEUTROPHILS; OLEANOLIC ACID; OXIDATION-REDUCTION; PEROXIDASE; PISTACIA; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLIUM SALTS; THIAZOLES; TRITERPENES;

EID: 0035964699     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01290-0     Document Type: Article

References (19)

1. Influence of 16α,17α-acetal substitution and steroid nucleus fluorination on the topical to systemic activity ratio of glucocorticoids
2. 2-induced oedema in rat paw
3. Edema and cell infiltration in the phorbol ester-treated mouse ear oedema are temporally separate and can be differentially modulated by pharmacological agents
4. Anti-inflammatory glycoterpenoids from Scrophularia auriculata
5. In vivo studies on the anti-inflammatory activity of pachymic and dehydrotumulosic acids
6. 2 activity of extracts from lanostane-rich species
7. On the activity of trifluoperazine and palmitoylcarnitine in mice delayed hypersensitivity models
8. Effect of triterpenoids on the inflammation induced by protein kinase C activators, neuronally-acting irritants and other agents
9. Inhibitory effects of lantadenes and related triterpenoids on Epstein-Barr virus activation
10. In vitro test system for the evaluation of dual cyclooxygenase and 5-lipoxygenase inhibitors
11. Rapid colorimetric assay for cellular growth and survival: Applications to proliferation and cytotoxic assays
12. 2 and phospholipase C
13. Study of the antioedema activity of some seaweed and sponge extracts from the Mediterranean coast in mice
14. Oxidation of brefeldin A
15. Structural requirements for the anti-inflammatory of natural triterpenoids
16. Natural triterpenoids as anti-inflammatory agents
17. Mechanism of 5-lipoxygenase inhibition by acetil-11-keto-β-boswellic acid
18. Mouse skin inflammation induced by multiple topical applications of 12-O-tetradecanoylphorbol-13-acetate
19. Blockade by antiglucocorticoids, actinomycin D and cycloheximide of anti-inflammatory action of dexamethasone against bradykinin