Novel anti-inflammatory chalcone derivatives inhibit the induction of nitric oxide synthase and cyclooxygenase-2 in mouse peritoneal macrophages

FEBS Letters

Volumn 453, Issue 1-2, 1999, Pages 129-134

  Herencia, Felipe ^a   Ferrándiz, M Luisa ^a   Ubeda, Amalia ^a   Guillén, Isabel ^a   Dominguez, José N ^b   Charris, Jaime E ^b   Lobo, Gricela M ^b   Alcaraz, M José ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

Author keywords

Chalcone; Cyclooxygenase 2; Inducible nitric oxide synthase; Lipopolysaccharide; Mouse air pouch; Mouse peritoneal macrophage

Indexed keywords

ANTIINFLAMMATORY AGENT; CHALCONE DERIVATIVE; CYCLOOXYGENASE 2; ENZYME INHIBITOR; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; PROSTAGLANDIN E2; ZYMOSAN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHALCONE; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; FEMALE; ISOENZYMES; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; ZYMOSAN;

EID: 0345551893     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(99)00707-3     Document Type: Article

References (44)

1. Lee, S.H., Soyoola, E., Chanmugam, P., Hart, S., Sun, W., Zhong, H., Liou, S., Simmons, D. and Hwang, D. (1992) J. Biol. Chem. 267, 25934-25938.
2. Nathan, C. and Xie, Q.W. (1994) J. Biol. Chem. 269, 13725-13728.
3. Reddy, S.T. and Herschman, H.R. (1994) J. Biol. Chem. 269, 15473-15480.
4. Wallace, J.L., Bak, A., McKnight, W., Asfaha, S., Sharkey, K.A. and MacNaughton, W.K. (1998) Gastroenterology 115, 101-109.
5. Marcinkiewicz, J., Grabowska, A. and Chain, B. (1995) Eur. J. Immunol. 25, 947-951.
6. Salkowski, C.A., Detore, G., McNally, R., van Rooijen, N. and Vogel, S.N. (1997) J. Immunol. 158, 905-912.
7. Salvemini, D., Misko, T.P., Masferrer, J.L., Seibert, K., Currie, M.G. and Needleman, P. (1993) Proc. Natl. Acad. Sci. USA 90, 7240-7244.
8. Swierkosz, T.A., Mitchell, J.A., Warner, T.D., Botting, R.M. and Vane, J.R. (1995) Br. J. Pharmacol. 114, 1335-1342.
9. Akarasereenont, P., Mitchell, J.A., Appleton, I., Thiemermann, C. and Vane, J.R. (1994) Br. J. Pharmacol. 113, 1522-1528.
10. Vane, J.R., Mitchell, J.A., Appleton, I., Tomlison, A., Bishop-Bailey, D., Croxtall, J. and Willoughby, D.A. (1994) Proc. Natl. Acad. Sci. USA 91, 2046-2050.
11. Tomlinson, A., Appleton, I., Moore, A.R., Gilroy, D.W., Willis, D., Mitchell, J.A. and Willoughby, D.A. (1994) Br. J. Pharmacol. 113, 693-698.
12. Salvemini, D., Seibert, K., Masferrer, J., Misko, T.P., Currie, M.G. and Needleman, P. (1994) J. Clin. Invest. 93, 1940-1947.
13. Payá, M., García Pastor, P., Coloma, J. and Alcaraz, M.J. (1997) Br. J. Pharmacol. 120, 1445-1452.
14. Alcaraz, M.J., Posadas, I., Terencio, M.C., Payá, M. and Ferrándiz, M.L. (1997) Inflamm. Res. 46, S238.
15. Herencia, F., Ferrándiz, M.L., Ubeda, A., Domínguez, J.N., Charris, J.E., Lobo, G.M. and Alcaraz, M.J. (1998) Bioorg. Med. Chem. Lett. 8, 1169-1174.
16. Terenzi, F., Diaz-Guerra, M.J., Casado, M., Hortelano, S., Leoni, S. and Bosca, L. (1995) J. Biol. Chem. 270, 6017-6021.
17. Gross, S.S. and Levi, R. (1992) J. Biol. Chem. 267, 25722-25729.
18. Misko, T.P., Schilling, R.J., Salvemini, D., Moore, W.M. and Currie, M.G. (1993) Anal. Biochem. 214, 11-16.
19. Moroney, M.A., Alcaraz, M.J., Forder, R.A., Carey, F. and Hoult, J.R.S. (1988) J. Pharm. Pharmacol. 40, 787-792.
20. Mitchell, J.A., Sheng, H., Förstermann, U. and Murad, F. (1991) Br. J. Pharmacol. 104, 289-291.
21. Escrig, V., Ubeda, A., Ferrándiz, M.L., Darias, J., Sánchez, J.M., Alcaraz, M.J. and Paya, M. (1997) J. Pharmacol. Exp. Ther. 282, 123-131.
22. Bradford, M.M. (1976) Anal. Biochem. 72, 248-254.
23. Connor, J.R., Manning, P.T., Settle, S.L., Moore, W.M., Jerome, G.M., Webber, R.K., Tjoeng, F.S. and Currie, M.G. (1995) Eur. J. Pharmacol. 273, 15-24.
24. luvone, T., Carnuccio, R. and Di Rosa, M. (1994) Eur. J. Pharmacol. 265, 89-92.
25. Yamada, T., Sartor, R.B., Marshall, S., Specian, R.D. and Grisham, M.B. (1993) Gastroenterology 104, 759-771.
26. Ianaro, A., O'Donnell, C.A., Di Rosa, M. and Liew, F.Y. (1994) Immunology 82, 370-375.
27. Alving, K., Weitzberg, E. and Lundberg, J.M. (1993) Eur. Respir. J. 6, 1368-1370.
28. Grabowski, P.S., England, A.J., Dykhuizen, R., Copland, M., Benjamin, N., Reid, D.M. and Ralston, S.H. (1996) Arthritis Rheum. 39, 643-647.
29. Farrell, A.J., Blake, D.R., Palmer, R.M.J. and Moncada, S. (1992) Ann. Rheum. Dis. 51, 1219-1222.
30. Kaur, H. and Halliwell, B. (1994) FEBS Lett. 350, 9-12.
31. Amin, A.R., Di Cesare, P.E., Vyas, P., Attur, M., Tzeng, E., Billiar, T.R., Stuchin, S.A. and Abramson, S.B. (1995) J. Exp. Med. 182, 2097-2102.
32. Habib, A., Bernard, C., Lebret, M., Créminon, C., Esposito, B., Tedgui, A. and Maclouf, J. (1997) J. Immunol. 158, 3845-3851.
33. Bishop-Bailey, D., Larkin, S.W., Warner, T.D., Chen, G. and Mitchell, J.A. (1997) Br. J. Pharmacol. 121, 125-133.
34. Guastadisegni, C., Minghetti, L., Nicolini, A., Polazzi, E., Ade, P., Balduzzi, M. and Levi, G. (1997) FEBS Lett. 413, 314-318.
35. Zingarelli, B., Southan, G.J., Gilad, E., O'Connor, M., Salzman, A.L. and Szabo, C. (1998) Immunology 95, 625-630.
36. Hamilton, L.C. and Warner, T.D. (1998) Br. J. Pharmacol. 125, 335-340.
37. Pang, L. and Hoult, J.R.S. (1996) Eur. J. Pharmacol. 317, 151-155.
38. D'Acquisto, F., Sautebin, L., luvone, T., Di Rosa, M. and Carnuccio, R. (1998) FEBS Lett. 440, 76-80.
39. Medeiros, M.V., Binhara, I.M., Moreno, H., Zatz, R., de Nucci, G. and Antunes, E. (1995) Eur. J. Pharmacol. 285, 109-114.
40. Miller, M.J., Munshi, U.K., Sadowska Krowicka, H., Kakkis, J.L., Zhang, X.J., Eloby Childress, S. and Clark, D.A. (1994) Dig. Dis. Sci. 39, 1185-1192.
41. Luss, H., DiSilvio, M., Litton, A.L., Molina, V., Nussler, A.K. and Billiar, T.R. (1994) Biochem. Biophys. Res. Commun. 204, 635-640.
42. Hecker, M., Preiß, C., Klemm, P. and Busse, R. (1996) Br. J. Pharmacol. 118, 2178-2184.
43. Callejas, N.A., Castrillo, A., Boscá, L. and Martín-Sanz, P. (1999) J. Pharmacol. Exp. Ther. 288, 1235-1241.
44. Hamilton, L.C., Mitchell, J.A., Tomlison, A.M. and Warner, T.D. (1999) FASEB J. 13, 245-251.