Plant extracts from Central Asia showing antiinflammatory activities in gene expression assays

Phytotherapy Research

Volumn 22, Issue 7, 2008, Pages 929-934

  Dey, Moul ^a   Ripoll, Christophe ^a   Pouleva, Reneta ^a   Dorn, Ruth ^a   Aranovich, Irina ^a   Zaurov, David ^a   Kurmukov, Anvar ^b   Eliseyeva, Marietta ^b   Belolipov, Igor ^c   Akimaliev, Anarbek ^d   Sodombekov, Ishenbay ^d   Akimaliev, Djamin ^e   Lila, Mary Ann ^f   Raskin, Ilya ^a  

^a RUTGERS UNIVERSITY   (United States)

^b Institute of Cardiology   (Uzbekistan)

^c TASHKENT STATE AGRARIAN UNIVERSITY   (Uzbekistan)

^d Kyrgyz National Academy of Sciences   (Kyrgyzstan)

^e Kyrgyz Agriculture Research Institute   (Kyrgyzstan)

^f UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Antiinflammatory natural product; Gene expression; Real time RT PCR

Indexed keywords

ACHILLEA FILIPENDULINA EXTRACT; APIACEAE EXTRACT; APOCYNACEAE EXTRACT; BERBERIDACEAE EXTRACT; BORAGINACAEAE EXTRACT; CAMPANULACEAE EXTRACT; CENTAUREA SOLSTITIALIS EXTRACT; CYCLOOXYGENASE 2; EUPHORBIA EXTRACT; FABACEAE EXTRACT; GERANIACEAE EXTRACT; HAPLOPHYLLUM PERFORATUM EXTRACT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; IRIDACEAE EXTRACT; LAMIACEAE EXTRACT; MALVACEAE EXTRACT; MESSENGER RNA; PLANT EXTRACT; PLANTAGINACEAE EXTRACT; POACEAE EXTRACT; POLYGONACEAE EXTRACT; RANUNCULACEAE EXTRACT; ROSACEAE EXTRACT; RUTACEAE EXTRACT; SALICACEAE EXTRACT; TANACETUM PSEUDOACHILLEA EXTRACT; UNCLASSIFIED DRUG; VALERIANACEAE EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASIA; CONTROLLED STUDY; GENE EXPRESSION; GENETIC MARKER; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASIA, CENTRAL; CELL SURVIVAL; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; GENE EXPRESSION PROFILING; INHIBITORY CONCENTRATION 50; INTERLEUKIN-1BETA; MACROPHAGES; MEDICINE, ORIENTAL TRADITIONAL; MICE; NITRIC OXIDE SYNTHASE TYPE II; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 48749091479     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2427     Document Type: Article

References (24)

1. Adang AE, Hermkens PH. 2001. The contribution of combinatorial approaches to lead generation: an interim analysis. Curr Med Chem 8: 985-998.
2. Clark DE, Pickett SD. 2000. Computational methods for the prediction of drug-likeness. Drug Discov Today 5: 49-58.
3. Dey M, Ribnicky D, Kurmukov AG, Raskin I. 2006. Transcriptional modulation and in vivo anti-inflammatory activity of a seed preparation containing phenethylisothiocyanate. J Pharmacol Exp Ther 317: 326-333.
4. Esposito K, Giugliano D. 1994. The metabolic syndrome and inflammation, association or causation? Nutr Metab Cardiovasc Dis 14: 228-232.
5. Farnsworth NR. 1988. Screening plants for new medicines. In Biodiversity, Wilson EO (ed.). National Academy Press: Washington DC, 83-97.
6. Gentry AH. 1993. Tropical forest biodiversity and the potential for new medicinal plants. ACS Symp Ser 534: 13-20.
7. Gerhauser C, Klimo K, Heiss E et al. 2003. Mechanism-based in vitro screening of potential cancer chemopreventive agents. Mutat Res 523: 163-172.
8. Juni P, Reichenbach S, Egger M. 2005. COX2 inhibitors, traditional NSAIDs and the heart. Br Med J 330: 1342-1343.
9. Krakauer T. 2004. Molecular therapeutic targets in inflammation, cyclooxygenase and NFκβ. Curr Drug Targets 3: 317-324.
10. Kwok BH, Koh B, Ndubuisi Ml, Elofsson M, Crews CM. 2001. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol 8: 759-766.
11. Li Q, Withoff S, Verma IM. 2005. Inflammation-associated cancer, NF-kappaB is the lynchpin. Trends Immunol 26: 318-325.
12. Mendelson R, Balick MJ. 1995. The value of undiscovered pharmaceuticals in tropical forests. Econ Bot 49: 223-228.
13. Nathan C, Xie QW. 1994. Nitric oxide synthases: roles, tolls and controls. Cell 78: 915-918.
14. Newman DJ, Cragg GM, Snader KM. 2000. The influence of natural products upon drug discovery. Nat Prod Rep 17: 215-234.
15. Ohshima H, Bartsch H. 1994. Chronic infections and inflammatory processes as cancer risk factors, possible role of nitric oxide in carcinogenesis. Mutat Res 305: 253-264.
16. Pathak SK, Sharma RA, Steward WP, Mellon JK, Griffiths TR, Gescher AJ. 2005. Oxidative stress and cyclooxygenase activity in prostate carcinogenesis, targets for chemopreventive strategies. Eur J Cancer 41: 61-70.
17. Picman AK. 1986. Biological activities of sesquiterpene lactones. Biochem Syst Ecol 14: 255-281.
18. Raskin I, Ribnicky DM, Komarnytsky S et al. 2002. Plants and human health in the 21st century. Trends Biotechnol 20: 522-531.
19. Raskin I, Ripoll C. 2004. Can an apple a day keep the doctor away? Curr Pharm Design 10: 3419-3429.
20. Rose P, Won YK, Ong CN, Whiteman M. 2005. [beta]-Phenylethyl and 8-methylsulphinyloctyl isothiocyanates constituents of watercress suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 2647 macrophages. Nitric Oxide 12: 237-243.
21. Schenk T, Breel GJ, Koevoets P et al. 2003. Screening of natural products extracts for the presence of phosphodiesterase inhibitors using liquid chromatography coupled online to parallel biochemical detection and chemical characterization. J Biomol Screen 8: 421-429.
22. Schreiber SL. 2000. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science 287: 1964-1969.
23. Tukey JW. 1972. Robust Estimates of Location: Survey and Advances. Princeton University Press: Princeton, USA.
24. Winer J, Jung CK, Shackel I, Williams PM. 1999. Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem 270: 41-49.