The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase

Chemistry and Biology

Volumn 8, Issue 8, 2001, Pages 759-766

  Kwok, Benjamin H B ^a   Koh, Brian ^a   Ndubuisi, MacKevin I ^a   Elofsson, Mikael ^a,c   Crews, Craig M ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

Anti inflammatory; Feverfew; I B kinase; Parthenolide

Indexed keywords

ANTIINFLAMMATORY AGENT; CHUK PROTEIN, HUMAN; CHUK PROTEIN, MOUSE; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKB PROTEIN, MOUSE; IKBKE PROTEIN, HUMAN; IKBKE PROTEIN, MOUSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; PARTHENOLIDE; PROTEIN SERINE THREONINE KINASE; SESQUITERPENE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BIOTINYLATION; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG ANTAGONISM; EDEMA; GENETIC TRANSFECTION; GENETICS; HELA CELL; HUMAN; MEDICINAL PLANT; METABOLISM; MOUSE; MUTATION; STRUCTURE ACTIVITY RELATION; TANACETUM PARTHENIUM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOTINYLATION; EDEMA; HELA CELLS; HUMANS; I-KAPPA B KINASE; LUCIFERASES; MICE; MUTATION; NF-KAPPA B; PLANTS, MEDICINAL; PROTEIN-SERINE-THREONINE KINASES; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP; TANACETUM PARTHENIUM; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034879173     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00049-7     Document Type: Article

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