Luteolin inhibits the nuclear factor-κB transcriptional activity in Rat-1 fibroblasts

Biochemical Pharmacology

Volumn 66, Issue 6, 2003, Pages 955-963

  Kim, Sun Hee ^a   Shin, Kum Joo ^a   Kim, Dohan ^a   Kim, Yun Hee ^a   Han, Myoung Sook ^a   Lee, Taehoon G ^a   Kim, Euikyung ^a   Ryu, Sung Ho ^a   Suh, Pann Ghill ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Anti inflammation; Coactivator; Fibroblast; Lipopolysaccharide; Luteolin; Nuclear factor kappa B

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FLAVONOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LUCIFERASE; LUTEOLIN; PROTEIN C JUN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DATA ANALYSIS; DNA BINDING; DRUG EFFECT; DRUG POTENCY; ENZYME ASSAY; FIBROBLAST; INHIBITION KINETICS; MOLECULAR DYNAMICS; NONHUMAN; PHARMACOLOGICAL BLOCKING; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; RECEPTOR GENE; TRANSCRIPTION INITIATION;

EID: 0042762838     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00465-9     Document Type: Article

References (30)

1. Di Carlo G., Mascolo N., Izzo A.A., Capasso F. Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci. 65:1999;337-353.
2. Shimoi K., Okada H., Furugori M., Goda T., Takase S., Suzuki M., Hara Y., Kinae N. Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. FEBS Lett. 438:1998;220-224.
3. Samejima K., Kanazawa K., Ashida H., Danno G. Luteolin: a strong antimutagen against dietary carcinogen, Trp-P-2, in peppermint, sage, and thyme. J. Agric. Food Chem. 43:1995;410-414.
4. Casagrande F., Darbon J.M. Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem. Pharmacol. 61:2001;1205-1215.
5. Kim H.K., Cheon B.S., Kim Y.-H., Kim S.Y., Kim H.P. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem. Pharm. 58:1999;759-765.
6. Xagorari A., Papapetropoulos A., Economou M., Fotsis T., Roussos C. Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. Pharmacol. Exp. Ther. 296:2001;181-187.
7. Rothwarf DM, Karin M. The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Sci STKE 1999;1999:RE1.
8. Gerritsen M.E., Williams A.J., Neish A.S., Moore S., Shi Y., Collins T. CREB-binding protein/p300 are transcriptional coactivators of p65. Proc. Natl. Acad. Sci. U.S.A. 94:1997;2927-2932.
9. Chan H.M., La Thangue N.B. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J. Biol. Chem. 276:2001;13505-13508.
10. Kwok R.P., Lundblad J.R., Chrivia J.C., Richards J.P., Bachinger H.P., Brennan R.G., Roberts S.G., Green M.R., Goodman R.H. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature. 370:1994;223-226.
11. Bannister A.J., Koizarides T. CBP-induced stimulation of c-Fos activity is abrogated by E1A. EMBO J. 14:1995;4758-4762.
12. Lee J.S., See R.H., Deng T., Shi Y. Adenovirus E1A downregulates cJun- and JunB-mediated transcription by targeting their coactivator p300. Mol. Cell Biol. 16:1996;4312-4326.
13. Grossman S.R. p300/CBP/p53 interaction and regulation of the p53 response. Eur. J. Biochem. 268:2001;2773-2778.
14. Jennifer A., Shumilla J.A., Wang Y., Barchowsyk A., Broderick R.J. Chromium(VI) inhibits the transcriptional activity of nuclear factor-kappa B by decreasing the interaction of p65 with cAMP-responsive element-binding protein-binding protein. J. Biol. Chem. 274:1999;36207-36212.
15. Delgado M., Ganea D. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit nuclear factor-kappa B-dependent gene activation at multiple levels in the human monocytic cell line THP-1. J. Biol. Chem. 276:2001;369-380.
16. De Bosscherk K, Vanden Berghe W, Haegerman G. Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators. Mol Endocrinol 2001;15:219-27.
17. Ito K., Barnes P.J., Adcock I.M. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol. Cell Biol. 20:2000;6891-6903.
18. Suk K., Chang I., Kim Y.-H., Kim S., Kim J.Y., Kim H., Lee M.S. Interferon gamma (IFNgamma) and tumor necrosis factor alpha synergism in ME-180 cervical cancer cell apoptosis and necrosis. IFNgamma inhibits cytoprotective NF-kappa B through STAT1/IRF-1 pathways. J. Biol. Chem. 276:2001;13153-13159.
19. Naumann M., Sheiderent C. Activation of NF-kappa B in vivo is regulated by multiple phosphorylations. EMBO J. 13:1994;4597-4607.
20. Jeong S.Y., Ahn S.G., Lee J.H., Kim H.S., Kim J.W., Rhim H., Jeong S.W., Kim I.K. 3-Deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. J. Biol. Chem. 274:1999;18981-18988.
21. Chrivia J.C., Kwok R.P., Lamb N., Hagiwara M., Montminy M.R., Goodman R.H. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 365:1993;855-859.
22. Bannister A.J., Oehler T., Wilhelm D., Angel P., Kouzarides T. Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene. 1:1995;2509-2514.
23. Zhong H., Voll R.E., Ghosh S. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell. 1:1998;661-671.
24. Buckley C.D., Pilling D., Lord J.M., Akbar A.N., Scheel-Toellner D., Salmon M. Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol. 22:2001;199-204. Review.
25. Miagkov A.V., Kovalenko D.V., Brown C.E., Didsbury J.R., Cogswell J.P., Stimpson S.A., Baldwin A.S., Makarov S.S. NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc. Natl. Acad. Sci. U.S.A. 95:1998;13859-13864.
26. Liang Y.C., Huang Y.T., Tsaim S.H., Lin-Shiau S.Y., Chen C.F., Lin J.K. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis. 20:1999;1945-1952.
27. Wadsworth T.L., McDonald T.L., Koop D.R. Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-alpha. Biochem. Pharmacol. 62:2001;963-974.
28. Ollivier V., Parry G.C., Cobb R.R., de Prost D., Mackman N. Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells. J. Biol. Chem. 271:1996;20828-20835.
29. Kuppusamy U.R., Das N.P. Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes. Biochem. Pharmacol. 44:1992;1307-1315.
30. de Groot R.P., Sassone-Corsi P. Activation of Jun/AP-1 by protein kinase A. Oncogene. 7:1992;2281-2286.