Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms

Free Radical Biology and Medicine

Volumn 49, Issue 9, 2010, Pages 1328-1341

  Matés, José M ^a   Segura, Juan A ^a   Alonso, Francisco J ^a   Márquez, Javier ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Alzheimer; Cadmium; Cobalt; Copper; Free radicals; Idazoxan; Parkinson; ROS; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AMYLOID BETA PROTEIN; CADMIUM; CASPASE 3; COBALT; COPPER; CYCLOOXYGENASE 2; CYCLOPHILIN A; CYTOCHROME P450; DIOXIN; ENDOTHELIN 1; ENDOTHELIN 2; EXTRACELLULAR SUPEROXIDE DISMUTASE; GLUTATHIONE PEROXIDASE; HEAT SHOCK PROTEIN; IDAZOXAN; INTERLEUKIN 6; METALLOTHIONEIN; PEROXIREDOXIN; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOREDOXIN;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; BRAIN TISSUE; BRAIN VASOSPASM; CANCER CELL; CARCINOGENESIS; CELL DIFFERENTIATION; CELL DIVISION; CELL GROWTH; CELL PROLIFERATION; CLINICAL ASSESSMENT; CYTOTOXICITY; DISEASE ASSOCIATION; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; GENE EXPRESSION; LIPID PEROXIDATION; NEUROLOGIC DISEASE; NEUROTRANSMISSION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DIOXINS; ENVIRONMENTAL POLLUTANTS; HUMANS; METALS, HEAVY; NEOPLASMS; NERVOUS SYSTEM DISEASES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 77957128195     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.07.028     Document Type: Review

References (173)

1. Matés J.M., Segura J.A., Alonso F.J., Márquez J. Pathways from glutamine to apoptosis. Front. Biosci. 2006, 11:3164-3180.
2. Agarwal A., Gupta S., Sekhon L., Shah R. Redox considerations in female reproductive function and assisted reproduction, from molecular mechanisms to health implications. Antioxid. Redox Signaling 2008, 10:1375-1403.
3. Matés J.M., Pérez-Gómez C., Núñez de Castro I., Asenjo M., Márquez J. Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death. Int. J. Biochem. Cell Biol. 2002, 34:439-458.
4. Matés J.M., Segura J.A., Alonso F.J., Márquez J. Intracellular redox status and oxidative stress, implications for cell proliferation, apoptosis, and carcinogenesis. Arch. Toxicol. 2008, 82:273-299.
5. Forman H.J., Maiorino M., Ursini F. Signaling functions of reactive oxygen species. Biochemistry 2010, 49:835-842.
6. Matés J.M. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 2000, 153:83-104.
7. Fishel M.L., Vasko M.R., Kelley M.R. DNA repair in neurons, so if they don't divide what's to repair?. Mutat. Res. 2007, 614:24-36.
8. Ramasamy K., Agarwal R. Multitargeted therapy of cancer by silymarin. Cancer Lett. 2008, 269:352-362.
9. Landolph J.R. Chemically induced morphological and neoplastic transformation in C3H/10T1/2 Cl 8 mouse embryo cells. Molecular Carcinogenesis and the Molecular Biology of Human Cancer, Chap. 9 2006, 199-219. CRC Taylor & Francis, Boca Raton. D. Warshawsky, J.R. Landolph (Eds.).
10. Verma R., Ramnath J., Clemens F., Kaspin L.C., Landolph J.R. Molecular biology of nickel carcinogenesis: identification of differentially expressed genes in morphologically transformed C3H/10T1/2 C1/2 Cl 8 mouse embryo fibroblast cell lines induced by specific insoluble nickel compounds. Mol. Cell. Biochem. 2004, 255:203-216.
11. Nagano T. Bioimaging probes for reactive oxygen species and reactive nitrogen species. J. Clin. Biochem. Nutr. 2009, 45:111-124.
12. Bahar G., Feinmesser R., Shpitzer T., Popovtzer A., Nagler R.M. Salivary analysis in oral cancer patients, DNA and protein oxidation, reactive nitrogen species, and antioxidant profile. Cancer 2007, 109:54-59.
13. Landolph J.R. Arachidonic acid metabolism, oxygen radicals, and chemical carcinogenesis. Biological Oxidants and Antioxidants 1994, 133-143. Hippokrates Verlag, Stuttgart. L. Packer, E. Cadenas (Eds.).
14. Landolph J.R. Role of free radicals in metal-induced carcinogenesis. Metal Ions in Biological Systems, Vol. 36, Chap. 14, Interrelations between free radicals and metal ions in life processes 1999, 445-483. Dekker, New York/Basel. A. Sigel, H. Sigel (Eds.).
15. Landolph J.R., Verma A., Ramnath J., Clemens F. Molecular biology of deregulated gene expression in transformed C3H/10T1/2 mouse embryo cell lines induced by specific insoluble carcinogenic nickel compounds. Environ. Health Perspect. 2002, 110:845-850.
16. Landolph J.R. The role of free radicals in chemical carcinogenesis. Series in Pharmaceutical Sciences, Chap. 17, Toxicology of the human environment: the critical role of free radicals 2000, 339-363. Taylor & Francis, London/New York. C.J. Rhodes (Ed.).
17. Cooke M.S., Loft S., Olinski R., Evans M.D., Bialkowski K., Wagner J.R., Dedon P.C., Møller P., Greenberg M.M., Cadet J. Recommendations for standardized description of and nomenclature concerning oxidatively damaged nucleobases in DNA. Chem. Res. Toxicol. 2010, 23:705-707.
18. Kaindl U., Eyberg I., Rohr-Udilova N., Heinzle C., Marian B. The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage. Food Chem. Toxicol. 2008, 46:1320-1326.
19. Mukherjee S., Koner B.C., Ray S., Ray A. Environmental contaminants in pathogenesis of breast cancer. Indian J. Exp. Biol. 2006, 44:597-617.
20. Wittgen H.G., van Kempen L.C. Reactive oxygen species in melanoma and its therapeutic implications. Melanoma Res. 2007, 17:400-409.
21. Pani G., Giannoni E., Galeotti T., Chiarugi P. Redox-based escape mechanism from death, the cancer lesson. Antioxid. Redox Signaling 2009, 11:2791-2806.
22. Trachootham D., Alexandre J., Huang P. Targeting cancer cells by ROS-mediated mechanisms, a radical therapeutic approach?. Nat. Rev. Drug Discovery 2009, 8:579-591.
23. Wells P.G., McCallum G.P., Chen C.S., Henderson J.T., Lee C.J., Perstin J., Preston T.J., Wiley M.J., Wong A.W. Oxidative stress in developmental origins of disease, teratogenesis, neurodevelopmental deficits, and cancer. Toxicol. Sci. 2009, 108:4-18.
24. Melnick R.L., Kohn M.C., Portier C.J. Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis. Environ. Health Perspect. 1996, 104:23-34.
25. Matsumara F. Mechanism of action of dioxin-type chemicals, pesticides, and other xenobiotics affecting nutritional indexes. Am. J. Clin. Nutr. 1995, 61:695S-701S.
26. Pavan M., Todeschini R., Orlandi M. Data mining by total ranking methods, a case study on optimisation of the "pulp and bleaching" process in the paper industry. Ann. Chim. 2006, 96:13-27.
27. Knerr S., Schrenk D. Carcinogenicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in experimental models. Mol. Nutr. Food Res. 2006, 50:897-907.
28. Popp J.A., Crouch E., McConnell E.E. A weight-of-evidence analysis of the cancer dose-response characteristics of 2, 3, 7, 8-tetrachlorodibenzodioxin (TCDD). Toxicol. Sci. 2006, 89:361-369.
29. Keller J.M., Zelditch M.L., Huet Y.M., Leamy L.J. Genetic differences in sensitivity to alterations of mandible structure caused by the teratogen 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Toxicol. Pathol. 2008, 36:1006-1013.
30. Akahoshi E., Yoshimura S., Uruno S., Ishihara-Sugano M. Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor, a neurotoxicology study. Environ. Health 2009, 8:24.
31. Murray I.A., Morales J.L., Flaveny C.A., Dinatale B.C., Chiaro C., Gowdahalli K., Amin S., Perdew G.H. Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity. Mol. Pharmacol. 2010, 77:247-254.
32. Besischlag T.V., Luis Morales J., Hollingshead B.D., Perdew G.H. The aryl hydrocarbon receptor complex and the control of gene expression. Crit. Rev. Eukaryot. Gene Expr. 2008, 18:207-250.
33. Patel R.D., Kim D.J., Peters J.M., Perdew G.H. The aryl hydrocarbon receptor directly regulates expression of the potent mitogen epiregulin. Toxicol. Sci. 2006, 89:75-82.
34. Patel R.D., Hollingshead B.D., Omiecinski C.J., Perdew G.H. Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver. Hepatology 2007, 46:209-218.
35. Lavigne J.A., Goodman J.E., Fonong T., Odwin S., He P., Roberts D.W., Yager J.D. The effects of catechol-O-methyltransferase inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells. Cancer Res. 2001, 61:7488-7494.
36. Schreck I., Chudziak D., Schneider S., Seidel A., Platt K.L., Oesch F., Weiss C. Influence of aryl hydrocarbon (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells. Toxicology 2009, 259:91-96.
37. MacDonald C.J., Cheng R.Y., Roberts D.D., Wink D.A., Yeh G.C. Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation. J. Biol. Chem. 2009, 284:22099-22107.
38. Park J.Y., Shigenaga M.K., Ames B.N. Induction of cytochrome P4501A1 by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin or indolo(3, 2-b)carbazole is associated with oxidative DNA damage. Proc. Natl Acad. Sci. USA 1996, 93:2322-2327.
39. Kamiya, H. Mutagenicity of oxidized DNA precursors in living cells: roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases. Mutat. Res. (2010), doi:10.1016/j.mrgentox.2010.06.003.
40. Loft S., Høgh Danielsen P., Mikkelsen L., Risom L., Forchhammer L., Møller P. Biomarkers of oxidative damage to DNA and repair. Biochem. Soc. Trans. 2008, 36:1071-1076.
41. Cheng Y., Chang L.W., Cheng L.C., Tsai M.H., Lin P. 4-Methoxyestradiol-induced oxidative injuries in human lung epithelial cells. Toxicol. Appl. Pharmacol. 2007, 220:271-277.
42. Tritscher A.M., Seacat A.M., Yager J.D., Groopman J.D., Miller B.D., Bell D., Sutter T.R., Lucier G.W. Increased oxidative DNA damage in livers of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomized rats. Cancer Lett. 1996, 98:219-225.
43. Wyde M.E., Wong V.A., Kim A.H., Lucier G.W., Walker N.J. Induction of hepatic 8-oxo-deoxyguanosine adducts by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in Sprague-Dawley rats is female-specific and estrogen-dependent. Chem. Res. Toxicol. 2001, 14:849-855.
44. Lin P.H., Lin C.H., Huang C.C., Chuang M.C., Lin P. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress; DNA strand breaks; and poly(ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines. Toxicol. Lett. 2007, 172:146-158.
45. Wen S., Yang F.X., Gong Y., Zhang X.L., Hui Y., Li J.G., Liu A.L., Wu Y.N., Lu W.Q., Xu Y. Elevated levels of urinary 8-hydroxy-2'-deoxyguanosine in male electrical and electronic equipment dismantling workers exposed to high concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans, polybrominated diphenyl ethers, and polychlorinated biphenyls. Environ. Sci. Technol. 2008, 42:4202-4207.
46. Furst A. Can nutrition affect chemical toxicity?. Int. J. Toxicol. 2002, 21:419-424.
47. Witkiewicz-Kucharczyk A., Bal W. Damage of zinc fingers in DNA repair proteins, a novel molecular mechanism in carcinogenesis. Toxicol. Lett. 2006, 162:29-42.
48. Valko M., Rhodes C.J., Moncol J., Izakovic M., Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 2006, 160:1-40.
49. Adamis P.D., Mannarino S.C., Eleutherio E.C. Glutathione and gamma-glutamyl transferases are involved in the formation of cadmium-glutathione complex. FEBS Lett. 2009, 583:1489-1492.
50. Stohs S.J., Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med. 1995, 18:321-336.
51. Kasprzak K.S., Bialkowski K. Inhibition of antimutagenic enzymes, 8-oxo-dGTPases, by carcinogenic metals: recent developments. J. Inorg. Biochem. 2000, 79:231-236.
52. Gault N., Sandre C., Poncy J.L., Moulin C., Lefaix J.L., Bresson C. Cobalt toxicity: chemical and radiological combined effects on HaCaT keratinocyte cell line. Toxicol. in Vitro 2010, 24:92-98.
53. Porter D.W., Yakushiji H., Nakabeppu Y., Sekiguchi M., Fivash M.J., Kasprzak K.S. Sensitivity of Escherichia coli (MutT) and human (MTH1) 8-oxo-dGTPases to in vitro inhibition by the carcinogenic metals, nickel(II), copper(II), cobalt(II) and cadmium(II). Carcinogenesis 1997, 18:1785-1791.
54. Satarug S., Garrett S.H., Sens M.A., Sens D.A. Cadmium, environmental exposure, and health outcomes. Environ. Health Perspect. 2010, 118:182-190.
55. Bertin G., Averbeck D. Cadmium, cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review). Biochimie 2006, 88:1549-1559.
56. Apinan R., Satarug S., Ruengweerayut R., Tassaneeyakul W., Na-Bangchang K. Cadmium exposure in Thai populations from central, northern and northeastern Thailand and the effects of food consumption on cadmium levels. Southeast Asian J. Trop. Med. Public Health 2009, 40:177-186.
57. Filipic M., Fatur T., Vudrag M. Molecular mechanisms of cadmium induced mutagenicity. Hum. Exp. Toxicol. 2006, 25:67-77.
58. Liu J., Qu W., Kadiiska M.B. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol. Appl. Pharmacol. 2009, 238:209-214.
59. Nzengue Y., Lefebvre E., Cadet J., Favier A., Rachidi W., Steiman R., Guiraud P.J. Metallothionein expression in HaCaT and C6 cell lines exposed to cadmium. Trace Elem. Med. Biol. 2009, 23:314-323.
60. Alonso F.J., Segura J.A., Lora J., Lobo C., Fernández-Molina B., Márquez J., Matés J.M. Sensitisation of Ehrlich ascitic tumour cells to methotrexate by inhibiting glutaminase. Anticancer Res. 2005, 25:3315-3320.
61. Yang C.F., Shen H.M., Shen Y., Zhuang Z.X., Ong C.N. Cadmium-induced oxidative cellular damage in human fetal lung fibroblasts (MRC-5 cells). Environ. Health Perspect. 1997, 105:712-716.
62. Acharya U.R., Mishra M., Patro J., Panda M.K. Effect of vitamins C and E on spermatogenesis in mice exposed to cadmium. Reprod. Toxicol. 2008, 25:84-88.
63. Ikediobi C.O., Badisa V.L., Ayuk-Takem L.T., Latinwo L.M., West J. Response of antioxidant enzymes and redox metabolites to cadmium-induced oxidative stress in CRL-1439 normal rat liver cells. Int. J. Mol. Med. 2004, 14:87-92.
64. 2+ on DNA repair in liver of silver crucian carp. Fish Physiol. Biochem. 2008, 34:43-51.
65. He X., Chen M.G., Ma Q. Activation of Nrf2 in defense against cadmium-induced oxidative stress. Chem. Res. Toxicol. 2008, 21:1375-1383.
66. Yang S., Misner B.J., Chiu R.J., Meyskens F.L. Redox effector factor-1, combined with reactive oxygen species, plays an important role in the transformation of JB6 cells. Carcinogenesis 2007, 28:2382-2390.
67. Eybl V., Kotyzová D., Lesetickỳ L., Bludovská M., Koutenskỳ J. The influence of curcumin and manganese complex of curcumin on cadmium-induced oxidative damage and trace elements status in tissues of mice. J. Appl. Toxicol. 2006, 26:207-212.
68. Hartwig A., Schlepegrell R., Dally H., Hartmann M. Interaction of carcinogenic metal compounds with deoxyribonucleic acid repair processes. Ann. Clin. Lab. Sci. 1996, 26:31-38.
69. Fenoglio I., Corazzari I., Francia C., Bodoardo S., Fubini B. The oxidation of glutathione by cobalt/tungsten carbide contributes to hard metal-induced oxidative stress. Free Radic. Res. 2008, 42:437-745.
70. De Boeck M., Lison D., Kirsch-Volders M. Evaluation of the in vitro direct and indirect genotoxic effects of cobalt compounds using the alkaline comet assay: influence of interdonor and interexperimental variability. Carcinogenesis 1998, 19:2021-2029.
71. Kawanishi S., Hiraku Y., Murata M., Oikawa S. The role of metals in site-specific DNA damage with reference to carcinogenesis. Free Radic. Biol. Med. 2002, 32:822-832.
72. Wang P., Guliaev A.B., Hang B. Metal inhibition of human N-methylpurine-DNA glycosylase activity in base excision repair. Toxicol. Lett. 2006, 166:237-247.
73. Kasprzak K.S., Zastawny T.H., North S.L., Riggs C.W., Diwan B.A., Rice J.M., Dizdaroglu M. Oxidative DNA base damage in renal, hepatic, and pulmonary chromatin of rats after intraperitoneal injection of cobalt(II) acetate. Chem. Res. Toxicol. 1994, 7:329-335.
74. Cadet J., Poulsen H. Measurement of oxidatively generated base damage in cellular DNA and urine. Free Radic. Biol. Med. 2010, 48:1457-1459.
75. Hervouet E., Cízková A., Demont J., Vojtísková A., Pecina P., Franssen-van Hal N.L., Keijer J., Simonnet H., Ivánek R., Kmoch S., Godinot C., Houstek J. HIF and reactive oxygen species regulate oxidative phosphorylation in cancer. Carcinogenesis 2008, 29:1528-1537.
76. Mikami Y., Hisatsune A., Tashiro T., Isohama Y., Katsuki H. Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line. Biochem. Biophys. Res. Commun. 2009, 379:1060-1065.
77. Chen F., Vallyathan V., Castranova V., Shi X. Cell apoptosis induced by carcinogenic metals. Mol. Cell. Biochem. 2001, 222:183-188.
78. Ames B.N. Delaying the mitochondrial decay of aging. Ann. NY Acad. Sci. 2004, 1019:406-411.
79. Frelon S., Douki T., Favier A., Cadet J. Hydroxyl radical is not the main reactive species involved in the degradation of DNA bases by copper in the presence of hydrogen peroxide. Chem. Res. Toxicol. 2003, 16:191-197.
80. Hung Y.H., Bush A.I., Cherny R.A., Hung Y.H., Bush A.I., Cherny R.A. Copper in the brain and Alzheimer's disease. J. Biol. Inorg. Chem. 2010, 15:61-76.
81. Tisato F., Marzano C., Porchia M., Pellei M., Santini C. Copper in diseases and treatments, and copper-based anticancer strategies. Med. Res. Rev. 2010, 30:708-749.
82. Alcaraz-Zubeldia M., Boll-Woehrlen M.C., Montes-López S., Pérez-Severiano F., Martínez-Lazcano J.C., Díaz-Ruiz A., Ríos C. Copper sulfate prevents tyrosine hydroxylase reduced activity and motor deficits in a Parkinson's disease model in mice. Rev. Investig. Clin. 2009, 61:405-411.
83. Nair J., Sone H., Nagao M., Barbin A., Bartsch H. Copper-dependent formation of miscoding etheno-DNA adducts in the liver of Long Evans Cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma. Cancer Res. 1996, 56:1267-1271.
84. Nair J., Strand S., Frank N., Knauft J., Wesch H., Galle P.R., Bartsch H. Apoptosis and age-dependant induction of nuclear and mitochondrial etheno-DNA adducts in Long-Evans Cinnamon (LEC) rats: enhanced DNA damage by dietary curcumin upon copper accumulation. Carcinogenesis 2005, 26:1307-1315.
85. Finney L., Vogt S., Fukai T., Glesne D. Copper and angiogenesis, unravelling a relationship key to cancer progression. Clin. Exp. Pharmacol. Physiol. 2009, 36:88-94.
86. Theophanides T., Anastassopoulou J. Copper and carcinogenesis. Crit. Rev. Oncol. Hematol. 2002, 42:57-64.
87. Reid T.M., Feig D.I., Loeb L.A. Mutagenesis by metal-induced oxygen radicals. Environ. Health Perspect. 1994, 102:57-61.
88. Lin P.H., Pan W.C., Kang Y.W., Chen Y.L., Lin C.H., Lee M.C., Chou Y.H., Nakamura J. Effects of naphthalene quinonoids on the induction of oxidative DNA damage and cytotoxicity in calf thymus DNA and in human cultured cells. Chem. Res. Toxicol. 2005, 18:1262-1270.
89. Khan W.A., Alam K. Moinuddin. Catechol-estrogen modified DNA, a better antigen for cancer autoantibody. Arch. Biochem. Biophys. 2007, 465:293-300.
90. Thibodeau P.A., Paquette B. DNA damage induced by catecholestrogens in the presence of copper(II): generation of reactive oxygen species and enhancement by NADH. Free Radic. Biol. Med. 1999, 27:1367-1377.
91. Alemón-Medina R., Breña-Valle M., Muñoz-Sánchez J.L., Gracia-Mora M.I., Ruiz-Azuara L. Induction of oxidative damage by copper-based antineoplastic drugs (Casiopeínas). Cancer Chemother. Pharmacol. 2007, 60:219-228.
92. Cai X., Pan N., Zou G. Copper-1, 10-phenanthroline-induced apoptosis in liver carcinoma Bel-7402 cells associates with copper overload, reactive oxygen species production, glutathione depletion and oxidative DNA damage. Biometals 2007, 20:1-11.
93. Eckers A., Reimann K., Klotz L.O. Nickel and copper ion-induced stress signaling in human hepatoma cells, analysis of phosphoinositide 3'-kinase/Akt signaling. Biometals 2009, 22:307-316.
94. Joshi P.C. Copper(II) as an efficient scavenger of singlet molecular oxygen. Indian J. Biochem. Biophys. 1998, 35:208-215.
95. Marlatt M., Lee H.G., Perry G., Smith M.A., Zhu X. Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease. Acta Neurobiol. Exp. (Warsaw) 2004, 64:81-87.
96. Matés J.M., Segura J.A., Alonso F.J., Márquez J. Natural antioxidants, therapeutic prospects for cancer and neurological diseases. Mini Rev. Med. Chem. 2009, 9:1202-1214.
97. Limoli C.L., Rola R., Giedzinski E., Mantha S., Huang T.T., Fike J.R. Cell-density-dependent regulation of neural precursor cell function. Proc. Natl Acad. Sci. USA 2004, 101:16052-16057.
98. Loh K.P., Huang S.H., De Silva R., Tan B.K., Zhu Y.Z. Oxidative stress, apoptosis in neuronal injury. Curr. Alzheimer Res. 2006, 3:327-337.
99. Orhan G., Orhan I., Subutay-Oztekin N., Ak F., Sener B. Contemporary anticholinesterase pharmaceuticals of natural origin and their synthetic analogues for the treatment of Alzheimer's disease. Recent Pat. CNS Drug Discov. 2009, 4:43-51.
100. Cole G.M., Frautschy S.A. Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model. Nutr. Health 2006, 18:249-259.
101. Zhu X., Su B., Wang X., Smith M.A., Perry G. Causes of oxidative stress in Alzheimer disease. Cell. Mol. Life Sci. 2007, 64:2202-2210.
102. Du H., Guo L., Fang F., Chen D., Sosunov A.A., McKhann G.M., Yan Y., Wang C., Zhang H., Molkentin J.D., Gunn-Moore F.J., Vonsattel J.P., Arancio O., Chen J.X., Yan S.D. Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat. Med. 2008, 14:1097-1105.
103. Stolzing A., Grune T. Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells. FASEB J. 2004, 18:743-745.
104. Zemlyak I., Nimon V., Brooke S., Moore T., McLaughlin J., Sapolsky R. Gene therapy in the nervous system with superoxide dismutase. Brain Res. 2006, 1088:12-18.
105. Wang H., Cheng E., Brooke S., Chang P., Sapolsky R. Over-expression of antioxidant enzymes protects cultured hippocampal and cortical neurons from necrotic insults. J. Neurochem. 2003, 87:1527-1534.
106. Mandel S.A., Avramovich-Tirosh Y., Reznichenko L., Zheng H., Weinreb O., Amit T., Youdim M.B. Multifunctional activities of green tea catechins in neuroprotection: modulation of cell survival genes; iron-dependent oxidative stress and PKC signaling pathway. Neurosignals 2005, 14:46-60.
107. Liu G., Men P., Kudo W., Perry G., Smith M.A. Nanoparticle-chelator conjugates as inhibitors of amyloid-beta aggregation and neurotoxicity: a novel therapeutic approach for Alzheimer disease. Neurosci. Lett. 2009, 455:187-190.
108. Mariussen E., Fonnum F. Neurochemical targets and behavioral effects of organohalogen compounds, an update. Crit. Rev. Toxicol. 2006, 36:253-289.
109. Legare M.E., Hanneman W.H., Barhoumi R., Tiffany-Castiglioni E. The effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin exposure in primary rat astroglia, identification of biochemical and cellular targets. Neurotoxicology 1997, 18:515-524.
110. Sweeney, M. H.; Calvert, G. M.; Egeland, G. A.; Fingerhut, M. A.; Haperin E. E.; Piacitelli, L. A. Review and update of the results of the NIOSH medical study of workers exposed to chemicals contaminated with 2,3,7,8-tetrachlorodibenzodioxin. Teratog. Carcinog. Mutagen. 17:241-247; 1997-1998.
111. Lee Y.S., Jin D.Q., Park S.H., Han S.Y., Kim H.S., Jeong T.C., Huh K., Kim J.A. 2, 3, 7, 8-Tetrachlorobenzo-p-dioxin inhibits proliferation of SK-N-SH human neuronal cells through decreased production of reactive oxygen species. Free Radic. Res. 2002, 36:1283-1289.
112. Takahasi H., Yanagi K., Ueda M., Nakade K., Fukuyama Y. Structures of 1,4-benzodioxane derivatives from the seeds of Phytolacca americana and their neuritogenic activity in primary cultured rat cortical neurons. Chem. Pharm. Bull. (Tokyo) 2003, 51:1377-1381.
113. Sato M., Noble L.J. Involvement of the endothelin receptor subtype A in neuronal pathogenesis after traumatic brain injury. Brain Res. 1998, 809:39-49.
114. Roux S., Breu V., Giller T., Neidhart W., Ramuz H., Coassolo P., Clozel J.P., Clozel M. Ro 61-1790, a new hydrosoluble endothelin antagonist, general pharmacology and effects on experimental cerebral vasospasm. J. Pharmacol. Exp. Ther. 1997, 283:1110-1118.
115. Garrat J.C., Crespi F., Mason R., Marsden C.A. Effects of idazoxan on dorsal raphe 5-hydroxytryptamine neuronal function. Eur. J. Pharmacol. 1991, 193:87-93.
116. Clarke R.W., Harris J. RX 821002 as a tool for physiological investigation of alpha(2)-adrenoceptors. CNS Drug Rev. 2002, 8:177-192.
117. Budhram R., Lau-Cam C.A. Attenuating effect of melatonin on pyridoxal-stimulated release of adrenomedullary catecholamines in the rat. Life Sci. 2009, 84:696-704.
118. Lai Y.C., Tsai P.S., Huang C.J. Effects of dexmedetomidine on regulating endotoxin-induced up-regulation of inflammatory molecules in murine macrophages. J. Surg. Res. 2009, 154:212-219.
119. Migliore L., Coppedè F. Environmental-induced oxidative stress in neurodegenerative disorders and aging. Mutat. Res. 2009, 674:73-84.
120. Uversky V.N., Li J., Fink A.L. Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein: a possible molecular NK between Parkinson's disease and heavy metal exposure. J. Biol. Chem. 2001, 276:44284-44296.
121. Moschou M., Papaefthimiou C., Kagiava A., Antonopoulou E., Theophilidis G. In vitro assessment of the effects of cadmium and zinc on mammalian nerve fibres. Chemosphere 2008, 71:1996-2002.
122. López E., Arce C., Oset-Gasque M.J., Cañadas S., González M.P. Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture. Free Radic. Biol. Med. 2006, 40:940-951.
123. Yang C.S., Tzou B.C., Liu Y.P., Tsai M.J., Shyue S.K., Tzeng S.F. Inhibition of cadmium-induced oxidative injury in rat primary astrocytes by the addition of antioxidants and the reduction of intracellular calcium. Cell Biochem. 2008, 103:825-834.
124. Huang Y.H., Shih C.M., Huang C.J., Lin C.M., Chou C.M., Tsai M.L., Liu T.P., Chiu J.F., Chen C.T. Effects of cadmium on structure and enzymatic activity of Cu,Zn-SOD and oxidative status in neural cells. J. Cell. Biochem. 2006, 98:577-589.
125. Trumbull K.A., Beckman J.S. A role for copper in the toxicity of zinc-deficient superoxide dismutase to motor neurons in amyotrophic lateral sclerosis. Antioxid. Redox Signaling 2009, 11:1627-1639.
126. Rockwell P., Martinez J., Papa L., Gomes E. Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium. Cell Signal. 2004, 16:343-353.
127. Borges V.C., Santos F.W., Rocha J.B., Nogueira C.W. Heavy metals modulate glutamatergic system in human platelets. Neurochem. Res. 2007, 32:953-958.
128. Zhu X., Zhou W., Cui Y., Zhu L., Li J., Xia Z., Shao B., Wang H., Chen H. Muscarinic activation attenuates abnormal processing of β-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells. Biochem. Biophys. Res. Commun. 2009, 384:110-113.
129. Li G.Y., Osborne N.N. Oxidative-induced apoptosis to an immortalized ganglion cell line is caspase independent but involves the activation of poly(ADP-ribose)polymerase and apoptosis-inducing factor. Brain Res. 2008, 1188:35-43.
130. 2 are not. Neurosci. Lett. 2007, 422:223-227.
131. Zou W., Yan M., Xu W., Huo H., Sun L., Zheng Z., Liu X. Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. J. Neurosci. Res. 2001, 64:646-653.
132. 2 in rat neuronal PC12 cells. Nucleic Acids Res. 2000, 28:2135-2140.
133. 2, and biological activities including neurite outgrowth in PC12 cells. Sci. World J. 2006, 6:176-186.
134. Kotake-Nara E., Takizawa S., Quan J., Wang H., Saida K. Cobalt chloride induces neurite outgrowth in rat pheochromocytoma PC-12 cells through regulation of endothelin-2/vasoactive intestinal contractor. J. Neurosci. Res. 2005, 81:563-571.
135. Merker K., Hapke D., Reckzeh K., Schmidt H., Lochs H., Grune T. Copper related toxic effects on cellular protein metabolism in human astrocytes. Biofactors 2005, 24:255-261.
136. Spisni E., Valerii M.C., Manerba M., Strillacci A., Polazzi E., Mattia T., Griffoni C., Tomasi V. Effect of copper on extracellular levels of key pro-inflammatory molecules in hypothalamic GN11 and primary neurons. Neurotoxicology 2009, 30:605-612.
137. Guilloreau L., Combalbert S., Sournia-Saquet A., Mazarguil H., Faller P. Redox chemistry of copper-amyloid-beta, the generation of hydroxyl radical in the presence of ascorbate is linked to redox-potentials and aggregation state. Chembiochem 2007, 8:1317-1325.
138. Castellani R.J., Honda K., Zhu X., Cash A.D., Nunomura A., Perry G., Smith M.A. Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease. Ageing Res. Rev. 2004, 3:319-326.
139. Zhu X., Su B., Wang X., Smith M.A., Perry G. Causes of oxidative stress in Alzheimer disease. Cell. Mol. Life Sci. 2007, 64:2202-2210.
140. Dikalov S.I., Vitek M.P., Mason R.P. Cupric-amyloid β peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical. Free Radic. Biol. Med. 2004, 36:340-347.
141. Meloni G., Sonois V., Delaine T., Guilloreau L., Gillet A., Teissié J., Faller P., Vasák M. Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity. Nat. Chem. Biol. 2008, 4:366-372.
142. +-ATPase, a possible contributing factor to neurotoxicity. J. Neurochem. 2007, 101:313-326.
143. Qian Y., Zheng Y., Abraham L., Ramos K.S., Tiffany-Castiglioni E. Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells. Brain Res. Mol. Brain Res. 2005, 134:323-332.
144. McCoy J.G., Strawbridge C., McMurtrey K.D., Kane V.B., Ward C.P. A re-evaluation of the role of tetrahydropapaveroline in ethanol consumption in rats. Brain Res. Bull. 2003, 60:59-65.
145. Kim H.J., Soh Y., Jang J.H., Lee J.S., Oh Y.J., Surh Y.J. Differential cell death induced by salsolinol with and without copper, possible role of reactive oxygen species. Mol. Pharmacol. 2001, 60:440-449.
146. Soh Y., Shin M.H., Lee J.S., Jang J.H., Kim O.H., Kang H., Surh Y.J. Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline. Mutat. Res. 2003, 544:129-142.
147. Aboul-Enein H.Y., Kładna A., Kruk I., Lichszteld K., Michalska T. Effect of psoralens on Fenton-like reaction generating reactive oxygen species. Biopolymers 2003, 72:59-68.
148. 2+ ions underlies the ability of ascorbate to induce vascular dysfunction in the rat perfused mesentery. Eur. J. Pharmacol. 2009, 614:84-90.
149. Zhang Z., Buffle J. Interfacial metal flux in ligand mixtures. 3. Unexpected flux enhancement due to kinetic interplay at the consuming surface; computed for aquatic systems. Environ. Sci. Technol. 2009, 43:5762-5768.
150. Uttara B., Singh A.V., Zamboni P., Mahajan R.T. Oxidative stress and neurodegenerative diseases, a review of upstream and downstream antioxidant therapeutic options. Curr. Neuropharmacol. 2009, 7:65-74.
151. Koenig M.L., Meyerhoff J.L. In vitro neuroprotection against oxidative stress by pre-treatment with a combination of dihydrolipoic acid and phenyl-butyl nitrones. Neurotox. Res. 2003, 5:265-272.
152. Polasa K., Naidu A.N., Ravindranath I., Krishnaswamy K. Inhibition of B(a)P induced strand breaks in presence of curcumin. Mutat. Res. 2004, 557:203-213.
153. Pallàs M., Verdaguer E., Tajes M., Gutierrez-Cuesta J., Camins A. Modulation of sirtuins, new targets for antiageing. Recent Pat. CNS Drug Discov. 2008, 3:61-69.
154. Ozben T. Oxidative stress and apoptosis, impact on cancer therapy. J. Pharm. Sci. 2007, 96:2181-2196.
155. Kong Q., Beel J.A., Lillehei K.O. A threshold concept for cancer therapy. Med. Hypotheses 2000, 55:29-35.
156. Akan I., Akan S., Akca H., Savas B., Ozben T. Multidrug resistance-associated protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and buthionine sulfoximine. Cancer Cell Int. 2005, 5:22.
157. Davison K., Cote S., Mader S., Miller W.H. Glutathione depletion overcomes resistance to arsenic trioxide in arsenic-resistant cell lines. Leukemia 2003, 17:931-940.
158. Sanada N., Gotoh Y., Shimazawa R., Klinge C.M., Kizu R. Repression of activated aryl hydrocarbon receptor-induced transcriptional activation by 5alpha-dihydrotestosterone in human prostate cancer LNCaP and human breast cancer T47D cells. J. Pharmacol. Sci. 2009, 109:380-387.
159. Vondrácek J., Krcmár P., Procházková J., Trilecová L., Gavelová M., Skálová L., Szotáková B., Buncek M., Radilová H., Kozubík A., Machala M. The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells. Chem. Biol. Interact. 2009, 180:226-237.
160. Desoize B. Metals and metal compounds in carcinogenesis. In Vivo 2003, 17:529-539.
161. Knutson C.G., Rubinson E.H., Akingbade D., Anderson C.S., Stec D.F., Petrova K.V., Kozekov I.D., Guengerich F.P., Rizzo C.J., Marnett L.J. Oxidation and glycolytic cleavage of etheno and propano DNA base adducts. Biochemistry 2009, 48:800-809.
162. Tseng L.M., Yin P.H., Tsai Y.F., Chi C.W., Wu C.W., Lee L.M., Lee H.C. Association between mitochondrial DNA 4, 977 bp deletion and NAD(P)H, quinone oxidoreductase 1 C609T polymorphism in human breast tissues. Oncol. Rep. 2009, 21:1169-1174.
163. Faria M., Carrasco L., Diez S., Riva M.C., Bayona J.M., Barata C. Multi-biomarker responses in the freshwater mussel Dreissena polymorpha exposed to polychlorobiphenyls and metals. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2009, 149:281-288.
164. Stasinopoulos I., O'Brien D.R., Bhujwalla Z.M. Inflammation, but not hypoxia, mediated HIF-1alpha activation depends on COX-2. Cancer Biol. Ther. 2009, 8:31-35.
165. Gosslau A., Rensing L. Oxidative stress; age-dependent [correction of age-related] cell damage and antioxidative mechanisms. Z. Gerontol. Geriatr. 2002, 35:139-150.
166. Bartosz G. Reactive oxygen species: destroyers or messengers?. Biochem. Pharmacol. 2009, 77:1303-1315.
167. Perrone L., Mothes E., Vignes M., Mockel A., Figueroa C., Miquel M.C., Maddelein M.L., Faller P. Copper transfer from Cu-Aβ to human serum albumin inhibits aggregation, radical production and reduces Aβ toxicity. Chembiochem 2010, 11:110-118.
168. Rana S.V. Metals and apoptosis: recent developments. J. Trace Elem. Med. Biol. 2008, 22:262-284.
169. Wang J., Rahman M.F., Duhart H.M., Newport G.D., Patterson T.A., Murdock R.C., Hussain S.M., Schlager J.J., Ali S.F. Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese; silver; or copper nanoparticles. Neurotoxicology 2009, 30:926-933.
170. Gérard C., Bordeleau L.J., Barralet J., Doillon C.J. The stimulation of angiogenesis and collagen deposition by copper. Biomaterials 2010, 31:824-831.
171. Martin P., Pognonec P. ERK and cell death: cadmium toxicity, sustained ERK activation and cell death. FEBS J. 2010, 277:39-46.
172. Forti E., Bulgheroni A., Cetin Y., Hartung T., Jennings P., Pfaller W., Prieto P. Characterisation of cadmium chloride induced molecular and functional alterations in airway epithelial cells. Cell. Physiol. Biochem. 2010, 25:159-168.
173. Duffy A.M., O'Brien T., McMahon J.M. Generation of antioxidant adenovirus gene transfer vectors encoding CuZnSOD, MnSOD, and catalase. Meth. Mol. Biol. 2010, 594:381-393.