Oxidation by trace Cu2+ ions underlies the ability of ascorbate to induce vascular dysfunction in the rat perfused mesentery

European Journal of Pharmacology

Volumn 614, Issue 1-3, 2009, Pages 206-211

  Nelli, Silvia ^a   Craig, John ^a   Martin, William ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Ascorbate; Copper; EDHF; Endothelium derived hyperpolarizing factor; Hydrogen peroxide; Oxidant stress

Indexed keywords

ACETYLCHOLINE; ASCORBIC ACID; CATALASE; COPPER ION; COPPER SULFATE; CUPRIZONE; DEFEROXAMINE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; FERRIC CHLORIDE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; MANNITOL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; BIOLOGICAL FACTOR; COPPER; ENDOTHELIUM DEPENDENT HYPERPOLARIZATION FACTOR; ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION FACTOR; VASOCONSTRICTOR AGENT;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; MALE; MESENTERY BLOOD FLOW; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; SUPERIOR MESENTERIC ARTERY; TREATMENT OUTCOME; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION; ANIMAL; DRUG EFFECT; MESENTERIC ARTERY; METABOLISM; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PERFUSION; WISTAR RAT;

ANIMALS; ASCORBIC ACID; BIOLOGICAL FACTORS; COPPER; HYDROGEN PEROXIDE; IRON; MALE; MESENTERIC ARTERIES; OXIDATION-REDUCTION; PERFUSION; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 67349123864     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.04.033     Document Type: Article

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