Biomarkers of oxidative damage to DNA and repair

Biochemical Society Transactions

Volumn 36, Issue 5, 2008, Pages 1071-1076

  Loft, Steffen ^a   Danielsen, Pernille Høgh ^a   Mikkelsen, Lone ^a   Risom, Lotte ^a   Forchhammer, Lykke ^a   Møller, Peter ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Base excision repair; Biomarker; DNA damage; DNA repair; Nucleotide excision repair; Oxidative damage

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8 HYDROXYGUANINE DNA GLYCOSYLASE 1; DNA GLYCOSYLASE MUTY; DNA GLYCOSYLTRANSFERASE; NEI LIKE 1; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN NEIL 1; UNCLASSIFIED DRUG;

CANCER RISK; COMET ASSAY; CONFERENCE PAPER; DIET; DNA DAMAGE; DNA MODIFICATION; DNA OXIDATION; DNA REPAIR; ENZYME SUBSTRATE; EXCISION REPAIR; EXHAUST GAS; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; LUNG CANCER; MASS SPECTROMETRY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; SMOKING; URINARY EXCRETION;

BIOLOGICAL MARKERS; DIET; DIETARY SUPPLEMENTS; DNA DAMAGE; DNA REPAIR; ENVIRONMENT; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; OXIDATION-REDUCTION; OXIDATIVE STRESS;

EID: 53849091350     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0361071     Document Type: Conference Paper

References (50)

1. Halliwell, B. (2007) Biochemistry of oxidative stress. Biochem. Soc. Trans. 35, 1147-1150
2. Cadet, J., Douki, T., Gasparutto, D. and Ravanat, J.L. (2003) Oxidative damage to DNA: formation, measurement and biochemical features. Mulat. Res. 531, 5-23
3. Evans, M.D., Dizdaroglu, M. and Cooke, M.S. (2004) Oxidative DNA damage and disease: induction, repair and significance. Mutat. Res. 567, 1-61
4. Hazra, T.K., Das, A., Das, S., Choudhury, S., Kow, Y.W. and Roy, R. (2007) Oxidative DNA damage repair in mammalian cells: a new perspective. DNA Repair 6, 470-480
5. David, S.S., O'Shea, V.L. and Kundu, S. (2007) Base-excision repair of oxidative DNA damage. Nature 447, 941-950
6. Loft, S. and Moller, P. (2006) Oxidative DNA damage and human cancer: need for cohort studies. Antioxid. Redox Signaling 8, 1021-1031
7. Loft, S., Svolboda, P., Kasai, H., Tjonneland, A., Vogel, U., Møller, P., Overvad, K. and Raaschou-Nielsen, O. (2006) Prospective study of 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion and the risk of lung cancer. Carcinogenesis 27, 1245-1250
8. Møller, P. and Loft, S. (2006) Dietary antioxidants and beneficial effect on oxidatively damaged DNA. Free Radical Biol. Med. 41, 388-415
9. European Standards Committee on Oxidative DNA Damage (ESCODD) (2003) Measurement of DNA oxidation in human cells by chromatographic and enzymic methods. Free Radical Biol. Med. 34, 1089-1099
10. Dizdaroglu, M., Jaruga, P., Birincioglu, M. and Rodriguez, H. (2002) Free radical-induced damage to DNA: mechanisms and measurement. Free Radical Biol. Med. 32, 1102-1115
11. Cadet, J., Douki, T., Frelon, S., Sauvaigo, S., Pouget, J.P. and Ravanat, J.L. (2002) Assessment of oxidative base damage to isolated and cellular DNA by HPLC-MS/MS measurement. Free Radical Biol. Med. 33, 441-449
12. Weimann, A., Belling, D. and Poulsen, H.E. (2002) Quantification of 8-oxo-guanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography-electrospray tandem mass spectrometry. Nucleic Acids Res. 30, E7
13. Gedik, C.M. and Collins, A. (2005) Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study. FASEB J. 19, 82-84
14. Collins, A.R. (2002) The comet assay: principles, applications, and limitations. Methods Mol. Biol. 203, 163-177
15. Hah, S.S., Mundt, J.M., Kim, H.M., Sumbad, R.A., Turteltaub, K.W. and Henderson, P.T. (2007) Measurement of 7,8-dihydro-8-oxo-2′-deoxyguanosine metabolism in MCF-7 cells at low concentrations using accelerator mass spectrometry. Proc. Natl. Acad. Sci. U.S.A. 104, 11203-11208
16. Cooke, M.S. and Evans, M.D. (2007) 8-Oxo-deoxyguanosine: reduce, reuse, recycle? Proc. Natl. Acad. Sci, U.S.A. 104, 13535-13536
17. Guarnieri, S., Loft, S., Riso, P., Porrini, M., Risom, L., Poulsen, H.E., Dragsted, L.O. and Møller, P. (2008) DNA repair phenotype and dietary antioxicant supplementation. Br. J. Nutr. 99, 1018-1024
18. Torbergsen, A.C. and Collins, A.R. (2000) Recovery of human lymphocytes from oxidative DNA damage: the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant effect. Eur. J Nutr. 39, 80-85
19. Paz-Elizur, T., Krupsky, M., Blumenstein, S., Elinger, D., Schechtman, E. and Livneh, Z. (2003) DNA repair activity for oxidative damage and risk of lung cancer. J. Natl. Cancer Inst. 95, 1312-1319
20. Paz-Elizur, T., Elinger, D., Leitner-Dagan, Y., Blumenstein, S., Krupsky, M., Berrebi, A., Schechtman, E. and Livneh, Z. (2007) Development of an enzymatic DNA repair assay for molecular epidemiology studies: distribution of OGG activity in healthy individuals. DNA Repair 6, 45-60
21. Gackowski, D., Speina, E., Zielinska, M., Kowalewski, J., Rozalski, R., Siomek, A., Paciorek, T., Tudek, B. and Olinski, R. (2003) Products of oxidative DNA damage and repair as possible biomarkers of susceptibility to lung cancer. Cancer Res. 63, 4899-4902
22. Collins, A.R., Dusinska, M., Horvathova, E., Munro, E., Savio, M. and Stetina, R. (2001) Inter-individual differences in repair of DNA base oxidation, measured in vitro with the comet assay. Mutagenesis 16, 297-301
23. Collins, A.R., Harrington, V., Drew, J. and Melvin, R. (2003) Nutritional modulation of DNA repair in a human intervention study. Carcinogenesis 24, 511-515
24. Bialkowski, K. and Kasprzak, K.S. (2004) Cellular 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate pyrophosphohydrolase activity of human and mouse MTH1 proteins does not depend on the proliferation rate. Free Radical Biol. Med. 37, 1534-1541
25. Risom, L., Dybdahl, M., Bornholdt, J., Vogel, U., Wallin, H., Mwøller, P. and Loft, S. (2003) Oxidative DNA damage and defence gene expression in the mouse lung after short-term exposure to diesel exhaust particles by inhalation. Carcinogenesis 24, 1847-1852
26. Risom, L., Møller, P., Vogel, U., Kristjansen, P.E.G. and Loft, S. (2003) X-ray-induced oxidative stress: DNA damage and gene expression of HO-1, ERCC1 and OGG1 in mouse lung. Free Radical Res. 37, 957-966
27. Brauner, E.V., Forchhammer, L., Møller, P., Simonsen, J., Glasius, M., Wahlin, P., Raaschou-Nielsen, O. and Loft, S. (2007) Exposure to ultrafine particles from ambient air and oxidative stress-induced DNA damage. Environ. Health Perspect. 115, 1177-1182
28. Haghdoost, S., Sjolander, L., Czene, S. and Harms-Ringdahl, M. (2006) The nucleotide pool is a significant target for oxidative stress. Free Radical Biol. Med. 41, 620-626
29. Vodicka, P., Stetina, R., Polakova, V., Tulupova, E., Naccarati, A., Vodickova, L., Kumar, R., Hanova, M., Pardini, B., Slyskova, J. et al. (2007) Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects. Carcinogenesis 28, 657-664
30. Cooke, M.S., Olinski, R. and Loft, S. (2008) Measurement and meaning of oxidatively modified DNA lesions in urine. Cancer Epidemiol. Biomarkers Prev. 17, 3-14
31. Cooke, M.S., Singh, R., Hall, G.K., Mistry, V., Duarte, T.L., Farmer, P.B. and Evans, M.D. (2006) Evaluation of enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry methodology for the analysis of 8-oxo-7,8-dihydro-2′-deoxyguanosine in saliva and urine. Free Radical Biol. Med. 41, 1829-1836
32. Rozalski, R., Siomek, A., Gackowski, D., Foksinski, M., Gran, C., Klungland, A. and Olinski, R. (2005) Substantial decrease of urinary 8-oxo-7,8-dihydroguanine, a product of the base excision repair pathway, in DNA glycosylase defective mice. Int. J. Biochem. Cell Biol. 37, 1331-1336
33. Cooke, M.S., Evans, M.D., Dove, R., Rozalski, R., Gackowski, D., Siomek, A., Lunec, J. and Olinski, R. (2005) DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine. Mutat. Res. 574, 58-66
34. Rozalski, R., Siomek, A., Gackowski, D., Foksinski, M., Gran, C., Klungland, A. and Olinski, R. (2004) Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine. Free Radical Res. 38, 1201-1205
35. Vinzents, P., Møller, P., Sørensen, M., Knudsen, L.E., Hertel, O., Schibye, B. and Loft, S. (2005) Personal exposure to ultrafine particles and oxidative DNA damage. Environ. Health Perspect. 113, 1485-1490
36. 2.5 and oxidative stress in human volunteers. Cancer Epidemiol. Biomarkers Prev. 14, 1340-1343
37. Avobge, P., Ayi-Fanou, L., Autrup, H., Loftm, S., Fayomi, B., Sanni, A., Vinzents, P. and Møller, P. (2005) Ultrafine particulate matter and high-level benzene urban air pollution in relation to oxidative DNA damage. Carcinogenesis 26, 613-620
38. Danielsen, P.H., Brauner, E.V., Barregard, L., Sallsten, G., Wallin, M., Olinski, R., Rozalski, R., Møller, P. and Loft, S. (2008) Oxidatively damaged DNA and its repair after experimental exposure to wood smoke in healthy humans. Mutat. Res. 642, 37-42
39. Loft, S., Poulsen, H.E., Vistisen, K. and Knudsen, L.E. (1999) Increased urinary excretion of 8-oxo-2′-deoxyguanosine, a biomarker of oxidative DNA damage, in urban bus drivers. Mutat. Res. 441, 11-19
40. Asami, S., Hirano, T., Yamaguchi, R., Tomioka, Y., Itoh, H. and Kasai, H. (1996) Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking. Cancer Res. 56, 2546-2549
41. Møller, P, and Loft, S. (2002) Oxidative DNA damage in human white blood cells in dietary antioxidant intervention studies. Am. J. Clin. Nutr. 76, 303-310
42. Møller, P. and Loft, S. (2004) Interventions with antioxidants and nutrients in relation to oxidative DNA damage and repair. Mutat. Res. 551, 79-89
43. Loft, S., Møller, P., Cooke, M.S., Rozalski, R. and Olinski, R. (2008) Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker? Eur. J Nutr. 47, (Suppl. 2), 19-28
44. Hung, R.J,, Brennan, P., Canzian, F., Szeszenia-Dabrowska, N., Zaridze, D., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Foretova, L. et al. (2005) Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study. J. Natl. Cancer Inst. 97, 567-576
45. Hung, R.J., Hall, J., Brennan, P. and Boffetta, P. (2005) Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. Am. J. Epidemiol. 162, 925-942
46. Lan, Q., Mumford, J.L., Shen, M., DeMarini, D.M., Bonner, M.R., He, X., Yeager, M., Welch, R., Chanock, S., Tian, L. et al. (2004) Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions. Carcinogenesis 25, 2177-2181
47. Sørensen, M., Raaschou-Nielsen, O., Hansen, R.D., Tjonneland, A., Overvad, K. and Vogel, U. (2006) Interactions between the OGG1 Ser326Cys polymorphism and intake of fruit and vegetables in relation to lung cancer. Free Radical Res. 40, 885-891
48. Paz-Elizur, T., Ben-Yosef, R., Elinger, D., Vexler, A., Krupsky, M., Berrebi, A., Shani, A., Schechtman, E., Freedman, L. and Livneh, Z. (2006) Reduced repair of the oxidative 8-oxoguanine DNA damage and risk of head and neck cancer. Cancer Res. 66, 11683-11689
49. Speina, E., Arczewska, K.D., Gackowski, D., Zielinska, M., Siomek, A., Kowalewski, J., Olinski, R., Tudek, B. and Kusmierek, J.T. (2005) Contribution of hMTH1 to the maintenance of 8-oxoguanine levels in lung DNA of non-small-cell lung cancer patients. J. Natl. Cancer Inst. 97, 384-395
50. Hatt, L., Loft, S., Risom, L., Møller, P., Sorensen, M., Raaschou-Nielsen, O., Overvad, K., Tjonneland, A. and Vogel, U. (2008) OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study. Mutat. Res. 639, 45-54