Delaying the mitochondrial decay of aging

Annals of the New York Academy of Sciences

Volumn 1019, Issue , 2004, Pages 406-411

  Ames, Bruce N ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

Acetyl carnitine; Biotin deficiency; Copper deficiency; Heme deficiency; High dose B vitamin; Lipoic acid; Pantothenic acid; Reversing genetic disease; Vitamin B6; Vitamin, minerals, and aging; Zinc deficiency

Indexed keywords

AGING; BRAIN DEGENERATION; CONFERENCE PAPER; DEGENERATIVE DISEASE; ENERGY; HUMAN; METABOLISM; MITOCHONDRIAL DNA DISORDER; NONHUMAN; NUTRITIONAL DEFICIENCY;

EID: 3242670597     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1297.073     Document Type: Conference Paper

References (37)

1. HARMAN, D. 1983. Free radical theory of aging: consequences of mitochondrial aging. Age 6: 86-94.
2. MIQUEL, J. & J.E. FLEMING. 1984. A two-step hypothesis on the mechanisms of in vitro cell aging: cell differentiation followed by intrinsic mitochondrial mutagenesis. Exp. Gerontol. 19: 31-36.
3. SHIGENAGA, M.K., T.M. HAGEN & B.N. AMES. 1994. Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. USA 91: 10771-10778.
4. HAGEN, T.M., D.L. YOWE, J.C. BARTHOLOMEW, et al. 1997. Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc. Natl. Acad. Sci. USA 94: 3064-3069.
5. BECKMAN, K.B. & B.N. AMES. 1998. Mitochondrial aging: open questions. Ann. N.Y. Acad. Sci. 854: 118-127.
6. BECKMAN, K.B. & B.N. AMES. 1998. The free radical theory of aging matures. Physiol. Rev. 78: 547-581.
7. HELBOCK, H.J., K.B. BECKMAN, M.K. SHIGENAGA, et al. 1998. DNA oxidation matters: the HPLC-EC assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc. Natl. Acad. Sci. USA 95: 288-293.
8. LIU, J., D. KILLILEA & B.N. AMES. 2002. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-α-lipoic acid. Proc. Natl. Acad. Sci. USA 99: 1876-1881.
9. HAGEN, T.M., R.T. INGERSOLL, C.M. WEHR, et al. 1998. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc. Natl. Acad. Sci. USA 95: 9562-9566.
10. HAGEN, T.M., C.M. WEHR & B.N. AMES. 1998. Mitochondrial decay in aging. Reversal through dietary supplementation of acetyl-L-carnitine and N-tert-butyl-α-phenylnitrone. Ann. N.Y Acad. Sci. 854: 214-223.
11. HAGEN, T.M., R.T. INGERSOLL, J. LIU, et al. 1999. (R)-α-Lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 13: 411-418.
12. LYKKESFELDT, J., T.M. HAGEN, V. VINARSKY & B.N. AMES. 1998. Age-associated decline in ascorbic acid concentration, recycling and biosynthesis in rat hepatocytes - reversal with (R)-α-lipoic acid supplementation. FASEB J. 12: 1183-1189.
13. HAGEN, T.M., V. VINARSKY, C.M. WEHR & B.N. AMES. 2000. (R)-α-Lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butyl-hydroperoxide both in vitro and in vivo. Antiox. Redox Signal. 2: 473-483.
14. HAGEN, T.M., J. LIU, J. LYKKESFELDT, et al. 2002. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc. Natl. Acad. Sci. USA 99: 1870-1875.
15. LIU, J., E. HEAD, A.M. GHARIB, et al. 2002. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-α-lipoic acid. Proc. Natl. Acad. Sci. USA 99: 2356-2361.
16. AMES, B.N., I. ELSON-SCHWAB & E.A. SILVER. 2002. High-dose vitamins stimulate variant enzymes with decreased coenzyme-binding affinity (increased Km): relevance to genetic disease and polymorphisms. Am. J. Clin. Nutr. 75: 616-658.
17. WALTER, P.W., M.D. KNUTSON, A. PALER-MARTINEZ, et al. 2002. Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proc. Natl. Acad. Sci. USA 99: 2264-2269.
18. ATAMNA, H., J. LIU & B.N. AMES. 2001. Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: relevance to aging. J. Biol. Chem. 276: 48410-48416.
19. ATAMNA, H., P.W. WALTER & B.N. AMES. 2002. The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age. Arch. Biochem. Biophys. 397: 345-353.
20. ATAMNA, H., D.W. KILLILEA, A.N. KILLILEA & B.N. AMES. 2002. Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging. Proc. Natl. Acad. Sci. USA 99: 14807-14812.
21. BENTON, D. 2001. Micro-nutrient supplementation and the intelligence of children. Neurosci. Biobehav. Rev. 25: 297-309.
22. TAMURA, T., R.L. GOLDENBERG, J. Hou, et al. 2002. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J. Pediatr. 140: 165-170.
23. HO, E. & B.N. AMES. 2002. Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFκB, and AP1 DNA-binding, and affects DNA repair in a rat glioma cell line. Proc. Natl. Acad. Sci. USA 99: 16770-16775.
24. HO, E., C. COURTEMANCHE & B.N. AMES. 2003. Zinc deficiency induces oxidative DNA damage and increases P53 expression in human lung fibroblasts. J. Nutr. 133: 2543-2548.
25. SANDSTEAD, H.H., C.J. FREDERICKSON & J.G. PENLAND. 2000. History of zinc as related to brain function. J. Nutr. 130: 496S-502S.
26. MOCK, D.M., J.G. QUIRK & N.I. MOCK. 2002. Marginal biotin deficiency during normal pregnancy. Am. J. Clin. Nutr. 75: 295-299.
27. MOCK, D.M., C.L. HENRICH, N. CARNELL & N.I. MOCK. 2002. Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge. Am. J. Clin. Nutr. 76: 1061-1068.
28. MOCK, D.M. 1989. Biotin. International Life Sciences Institute. Washington, D.C.
29. SCHOLNICK, P.L., L.E. HAMMAKER & H.S. MARVER. 1972. Soluble-aminolevulinic acid synthetase of rat liver. II. Studies related to the mechanism of enzyme action and hemin inhibition. J. Biol. Chem. 247: 4132-4137.
30. WAKIMOTO, P. & G. BLOCK. 2001. Dietary intake, dietary patterns, and changes with age: an epidemiological perspective. J. Gerontol. A Biol. Sci. Med. Sci. 56: 65-80.
31. PLESOFSKY-VIG, N. 1996. Pantothenic Acid. ILSI Press. New York.
32. BRAMBL, R. & N. PLESOFSKY-VIG. 1986. Pantothenate is required in Neurospora crassa for assembly of subunit peptides of cytochrome c oxidase and ATPase/ATP synthase. Proc. Natl. Acad. Sci. USA 83: 3644-3648.
33. ROSSI, L., G. LIPPE, E. MARCHESE, et al. 1998. Decrease of cytochrome c oxidase protein in heart mitochondria of copper-deficient rats. Biometals 11: 207-212.
34. STEFFENS, G.C., R. BIEWALD & G. BUSE. 1987. Cytochrome c oxidase is a three-copper, two-heme-A protein. Eur. J. Biochem. 164: 295-300.
35. WILLIAMS, D.M., F.S. KENNEDY & B.G. GREEN. 1985. The effect of iron substrate on mitochondrial haem synthesis in copper deficiency. Br. J. Nutr. 53: 131-136.
36. KEYHANI, E. & J. KEYHANI. 1980. Identification of porphyrin present in apo-cytochrome c oxidase of copper-deficient yeast cells. Biochim. Biophys. Acta 633: 211-227.
37. NAKAYAMA, K., A. TAKASAWA, I. TERAI, et al. 2000. Spontaneous porphyria of the Long-Evans cinnamon rat: an animal model of Wilson's disease. Arch. Biochem. Biophys. 375: 240-250.