Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation

Journal of Biological Chemistry

Volumn 284, Issue 33, 2009, Pages 22099-22107

  MacDonald, Christopher J ^a   Cheng, Robert Y S ^a   Roberts, David D ^a   Wink, David A ^a   Yeh, Grace Chao ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOCARCINOMA CELLS; ARYL HYDROCARBON RECEPTOR; BENZO [A] PYRENE; CHEMOPREVENTION; CHEMOPREVENTIVE AGENTS; CYTOCHROME P450; DIETHYLENETRIAMINE; DNA ADDUCTS; DNA DAMAGES; ENHANCING EFFECT; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE-S-TRANSFERASE; HUMAN HEPATOMA CELLS; INHIBITORY EFFECT; ISOSORBIDE; MRNA EXPRESSION; NAD(P)H; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; NUCLEAR RNA; ORGANIC NITRATES; OXIDOREDUCTASES; PHASE I; PHASE II; TRANSCRIPTIONAL REGULATION;

BIOCHEMISTRY; CARCINOGENS; CATALYSTS; DETOXIFICATION; DNA; ENZYME ACTIVITY; GENES; HYDROCARBONS; METABOLISM; NITRIC OXIDE; NUCLEIC ACIDS; RNA; SYSTEM THEORY;

ENZYMES;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ACETYLSALICYLIC ACID; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; CARCINOGEN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DIETHYLENETRIAMINE NITRIC OXIDE; DNA; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE TRANSFERASE P1; HETEROGENEOUS NUCLEAR RNA; ISOSORBIDE DINITRATE; MESSENGER RNA; NCX 4040; NITRIC OXIDE 2 (ACETYLOXY)BENZOIC ACID 4 [(NITROOXY)METHYL]PHENYL ESTER; NITRIC OXIDE DONOR; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANIC NITRATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CARCINOGEN DNA INTERACTION; CELL STRAIN HEPG2; CONTROLLED STUDY; DETOXIFICATION; DNA ADDUCT; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENHANCER REGION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIGAND BINDING; METABOLITE; MODULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

ARYL HYDROCARBON HYDROXYLASES; ASPIRIN; CARCINOGENS; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; DNA ADDUCTS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, BIOLOGICAL; NITRIC OXIDE; OXYGEN; RECEPTORS, ARYL HYDROCARBON; RECOMBINANT PROTEINS; TETRACHLORODIBENZODIOXIN;

EID: 69249083614     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.021063     Document Type: Article

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