Influence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells

Toxicology

Volumn 259, Issue 3, 2009, Pages 91-96

  Schreck, Ilona ^a   Chudziak, Doreen ^a   Schneider, Sandra ^a   Seidel, Albrecht ^b   Platt, Karl L ^c   Oesch, Franz ^c   Weiss, Carsten ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b Biochemical Institute for Environmental Carcinogens   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; Aryl hydrocarbon receptor; Benzo a pyrene; cis Platin; Nucleotide excision repair; p53

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; BINDING PROTEIN; CISPLATIN; DIOXIN; DNA; DNA POLYMERASE; HYPOXIA INDUCIBLE FACTOR 1BETA; LIGAND; POLYCYCLIC AROMATIC HYDROCARBON; POLYCYCLIC HYDROCARBON; PROTEIN P21; PROTEIN P53; PYRENE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL DEGENERATION; CELL MATURATION; CELL MEMBRANE PERMEABILITY; CELL PROTECTION; CELL SURVIVAL; CELL TYPE; CYTOTOXICITY; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVATION; EXCISION REPAIR; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; GENOTOXICITY; HEPATOMA CELL; MOUSE; NONHUMAN; POLLUTANT; PRIORITY JOURNAL; PROMOTER REGION; STEM CELL; ULTRAVIOLET RADIATION; UPREGULATION;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; DNA REPAIR; DNA-DIRECTED DNA POLYMERASE; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES, P53; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MUTAGENS; RECEPTORS, ARYL HYDROCARBON;

EID: 63449118032     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.02.006     Document Type: Article

References (28)

1. Adimoolam S., and Ford J.M. p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 12985-12990
2. Adimoolam S., and Ford J.M. p53 and regulation of DNA damage recognition during nucleotide excision repair. DNA Repair (Amst.) 2 (2003) 947-954
3. Arand M., and Oesch F. Mammalian xenobiotic epoxide hydrolases. In: Ioannides C. (Ed). Handbook of Enzyme Systems that Metabolise Drugs and Other Xenobiotics (2002), John Wiley & Sons, Chichester 459-483
4. Bock K.W., and Kohle C. Ah receptor- and TCDD-mediated liver tumor promotion: clonal selection and expansion of cells evading growth arrest and apoptosis. Biochem. Pharmacol. 69 (2005) 1403-1408
5. Bock K.W., and Kohle C. Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions. Biochem. Pharmacol. 72 (2006) 393-404
6. Chung J.Y., Kim J.Y., Kim W.R., Lee S.G., Kim Y.J., Park J.E., Hong Y.P., Chun Y.J., Park Y.C., Oh S., Yoo K.S., Yoo Y.H., and Kim J.M. Abundance of aryl hydrocarbon receptor potentiates benzo[a]pyrene-induced apoptosis in Hepa1c1c7 cells via CYP1A1 activation. Toxicology 235 (2007) 62-72
7. Hanawalt P.C. Subpathways of nucleotide excision repair and their regulation. Oncogene 21 (2002) 8949-8956
8. Hengstler J.G., Bogdanffy M.S., Bolt H.M., and Oesch F. Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate. Annu. Rev. Pharmacol. Toxicol. 43 (2003) 485-520
9. Herrlich P., Karin M., and Weiss C. Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response. Mol. Cell 29 (2008) 279-290
10. Hockley S.L., Arlt V.M., Jahnke G., Hartwig A., Giddings I., and Phillips D.H. Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53. Carcinogenesis 29 (2008) 202-210
11. Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 411 (2001) 366-374
12. IARC, 1987. Monogr. Eval. Carcinog. Risks Hum. (Suppl. 7) 58.
13. IARC, 1997. Monogr. Eval. Carcinog. Risks Hum. 69, 1-631.
14. Kolluri S.K., Weiss C., Koff A., and Gottlicher M. p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Genes Dev. 13 (1999) 1742-1753
15. Nebert D.W., Dalton T.P., Okey A.B., and Gonzalez F.J. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J. Biol. Chem. 279 (2004) 23847-23850
16. Oesch F., Herrero M.E., Hengstler J.G., Lohmann M., and Arand M. Metabolic detoxification: implications for thresholds. Toxicol. Pathol. 28 (2000) 382-387
17. Ogi T., Mimura J., Hikida M., Fujimoto H., Fujii-Kuriyama Y., and Ohmori H. Expression of human and mouse genes encoding polkappa: testis-specific developmental regulation and AhR-dependent inducible transcription. Genes Cells 6 (2001) 943-953
18. Platt K.L., and Oesch F. Efficient synthesis of non-K-region trans-dihydro diols of polycyclic aromatic hydrocarbons from o-quinones and catechols. J. Org. Chem. 48 (1983) 265-268
19. Rubin H. Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates. Carcinogenesis 22 (2001) 1903-1930
20. Schrenk D., Schmitz H.J., Bohnenberger S., Wagner B., and Worner W. Tumor promoters as inhibitors of apoptosis in rat hepatocytes. Toxicol. Lett. 149 (2004) 43-50
21. Solhaug A., Refsnes M., Lag M., Schwarze P.E., Husoy T., and Holme J.A. Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells. Carcinogenesis 25 (2004) 809-819
22. Straif K., Baan R., Grosse Y., Secretan B., El Ghissassi F., and Cogliano V. Carcinogenicity of polycyclic aromatic hydrocarbons. Lancet Oncol. 6 (2005) 931-932
23. Tan T., and Chu G. p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice. Mol. Cell Biol. 22 (2002) 3247-3254
24. Weiss C., Kolluri S.K., Kiefer F., and Gottlicher M. Complementation of Ah receptor deficiency in hepatoma cells: negative feedback regulation and cell cycle control by the Ah receptor. Exp. Cell Res. 226 (1996) 154-163
25. Weiss C., Faust D., Durk H., Kolluri S.K., Pelzer A., Schneider S., Dietrich C., Oesch F., and Gottlicher M. TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway. Oncogene 24 (2005) 4975-4983
26. Weiss C., Faust D., Schreck I., Ruff A., Farwerck T., Melenberg A., Schneider S., Oesch-Bartlomowicz B., Zatloukalova J., Vondracek J., Oesch F., and Dietrich C. TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, junD and cyclin A. Oncogene 27 (2008) 2198-2207
27. Worner W., and Schrenk D. Influence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofluorene, ultraviolet light, or transforming growth factor beta 1. Cancer Res. 56 (1996) 1272-1278
28. Yagi H., Thakker D.R., Hernandez O., Koreeda M., and Jerina D.M. Synthesis and reactions of the highly mutagenic 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene. J. Am. Chem. Soc. 99 (1977) 1604-1611