In vitro neuroprotection against oxidative stress by pre-treatment with a combination of dihydrolipoic acid and phenyl-butyl nitrones

Neurotoxicity Research

Volumn 5, Issue 4, 2003, Pages 265-272

  Koenig, Michael L ^a   Meyerhoff, James L ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Antioxidant; Free radical scavenger; Neuronal culture; Neuroprotection; ROS

Indexed keywords

ANTIOXIDANT; BENZENESULFONIC ACID DERIVATIVE; DIHYDROLIPOATE; DRUG DERIVATIVE; HYDROGEN PEROXIDE; N TERT BUTYL (2 SULFOPHENYL)NITRONE; N TERT BUTYL ALPHA PHENYLNITRONE; N-TERT-BUTYL-(2-SULFOPHENYL)NITRONE; NEUROPROTECTIVE AGENT; NITROGEN OXIDE; OXIDIZING AGENT; PHENYL-N-TERT-BUTYLNITRONE; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID;

ANIMAL; ARTICLE; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; FOREBRAIN; IN VITRO STUDY; METABOLISM; NERVE CELL; OXIDATIVE STRESS; RAT;

ANIMALS; ANTIOXIDANTS; BENZENESULFONATES; CELL SURVIVAL; CELLS, CULTURED; DRUG SYNERGISM; HYDROGEN PEROXIDE; NEURONS; NEUROPROTECTIVE AGENTS; NITROGEN OXIDES; OXIDANTS; OXIDATIVE STRESS; PROSENCEPHALON; RATS; REACTIVE OXYGEN SPECIES; THIOCTIC ACID;

EID: 0141500250     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033384     Document Type: Article

References (44)

1. Almli LM, SEG Hamrick, AA Koshy, MG Tauber and DM Ferriero (2001) Multiple pathways of neuroprotection against oxidative stress and excitotoxic injury in immature primary hippocampal neurons. Dev. Brain Res. 132, 121-129.
2. Arivazhagan P and C Panneerselvam (2000) Effect of DL-α-lipoic acid on neural antioxidants in aged rats. Pharmacol. Res. 42, 219-222.
3. Chan AC (2000) A cocktail approach to antioxidant therapy. Nutrition 16, 1098-1100.
4. Chen H, D Li, T Saldeen, F Romeo and JL Mehta (2002) Mixed tocopherol preparation is superior to α-tocopherol alone against hypoxia-reoxygenation injury. Biochem. Biophys. Res. Commun. 291, 349-353.
5. Cheng Y and AY Sun (1994) Oxidative mechanisms involved in kainate-induced cytotoxicity in cortical neurons. Neurochem. Res. 19, 1557-1564.
6. Choi DW (1988b) Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage. Trends Neurosci. 11, 465-469.
7. Choi DW (1988b) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
8. Choi DW (1990) Methods for antagonizing glutamate neurotoxicity. Cereb. Brain Metab. Rev. 2, 105-147.
9. Chidlow G, K-G Schmidt, JPM Wood, J Melena and NN Osborne (2002) α-lipoic acid protects the retina against ischemia-reperfusion. Neuropharmacol. 43, 1015-1025.
10. Cuzzocrea S, DP Riley, AP Caputi and D Salvemini (2001) Antioxidant therapy a new pharmacological approach in shock inflammation and ischemia/reperfusion injury. Pharmacol. Rev., 53, 135-159.
11. De Keyser J, G Sulter and PG Luiten (1999) Clinical trials with new croprotective drugs in acute ischaemic stroke: Are we doing the right thing? Irends Neurosci. 22, 535-540.
12. Gilgun-Sherki Y. E. Melamed and D Offen (2001) Oxidative stress induced-neurodegenerative diseases: The need for antioxidants that penetrate the blood brain barrier. Neuropharmacol. 40, 959-975.
13. Gilgun-Sherki Y, Z Rosenbaum, E Melamed and D Offen (2002) Antioxidant therapy in acute central nervous system injury: Current state. Pharmacol. Rev. 54 271-284.
14. Ginsburg MD (1995) Neuroprotection in brain ischemia: An update (part II). Neuroscientist 1, 164-175.
15. Hagen TM, RT Ingersoll, J Lykkesfeldt, JK Liu, CM Wehr, V Vinarsky, JC Bartholomew and BN Ames (1999) (R) -alpha-lipoiction, acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J, 13, 411-418.
16. Halliwell B and JMC Gutteridge (1999) Free Radicals in Biology and Medicine, 3rd Edition (Oxford, Univ, Press: New York, NY).
17. Han D, CK Sen, S Roy, MS Kobayashi, HJ Tritschler and L Packer (1997) Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am. J. Physiol. 273, R1771-R1778.
18. Jones W, X Li, Z Qu, L Perriott RR Whitesell and JM May (2002) Uptake, recycling, and antioxidant actions of α-lipoic acid in endothelial cells. Frec Radic. Biol. Med. 33, 83-93.
19. Klocker N, A Callerino and M Bahr (1998) Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells in vivo. J. Neurosci. 18, 1038-1046.
20. 2 (EEP). Peptides 22, 2091-2097.
21. Kozlov AV, L Gille, K Staniek and L Nohl (1999) Dihydrolipoic acid maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone. Arch. Biochem. Biophys. 363, 148-154.
22. Lipton P (1999) Ischemic cell death in brain neurons. Physiol. Rev. 79, 1431-1568.
23. Lockhart B, C Jones, C Cuisinier, N Villain, D Peyroulan and P Lestage (2000) Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with α-lipoic acid enantiomers. Brain Res. 855, 292-297.
24. MacDonald JF, LM Nowak (1990) Mechanisms of blockade of excitatory amino acid receptor channels. Trends Pharmacol. Sci. 11, 167-172.
25. 2+ release. Trends Pharmacol. Sci. 16, 356-359.
26. Muller U and J Kriegelstein (1995) Prolonged pretreatment with α-lipoic acid protects cultured neurons against hypoxic, glutamateor iron-induced injury. J. Cereb. Blood Flow Metab. 15, 624-630.
27. Nishizawa Y (2001) Glutamate release and neuronal damage in ischemia. Life Sci. 69, 369-381.
28. Ou P, HJ Tritschler and SP Wolff (1995) Thioctic (lipoic) acid: A therapeutic metal-chelating antioxidant. Biochem. Pharmacol. 50, 123-126.
29. Panigrahi M, Y Sadguna, BR Shivakumar, SVR Kolluri, S Roy, L Packer and V Ravindranath (1996) α-lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 717, 184-188.
30. Perez MJ and AL Cederbaum (2001) Spin trapping agents (Tempol and POBN) protect HepG2 cells overexpressing CYP2E1 against arachidonic acid toxicity, Fere Radic. Biol. Med. 30, 734-746.
31. Prehn JHM, C Karkoutly, J Nuglisch, B Peruche, J Kriegelstein (1992) Dihydrolipoate reduces neuronal injury after cerebral ischemia. J. Cereb. Blood Floic Metab. 12, 78-87.
32. Roy S, CK Sen, HJ Tritschler and L Packer (1997) Modulation of cellular reducing equivalent homeostasis by α-lipoic acid. Biochem. Pharmacol. 53, 393-399.
33. Schmuck G, E Rohrdanz, Q-H Tran-Thi, R Kahl and G Schluter (2002) Oxidative stress in rat cortical neurons and astrocytes induced by paraquat in vitro. Neurotoxicity Res. 4, 1-13.
34. Schulz JB, DR Henshaw, D Siwek, BG Jenkins, RJ Ferrante, PB Cipolloni, NW Kowall, BR Rosen and MF Beal (1995) Involvement of free radicals in excitotoxicity in vivo. J. Neurochem. 64, 2239-2247.
35. Schulz JB, RT Matthews, DR Henshaw and MF Beal (1996) Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. Neurosciences 71, 1043-1048.
36. Sheline CT, EH Choi, JS Kim-Han, LL Dugan and DW Choi (2002) Cofactors of mitochondrial enzymes attenuate copper-induced death in vitro and in vivo. Ann. Neurol. 52, 195-204.
37. Smythies J (1999) The neurotoxicity of glutamate, dopamine, iron, and reactive oxygen species: Functional interrelationships in health and disease: A review - discussion. Neurotoxicity Res. 1 27-39.
38. Thomas CE, DF Ohlweiler, VL Taylor and CJ Schmidt (1997) Radical trapping and inhibition of iron-dependent CNS damage by cyclic nitrone spin traps. J. Neurochem. 68, 1173-1182.
39. Tirosh O CK Sen, S Roy, MS Kobayashi and L Packer (1999) Neuroprotective effects of α-lipoic acid and its positively charged amide analogue. Free Radic. Biol. Med. 26, 1418-1426.
40. Whetsell WO (1996) Current concepts of excitotoxicty. J. Neuropathol. Exp. Neurol. 55, 1-13.
41. Wickramsinghe SN and R Hasan (1992) in vitro effects of vitamin C, thioctic acid, and dihydrolipoic acid on the cytotoxicity of post ethanol serum. Biochem. Pharmacol. 43, 407-411.
42. Yue T-L, J-L Gu, PG Lysko, H-Y Cheng, FC Barone and G Feuerstein (1992) Neuroprotective effects of phenyl-t-butyl nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons. Brain Res. 574, 193-197.
43. Zeevalk GD, LP Bernhard and WP Nicklas (1998) Role of oxidative stress and the glutathione system in loss of dopamine neurons due to impairment of energy metabolism. J. Neurochem 70, 1421-1430.
44. Zhang L, G Xing, JL Barker, Y Chang, D Maric, W Ma, B Li and D Rubinow (2001) α-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signaling pathway. Neurosci. Lett. 312, 125-128.