Glutathione and gamma-glutamyl transferases are involved in the formation of cadmium-glutathione complex

FEBS Letters

Volumn 583, Issue 9, 2009, Pages 1489-1492

  Adamis, Paula Daniela Braga ^a   Mannarino, Sérgio Cantú ^a   Eleutherio, Elis Cristina Araújo ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Cadmium; Gamma glutamyl transferase; Glutathione; Glutathione transferase; Saccharomyces cerevisiae

Indexed keywords

CADMIUM; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE 2; UNCLASSIFIED DRUG;

ARTICLE; CYTOPLASM; CYTOSOL; DETOXIFICATION; ENZYME ACTIVITY; FUNGAL STRAIN; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; WILD TYPE;

CADMIUM; GAMMA-GLUTAMYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 67349100775     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.03.066     Document Type: Article

References (21)

1. Martelli A., Rousselet E., Dycke C., Bouron A., and d Moulis J.M. Cadmium toxicity in animal cells by interference with essential metals. Biochimie 88 (2006) 1807-1814
2. International Agency for Research on Cancer (IARC) (Ed.) (1993) IARC on Cancer Monographs on the Evaluations of Carcinogenic Risks to Humans. IARC Scientific Publications, Lyon, France.
3. Jin Y.H., Clark A.B., Slebos R.J., Al-Refai H., Taylor J.A., Kunkel T.A., Resnick M.A., and Gordenin D.A. Cadmium is a mutagen that acts by inhibiting mismatch repair. Nat. Genet. 34 (2003) 326-329
4. Gomes D.S., Pereira M.D., Panek A.D., Andrade L.R., and Eleutherio E.C. Apoptosis as a mechanism for removal of mutated cells of Saccharomyces cerevisiae: the role of Grx2 under cadmium exposure. Biochim. Biophys. Acta 1780 (2008) 160-166
5. Penninckx M.J. An overview on glutathione in Saccharomyces versus non-conventional yeasts. FEMS Yeast Res. 2 (2002) 295-305
6. Dringen R. Metabolism and functions of glutathione in brain. Prog. Neurobiol. 62 (2000) 649-671
7. Li Z.S., Lu Y.P., Zhen R.G., Szczypka M., Thiele D.J., and Rea P.A. A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. Proc. Natl. Acad. Sci. USA 94 (1997) 42-47
8. Kim H.G., Park K.N., Cho Y.W., Park E.H., Fuchs J.A., and Lim C.J. Characterization and regulation of glutathione S-transferase gene from Schizosaccharomyces pombe. Biochim. Biophys. Acta 1520 (2001) 179-185
9. Vuilleumier S. Bacterial glutathione S-transferases: what are they good for?. J. Bacteriol. 179 (1997) 1431-1441
10. Adamis P.D., Gomes D.S., Pinto M.L., Panek A.D., and Eleutherio E.C. The role of glutathione transferases in cadmium stress. Toxicol. Lett. 154 (2004) 81-88
11. Gomes D.S., Fragoso L.C., Riger C.J., Panek A.D., and Eleutherio E.C. Regulation of cadmium uptake by Saccharomyces cerevisiae. Biochim. Biophys. Acta 1573 (2002) 21-25
12. Adamis P.D., Panek A.D., and Eleutherio E.C. Vacuolar compartmentation of the cadmium-glutathione complex protects Saccharomyces cerevisiae from mutagenesis. Toxicol. Lett. 173 (2007) 1-7
13. Adamis, P.D., Mannarino, S.C., Riger, C.J., Duarte, G., Cruz, A., Pereira, M.D. and Eleutherio, E.C. (2008) Lap4, a vacuolar aminopeptidase I, is involved in cadmium-glutathione metabolism. Biometals.
14. Stickland L.H. The determination of small quantities of bacteria by means of the biuret reaction. J. Gen. Microbiol. 5 (1951) 698-703
15. Wellner V.P., Anderson M.E., Puri R.N., Jensen G.L., and Meister A. Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts. Proc. Natl. Acad. Sci. USA 81 (1984) 4732-4735
16. Fauchon M., et al. Sulfur sparing in the yeast proteome in response to sulfur demand. Mol. Cell 9 (2002) 713-723
17. Preveral S., Ansoborlo E., Mari S., Vavasseur A., and Forestier C. Metal(loid)s and radionuclides cytotoxicity in Saccharomyces cerevisiae. Role of YCF1, glutathione and effect of buthionine sulfoximine. Biochimie 88 (2006) 1651-1663
18. Anderson M.E. Glutathione: an overview of biosynthesis and modulation. Chem. Biol. Interact. 111-112 (1998) 1-14
19. Mehdi K., Thierie J., and Penninckx M.J. Gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae and its role in the vacuolar transport and metabolism of glutathione. Biochem. J. 359 (2001) 631-637
20. Mehdi K., and Penninckx M.J. An important role for glutathione and gamma-glutamyltranspeptidase in the supply of growth requirements during nitrogen starvation of the yeast Saccharomyces cerevisiae. Microbiology 143 Pt. 6 (1997) 1885-1889
21. Kumar C., Sharma R., and Bachhawat A.K. Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation pathway. FEMS Microbiol. Lett. 219 (2003) 187-194