Muscarinic activation attenuates abnormal processing of β-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells

Biochemical and Biophysical Research Communications

Volumn 384, Issue 1, 2009, Pages 110-113

  Zhu, Xu ^a   Zhou, Wei ^a   Cui, Yongyao ^a   Zhu, Liang ^a   Li, Juan ^a   Xia, Zheng ^a   Shao, Biyun ^a   Wang, Hao ^a   Chen, Hongzhuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Amyloid peptide; Amyloid precursor protein; Site APP cleaving enzyme 1; Hypoxia; Presenilin 1; Retinal ganglion cells

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; COBALT CHLORIDE; GAMMA SECRETASE; MUSCARINIC RECEPTOR; PILOCARPINE; PRESENILIN 1;

ANIMAL CELL; ARTICLE; CELL HYPOXIA; CHOLINERGIC STIMULATION; CONTROLLED STUDY; GLAUCOMA; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROCESSING; RAT; RETINA GANGLION CELL; UPREGULATION;

ADAM PROTEINS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANOXIA; ASPARTIC ENDOPEPTIDASES; COBALT; GLAUCOMA; MUSCARINIC AGONISTS; RATS; RECEPTORS, MUSCARINIC; RETINAL GANGLION CELLS; RNA, MESSENGER;

EID: 65549159891     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.04.080     Document Type: Article

References (25)

1. McKinnon S.J., Lehman D.M., Kerrigan-Baumrind L.A., Merges C.A., Pease M.E., Kerrigan D.F., Ransom N.L., Tahzib N.G., Reitsamer H.A., Levkovitch-Verbin H., Quigley H.A., and Zack D.J. Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest. Ophthalmol. Vis. Sci. 43 (2002) 1077-1087
2. Yoneda S., Hara H., Hirata A., Fukushima M., Inomata Y., and Tanihara H. Vitreous fluid levels of beta-amyloid ((1-42)) and tau in patients with retinal diseases. Jpn. J. Ophthalmol. 49 (2005) 106-108
3. Parisi V., Restuccia R., Fattapposta F., Mina C., Bucci M.G., and Pierelli F. Morphological and functional retinal impairment in Alzheimer's disease patients. Clin. Neurophysiol. 112 (2001) 1860-1867
4. Iseri P.K., Altinas O., Tokay T., and Yuksel N. Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease. J. Neuroophthalmol. 26 (2006) 18-24
5. Guo L., Salt T.E., Luong V., Wood N., Cheung W., Maass A., Ferrari G., Russo-Marie F., Sillito A.M., Cheetham M.E., Moss S.E., Fitzke F.W., and Cordeiro M.F. Targeting amyloid-beta in glaucoma treatment. Proc. Natl. Acad. Sci. USA 104 (2007) 13444-13449
6. Zheng H., and Koo E.H. The amyloid precursor protein: beyond amyloid. Mol. Neurodegener. 3 (2006) 1-5
7. Wong P.C. Translational control of BACE1 may go awry in Alzheimer's disease. Neuron 60 (2008) 941-943
8. Kukar T.L., Ladd T.B., Bann M.A., Fraering P.C., Narlawar R., Maharvi G.M., Healy B., Chapman R., Welzel A.T., Price R.W., Moore B., Rangachari V., Cusack B., Eriksen J., Jansen-West K., Verbeeck C., Yager D., Eckman C., Ye W., Sagi S., Cottrel B.A., Torpey J., Rosenberry T.L., Fauq A., Wolfe M.S., Schmidt B., Walsh D.M., Koo E.H., and Golde T.E. Substrate-targeting gamma-secretase modulators. Nature 453 (2008) 925-929
9. L.V. Johnson, W.P. Leitner, A.J. Rivest, M.K. Staples, M.J. Radeke, D.H. Anderson, The Alzheimer's A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration, Proc. Natl. Acad. Sci. USA 99 (2002) 11830-11835.
10. Agar A., Li S., Agarwal N., Coroneo M.T., and Hill M.A. Retinal ganglion cell line apoptosis induced by hydrostatic pressure. Brain Res. 1086 (2006) 191-200
11. Tezel G., and Wax M.B. Hypoxia-inducible factor 1 alpha in the glaucomatous retinal and optic nerve head. Arch. Ophthalmol. 122 (2004) 1348-1356
12. Caccamo A., Oddo S., Billings L.M., Green K.N., Martinez-Coria H., Fisher A., and LaFerla F.M. M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron 49 (2006) 671-682
13. Qiu Y., Chen H.Z., Wu X.J., and Jin Z.J. 6beta-acetoxy nortropane regulated processing of amyloid precursor protein in CHOm1 cells and rat brain. Eur. J. Pharmacol. 468 (2003) 1-8
14. Qiu Y., Wu X.J., and Chen H.Z. Simultaneous changes in secretory amyloid precursor protein and beta-amyloid peptide release from rat hippocampus by activation of muscarinic receptors. Neurosci. Lett. 352 (2003) 41-44
15. Postina R. A closer look at alpha-secretase. Curr. Alzheimer Res. 5 (2008) 179-186
16. Miki A., Otori Y., Morimoto T., Okada M., and Tano Y. Protective effect of donepezil on retinal ganglion cells in vitro and in vivo. Curr. Eye Res. 31 (2006) 69-77
17. Zhou W., Zhu X., Zhu L., Cui Y.Y., Wang H., Qi H., Ren Q.S., and Chen H.Z. Neuroprotection of muscarinic receptor agonist pilocarpine against glutamate-induced apoptosis in retinal neurons. Cell. Mol. Neurobiol. 28 (2008) 263-275
18. Krishnamoorthy R.R., Agarwal P., Prasanna G., Vopat K., Lambert W., Sheedlo H.J., Pang I.H., Shade D., Wordinger R.J., Yorio T., Clark A.F., and Agarwal N. Characterization of a transformed rat retinal ganglion cell line. Brain Res. Mol. Brain Res. 86 (2001) 1-12
19. Borenstein A.R., Wu Y., Mortimer J.A., Schellenberg G.D., McCormick W.C., Bowen J.D., McCurry S., and Larson E.B. Developmental and vascular risk factors for Alzheimer's disease. Neurobiol. Aging 26 (2005) 325-334
20. Skoog I., and Gustafson D. Update on hypertension and Alzheimer's disease. Neurol. Res. 28 (2006) 605-611
21. Sun X., He G., Qing H., Zhou W., Dobie F., Cai F., Staufenbiel M., Huang L.E., and Song W. Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. Proc. Natl. Acad. Sci. USA 103 (2006) 18727-18732
22. Wang R., Zhang Y.W., Zhang X., Liu R., Zhang X., Hong S., Xia K., Xia J., Zhang Z., and Xu H. Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J. 20 (2006) 1275-1277
23. Zhang X., Zhou K., Wang R., Cui J., Lipton S.A., Liao F.F., Xu H., and Zhang Y.W. Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. J. Biol. Chem. 282 (2007) 10873-10880
24. Wen Y., Onyewuchi O., Yang S., Liu R., and Simpkins J.W. Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Brain Res. 1009 (2004) 1-8
25. Marshall A.J., Rattray M., and Vaughan P.F. Chronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative alpha-secretases, ADAM10 and TACE, without altering their mRNA levels. Brain Res. 1099 (2006) 18-24