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Volumn 30, Issue 3, 2009, Pages 324-335

Follicular Helper T Cells: Lineage and Location

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR5;

EID: 61949131896     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2009.03.003     Document Type: Review
Times cited : (496)

References (122)
  • 1
    • 34548036949 scopus 로고    scopus 로고
    • Germinal-center organization and cellular dynamics
    • Allen C.D., Okada T., and Cyster J.G. Germinal-center organization and cellular dynamics. Immunity 27 (2007) 190-202
    • (2007) Immunity , vol.27 , pp. 190-202
    • Allen, C.D.1    Okada, T.2    Cyster, J.G.3
  • 2
    • 33846635838 scopus 로고    scopus 로고
    • Imaging of germinal center selection events during affinity maturation
    • Allen C.D., Okada T., Tang H.L., and Cyster J.G. Imaging of germinal center selection events during affinity maturation. Science 315 (2007) 528-531
    • (2007) Science , vol.315 , pp. 528-531
    • Allen, C.D.1    Okada, T.2    Tang, H.L.3    Cyster, J.G.4
  • 4
    • 0032701695 scopus 로고    scopus 로고
    • In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
    • Ansel K.M., McHeyzer-Williams L.J., Ngo V.N., McHeyzer-Williams M.G., and Cyster J.G. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med. 190 (1999) 1123-1134
    • (1999) J. Exp. Med. , vol.190 , pp. 1123-1134
    • Ansel, K.M.1    McHeyzer-Williams, L.J.2    Ngo, V.N.3    McHeyzer-Williams, M.G.4    Cyster, J.G.5
  • 7
    • 33846400415 scopus 로고    scopus 로고
    • The germinal center response is impaired in the absence of T cell-expressed CXCR5
    • Arnold C.N., Campbell D.J., Lipp M., and Butcher E.C. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur. J. Immunol. 37 (2007) 100-109
    • (2007) Eur. J. Immunol. , vol.37 , pp. 100-109
    • Arnold, C.N.1    Campbell, D.J.2    Lipp, M.3    Butcher, E.C.4
  • 8
    • 58149097584 scopus 로고    scopus 로고
    • The who, how and where of antigen presentation to B cells
    • Batista F.D., and Harwood N.E. The who, how and where of antigen presentation to B cells. Nat. Rev. Immunol. 9 (2009) 15-27
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 15-27
    • Batista, F.D.1    Harwood, N.E.2
  • 9
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular helper T cells anf TH-17 cells
    • Bauquet A.T., Jin H., Paterson A.M., Mitsdoerffer M., Ho C.-I., Sharpe A.H., and Vuchroo V.K. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular helper T cells anf TH-17 cells. Nat. Immunol. 10 (2008) 167-175
    • (2008) Nat. Immunol. , vol.10 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3    Mitsdoerffer, M.4    Ho, C.-I.5    Sharpe, A.H.6    Vuchroo, V.K.7
  • 10
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., and Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 13
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld D., Ohl L., Kremmer E., Ellwart J., Sallusto F., Lipp M., and Forster R. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 192 (2000) 1545-1552
    • (2000) J. Exp. Med. , vol.192 , pp. 1545-1552
    • Breitfeld, D.1    Ohl, L.2    Kremmer, E.3    Ellwart, J.4    Sallusto, F.5    Lipp, M.6    Forster, R.7
  • 15
    • 0002225186 scopus 로고
    • A modification of Jerne's theory of antibody production using the concept of clonal selection
    • Burnet F.M. A modification of Jerne's theory of antibody production using the concept of clonal selection. Aust. J. Sci. 20 (1957) 67-69
    • (1957) Aust. J. Sci. , vol.20 , pp. 67-69
    • Burnet, F.M.1
  • 16
    • 0035554935 scopus 로고    scopus 로고
    • Separable effector T cell populations specialized for B cell help or tissue inflammation
    • Campbell D.J., Kim C.H., and Butcher E.C. Separable effector T cell populations specialized for B cell help or tissue inflammation. Nat. Immunol. 2 (2001) 876-881
    • (2001) Nat. Immunol. , vol.2 , pp. 876-881
    • Campbell, D.J.1    Kim, C.H.2    Butcher, E.C.3
  • 18
    • 0033697670 scopus 로고    scopus 로고
    • TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo
    • Cazac B.B., and Roes J. TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity 13 (2000) 443-451
    • (2000) Immunity , vol.13 , pp. 443-451
    • Cazac, B.B.1    Roes, J.2
  • 19
    • 35348978611 scopus 로고    scopus 로고
    • Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation
    • Celli S., Lemaitre F., and Bousso P. Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation. Immunity 27 (2007) 625-634
    • (2007) Immunity , vol.27 , pp. 625-634
    • Celli, S.1    Lemaitre, F.2    Bousso, P.3
  • 20
    • 57449105853 scopus 로고    scopus 로고
    • IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor
    • Chen Q., Yang W., Gupta S., Biswas P., Smith P., Bhagat G., and Pernis A.B. IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity 29 (2008) 899-911
    • (2008) Immunity , vol.29 , pp. 899-911
    • Chen, Q.1    Yang, W.2    Gupta, S.3    Biswas, P.4    Smith, P.5    Bhagat, G.6    Pernis, A.B.7
  • 21
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova T., Tangye S.G., Newton R., Frank N., Hodge M.R., Rolph M.S., and Mackay C.R. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J. Immunol. 173 (2004) 68-78
    • (2004) J. Immunol. , vol.173 , pp. 68-78
    • Chtanova, T.1    Tangye, S.G.2    Newton, R.3    Frank, N.4    Hodge, M.R.5    Rolph, M.S.6    Mackay, C.R.7
  • 22
    • 0013939825 scopus 로고
    • Thymus-marrow cell combinations. Synergism in antibody production
    • Claman H.N., Chaperon E.A., and Triplett R.F. Thymus-marrow cell combinations. Synergism in antibody production. Proc. Soc. Exp. Biol. Med. 122 (1966) 1167-1171
    • (1966) Proc. Soc. Exp. Biol. Med. , vol.122 , pp. 1167-1171
    • Claman, H.N.1    Chaperon, E.A.2    Triplett, R.F.3
  • 25
    • 0030901289 scopus 로고    scopus 로고
    • Control of inflammation, cytokine expression, and germinal center formation by BCL-6
    • Dent A.L., Shaffer A.L., Yu X., Allman D., and Staudt L.M. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276 (1997) 589-592
    • (1997) Science , vol.276 , pp. 589-592
    • Dent, A.L.1    Shaffer, A.L.2    Yu, X.3    Allman, D.4    Staudt, L.M.5
  • 27
    • 58149242530 scopus 로고    scopus 로고
    • A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts
    • Dullaers M., Li D., Xue Y., Ni L., Gayet I., Morita R., Ueno H., Palucka K.A., Banchereau J., and Oh S. A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts. Immunity 30 (2009) 120-129
    • (2009) Immunity , vol.30 , pp. 120-129
    • Dullaers, M.1    Li, D.2    Xue, Y.3    Ni, L.4    Gayet, I.5    Morita, R.6    Ueno, H.7    Palucka, K.A.8    Banchereau, J.9    Oh, S.10
  • 30
    • 62849126473 scopus 로고    scopus 로고
    • The function of follicular helper T cells is regulated by the strength of T cell receptor binding
    • 10.1038/ni.1704 in press. Published online March 1, 2009
    • Fazilleau N., McHeyzer-Williams L.J., Rosen H., and McHeyzer-Williams M.G. The function of follicular helper T cells is regulated by the strength of T cell receptor binding. Nat. Immunol. (2009) 10.1038/ni.1704 in press. Published online March 1, 2009
    • (2009) Nat. Immunol.
    • Fazilleau, N.1    McHeyzer-Williams, L.J.2    Rosen, H.3    McHeyzer-Williams, M.G.4
  • 31
    • 0031872028 scopus 로고    scopus 로고
    • CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1
    • Flynn S., Toellner K.M., Raykundalia C., Goodall M., and Lane P. CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J. Exp. Med. 188 (1998) 297-304
    • (1998) J. Exp. Med. , vol.188 , pp. 297-304
    • Flynn, S.1    Toellner, K.M.2    Raykundalia, C.3    Goodall, M.4    Lane, P.5
  • 32
    • 0028283841 scopus 로고
    • Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells
    • Forster R., Emrich T., Kremmer E., and Lipp M. Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells. Blood 84 (1994) 830-840
    • (1994) Blood , vol.84 , pp. 830-840
    • Forster, R.1    Emrich, T.2    Kremmer, E.3    Lipp, M.4
  • 33
    • 0030582773 scopus 로고    scopus 로고
    • A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    • Forster R., Mattis A.E., Kremmer E., Wolf E., Brem G., and Lipp M. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87 (1996) 1037-1047
    • (1996) Cell , vol.87 , pp. 1037-1047
    • Forster, R.1    Mattis, A.E.2    Kremmer, E.3    Wolf, E.4    Brem, G.5    Lipp, M.6
  • 34
    • 0033214348 scopus 로고    scopus 로고
    • CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    • Forster R., Schubel A., Breitfeld D., Kremmer E., Renner-Muller I., Wolf E., and Lipp M. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99 (1999) 23-33
    • (1999) Cell , vol.99 , pp. 23-33
    • Forster, R.1    Schubel, A.2    Breitfeld, D.3    Kremmer, E.4    Renner-Muller, I.5    Wolf, E.6    Lipp, M.7
  • 37
    • 0029813549 scopus 로고    scopus 로고
    • Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c
    • Gulbranson-Judge A., and MacLennan I. Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c. Eur. J. Immunol. 26 (1996) 1830-1837
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1830-1837
    • Gulbranson-Judge, A.1    MacLennan, I.2
  • 38
    • 0029052398 scopus 로고
    • Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers
    • Han S., Hathcock K., Zheng B., Kepler T.B., Hodes R., and Kelsoe G. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155 (1995) 556-567
    • (1995) J. Immunol. , vol.155 , pp. 556-567
    • Han, S.1    Hathcock, K.2    Zheng, B.3    Kepler, T.B.4    Hodes, R.5    Kelsoe, G.6
  • 39
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., and Weaver C.T. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6 (2005) 1123-1132
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 41
    • 38049144850 scopus 로고    scopus 로고
    • Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    • Haynes N.M., Allen C.D., Lesley R., Ansel K.M., Killeen N., and Cyster J.G. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J. Immunol. 179 (2007) 5099-5108
    • (2007) J. Immunol. , vol.179 , pp. 5099-5108
    • Haynes, N.M.1    Allen, C.D.2    Lesley, R.3    Ansel, K.M.4    Killeen, N.5    Cyster, J.G.6
  • 42
    • 38349178776 scopus 로고    scopus 로고
    • Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    • Hsu H.C., Yang P., Wang J., Wu Q., Myers R., Chen J., Yi J., Guentert T., Tousson A., Stanus A.L., et al. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat. Immunol. 9 (2008) 166-175
    • (2008) Nat. Immunol. , vol.9 , pp. 166-175
    • Hsu, H.C.1    Yang, P.2    Wang, J.3    Wu, Q.4    Myers, R.5    Chen, J.6    Yi, J.7    Guentert, T.8    Tousson, A.9    Stanus, A.L.10
  • 44
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., and Littman D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 (2006) 1121-1133
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6    Cua, D.J.7    Littman, D.R.8
  • 45
    • 0025726702 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations
    • Jacob J., Kassir R., and Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173 (1991) 1165-1175
    • (1991) J. Exp. Med. , vol.173 , pp. 1165-1175
    • Jacob, J.1    Kassir, R.2    Kelsoe, G.3
  • 47
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan M.H., Schindler U., Smiley S.T., and Grusby M.J. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4 (1996) 313-319
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 49
    • 0035908122 scopus 로고    scopus 로고
    • Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells
    • Kim C.H., Rott L.S., Clark-Lewis I., Campbell D.J., Wu L., and Butcher E.C. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. J. Exp. Med. 193 (2001) 1373-1381
    • (2001) J. Exp. Med. , vol.193 , pp. 1373-1381
    • Kim, C.H.1    Rott, L.S.2    Clark-Lewis, I.3    Campbell, D.J.4    Wu, L.5    Butcher, E.C.6
  • 51
    • 4644325602 scopus 로고    scopus 로고
    • Unique gene expression program of human germinal center T helper cells
    • Kim C.H., Lim H.W., Kim J.R., Rott L., Hillsamer P., and Butcher E.C. Unique gene expression program of human germinal center T helper cells. Blood 104 (2004) 1952-1960
    • (2004) Blood , vol.104 , pp. 1952-1960
    • Kim, C.H.1    Lim, H.W.2    Kim, J.R.3    Rott, L.4    Hillsamer, P.5    Butcher, E.C.6
  • 52
    • 41549131849 scopus 로고    scopus 로고
    • T follicular helper (TFH) cells in normal and dysregulated immune responses
    • King C., Tangye S.G., and Mackay C.R. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu. Rev. Immunol. 26 (2008) 741-766
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 741-766
    • King, C.1    Tangye, S.G.2    Mackay, C.R.3
  • 54
    • 61949463911 scopus 로고    scopus 로고
    • IL-17 and Th17 Cells
    • 10.1146/annurev.immunol.021908.132710 in press. Published online January 8, 2009
    • Korn T., Bettelli E., Oukka M., and Kuchroo V.K. IL-17 and Th17 Cells. Annu. Rev. Immunol. (2009) 10.1146/annurev.immunol.021908.132710 in press. Published online January 8, 2009
    • (2009) Annu. Rev. Immunol.
    • Korn, T.1    Bettelli, E.2    Oukka, M.3    Kuchroo, V.K.4
  • 55
    • 25444497719 scopus 로고    scopus 로고
    • Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells
    • Lim H.W., Hillsamer P., Banham A.H., and Kim C.H. Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. J. Immunol. 175 (2005) 4180-4183
    • (2005) J. Immunol. , vol.175 , pp. 4180-4183
    • Lim, H.W.1    Hillsamer, P.2    Banham, A.H.3    Kim, C.H.4
  • 60
    • 8444236620 scopus 로고    scopus 로고
    • Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties
    • Malherbe L., Hausl C., Teyton L., and McHeyzer-Williams M.G. Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties. Immunity 21 (2004) 669-679
    • (2004) Immunity , vol.21 , pp. 669-679
    • Malherbe, L.1    Hausl, C.2    Teyton, L.3    McHeyzer-Williams, M.G.4
  • 62
    • 42649120075 scopus 로고    scopus 로고
    • Regulation and functions of Blimp-1 in T and B lymphocytes
    • Martins G., and Calame K. Regulation and functions of Blimp-1 in T and B lymphocytes. Annu. Rev. Immunol. 26 (2008) 133-169
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 133-169
    • Martins, G.1    Calame, K.2
  • 65
    • 0028927653 scopus 로고
    • Antigen-specific development of primary and memory T cells in vivo
    • McHeyzer-Williams M.G., and Davis M.M. Antigen-specific development of primary and memory T cells in vivo. Science 268 (1995) 106-111
    • (1995) Science , vol.268 , pp. 106-111
    • McHeyzer-Williams, M.G.1    Davis, M.M.2
  • 67
    • 0033532540 scopus 로고    scopus 로고
    • Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs
    • McHeyzer-Williams L.J., Panus J.F., Mikszta J.A., and McHeyzer-Williams M.G. Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs. J. Exp. Med. 189 (1999) 1823-1838
    • (1999) J. Exp. Med. , vol.189 , pp. 1823-1838
    • McHeyzer-Williams, L.J.1    Panus, J.F.2    Mikszta, J.A.3    McHeyzer-Williams, M.G.4
  • 68
    • 60149101114 scopus 로고    scopus 로고
    • Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin
    • McLachlan J.B., Catron D.M., Moon J.J., and Jenkins M.K. Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin. Immunity 30 (2009) 277-288
    • (2009) Immunity , vol.30 , pp. 277-288
    • McLachlan, J.B.1    Catron, D.M.2    Moon, J.J.3    Jenkins, M.K.4
  • 69
    • 0033485767 scopus 로고    scopus 로고
    • Antigen-driven selection of TCR In vivo: related TCR alpha-chains pair with diverse TCR beta-chains
    • Mikszta J.A., McHeyzer-Williams L.J., and McHeyzer-Williams M.G. Antigen-driven selection of TCR In vivo: related TCR alpha-chains pair with diverse TCR beta-chains. J. Immunol. 163 (1999) 5978-5988
    • (1999) J. Immunol. , vol.163 , pp. 5978-5988
    • Mikszta, J.A.1    McHeyzer-Williams, L.J.2    McHeyzer-Williams, M.G.3
  • 70
    • 0014210541 scopus 로고
    • The thymus and the precursors of antigen reactive cells
    • Miller J.F., and Mitchell G.F. The thymus and the precursors of antigen reactive cells. Nature 216 (1967) 659-663
    • (1967) Nature , vol.216 , pp. 659-663
    • Miller, J.F.1    Mitchell, G.F.2
  • 71
    • 0037036142 scopus 로고    scopus 로고
    • Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
    • Miller M.J., Wei S.H., Parker I., and Cahalan M.D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296 (2002) 1869-1873
    • (2002) Science , vol.296 , pp. 1869-1873
    • Miller, M.J.1    Wei, S.H.2    Parker, I.3    Cahalan, M.D.4
  • 72
    • 0011235258 scopus 로고
    • The carrier effect in the secondary response to hapten-protein conjugates. I. Measurement of the effect with transferred cells and objections to the local environment hypothesis
    • Mitchison N.A. The carrier effect in the secondary response to hapten-protein conjugates. I. Measurement of the effect with transferred cells and objections to the local environment hypothesis. Eur. J. Immunol. 1 (1971) 10-17
    • (1971) Eur. J. Immunol. , vol.1 , pp. 10-17
    • Mitchison, N.A.1
  • 73
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular activation clusters in T cells
    • Monks C.R., Freiberg B.A., Kupfer H., Sciaky N., and Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395 (1998) 82-86
    • (1998) Nature , vol.395 , pp. 82-86
    • Monks, C.R.1    Freiberg, B.A.2    Kupfer, H.3    Sciaky, N.4    Kupfer, A.5
  • 74
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
    • Mosmann T.R., and Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7 (1989) 145-173
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 75
    • 0005382055 scopus 로고
    • Antibody production by single cells. III. The histology of antibody production
    • Nossal G.J.V. Antibody production by single cells. III. The histology of antibody production. Br. J. Exp. Pathol. 40 (1959) 301-311
    • (1959) Br. J. Exp. Pathol. , vol.40 , pp. 301-311
    • Nossal, G.J.V.1
  • 81
    • 0034613685 scopus 로고    scopus 로고
    • Antigen-specific T helper cell function: differential cytokine expression in primary and memory responses
    • Panus J.F., McHeyzer-Williams L.J., and McHeyzer-Williams M.G. Antigen-specific T helper cell function: differential cytokine expression in primary and memory responses. J. Exp. Med. 192 (2000) 1301-1316
    • (2000) J. Exp. Med. , vol.192 , pp. 1301-1316
    • Panus, J.F.1    McHeyzer-Williams, L.J.2    McHeyzer-Williams, M.G.3
  • 85
    • 0028179006 scopus 로고
    • Lymphocyte responses and cytokines
    • Paul W.E., and Seder R.A. Lymphocyte responses and cytokines. Cell 76 (1994) 241-251
    • (1994) Cell , vol.76 , pp. 241-251
    • Paul, W.E.1    Seder, R.A.2
  • 86
    • 0013898788 scopus 로고
    • Studies on the effect of the carrier molecule on antihapten antibody synthesis. II. Carrier specificity of anti-2,4-dinitrophenyl-poly-l-lysine antibodies
    • Paul W.E., Siskind G.W., and Benacerraf B. Studies on the effect of the carrier molecule on antihapten antibody synthesis. II. Carrier specificity of anti-2,4-dinitrophenyl-poly-l-lysine antibodies. J. Exp. Med. 123 (1966) 689-705
    • (1966) J. Exp. Med. , vol.123 , pp. 689-705
    • Paul, W.E.1    Siskind, G.W.2    Benacerraf, B.3
  • 87
    • 53649107278 scopus 로고    scopus 로고
    • SAP-controlled T-B cell interactions underlie germinal center formation
    • Qi H., Cannons J.L., Klauschen F., Schwartzberg P.L., and Germain R.N. SAP-controlled T-B cell interactions underlie germinal center formation. Nature 455 (2008) 764-769
    • (2008) Nature , vol.455 , pp. 764-769
    • Qi, H.1    Cannons, J.L.2    Klauschen, F.3    Schwartzberg, P.L.4    Germain, R.N.5
  • 88
    • 0014530949 scopus 로고
    • The requirement of more than one antigenic determinant for immunogenicity
    • Rajewsky K., Schirrmacher V., Nase S., and Jerne N.K. The requirement of more than one antigenic determinant for immunogenicity. J. Exp. Med. 129 (1969) 1131-1143
    • (1969) J. Exp. Med. , vol.129 , pp. 1131-1143
    • Rajewsky, K.1    Schirrmacher, V.2    Nase, S.3    Jerne, N.K.4
  • 89
    • 33746256850 scopus 로고    scopus 로고
    • Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression
    • Rasheed A.U., Rahn H.P., Sallusto F., Lipp M., and Muller G. Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression. Eur. J. Immunol. 36 (2006) 1892-1903
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1892-1903
    • Rasheed, A.U.1    Rahn, H.P.2    Sallusto, F.3    Lipp, M.4    Muller, G.5
  • 90
    • 0033578388 scopus 로고    scopus 로고
    • An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro
    • Rees W., Bender J., Teague T.K., Kedl R.M., Crawford F., Marrack P., and Kappler J. An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro. Proc. Natl. Acad. Sci. USA 96 (1999) 9781-9786
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9781-9786
    • Rees, W.1    Bender, J.2    Teague, T.K.3    Kedl, R.M.4    Crawford, F.5    Marrack, P.6    Kappler, J.7
  • 91
    • 0037034880 scopus 로고    scopus 로고
    • Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
    • Reif K., Ekland E.H., Ohl L., Nakano H., Lipp M., Forster R., and Cyster J.G. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature 416 (2002) 94-99
    • (2002) Nature , vol.416 , pp. 94-99
    • Reif, K.1    Ekland, E.H.2    Ohl, L.3    Nakano, H.4    Lipp, M.5    Forster, R.6    Cyster, J.G.7
  • 92
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
    • Sakaguchi S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22 (2004) 531-562
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 93
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory T cell subsets: function, generation, and maintenance
    • Sallusto F., Geginat J., and Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 22 (2004) 745-763
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 94
    • 0033118739 scopus 로고    scopus 로고
    • A kinetic basis for T cell receptor repertoire selection during an immune response
    • Savage P.A., Boniface J.J., and Davis M.M. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 10 (1999) 485-492
    • (1999) Immunity , vol.10 , pp. 485-492
    • Savage, P.A.1    Boniface, J.J.2    Davis, M.M.3
  • 95
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli P., Willimann K., Lang A.B., Lipp M., Loetscher P., and Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 192 (2000) 1553-1562
    • (2000) J. Exp. Med. , vol.192 , pp. 1553-1562
    • Schaerli, P.1    Willimann, K.2    Lang, A.B.3    Lipp, M.4    Loetscher, P.5    Moser, B.6
  • 96
    • 58149099175 scopus 로고    scopus 로고
    • SLAM receptors and SAP influence lymphocyte interactions, development and function
    • Schwartzberg P.L., Mueller K.L., Qi H., and Cannons J.L. SLAM receptors and SAP influence lymphocyte interactions, development and function. Nat. Rev. Immunol. 9 (2009) 39-46
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 39-46
    • Schwartzberg, P.L.1    Mueller, K.L.2    Qi, H.3    Cannons, J.L.4
  • 99
    • 0023197097 scopus 로고
    • Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production
    • Snapper C.M., and Paul W.E. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236 (1987) 944-947
    • (1987) Science , vol.236 , pp. 944-947
    • Snapper, C.M.1    Paul, W.E.2
  • 100
    • 42649134105 scopus 로고    scopus 로고
    • Interleukin-21: basic biology and implications for cancer and autoimmunity
    • Spolski R., and Leonard W.J. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 26 (2008) 57-79
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 57-79
    • Spolski, R.1    Leonard, W.J.2
  • 101
    • 0036669784 scopus 로고    scopus 로고
    • Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo
    • Stetson D.B., Mohrs M., Mallet-Designe V., Teyton L., and Locksley R.M. Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo. Immunity 17 (2002) 191-200
    • (2002) Immunity , vol.17 , pp. 191-200
    • Stetson, D.B.1    Mohrs, M.2    Mallet-Designe, V.3    Teyton, L.4    Locksley, R.M.5
  • 104
    • 0001152394 scopus 로고
    • Allergy and immunology
    • Talmage D.W. Allergy and immunology. Annu. Rev. Med. 8 (1957) 239-256
    • (1957) Annu. Rev. Med. , vol.8 , pp. 239-256
    • Talmage, D.W.1
  • 105
    • 0037220807 scopus 로고    scopus 로고
    • A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells
    • Tangye S.G., Avery D.T., and Hodgkin P.D. A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells. J. Immunol. 170 (2003) 261-269
    • (2003) J. Immunol. , vol.170 , pp. 261-269
    • Tangye, S.G.1    Avery, D.T.2    Hodgkin, P.D.3
  • 106
    • 0032550353 scopus 로고    scopus 로고
    • T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching
    • Toellner K.M., Luther S.A., Sze D.M., Choy R.K., Taylor D.R., MacLennan I.C., and Acha-Orbea H. T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching. J. Exp. Med. 187 (1998) 1193-1204
    • (1998) J. Exp. Med. , vol.187 , pp. 1193-1204
    • Toellner, K.M.1    Luther, S.A.2    Sze, D.M.3    Choy, R.K.4    Taylor, D.R.5    MacLennan, I.C.6    Acha-Orbea, H.7
  • 107
    • 0037017391 scopus 로고    scopus 로고
    • Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers
    • Toellner K.M., Jenkinson W.E., Taylor D.R., Khan M., Sze D.M., Sansom D.M., Vinuesa C.G., and MacLennan I.C. Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers. J. Exp. Med. 195 (2002) 383-389
    • (2002) J. Exp. Med. , vol.195 , pp. 383-389
    • Toellner, K.M.1    Jenkinson, W.E.2    Taylor, D.R.3    Khan, M.4    Sze, D.M.5    Sansom, D.M.6    Vinuesa, C.G.7    MacLennan, I.C.8
  • 109
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 111
    • 27744498868 scopus 로고    scopus 로고
    • Follicular B helper T cells in antibody responses and autoimmunity
    • Vinuesa C.G., Tangye S.G., Moser B., and Mackay C.R. Follicular B helper T cells in antibody responses and autoimmunity. Nat. Rev. Immunol. 5 (2005) 853-865
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 853-865
    • Vinuesa, C.G.1    Tangye, S.G.2    Moser, B.3    Mackay, C.R.4
  • 112
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang A., McGuire H.M., Yu D., Sprent J., Mackay C.R., and King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29 (2008) 127-137
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1    McGuire, H.M.2    Yu, D.3    Sprent, J.4    Mackay, C.R.5    King, C.6
  • 113
    • 0032753621 scopus 로고    scopus 로고
    • Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers
    • Walker L.S., Gulbranson-Judge A., Flynn S., Brocker T., Raykundalia C., Goodall M., Forster R., Lipp M., and Lane P. Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers. J. Exp. Med. 190 (1999) 1115-1122
    • (1999) J. Exp. Med. , vol.190 , pp. 1115-1122
    • Walker, L.S.1    Gulbranson-Judge, A.2    Flynn, S.3    Brocker, T.4    Raykundalia, C.5    Goodall, M.6    Forster, R.7    Lipp, M.8    Lane, P.9
  • 117
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng W., and Flavell R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89 (1997) 587-596
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 118
    • 0029840392 scopus 로고    scopus 로고
    • T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1
    • Zheng B., Han S., and Kelsoe G. T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1. J. Exp. Med. 184 (1996) 1083-1091
    • (1996) J. Exp. Med. , vol.184 , pp. 1083-1091
    • Zheng, B.1    Han, S.2    Kelsoe, G.3
  • 121
    • 52649167708 scopus 로고    scopus 로고
    • CD4 T cells: fates, functions, and faults
    • Zhu J., and Paul W.E. CD4 T cells: fates, functions, and faults. Blood 112 (2008) 1557-1569
    • (2008) Blood , vol.112 , pp. 1557-1569
    • Zhu, J.1    Paul, W.E.2
  • 122
    • 0344064893 scopus 로고    scopus 로고
    • Stat5 activation plays a critical role in Th2 differentiation
    • Zhu J., Cote-Sierra J., Guo L., and Paul W.E. Stat5 activation plays a critical role in Th2 differentiation. Immunity 19 (2003) 739-748
    • (2003) Immunity , vol.19 , pp. 739-748
    • Zhu, J.1    Cote-Sierra, J.2    Guo, L.3    Paul, W.E.4


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