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Volumn , Issue , 2010, Pages 169-215

In vitro techniques to study drug-drug interactions of drug metabolism: Cytochrome P450

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EID: 77955274732     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-0840-7_7     Document Type: Chapter
Times cited : (12)

References (179)
  • 1
    • 0035478779 scopus 로고    scopus 로고
    • Predicting the impact of physiological and biochemical processes on oral drug bioavailability
    • Agoram B, Woltosz WS and Bolger MB (2001) Predicting the impact of physiological and biochemical processes on oral drug bioavailability. Adv Drug Deliv Rev 50 Suppl 1:S41-S67.
    • (2001) Adv Drug Deliv Rev , vol.50 , Issue.SUPPL. 1
    • Agoram, B.1    Woltosz, W.S.2    Bolger, M.B.3
  • 2
    • 27544446643 scopus 로고    scopus 로고
    • Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis
    • Atkinson A, Kenny JR and Grime K (2005) Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis. Drug Metab Dispos 33:1637-1647.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1637-1647
    • Atkinson, A.1    Kenny, J.R.2    Grime, K.3
  • 3
    • 0036891948 scopus 로고    scopus 로고
    • The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties
    • Austin RP, Barton P, Cockroft SL, Wenlock MC and Riley RJ (2002) The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties. Drug Metab Dispos 30:1497-1503.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1497-1503
    • Austin, R.P.1    Barton, P.2    Cockroft, S.L.3    Wenlock, M.C.4    Riley, R.J.5
  • 4
    • 14044251501 scopus 로고    scopus 로고
    • The binding of drugs to hepatocytes and its relationship to physicochemical properties
    • Austin RP, Barton P, Mohmed S and Riley RJ (2005) The binding of drugs to hepatocytes and its relationship to physicochemical properties. Drug Metab Dispos 33:419-425.
    • (2005) Drug Metab Dispos , vol.33 , pp. 419-425
    • Austin, R.P.1    Barton, P.2    Mohmed, S.3    Riley, R.J.4
  • 5
    • 67049114269 scopus 로고    scopus 로고
    • Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption
    • Badhan R, Penny J, Galetin A and Houston JB (2009) Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption. J Pharm Sci 98:2180-2197.
    • (2009) J Pharm Sci , vol.98 , pp. 2180-2197
    • Badhan, R.1    Penny, J.2    Galetin, A.3    Houston, J.B.4
  • 8
    • 35548948469 scopus 로고    scopus 로고
    • Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: Comparison with microsomes for Ki determination
    • Brown HS, Chadwick A and Houston JB (2007a) Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination. Drug Metab Dispos 35:2119-2126.
    • (2007) Drug Metab Dispos , vol.35 , pp. 2119-2126
    • Brown, H.S.1    Chadwick, A.2    Houston, J.B.3
  • 9
    • 33748946044 scopus 로고    scopus 로고
    • Prediction of in vivo drug-drug interactions from in vitro data: Factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4
    • Brown HS, Galetin A, Hallifax D and Houston JB (2006) Prediction of in vivo drug-drug interactions from in vitro data: factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4. Clin Pharmacokinet 45:1035-1050.
    • (2006) Clin Pharmacokinet , vol.45 , pp. 1035-1050
    • Brown, H.S.1    Galetin, A.2    Hallifax, D.3    Houston, J.B.4
  • 10
    • 33846405266 scopus 로고    scopus 로고
    • Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance
    • Brown HS, Griffin M and Houston JB (2007b) Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance. Drug Metab Dispos 35:293-301.
    • (2007) Drug Metab Dispos , vol.35 , pp. 293-301
    • Brown, H.S.1    Griffin, M.2    Houston, J.B.3
  • 11
    • 27444445468 scopus 로고    scopus 로고
    • Prediction of in vivo drug-drug interactions from in vitro data: Impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant
    • Brown HS, Ito K, Galetin A and Houston JB (2005) Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant. Br J Clin Pharmacol 60:508-518.
    • (2005) Br J Clin Pharmacol , vol.60 , pp. 508-518
    • Brown, H.S.1    Ito, K.2    Galetin, A.3    Houston, J.B.4
  • 13
    • 33645982578 scopus 로고    scopus 로고
    • Prediction of maximum exposure in poor metabolizers following inhibition of nonpolymorphic pathways
    • Collins C, Levy R, Ragueneau-Majlessi I and Hachad H (2006) Prediction of maximum exposure in poor metabolizers following inhibition of nonpolymorphic pathways. Curr Drug Metab 7:295-299.
    • (2006) Curr Drug Metab , vol.7 , pp. 295-299
    • Collins, C.1    Levy, R.2    Ragueneau-Majlessi, I.3    Hachad, H.4
  • 14
    • 0026356874 scopus 로고
    • Cytochrome P450 turnover
    • Correia MA (1991) Cytochrome P450 turnover. Methods Enzymol 206:315-325.
    • (1991) Methods Enzymol , vol.206 , pp. 315-325
    • Correia, M.A.1
  • 15
    • 63949084693 scopus 로고    scopus 로고
    • Relative importance of intestinal and hepatic glucuronidation-impact on the prediction of drug clearance
    • Cubitt HE, Houston JB and Galetin A (2009) Relative importance of intestinal and hepatic glucuronidation-impact on the prediction of drug clearance. Pharm Res 26:1073-1083.
    • (2009) Pharm Res , vol.26 , pp. 1073-1083
    • Cubitt, H.E.1    Houston, J.B.2    Galetin, A.3
  • 17
    • 84900597546 scopus 로고    scopus 로고
    • Ketoconazole based drug-drug interactions - An update
    • Davis J, Galetin A and Jones B (2008) Ketoconazole based drug-drug interactions - an update. Clin Pharmacol Ther 83(Suppl. 1):33.
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.SUPPL. 1 , pp. 33
    • Davis, J.1    Galetin, A.2    Jones, B.3
  • 18
    • 85047685271 scopus 로고    scopus 로고
    • Predictive models for oral drug absorption: From in silico methods to integrated dynamical models
    • Dokoumetzidis A, Kalantzi L and Fotaki N (2007) Predictive models for oral drug absorption: from in silico methods to integrated dynamical models. Expert Opin Drug Metab Toxicol 3:491-505.
    • (2007) Expert Opin Drug Metab Toxicol , vol.3 , pp. 491-505
    • Dokoumetzidis, A.1    Kalantzi, L.2    Fotaki, N.3
  • 20
    • 35648968125 scopus 로고    scopus 로고
    • Comparison of different approaches to predict metabolic drug-drug interactions
    • Einolf HJ (2007) Comparison of different approaches to predict metabolic drug-drug interactions. Xenobiotica 37:1257-1294.
    • (2007) Xenobiotica , vol.37 , pp. 1257-1294
    • Einolf, H.J.1
  • 21
    • 0034781795 scopus 로고    scopus 로고
    • Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers
    • El-Sankary W, Gibson GG, Ayrton A and Plant N (2001) Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers. Drug Metab Dispos 29:1499-1504.
    • (2001) Drug Metab Dispos , vol.29 , pp. 1499-1504
    • El-Sankary, W.1    Gibson, G.G.2    Ayrton, A.3    Plant, N.4
  • 22
    • 13244299150 scopus 로고    scopus 로고
    • Mechanism-based inactivation of CYP3A by HIV protease inhibitors
    • Ernest CS, 2nd, Hall SD and Jones DR (2005) Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther 312:583-591.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 583-591
    • Ernest II, C.S.1    Hall, S.D.2    Jones, D.R.3
  • 23
    • 50049091411 scopus 로고    scopus 로고
    • Prediction of drug-drug interactions from in vitro induction data: Application of the relative induction score approach using cryopreserved human hepatocytes
    • Fahmi OA, Boldt S, Kish M, Obach RS and Tremaine LM (2008a) Prediction of drug-drug interactions from in vitro induction data: application of the relative induction score approach using cryopreserved human hepatocytes. Drug Metab Dispos 36:1971-1974.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1971-1974
    • Fahmi, O.A.1    Boldt, S.2    Kish, M.3    Obach, R.S.4    Tremaine, L.M.5
  • 24
    • 47949115175 scopus 로고    scopus 로고
    • A combined model for predicting CYP3A4 clinical net drug-drug interaction based on CYP3A4 inhibition, inactivation, and induction determined in vitro
    • Fahmi OA, Maurer TS, Kish M, Cardenas E, Boldt S and Nettleton D (2008b) A combined model for predicting CYP3A4 clinical net drug-drug interaction based on CYP3A4 inhibition, inactivation, and induction determined in vitro. Drug Metab Dispos 36:1698-1708.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1698-1708
    • Fahmi, O.A.1    Maurer, T.S.2    Kish, M.3    Cardenas, E.4    Boldt, S.5    Nettleton, D.6
  • 25
    • 36349009310 scopus 로고    scopus 로고
    • Progress curve analysis of CYP1A2 inhibition: A more informative approach to the assessment of mechanism-based inactivation?
    • Fairman DA, Collins C and Chapple S (2007) Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation?. Drug Metab Dispos 35:2159-2165.
    • (2007) Drug Metab Dispos , vol.35 , pp. 2159-2165
    • Fairman, D.A.1    Collins, C.2    Chapple, S.3
  • 26
    • 53849084442 scopus 로고    scopus 로고
    • In vitro evaluation of reversible and irreversible cytochrome P450 inhibition: Current status on methodologies and their utility for predicting drug-drug interactions
    • Fowler S and Zhang H (2008) In vitro evaluation of reversible and irreversible cytochrome P450 inhibition: current status on methodologies and their utility for predicting drug-drug interactions. Aaps J 10:410-424.
    • (2008) Aaps J , vol.10 , pp. 410-424
    • Fowler, S.1    Zhang, H.2
  • 27
    • 29944446485 scopus 로고    scopus 로고
    • Prediction of time-dependent CYP3A4 drug-drug interactions: Impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition
    • Galetin A, Burt H, Gibbons L and Houston JB (2006) Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition. Drug Metab Dispos 34:166-175.
    • (2006) Drug Metab Dispos , vol.34 , pp. 166-175
    • Galetin, A.1    Burt, H.2    Gibbons, L.3    Houston, J.B.4
  • 28
    • 1842866515 scopus 로고    scopus 로고
    • Quinidine and haloperidol as modifiers of CYP3A4 activity: Multisite kinetic model approach
    • Galetin A, Clarke SE and Houston JB (2002) Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. Drug Metab Dispos 30:1512-1522.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1512-1522
    • Galetin, A.1    Clarke, S.E.2    Houston, J.B.3
  • 29
    • 0042357511 scopus 로고    scopus 로고
    • Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: Midazolam, testosterone, and nifedipine
    • Galetin A, Clarke SE and Houston JB (2003) Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine. Drug Metab Dispos 31:1108-1116.
    • (2003) Drug Metab Dispos , vol.31 , pp. 1108-1116
    • Galetin, A.1    Clarke, S.E.2    Houston, J.B.3
  • 30
    • 49649116162 scopus 로고    scopus 로고
    • Potential role of intestinal first-pass metabolism in the prediction of drug-drug interactions
    • Galetin A, Gertz M and Houston JB (2008) Potential role of intestinal first-pass metabolism in the prediction of drug-drug interactions. Expert Opin Drug Metab Toxicol 4:909-922.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , pp. 909-922
    • Galetin, A.1    Gertz, M.2    Houston, J.B.3
  • 31
    • 35348880290 scopus 로고    scopus 로고
    • Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs
    • Galetin A, Hinton LK, Burt H, Obach RS and Houston JB (2007) Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs. Curr Drug Metab 8:685-693.
    • (2007) Curr Drug Metab , vol.8 , pp. 685-693
    • Galetin, A.1    Hinton, L.K.2    Burt, H.3    Obach, R.S.4    Houston, J.B.5
  • 32
    • 23044500208 scopus 로고    scopus 로고
    • CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions
    • Galetin A, Ito K, Hallifax D and Houston JB (2005) CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions. J Pharmacol Exp Ther 314:180-190.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 180-190
    • Galetin, A.1    Ito, K.2    Hallifax, D.3    Houston, J.B.4
  • 33
    • 58149347476 scopus 로고    scopus 로고
    • Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: Utility and limitations
    • Gertz M, Davis JD, Harrison A, Houston JB and Galetin A (2008a) Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations. Curr Drug Metab 9:785-795.
    • (2008) Curr Drug Metab , vol.9 , pp. 785-795
    • Gertz, M.1    Davis, J.D.2    Harrison, A.3    Houston, J.B.4    Galetin, A.5
  • 34
    • 79951978003 scopus 로고    scopus 로고
    • Impact of permeability on in vitro predictions of intestinal availability in the QGut model
    • Gertz M, Fenner KS, Harrison A, Davis J, Houston JB and Galetin A (2008b) Impact of permeability on in vitro predictions of intestinal availability in the QGut model. Drug Metab Rev 40(Suppl. 1):92.
    • (2008) Drug Metab Rev , vol.40 , Issue.SUPPL. 1 , pp. 92
    • Gertz, M.1    Fenner, K.S.2    Harrison, A.3    Davis, J.4    Houston, J.B.5    Galetin, A.6
  • 35
    • 40849096159 scopus 로고    scopus 로고
    • Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations
    • Gertz M, Kilford PJ, Houston JB and Galetin A (2008c) Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations. Drug Metab Dispos 36:535-542.
    • (2008) Drug Metab Dispos , vol.36 , pp. 535-542
    • Gertz, M.1    Kilford, P.J.2    Houston, J.B.3    Galetin, A.4
  • 36
    • 33645980647 scopus 로고    scopus 로고
    • A critical evaluation of the experimental design of studies of mechanism based enzyme inhibition, with implications for in vitro-in vivo extrapolation
    • Ghanbari F, Rowland-Yeo K, Bloomer JC, Clarke SE, Lennard MS, Tucker GT and Rostami-Hodjegan A (2006) A critical evaluation of the experimental design of studies of mechanism based enzyme inhibition, with implications for in vitro-in vivo extrapolation. Curr Drug Metab 7:315-334.
    • (2006) Curr Drug Metab , vol.7 , pp. 315-334
    • Ghanbari, F.1    Rowland-Yeo, K.2    Bloomer, J.C.3    Clarke, S.E.4    Lennard, M.S.5    Tucker, G.T.6    Rostami-Hodjegan, A.7
  • 37
  • 38
    • 58149242547 scopus 로고    scopus 로고
    • Mechanism-based inhibition of cytochrome P450 enzymes: An evaluation of early decision making in vitro approaches and drug-drug interaction prediction methods
    • Grime KH, Bird J, Ferguson D and Riley RJ (2009) Mechanism-based inhibition of cytochrome P450 enzymes: an evaluation of early decision making in vitro approaches and drug-drug interaction prediction methods. Eur J Pharm Sci 36:175-191.
    • (2009) Eur J Pharm Sci , vol.36 , pp. 175-191
    • Grime, K.H.1    Bird, J.2    Ferguson, D.3    Riley, R.J.4
  • 39
    • 33645961595 scopus 로고    scopus 로고
    • The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions
    • Grime K and Riley RJ (2006) The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions. Curr Drug Metab 7:251-264.
    • (2006) Curr Drug Metab , vol.7 , pp. 251-264
    • Grime, K.1    Riley, R.J.2
  • 40
    • 34247517355 scopus 로고    scopus 로고
    • The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics
    • Guillouzo A, Corlu A, Aninat C, Glaise D, Morel F and Guguen-Guillouzo C (2007) The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact 168:66-73.
    • (2007) Chem Biol Interact , vol.168 , pp. 66-73
    • Guillouzo, A.1    Corlu, A.2    Aninat, C.3    Glaise, D.4    Morel, F.5    Guguen-Guillouzo, C.6
  • 42
    • 40749102194 scopus 로고    scopus 로고
    • Prediction of metabolic clearance using fresh human hepatocytes: Comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines
    • Hallifax D, Galetin A and Houston JB (2008) Prediction of metabolic clearance using fresh human hepatocytes: Comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines. Xenobiotica 38:353-367.
    • (2008) Xenobiotica , vol.38 , pp. 353-367
    • Hallifax, D.1    Galetin, A.2    Houston, J.B.3
  • 43
    • 33645100073 scopus 로고    scopus 로고
    • Binding of drugs to hepatic microsomes: Comment and assessment of current prediction methodology with recommendation for improvement
    • Hallifax D and Houston JB (2006) Binding of drugs to hepatic microsomes: comment and assessment of current prediction methodology with recommendation for improvement. Drug Metab Dispos 34:724-726.
    • (2006) Drug Metab Dispos , vol.34 , pp. 724-726
    • Hallifax, D.1    Houston, J.B.2
  • 44
    • 34547163963 scopus 로고    scopus 로고
    • Saturable uptake of lipophilic amine drugs into isolated hepatocytes: Mechanisms and consequences for quantitative clearance prediction
    • Hallifax D and Houston JB (2007) Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction. Drug Metab Dispos 35:1325-1332.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1325-1332
    • Hallifax, D.1    Houston, J.B.2
  • 45
    • 44149104931 scopus 로고    scopus 로고
    • Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction
    • Hariparsad N, Carr BA, Evers R and Chu X (2008) Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction. Drug Metab Dispos 36:1046-1055.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1046-1055
    • Hariparsad, N.1    Carr, B.A.2    Evers, R.3    Chu, X.4
  • 46
    • 46449133208 scopus 로고    scopus 로고
    • Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications
    • Henshall J, Galetin A, Harrison A and Houston JB (2008) Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications. Drug Metab Dispos 36:1332-1340.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1332-1340
    • Henshall, J.1    Galetin, A.2    Harrison, A.3    Houston, J.B.4
  • 48
    • 34247505094 scopus 로고    scopus 로고
    • Induction of drug metabolizing enzymes: A survey of in vitro methodologies and interpretations used in the pharmaceutical industry - Do they comply with FDA recommendations?
    • Hewitt NJ, De Kanter R and Le Cluyse E (2007a) Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry - do they comply with FDA recommendations?. Chem Biol Interact 168:51-65.
    • (2007) Chem Biol Interact , vol.168 , pp. 51-65
    • Hewitt, N.J.1    De Kanter, R.2    Le Cluyse, E.3
  • 49
    • 42049097101 scopus 로고    scopus 로고
    • Multiple inhibition mechanisms and prediction of drug-drug interactions: Status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions
    • Hinton LK, Galetin A and Houston JB (2008) Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions. Pharm Res 25:1063-1074.
    • (2008) Pharm Res , vol.25 , pp. 1063-1074
    • Hinton, L.K.1    Galetin, A.2    Houston, J.B.3
  • 50
    • 33745243715 scopus 로고    scopus 로고
    • Drug-drug interaction between pitavastatin and various drugs via OATP1B1
    • Hirano M, Maeda K, Shitara Y and Sugiyama Y (2006) Drug-drug interaction between pitavastatin and various drugs via OATP1B1. Drug Metab Dispos 34:1229-1236.
    • (2006) Drug Metab Dispos , vol.34 , pp. 1229-1236
    • Hirano, M.1    Maeda, K.2    Shitara, Y.3    Sugiyama, Y.4
  • 51
    • 33646536542 scopus 로고    scopus 로고
    • Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression, and pharmacogenetics
    • Ho RH, Tirona RG, Leake BF, Glaeser H, Lee W, Lemke CJ, Wang Y and Kim RB (2006) Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology 130:1793-1806.
    • (2006) Gastroenterology , vol.130 , pp. 1793-1806
    • Ho, R.H.1    Tirona, R.G.2    Leake, B.F.3    Glaeser, H.4    Lee, W.5    Lemke, C.J.6    Wang, Y.7    Kim, R.B.8
  • 52
    • 0346992330 scopus 로고    scopus 로고
    • Progress towards prediction of human pharmacokinetic parameters from in vitro technologies
    • Houston JB and Galetin A (2003) Progress towards prediction of human pharmacokinetic parameters from in vitro technologies. Drug Metab Rev 35:393-415.
    • (2003) Drug Metab Rev , vol.35 , pp. 393-415
    • Houston, J.B.1    Galetin, A.2
  • 53
    • 10044251943 scopus 로고    scopus 로고
    • Modelling atypical CYP3A4 kinetics: Principles and pragmatism
    • Houston JB and Galetin A (2005) Modelling atypical CYP3A4 kinetics: principles and pragmatism. Arch Biochem Biophys 433:351-360.
    • (2005) Arch Biochem Biophys , vol.433 , pp. 351-360
    • Houston, J.B.1    Galetin, A.2
  • 54
    • 60749133620 scopus 로고    scopus 로고
    • Methods for predicting in vivo pharmacokinetics using data from in vitro assays
    • Houston JB and Galetin A (2008) Methods for predicting in vivo pharmacokinetics using data from in vitro assays. Curr Drug Metab 9:940-951.
    • (2008) Curr Drug Metab , vol.9 , pp. 940-951
    • Houston, J.B.1    Galetin, A.2
  • 57
    • 33846577441 scopus 로고    scopus 로고
    • Drug interaction studies: Study design, data analysis, and implications for dosing and labeling
    • Huang SM, Temple R, Throckmorton DC and Lesko LJ (2007) Drug interaction studies: study design, data analysis, and implications for dosing and labeling. Clin Pharmacol Ther 81:298-304.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 298-304
    • Huang, S.M.1    Temple, R.2    Throckmorton, D.C.3    Lesko, L.J.4
  • 58
    • 0037325958 scopus 로고    scopus 로고
    • Activation of cytochrome P450 2C9-mediated metabolism: Mechanistic evidence in support of kinetic observations
    • Hutzler JM, Wienkers LC, Wahlstrom JL, Carlson TJ and Tracy TS (2003) Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations. Arch Biochem Biophys 410:16-24.
    • (2003) Arch Biochem Biophys , vol.410 , pp. 16-24
    • Hutzler, J.M.1    Wienkers, L.C.2    Wahlstrom, J.L.3    Carlson, T.J.4    Tracy, T.S.5
  • 60
    • 1942455361 scopus 로고    scopus 로고
    • Database analyses for the prediction of in vivo drug-drug interactions from in vitro data
    • Ito K, Brown HS and Houston JB (2004) Database analyses for the prediction of in vivo drug-drug interactions from in vitro data. Br J Clin Pharmacol 57:473-486.
    • (2004) Br J Clin Pharmacol , vol.57 , pp. 473-486
    • Ito, K.1    Brown, H.S.2    Houston, J.B.3
  • 61
    • 18844369894 scopus 로고    scopus 로고
    • Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm
    • Ito K, Hallifax D, Obach RS and Houston JB (2005) Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm. Drug Metab Dispos 33:837-844.
    • (2005) Drug Metab Dispos , vol.33 , pp. 837-844
    • Ito, K.1    Hallifax, D.2    Obach, R.S.3    Houston, J.B.4
  • 62
    • 17644381224 scopus 로고    scopus 로고
    • Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches
    • Ito K and Houston JB (2005) Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches. Pharm Res 22:103-112.
    • (2005) Pharm Res , vol.22 , pp. 103-112
    • Ito, K.1    Houston, J.B.2
  • 63
    • 0031723235 scopus 로고    scopus 로고
    • Prediction of pharmacokinetic alterations caused by drug-drug interactions: Metabolic interaction in the liver
    • Ito K, Iwatsubo T, Kanamitsu S, Ueda K, Suzuki H and Sugiyama Y (1998) Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver. Pharmacol Rev 50:387-412.
    • (1998) Pharmacol Rev , vol.50 , pp. 387-412
    • Ito, K.1    Iwatsubo, T.2    Kanamitsu, S.3    Ueda, K.4    Suzuki, H.5    Sugiyama, Y.6
  • 64
    • 0033007704 scopus 로고    scopus 로고
    • Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption - Theoretical approach
    • Ito K, Kusuhara H and Sugiyama Y (1999) Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption - theoretical approach. Pharm Res 16:225-231.
    • (1999) Pharm Res , vol.16 , pp. 225-231
    • Ito, K.1    Kusuhara, H.2    Sugiyama, Y.3
  • 65
    • 0038311984 scopus 로고    scopus 로고
    • Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes
    • Ito K, Ogihara K, Kanamitsu S and Itoh T (2003) Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes. Drug Metab Dispos 31:945-954.
    • (2003) Drug Metab Dispos , vol.31 , pp. 945-954
    • Ito, K.1    Ogihara, K.2    Kanamitsu, S.3    Itoh, T.4
  • 66
    • 67649392513 scopus 로고    scopus 로고
    • A framework for assessing interindividual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recognition of covariates
    • Jamei M, Dickinson GL and Rostami-Hodjegan A (2009a) A framework for assessing interindividual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: a tale of 'bottom-up' vs 'top-down' recognition of covariates. Drug Metab Pharmacokinet 24:53-75.
    • (2009) Drug Metab Pharmacokinet , vol.24 , pp. 53-75
    • Jamei, M.1    Dickinson, G.L.2    Rostami-Hodjegan, A.3
  • 68
    • 19444375135 scopus 로고    scopus 로고
    • Catalytic turnover of pyrene by CYP3A4: Evidence that cytochrome b5 directly induces positive cooperativity
    • Jushchyshyn MI, Hutzler JM, Schrag ML and Wienkers LC (2005) Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity. Arch Biochem Biophys 438:21-28.
    • (2005) Arch Biochem Biophys , vol.438 , pp. 21-28
    • Jushchyshyn, M.I.1    Hutzler, J.M.2    Schrag, M.L.3    Wienkers, L.C.4
  • 69
    • 34548805504 scopus 로고    scopus 로고
    • Mechanism-based inactivation of cytochrome P450 enzymes: Chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions
    • Kalgutkar AS, Obach RS and Maurer TS (2007) Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions. Curr Drug Metab 8:407-447.
    • (2007) Curr Drug Metab , vol.8 , pp. 407-447
    • Kalgutkar, A.S.1    Obach, R.S.2    Maurer, T.S.3
  • 70
    • 0034089555 scopus 로고    scopus 로고
    • Prediction of in vivo interaction between triazolam and erythromycin based on in vitro studies using human liver microsomes and recombinant human CYP3A4
    • Kanamitsu S, Ito K, Green CE, Tyson CA, Shimada N and Sugiyama Y (2000a) Prediction of in vivo interaction between triazolam and erythromycin based on in vitro studies using human liver microsomes and recombinant human CYP3A4. Pharm Res 17:419-426.
    • (2000) Pharm Res , vol.17 , pp. 419-426
    • Kanamitsu, S.1    Ito, K.2    Green, C.E.3    Tyson, C.A.4    Shimada, N.5    Sugiyama, Y.6
  • 71
    • 0033994866 scopus 로고    scopus 로고
    • Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: Use of maximum unbound concentration of inhibitor at the inlet to the liver
    • Kanamitsu S, Ito K and Sugiyama Y (2000b) Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver. Pharm Res 17:336-343.
    • (2000) Pharm Res , vol.17 , pp. 336-343
    • Kanamitsu, S.1    Ito, K.2    Sugiyama, Y.3
  • 72
    • 37549004782 scopus 로고    scopus 로고
    • HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans
    • Kanebratt KP and Andersson TB (2008) HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans. Drug Metab Dispos 36:137-145.
    • (2008) Drug Metab Dispos , vol.36 , pp. 137-145
    • Kanebratt, K.P.1    Andersson, T.B.2
  • 73
    • 33646498651 scopus 로고    scopus 로고
    • The quantitative prediction of in vivo enzyme-induction caused by drug exposure from in vitro information on human hepatocytes
    • Kato M, Chiba K, Horikawa M and Sugiyama Y (2005) The quantitative prediction of in vivo enzyme-induction caused by drug exposure from in vitro information on human hepatocytes. Drug Metab Pharmacokinet 20:236-243.
    • (2005) Drug Metab Pharmacokinet , vol.20 , pp. 236-243
    • Kato, M.1    Chiba, K.2    Horikawa, M.3    Sugiyama, Y.4
  • 74
    • 56749185575 scopus 로고    scopus 로고
    • Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies
    • Kenny JR, Chen L, McGinnity DF, Grime K, Shakesheff KM, Thomson B and Riley R (2008) Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies. Xenobiotica 38:1500-1517.
    • (2008) Xenobiotica , vol.38 , pp. 1500-1517
    • Kenny, J.R.1    Chen, L.2    McGinnity, D.F.3    Grime, K.4    Shakesheff, K.M.5    Thomson, B.6    Riley, R.7
  • 75
    • 0034869034 scopus 로고    scopus 로고
    • Mechanism-based inactivators as probes of cytochrome P450 structure and function
    • Kent UM, Juschyshyn MI and Hollenberg PF (2001) Mechanism-based inactivators as probes of cytochrome P450 structure and function. Curr Drug Metab 2:215-243.
    • (2001) Curr Drug Metab , vol.2 , pp. 215-243
    • Kent, U.M.1    Juschyshyn, M.I.2    Hollenberg, P.F.3
  • 77
    • 0035193493 scopus 로고    scopus 로고
    • Multisite kinetic models for CYP3A4: Simultaneous activation and inhibition of diazepam and testosterone metabolism
    • Kenworthy KE, Clarke SE, Andrews J and Houston JB (2001) Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism. Drug Metab Dispos 29:1644-1651.
    • (2001) Drug Metab Dispos , vol.29 , pp. 1644-1651
    • Kenworthy, K.E.1    Clarke, S.E.2    Andrews, J.3    Houston, J.B.4
  • 78
    • 46449126478 scopus 로고    scopus 로고
    • Hepatocellular binding of drugs: Correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data
    • Kilford PJ, Gertz M, Houston JB and Galetin A (2008) Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data. Drug Metab Dispos 36:1194-1197.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1194-1197
    • Kilford, P.J.1    Gertz, M.2    Houston, J.B.3    Galetin, A.4
  • 79
    • 58149472377 scopus 로고    scopus 로고
    • Prediction of drug clearance by glucuronidation from in vitro data: Use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes
    • Kilford PJ, Stringer R, Sohal B, Houston JB and Galetin A (2009) Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes. Drug Metab Dispos 37:82-89.
    • (2009) Drug Metab Dispos , vol.37 , pp. 82-89
    • Kilford, P.J.1    Stringer, R.2    Sohal, B.3    Houston, J.B.4    Galetin, A.5
  • 80
    • 66649134127 scopus 로고    scopus 로고
    • Quantitative prediction of in vivo profiles of CYP3A4 induction in humans from in vitro results with reporter gene assay
    • Kozawa M, Honma M and Suzuki H (2009) Quantitative prediction of in vivo profiles of CYP3A4 induction in humans from in vitro results with reporter gene assay. Drug Metab Dispos 37:1234-1241.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1234-1241
    • Kozawa, M.1    Honma, M.2    Suzuki, H.3
  • 81
    • 61549083067 scopus 로고    scopus 로고
    • Prediction of the effects of genetic polymorphism on the pharmacokinetics of CYP2C9 substrates from in vitro data
    • Kusama M, Maeda K, Chiba K, Aoyama A and Sugiyama Y (2009) Prediction of the effects of genetic polymorphism on the pharmacokinetics of CYP2C9 substrates from in vitro data. Pharm Res 26:822-835.
    • (2009) Pharm Res , vol.26 , pp. 822-835
    • Kusama, M.1    Maeda, K.2    Chiba, K.3    Aoyama, A.4    Sugiyama, Y.5
  • 82
    • 33846571368 scopus 로고    scopus 로고
    • Effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers
    • Lau YY, Huang Y, Frassetto L and Benet LZ (2007) Effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Clin Pharmacol Ther 81:194-204.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 194-204
    • Lau, Y.Y.1    Huang, Y.2    Frassetto, L.3    Benet, L.Z.4
  • 83
    • 0034964158 scopus 로고    scopus 로고
    • Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation
    • Le Cluyse EL (2001a) Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. Eur J Pharm Sci 13:343-368.
    • (2001) Eur J Pharm Sci , vol.13 , pp. 343-368
    • Le Cluyse, E.L.1
  • 84
    • 0035897713 scopus 로고    scopus 로고
    • Pregnane X receptor: Molecular basis for species differences in CYP3A induction by xenobiotics
    • Le Cluyse EL (2001b) Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics. Chem Biol Interact 134:283-289.
    • (2001) Chem Biol Interact , vol.134 , pp. 283-289
    • Le Cluyse, E.L.1
  • 85
    • 35348860160 scopus 로고    scopus 로고
    • Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: Experience from in vivo dissolution and permeability studies in humans
    • Lennernas H (2007) Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: experience from in vivo dissolution and permeability studies in humans. Curr Drug Metab 8:645-657.
    • (2007) Curr Drug Metab , vol.8 , pp. 645-657
    • Lennernas, H.1
  • 86
    • 33745395225 scopus 로고    scopus 로고
    • CYP induction-mediated drug interactions: In vitro assessment and clinical implications
    • Lin JH (2006) CYP induction-mediated drug interactions: in vitro assessment and clinical implications. Pharm Res 23:1089-1116.
    • (2006) Pharm Res , vol.23 , pp. 1089-1116
    • Lin, J.H.1
  • 87
    • 0030774776 scopus 로고    scopus 로고
    • In vivo assessment of intestinal drug metabolism
    • Lin JH, Chiba M and Baillie TA (1997) In vivo assessment of intestinal drug metabolism. Drug Metab Dispos 25:1107-1109.
    • (1997) Drug Metab Dispos , vol.25 , pp. 1107-1109
    • Lin, J.H.1    Chiba, M.2    Baillie, T.A.3
  • 88
    • 0037379318 scopus 로고    scopus 로고
    • Cytochrome P450 in vitro reaction phenotyping: A reevaluation of approaches used for P450 isoform identification
    • Lu AY, Wang RW and Lin JH (2003) Cytochrome P450 in vitro reaction phenotyping: a reevaluation of approaches used for P450 isoform identification. Drug Metab Dispos 31:345-350.
    • (2003) Drug Metab Dispos , vol.31 , pp. 345-350
    • Lu, A.Y.1    Wang, R.W.2    Lin, J.H.3
  • 92
    • 0037403747 scopus 로고    scopus 로고
    • Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6: Implications for relating in vitro inhibition data to in vivo drug interactions
    • Margolis JM and Obach RS (2003) Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6: implications for relating in vitro inhibition data to in vivo drug interactions. Drug Metab Dispos 31:606-611.
    • (2003) Drug Metab Dispos , vol.31 , pp. 606-611
    • Margolis, J.M.1    Obach, R.S.2
  • 93
    • 0033743402 scopus 로고    scopus 로고
    • Impact of mechanism-based enzyme inactivation on inhibitor potency: Implications for rational drug discovery
    • Maurer TS, Tabrizi-Fard MA and Fung HL (2000) Impact of mechanism-based enzyme inactivation on inhibitor potency: implications for rational drug discovery. J Pharm Sci 89:1404-1414.
    • (2000) J Pharm Sci , vol.89 , pp. 1404-1414
    • Maurer, T.S.1    Tabrizi-Fard, M.A.2    Fung, H.L.3
  • 94
    • 4644331461 scopus 로고    scopus 로고
    • Differences in the inhibition of cytochromes P450 3A4 and 3A5 by metabolite-inhibitor complex-forming drugs
    • McConn DJ, 2nd, Lin YS, Allen K, Kunze KL and Thummel KE (2004) Differences in the inhibition of cytochromes P450 3A4 and 3A5 by metabolite-inhibitor complex-forming drugs. Drug Metab Dispos 32:1083-1091.
    • (2004) Drug Metab Dispos , vol.32 , pp. 1083-1091
    • McConn II, D.J.1    Lin, Y.S.2    Allen, K.3    Kunze, K.L.4    Thummel, K.E.5
  • 95
    • 33746047547 scopus 로고    scopus 로고
    • Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes
    • McGinnity DF, Berry AJ, Kenny JR, Grime K and Riley RJ (2006) Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes. Drug Metab Dispos 34:1291-1300.
    • (2006) Drug Metab Dispos , vol.34 , pp. 1291-1300
    • McGinnity, D.F.1    Berry, A.J.2    Kenny, J.R.3    Grime, K.4    Riley, R.J.5
  • 96
    • 44149099572 scopus 로고    scopus 로고
    • Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions
    • McGinnity DF, Waters NJ, Tucker J and Riley RJ (2008) Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions. Drug Metab Dispos 36:1126-1134.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1126-1134
    • McGinnity, D.F.1    Waters, N.J.2    Tucker, J.3    Riley, R.J.4
  • 97
    • 66649089506 scopus 로고    scopus 로고
    • Evaluation of multiple in vitro systems for assessment of CYP3A4 Induction in Drug Discovery: Human hepatocytes, PXR reporter gene, Fa2N-4 and HepaRG cells
    • McGinnity DF, Zhang G, Kenny J, Hamilton G, Otmani S, Stams K, Haney S, Brassil P, Stresser DM and Riley RJ (2009) Evaluation of multiple in vitro systems for assessment of CYP3A4 Induction in Drug Discovery: Human hepatocytes, PXR reporter gene, Fa2N-4 and HepaRG cells. Drug Metab Dispos 37:1259-1268.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1259-1268
    • McGinnity, D.F.1    Zhang, G.2    Kenny, J.3    Hamilton, G.4    Otmani, S.5    Stams, K.6    Haney, S.7    Brassil, P.8    Stresser, D.M.9    Riley, R.J.10
  • 98
    • 0033624124 scopus 로고    scopus 로고
    • Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: A 10-year follow-up
    • Meunier V, Bourrie M, Julian B, Marti E, Guillou F, Berger Y and Fabre G (2000) Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up. Xenobiotica 30:589-607.
    • (2000) Xenobiotica , vol.30 , pp. 589-607
    • Meunier, V.1    Bourrie, M.2    Julian, B.3    Marti, E.4    Guillou, F.5    Berger, Y.6    Fabre, G.7
  • 99
    • 1642273510 scopus 로고    scopus 로고
    • Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line
    • Mills JB, Rose KA, Sadagopan N, Sahi J and De Morais SM (2004) Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line. J Pharmacol Exp Ther 309:303-309.
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 303-309
    • Mills, J.B.1    Rose, K.A.2    Sadagopan, N.3    Sahi, J.4    De Morais, S.M.5
  • 100
    • 34548103493 scopus 로고    scopus 로고
    • Role of OATP transporters in the disposition of drugs
    • Niemi M (2007) Role of OATP transporters in the disposition of drugs. Pharmacogenomics 8:787-802.
    • (2007) Pharmacogenomics , vol.8 , pp. 787-802
    • Niemi, M.1
  • 102
    • 0032733974 scopus 로고    scopus 로고
    • Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes
    • Obach RS (1999) Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes. Drug Metab Dispos 27:1350-1359.
    • (1999) Drug Metab Dispos , vol.27 , pp. 1350-1359
    • Obach, R.S.1
  • 103
    • 33846449874 scopus 로고    scopus 로고
    • Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions
    • Obach RS, Walsky RL and Venkatakrishnan K (2007) Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions. Drug Metab Dispos 35:246-255.
    • (2007) Drug Metab Dispos , vol.35 , pp. 246-255
    • Obach, R.S.1    Walsky, R.L.2    Venkatakrishnan, K.3
  • 105
    • 28844476587 scopus 로고    scopus 로고
    • In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach
    • Obach RS, Walsky RL, Venkatakrishnan K, Houston JB and Tremaine LM (2005) In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach. Clin Pharmacol Ther 78:582-592.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 582-592
    • Obach, R.S.1    Walsky, R.L.2    Venkatakrishnan, K.3    Houston, J.B.4    Tremaine, L.M.5
  • 106
    • 29944446317 scopus 로고    scopus 로고
    • Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: Implications for drug-drug interactions
    • Ogilvie BW, Zhang D, Li W, Rodrigues AD, Gipson AE, Holsapple J, Toren P and Parkinson A (2006) Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions. Drug Metab Dispos 34:191-197.
    • (2006) Drug Metab Dispos , vol.34 , pp. 191-197
    • Ogilvie, B.W.1    Zhang, D.2    Li, W.3    Rodrigues, A.D.4    Gipson, A.E.5    Holsapple, J.6    Toren, P.7    Parkinson, A.8
  • 107
    • 51649098439 scopus 로고    scopus 로고
    • General framework for the prediction of oral drug interactions caused by CYP3A4 induction from in vivo information
    • Ohno Y, Hisaka A, Ueno M and Suzuki H (2008) General framework for the prediction of oral drug interactions caused by CYP3A4 induction from in vivo information. Clin Pharmacokinet 47:669-680.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 669-680
    • Ohno, Y.1    Hisaka, A.2    Ueno, M.3    Suzuki, H.4
  • 110
    • 0032807936 scopus 로고    scopus 로고
    • Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam
    • Palkama VJ, Ahonen J, Neuvonen PJ and Olkkola KT (1999) Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam. Clin Pharmacol Ther 66:33-39.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 33-39
    • Palkama, V.J.1    Ahonen, J.2    Neuvonen, P.J.3    Olkkola, K.T.4
  • 111
    • 0345275778 scopus 로고    scopus 로고
    • Modeling of intestinal drug absorption: Roles of transporters and metabolic enzymes (for the Gillette Review Series)
    • Pang KS (2003) Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the Gillette Review Series). Drug Metab Dispos 31:1507-1519.
    • (2003) Drug Metab Dispos , vol.31 , pp. 1507-1519
    • Pang, K.S.1
  • 112
    • 0017603437 scopus 로고
    • Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance
    • Pang KS and Rowland M (1977) Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance. J Pharmacokinet Biopharm 5:625-653.
    • (1977) J Pharmacokinet Biopharm , vol.5 , pp. 625-653
    • Pang, K.S.1    Rowland, M.2
  • 113
    • 4444278991 scopus 로고    scopus 로고
    • The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes
    • Parkinson A, Mudra DR, Johnson C, Dwyer A and Carroll KM (2004) The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes. Toxicol Appl Pharmacol 199:193-209.
    • (2004) Toxicol Appl Pharmacol , vol.199 , pp. 193-209
    • Parkinson, A.1    Mudra, D.R.2    Johnson, C.3    Dwyer, A.4    Carroll, K.M.5
  • 116
    • 10044257558 scopus 로고    scopus 로고
    • Mechanism-based inactivation of human cytochrome P4502C8 by drugs in vitro
    • Polasek TM, Elliot DJ, Lewis BC and Miners JO (2004) Mechanism-based inactivation of human cytochrome P4502C8 by drugs in vitro. J Pharmacol Exp Ther 311:996-1007.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 996-1007
    • Polasek, T.M.1    Elliot, D.J.2    Lewis, B.C.3    Miners, J.O.4
  • 117
    • 33644827609 scopus 로고    scopus 로고
    • Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate
    • Polasek TM and Miners JO (2006) Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate. Eur J Clin Pharmacol 62:203-208.
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 203-208
    • Polasek, T.M.1    Miners, J.O.2
  • 118
    • 34548283499 scopus 로고    scopus 로고
    • In vitro approaches to investigate mechanism-based inactivation of CYP enzymes
    • Polasek TM and Miners JO (2007) In vitro approaches to investigate mechanism-based inactivation of CYP enzymes. Expert Opin Drug Metab Toxicol 3:321-329.
    • (2007) Expert Opin Drug Metab Toxicol , vol.3 , pp. 321-329
    • Polasek, T.M.1    Miners, J.O.2
  • 121
    • 33748905486 scopus 로고    scopus 로고
    • Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction
    • Ripp SL, Mills JB, Fahmi OA, Trevena KA, Liras JL, Maurer TS and De Morais SM (2006) Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction. Drug Metab Dispos 34:1742-1748.
    • (2006) Drug Metab Dispos , vol.34 , pp. 1742-1748
    • Ripp, S.L.1    Mills, J.B.2    Fahmi, O.A.3    Trevena, K.A.4    Liras, J.L.5    Maurer, T.S.6    De Morais, S.M.7
  • 122
    • 13244287685 scopus 로고    scopus 로고
    • In silico simulations to assess the 'in vivo' consequences of 'in vitro' metabolic drug-drug interactions
    • Rostami-Hodjegan A and Tucker G (2004) In silico simulations to assess the 'in vivo' consequences of 'in vitro' metabolic drug-drug interactions. Drug Discov Today Tech 1:441.
    • (2004) Drug Discov Today Tech , vol.1 , pp. 441
    • Rostami-Hodjegan, A.1    Tucker, G.2
  • 123
    • 33947587274 scopus 로고    scopus 로고
    • Simulation and prediction of in vivo drug metabolism in human populations from in vitro data
    • Rostami-Hodjegan A and Tucker GT (2007) Simulation and prediction of in vivo drug metabolism in human populations from in vitro data. Nat Rev Drug Discov 6:140.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 140
    • Rostami-Hodjegan, A.1    Tucker, G.T.2
  • 127
    • 33645847236 scopus 로고    scopus 로고
    • Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam
    • Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ and Olkkola KT (2006) Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam. Clin Pharmacol Ther 79:362-370.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 362-370
    • Saari, T.I.1    Laine, K.2    Leino, K.3    Valtonen, M.4    Neuvonen, P.J.5    Olkkola, K.T.6
  • 128
    • 23644436684 scopus 로고    scopus 로고
    • Undesirable effects of citrus juice on the pharmacokinetics of drugs: Focus on recent studies
    • Saito M, Hirata-Koizumi M, Matsumoto M, Urano T and Hasegawa R (2005) Undesirable effects of citrus juice on the pharmacokinetics of drugs: focus on recent studies. Drug Saf 28:677-694.
    • (2005) Drug Saf , vol.28 , pp. 677-694
    • Saito, M.1    Hirata-Koizumi, M.2    Matsumoto, M.3    Urano, T.4    Hasegawa, R.5
  • 132
    • 66449097352 scopus 로고    scopus 로고
    • Antibodies as a probe in cytochrome P450 research
    • Shou M and Lu AY (2009) Antibodies as a probe in cytochrome P450 research. Drug Metab Dispos 37:925-931.
    • (2009) Drug Metab Dispos , vol.37 , pp. 925-931
    • Shou, M.1    Lu, A.Y.2
  • 134
    • 0028930481 scopus 로고
    • Mechanism-based enzyme inactivators
    • Silverman RB (1995) Mechanism-based enzyme inactivators. Methods Enzymol 249:240-283.
    • (1995) Methods Enzymol , vol.249 , pp. 240-283
    • Silverman, R.B.1
  • 135
    • 33646517938 scopus 로고    scopus 로고
    • Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions
    • Sinz M, Kim S, Zhu Z, Chen T, Anthony M, Dickinson K and Rodrigues AD (2006) Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions. Curr Drug Metab 7:375-388.
    • (2006) Curr Drug Metab , vol.7 , pp. 375-388
    • Sinz, M.1    Kim, S.2    Zhu, Z.3    Chen, T.4    Anthony, M.5    Dickinson, K.6    Rodrigues, A.D.7
  • 136
    • 34249006024 scopus 로고    scopus 로고
    • Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo
    • Soars MG, Grime K, Sproston JL, Webborn PJ and Riley RJ (2007) Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo. Drug Metab Dispos 35:859-865.
    • (2007) Drug Metab Dispos , vol.35 , pp. 859-865
    • Soars, M.G.1    Grime, K.2    Sproston, J.L.3    Webborn, P.J.4    Riley, R.J.5
  • 137
    • 53849115780 scopus 로고    scopus 로고
    • Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance
    • Stringer R, Nicklin PL and Houston JB (2008) Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance. Xenobiotica 38:1313-1329.
    • (2008) Xenobiotica , vol.38 , pp. 1313-1329
    • Stringer, R.1    Nicklin, P.L.2    Houston, J.B.3
  • 138
    • 0037378726 scopus 로고    scopus 로고
    • Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption
    • Tam D, Tirona RG and Pang KS (2003) Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption. Drug Metab Dispos 31:373-383.
    • (2003) Drug Metab Dispos , vol.31 , pp. 373-383
    • Tam, D.1    Tirona, R.G.2    Pang, K.S.3
  • 139
    • 17844385047 scopus 로고    scopus 로고
    • Metabolism-based drug-drug interactions: What determines individual variability in cytochrome P450 induction?
    • Tang C, Lin JH and Lu AY (2005) Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?. Drug Metab Dispos 33:603-613.
    • (2005) Drug Metab Dispos , vol.33 , pp. 603-613
    • Tang, C.1    Lin, J.H.2    Lu, A.Y.3
  • 141
    • 0342437515 scopus 로고    scopus 로고
    • Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction
    • Thummel KE, Kunze KL and Shen DD (1997) Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction. Adv Drug Deliv Rev 27:99-127.
    • (1997) Adv Drug Deliv Rev , vol.27 , pp. 99-127
    • Thummel, K.E.1    Kunze, K.L.2    Shen, D.D.3
  • 143
    • 0032700543 scopus 로고    scopus 로고
    • Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: Effect of ketoconazole
    • Tsunoda SM, Velez RL, Von Moltke LL and Greenblatt DJ (1999) Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole. Clin Pharmacol Ther 66:461-471.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 461-471
    • Tsunoda, S.M.1    Velez, R.L.2    Von Moltke, L.L.3    Greenblatt, D.J.4
  • 144
    • 33746893861 scopus 로고    scopus 로고
    • In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect
    • Tubic M, Wagner D, Spahn-Langguth H, Bolger MB and Langguth P (2006) In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect. Pharm Res 23:1712-1720.
    • (2006) Pharm Res , vol.23 , pp. 1712-1720
    • Tubic, M.1    Wagner, D.2    Spahn-Langguth, H.3    Bolger, M.B.4    Langguth, P.5
  • 145
    • 0034883375 scopus 로고    scopus 로고
    • Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential-toward a consensus
    • Tucker GT, Houston JB and Huang SM (2001) Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus. Clin Pharmacol Ther 70:103-114.
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 103-114
    • Tucker, G.T.1    Houston, J.B.2    Huang, S.M.3
  • 146
    • 52949103260 scopus 로고    scopus 로고
    • Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites
    • Uchaipichat V, Galetin A, Houston JB, Mackenzie PI, Williams JA and Miners JO (2008) Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites. Mol Pharmacol 74:1152-1162.
    • (2008) Mol Pharmacol , vol.74 , pp. 1152-1162
    • Uchaipichat, V.1    Galetin, A.2    Houston, J.B.3    Mackenzie, P.I.4    Williams, J.A.5    Miners, J.O.6
  • 147
    • 1842536833 scopus 로고    scopus 로고
    • Human udp-glucuronosyltransferases: Isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid
    • Uchaipichat V, Mackenzie PI, Guo XH, Gardner-Stephen D, Galetin A, Houston JB and Miners JO (2004) Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid. Drug Metab Dispos 32:413-423.
    • (2004) Drug Metab Dispos , vol.32 , pp. 413-423
    • Uchaipichat, V.1    Mackenzie, P.I.2    Guo, X.H.3    Gardner-Stephen, D.4    Galetin, A.5    Houston, J.B.6    Miners, J.O.7
  • 149
    • 34247152053 scopus 로고    scopus 로고
    • Kinetics of the time-dependent inactivation of CYP2D6 in cryopreserved human hepatocytes by methylenedioxymethamphetamine (MDMA)
    • Van LM, Swales J, Hammond C, Wilson C, Hargreaves JA and Rostami-Hodjegan A (2007) Kinetics of the time-dependent inactivation of CYP2D6 in cryopreserved human hepatocytes by methylenedioxymethamphetamine (MDMA). Eur J Pharm Sci 31:53-61.
    • (2007) Eur J Pharm Sci , vol.31 , pp. 53-61
    • Van, L.M.1    Swales, J.2    Hammond, C.3    Wilson, C.4    Hargreaves, J.A.5    Rostami-Hodjegan, A.6
  • 150
    • 18844426008 scopus 로고    scopus 로고
    • In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: Prediction of nonstationary pharmacokinetics and drug interaction magnitude
    • Venkatakrishnan K and Obach RS (2005) In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: prediction of nonstationary pharmacokinetics and drug interaction magnitude. Drug Metab Dispos 33:845-852.
    • (2005) Drug Metab Dispos , vol.33 , pp. 845-852
    • Venkatakrishnan, K.1    Obach, R.S.2
  • 151
    • 34548738229 scopus 로고    scopus 로고
    • Drug-drug interactions via mechanism-based cytochrome P450 inactivation: Points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation
    • Venkatakrishnan K and Obach RS (2007) Drug-drug interactions via mechanism-based cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation. Curr Drug Metab 8:449-462.
    • (2007) Curr Drug Metab , vol.8 , pp. 449-462
    • Venkatakrishnan, K.1    Obach, R.S.2
  • 152
    • 0033674502 scopus 로고    scopus 로고
    • Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: Ratios of accessory proteins as sources of discrepancies between the approaches
    • Venkatakrishnan K, Von Moltke LL, Court MH, Harmatz JS, Crespi CL and Greenblatt DJ (2000) Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches. Drug Metab Dispos 28:1493-1504.
    • (2000) Drug Metab Dispos , vol.28 , pp. 1493-1504
    • Venkatakrishnan, K.1    Von Moltke, L.L.2    Court, M.H.3    Harmatz, J.S.4    Crespi, C.L.5    Greenblatt, D.J.6
  • 154
    • 0033948964 scopus 로고    scopus 로고
    • Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir: Comparison with ketoconazole
    • Von Moltke LL, Durol AL, Duan SX and Greenblatt DJ (2000) Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir: comparison with ketoconazole. Eur J Clin Pharmacol 56:259-261.
    • (2000) Eur J Clin Pharmacol , vol.56 , pp. 259-261
    • Von Moltke, L.L.1    Durol, A.L.2    Duan, S.X.3    Greenblatt, D.J.4
  • 155
    • 33750711672 scopus 로고    scopus 로고
    • Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6
    • Walsky RL, Astuccio AV and Obach RS (2006) Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol 46:1426-1438.
    • (2006) J Clin Pharmacol , vol.46 , pp. 1426-1438
    • Walsky, R.L.1    Astuccio, A.V.2    Obach, R.S.3
  • 156
    • 60749119589 scopus 로고    scopus 로고
    • In vitro cytochrome P450 inhibition and induction
    • Walsky RL and Boldt SE (2008) In vitro cytochrome P450 inhibition and induction. Curr Drug Metab 9:928-939.
    • (2008) Curr Drug Metab , vol.9 , pp. 928-939
    • Walsky, R.L.1    Boldt, S.E.2
  • 157
    • 2442690439 scopus 로고    scopus 로고
    • Validated assays for human cytochrome P450 activities
    • Walsky RL and Obach RS (2004) Validated assays for human cytochrome P450 activities. Drug Metab Dispos 32:647-660.
    • (2004) Drug Metab Dispos , vol.32 , pp. 647-660
    • Walsky, R.L.1    Obach, R.S.2
  • 158
    • 0842282550 scopus 로고    scopus 로고
    • Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites
    • Wang YH, Jones DR and Hall SD (2004) Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites. Drug Metab Dispos 32:259-266.
    • (2004) Drug Metab Dispos , vol.32 , pp. 259-266
    • Wang, Y.H.1    Jones, D.R.2    Hall, S.D.3
  • 159
    • 17844387084 scopus 로고    scopus 로고
    • Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil
    • Wang YH, Jones DR and Hall SD (2005) Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab Dispos 33:664-671.
    • (2005) Drug Metab Dispos , vol.33 , pp. 664-671
    • Wang, Y.H.1    Jones, D.R.2    Hall, S.D.3
  • 160
    • 0016566218 scopus 로고
    • Commentary: A physiological approach to hepatic drug clearance
    • Wilkinson GR and Shand DG (1975) Commentary: a physiological approach to hepatic drug clearance. Clin Pharmacol Ther 18:377-390.
    • (1975) Clin Pharmacol Ther , vol.18 , pp. 377-390
    • Wilkinson, G.R.1    Shand, D.G.2
  • 162
    • 0030058072 scopus 로고    scopus 로고
    • A general progress curve method for the kinetic analysis of suicide enzyme inhibitors
    • Wimalasena K and Haines DC (1996) A general progress curve method for the kinetic analysis of suicide enzyme inhibitors. Anal Biochem 234:175-182.
    • (1996) Anal Biochem , vol.234 , pp. 175-182
    • Wimalasena, K.1    Haines, D.C.2
  • 163
    • 0032480901 scopus 로고    scopus 로고
    • Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach
    • Winiwarter S, Bonham NM, Ax F, Hallberg A, Lennernas H and Karlen A (1998) Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. J Med Chem 41:4939-4949.
    • (1998) J Med Chem , vol.41 , pp. 4939-4949
    • Winiwarter, S.1    Bonham, N.M.2    Ax, F.3    Hallberg, A.4    Lennernas, H.5    Karlen, A.6
  • 165
    • 0442313590 scopus 로고    scopus 로고
    • High-throughput screening for the assessment of timedependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method
    • Yamamoto T, Suzuki A and Kohno Y (2004) High-throughput screening for the assessment of timedependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method. Xenobiotica 34:87-101.
    • (2004) Xenobiotica , vol.34 , pp. 87-101
    • Yamamoto, T.1    Suzuki, A.2    Kohno, Y.3
  • 166
    • 24644441043 scopus 로고    scopus 로고
    • Kinetic values for mechanism-based enzyme inhibition: Assessing the bias introduced by the conventional experimental protocol
    • Yang J, Jamei M, Yeo KR, Tucker GT and Rostami-Hodjegan A (2005) Kinetic values for mechanism-based enzyme inhibition: assessing the bias introduced by the conventional experimental protocol. Eur J Pharm Sci 26:334-340.
    • (2005) Eur J Pharm Sci , vol.26 , pp. 334-340
    • Yang, J.1    Jamei, M.2    Yeo, K.R.3    Tucker, G.T.4    Rostami-Hodjegan, A.5
  • 168
    • 34249274907 scopus 로고    scopus 로고
    • Theoretical assessment of a new experimental protocol for determining kinetic values describing mechanism (time)-based enzyme inhibition
    • Yang J, Jamei M, Yeo KR, Tucker GT and Rostami-Hodjegan A (2007b) Theoretical assessment of a new experimental protocol for determining kinetic values describing mechanism (time)-based enzyme inhibition. Eur J Pharm Sci 31:232-241.
    • (2007) Eur J Pharm Sci , vol.31 , pp. 232-241
    • Yang, J.1    Jamei, M.2    Yeo, K.R.3    Tucker, G.T.4    Rostami-Hodjegan, A.5
  • 169
    • 47749122616 scopus 로고    scopus 로고
    • Cytochrome p450 turnover: Regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions
    • Yang J, Liao M, Shou M, Jamei M, Yeo KR, Tucker GT and Rostami-Hodjegan A (2008) Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions. Curr Drug Metab 9:384-394.
    • (2008) Curr Drug Metab , vol.9 , pp. 384-394
    • Yang, J.1    Liao, M.2    Shou, M.3    Jamei, M.4    Yeo, K.R.5    Tucker, G.T.6    Rostami-Hodjegan, A.7
  • 170
    • 4644301430 scopus 로고    scopus 로고
    • The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution
    • Yano JK, Wester MR, Schoch GA, Griffin KJ, Stout CD and Johnson EF (2004) The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution. J Biol Chem 279:38091-38094.
    • (2004) J Biol Chem , vol.279 , pp. 38091-38094
    • Yano, J.K.1    Wester, M.R.2    Schoch, G.A.3    Griffin, K.J.4    Stout, C.D.5    Johnson, E.F.6
  • 171
    • 0036771085 scopus 로고    scopus 로고
    • Inhibition-based metabolic drug-drug interactions: Predictions from in vitro data
    • Yao C and Levy RH (2002) Inhibition-based metabolic drug-drug interactions: predictions from in vitro data. J Pharm Sci 91:1923-1935.
    • (2002) J Pharm Sci , vol.91 , pp. 1923-1935
    • Yao, C.1    Levy, R.H.2
  • 172
    • 0034854303 scopus 로고    scopus 로고
    • Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes
    • Yeo KR and Yeo WW (2001) Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes. Br J Clin Pharmacol 51:461-470.
    • (2001) Br J Clin Pharmacol , vol.51 , pp. 461-470
    • Yeo, K.R.1    Yeo, W.W.2
  • 174
    • 0032888376 scopus 로고    scopus 로고
    • A compartmental absorption and transit model for estimating oral drug absorption
    • Yu LX and Amidon GL (1999) A compartmental absorption and transit model for estimating oral drug absorption. Int J Pharm 186:119-125.
    • (1999) Int J Pharm , vol.186 , pp. 119-125
    • Yu, L.X.1    Amidon, G.L.2
  • 176
    • 58149464706 scopus 로고    scopus 로고
    • Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition
    • Zhang X, Jones DR and Hall SD (2009) Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition. Drug Metab Dispos 37:150-160.
    • (2009) Drug Metab Dispos , vol.37 , pp. 150-160
    • Zhang, X.1    Jones, D.R.2    Hall, S.D.3
  • 178
    • 57749171180 scopus 로고    scopus 로고
    • Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: Unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite
    • Zheng HX, Huang Y, Frassetto LA and Benet LZ (2009) Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite. Clin Pharmacol Ther 85:78-85.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 78-85
    • Zheng, H.X.1    Huang, Y.2    Frassetto, L.A.3    Benet, L.Z.4


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