Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

Drug Metabolism and Disposition

Volumn 31, Issue 4, 2003, Pages 421-431

  Madan, Ajay ^a,j   Graham, Richard A ^a   Carroll, Kathleen M ^a   Mudra, Daniel R ^a   Alayne Burton, L ^a   Krueger, Linda A ^a   Downey, April D ^a   Czerwinski, Maciej ^a   Forster, Jameson ^b   Ribadeneira, Maria D ^c   Gan, Liang Shang ^c,k   Lecluyse, Edward L ^d   Zech, Karl ^e   Robertson Jr , Philmore ^f   Koch, Patrick ^g   Antonian, Lida ^h   Wagner, Greg ^h   Yu, Li ⁱ   Parkinson, Andrew ^a  

^a XenoTech LLC   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c DUPONT COMPANY   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e ALTANA PHARMA AG   (Germany)

^f CEPHALON INC   (United States)

^g SUNOVION PHARMACEUTICALS INC   (United States)

^h SUGEN INC   (United States)

ⁱ PFIZER INC   (United States)

^j NEUROCRINE BIOSCIENCES INC   (United States)

^k ASTRAZENECA   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA NAPHTHOFLAVONE; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 3A; ENZYME INDUCING AGENT; ISONIAZID; MICROSOME ENZYME; OMEPRAZOLE; PHENOBARBITAL; RIFAMPICIN;

ARTICLE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; LIVER CELL; LIVER CELL CULTURE; LIVER MICROSOME; MICROSOME MEMBRANE; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ARYL HYDROCARBON HYDROXYLASES; BETA-NAPHTHOFLAVONE; BLOTTING, WESTERN; CELLS, CULTURED; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATOCYTES; HUMANS; ISONIAZID; LIVER; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOBARBITAL; RIFAMPIN;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0037379409     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.31.4.421     Document Type: Article

References (63)

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