Multisite kinetic models for CYP3A4: Simultaneous activation and inhibition of diazepam and testosterone metabolism

Drug Metabolism and Disposition

Volumn 29, Issue 12, 2001, Pages 1644-1651

  Kenworthy, K E ^a   Clarke, S E ^a   Andrews, J ^a   Houston, J B ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6BETA HYDROXYTESTOSTERONE; CYTOCHROME P450 3A4; DIAZEPAM; NORDAZEPAM; RECOMBINANT CYTOCHROME P450 3A4; TEMAZEPAM; TESTOSTERONE; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOBLAST; CONTROLLED STUDY; DRUG ACTIVATION; DRUG CLEARANCE; DRUG INHIBITION; DRUG METABOLISM; ENZYME KINETICS; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; LIVER METABOLISM; LYMPHOBLASTOID CELL; PRIORITY JOURNAL; TESTOSTERONE METABOLISM;

ALGORITHMS; ANTI-ANXIETY AGENTS; BINDING SITES; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; DIAZEPAM; DRUG INTERACTIONS; HUMANS; LEUKEMIA, LYMPHOCYTIC; MICROSOMES; MIXED FUNCTION OXYGENASES; MODELS, BIOLOGICAL; SUBSTRATE SPECIFICITY; TESTOSTERONE; TUMOR CELLS, CULTURED;

EID: 0035193493     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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